Pancytopenia and Peripheral Neuropathy in a Woman with Altered Liver Function Tests [Clinical Case Study]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Martinez-Morillo, E., Garcia-Garcia, M., Barneo-Caragol, C., Fernandez Fernandez, A., Alvarez, F. V. Tags: General Clinical Chemistry, Clinical Case Studies Clinical Case Study Source Type: research
Optimal Use of Biomarkers for Chronic Kidney Disease [Q&A]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Miller, W. G., Bachmann, L. M., Delanghe, J. R., Inker, L. A., Jones, G. R. D., Vassalotti, J. A. Tags: General Clinical Chemistry Q & amp;A Source Type: research
The Longest Mile: Moving Malaria from Clinical Care to Elimination of Transmission [Perspective]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Budge, P. J., Odom John, A. R. Tags: Infectious Disease, Perspective Source Type: research
Ultrahigh Performance Mass Spectrometry in Clinical Chemistry: A Taste of the Future? [Editorial]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Coelho Graca, D., Lescuyer, P. Tags: Proteomics and Protein Markers Editorial Source Type: research
Glycine: The Queen of Innovation [Unveiling the Right Side]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - June 27, 2019 Category: Chemistry Authors: Anand, U. Tags: Endocrinology and Metabolism Unveiling the Right Side Source Type: research
A Slight Shade of Green [What Is Your Guess?]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - June 27, 2019 Category: Chemistry Authors: Kononen, T. R., Mooney, K. M., Hoekstra, K. A. Tags: Hematology What Is Your Guess? Source Type: research
Hyperglycemia and Adverse Pregnancy Outcomes [Citation Classic]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - June 27, 2019 Category: Chemistry Authors: Metzger, B. E., Coustan, D. R., Trimble, E. R. Tags: Nutrition, Citation Classics Source Type: research
Noninvasive Detection of Bladder Cancer by Shallow-Depth Genome-Wide Bisulfite Sequencing of Urinary Cell-Free DNA for Methylation and Copy Number Profiling [Molecular Diagnostics and Genetics]
CONCLUSIONS:
Bladder cancer can be detected noninvasively in urinary cfDNA by methylomic and copy number analysis without previous knowledge or assumptions of specific aberrations. Such analysis could be used as a liquid biopsy to aid diagnosis and for potential longitudinal monitoring of tumor load. Further understanding of the differential size and fragmentation of cfDNA could improve the detection of bladder cancer. (Source: Clinical Chemistry)
Source: Clinical Chemistry - June 27, 2019 Category: Chemistry Authors: Cheng, T. H. T., Jiang, P., Teoh, J. Y. C., Heung, M. M. S., Tam, J. C. W., Sun, X., Lee, W.-S., Ni, M., Chan, R. C. K., Ng, C.-F., Chan, K. C. A., Chiu, R. W. K., Lo, Y. M. D. Tags: Molecular Diagnostics and Genetics Source Type: research
Detection of Colorectal Cancer in Circulating Cell-Free DNA by Methylated CpG Tandem Amplification and Sequencing [Cancer Diagnostics]
CONCLUSIONS:
MCTA-Seq is a promising method for the noninvasive detection of CRC. (Source: Clinical Chemistry)
Source: Clinical Chemistry - June 27, 2019 Category: Chemistry Authors: Li, J., Zhou, X., Liu, X., Ren, J., Wang, J., Wang, W., Zheng, Y., Shi, X., Sun, T., Li, Z., Kang, A., Tang, F., Wen, L., Fu, W. Tags: Cancer Diagnostics (since 2002) Source Type: research
Noncoding RNAs Serve as Diagnosis and Prognosis Biomarkers for Hepatocellular Carcinoma [Cancer Diagnostics]
CONCLUSIONS:
Our results show that various ncRNA species, not only miRNAs, identified in the small RNA sequencing of plasma are also able to serve as noninvasive biomarkers. Particularly, we identified a domain of srpRNA RN7SL1 with reliable clinical performance for HCC diagnosis and prognosis. (Source: Clinical Chemistry)
Source: Clinical Chemistry - June 27, 2019 Category: Chemistry Authors: Tan, C., Cao, J., Chen, L., Xi, X., Wang, S., Zhu, Y., Yang, L., Ma, L., Wang, D., Yin, J., Zhang, T., John Lu, Z. Tags: Cancer Diagnostics (since 2002) Source Type: research
High-Sensitivity Cardiac Troponin I Assay for Early Diagnosis of Acute Myocardial Infarction [Proteomics and Protein Markers]
CONCLUSIONS:
Diagnostic accuracy and clinical utility of the Beckman hs-cTnI Access assay are very high and at least comparable to Roche hs-cTnT and Abbott hs-cTnI assays. ClinicalTrials.gov Identifier: NCT00470587. (Source: Clinical Chemistry)
Source: Clinical Chemistry - June 27, 2019 Category: Chemistry Authors: Boeddinghaus, J., Nestelberger, T., Twerenbold, R., Koechlin, L., Meier, M., Troester, V., Wussler, D., Badertscher, P., Wildi, K., Puelacher, C., du Fay de Lavallaz, J., Rubini Gimenez, M., Zimmermann, T., Hafner, B., Potlukova, E., Miro, O., Martin-Sanc Tags: Proteomics and Protein Markers Source Type: research
Full-Size and Partially Truncated Cardiac Troponin Complexes in the Blood of Patients with Acute Myocardial Infarction [Proteomics and Protein Markers]
CONCLUSIONS:
A ternary troponin complex exists in 2 forms in the blood of patients with AMI: full-size ITC and LMW-ITC. The binary cTnI-cTnC complex and free cTnT fragments are also present in patient blood. (Source: Clinical Chemistry)
Source: Clinical Chemistry - June 27, 2019 Category: Chemistry Authors: Vylegzhanina, A. V., Kogan, A. E., Katrukha, I. A., Koshkina, E. V., Bereznikova, A. V., Filatov, V. L., Bloshchitsyna, M. N., Bogomolova, A. P., Katrukha, A. G. Tags: Proteomics and Protein Markers Source Type: research
Temporal Changes in Cardiac Troponin I Are Associated with Risk of Cardiovascular Events in the General Population: The Nord-Trondelag Health Study [Proteomics and Protein Markers]
CONCLUSIONS:
Both relative and absolute increases in hs-cTnI are independently associated with cardiovascular risk. For refinement of risk prediction models, the most recent measurement of hs-cTnI should be preferred in clinical practice. (Source: Clinical Chemistry)
Source: Clinical Chemistry - June 27, 2019 Category: Chemistry Authors: Lyngbakken, M. N., Rosjo, H., Holmen, O. L., Dalen, H., Hveem, K., Omland, T. Tags: Proteomics and Protein Markers Source Type: research
Optimization and Comparison of Information-Dependent Acquisition (IDA) to Sequential Window Acquisition of All Theoretical Fragment Ion Spectra (SWATH) for High-Resolution Mass Spectrometry in Clinical Toxicology [Drug Monitoring and Toxicology]
CONCLUSIONS:
This vSWATH method for clinical toxicology demonstrated equivalent analytical sensitivity and specificity for untargeted drug screening and identification in urine samples. vSWATH provided the additional benefit of collecting all tandem mass spectrometry spectra in a sample, which could be useful in discovering low-abundance compounds not discovered by IDA. (Source: Clinical Chemistry)
Source: Clinical Chemistry - June 27, 2019 Category: Chemistry Authors: Whitman, J. D., Lynch, K. L. Tags: Drug Monitoring and Toxicology Source Type: research
Iron Metabolism, Hepcidin, and Mortality (the Ludwigshafen Risk and Cardiovascular Health Study) [Hematology]
CONCLUSIONS:
In stable patients undergoing angiography, serum iron, transferrin saturation, sTfR, and ferritin had J-shaped associations and hemoglobin only a marginal association with cardiovascular and total mortality. Hepcidin was continuously and inversely related to mortality. (Source: Clinical Chemistry)
Source: Clinical Chemistry - June 27, 2019 Category: Chemistry Authors: Grammer, T. B., Scharnagl, H., Dressel, A., Kleber, M. E., Silbernagel, G., Pilz, S., Tomaschitz, A., Koenig, W., Mueller-Myhsok, B., Marz, W., Strnad, P. Tags: Hematology Source Type: research
