How Does the Analytical Quality of the High-Sensitivity Cardiac Troponin T Assay Affect the ESC Rule Out Algorithm for NSTEMI? [Letters to the Editor]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Haagensen, K., Collinson, P., Asberg, A., Aakre, K. M. Tags: Letters to the Editor Source Type: research
Measuring the Turnover Rate of Clinically Important Plasma Proteins using an Automated SISCAPA Workflow [Letters to the Editor]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Razavi, M., Farrokhi, V., Yip, R., Anderson, N. L., Pearson, T. W., Neubert, H. Tags: Proteomics and Protein Markers Letters to the Editor Source Type: research
Early Diagnosis of Myocardial Infarction with Sensitive Cardiac Troponin Assays [Citation Classic]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Mueller, C., Twerenbold, R., Reichlin, T. Tags: Evidence Based Laboratory Medicine and Test Utilization, Citation Classics Source Type: research
Global Adoption of High-Sensitivity Cardiac Troponins and the Universal Definition of Myocardial Infarction [Evidence-Based Medicine and Test Utilization]
CONCLUSIONS:
There has been global progress toward the recommendations of the UDMI, particularly in the use of the 99th percentile diagnostic threshold and serial sampling. However, high-sensitivity assays are still used by a minority of sites, and sex-specific thresholds by even fewer. Additional efforts are required to improve risk stratification and diagnosis of patients with myocardial infarction. (Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Anand, A., Shah, A. S. V., Beshiri, A., Jaffe, A. S., Mills, N. L. Tags: Evidence-Based Medicine and Test Utilization Source Type: research
Trueness Evaluation and Verification of Interassay Agreement of 11 Serum IgA Measuring Systems: Implications for Medical Decisions [Pediatric Clinical Chemistry]
CONCLUSIONS:
Although the harmonization among most commercially available IgA MSs is good, the implementation of traceability to higher order references is inadequate, especially at concentrations ≤0.7 g/L. This analytical background information needs to be considered carefully when defining traceable reference intervals in the pediatric population. (Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Braga, F., Infusino, I., Frusciante, E., Ceriotti, F., Panteghini, M. Tags: Pediatric Clinical Chemistry Source Type: research
Detection and Characterization of Circulating Tumor Cells in Patients with Merkel Cell Carcinoma [Cancer Diagnostics]
CONCLUSIONS:
The presence of CTCs is a prognostic factor of impaired clinical outcome, with the potential to monitor the progression of the disease in real time. Molecular characterization of CTCs might provide new insights into the biology of MCC. (Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Riethdorf, S., Hildebrandt, L., Heinzerling, L., Heitzer, E., Fischer, N., Bergmann, S., Mauermann, O., Waldispuhl-Geigl, J., Coith, C., Schon, G., Peine, S., Schuler, G., Speicher, M. R., Moll, I., Pantel, K. Tags: Cancer Diagnostics (since 2002) Source Type: research
Immunoglobulin-like Domain of HsFc{mu}R as a Capture Molecule for Detection of Crimean-Congo Hemorrhagic Fever Virus- and Zika Virus-Specific IgM Antibodies [Infectious Disease]
CONCLUSIONS:
Recombinant HsFcμR-Igl is a versatile capture molecule for IgM/antigen ICs of human and animal origin and can be applied for the development of both plate- and bead-based serological tests. (Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Rackow, A., Ehmen, C., von Possel, R., Medialdea-Carrera, R., Brown, D., Bispo de Filippis, A. M., Carvalho de Sequeira, P., Ribeiro Nogueira, R. M., Halili, B., Jakupi, X., Berisha, L., Ahmeti, S., Sherifi, K., Schmidt-Chanasit, J., Schmitz, H., Mika, A. Tags: Infectious Disease Source Type: research
Predicting Acute Myocardial Infarction with a Single Blood Draw [Proteomics and Protein Markers]
CONCLUSIONS:
Serial sampling does not seem necessary for predicting AMI and concurrent decision-making in about 10% of patients, as it only marginally increases the PPV for AMI and not in a statistically or clinically significant way.
ClinicalTrials.gov Identifier:
NCT00470587. (Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Boeddinghaus, J., Nestelberger, T., Badertscher, P., Twerenbold, R., Fitze, B., Wussler, D., Strebel, I., Rubini Gimenez, M., Wildi, K., Puelacher, C., du Fay de Lavallaz, J., Oehen, L., Walter, J., Miro, O., Martin-Sanchez, F. J., Morawiec, B., Potlukova Tags: Proteomics and Protein Markers Source Type: research
A Mendelian Randomization-Based Approach to Identify Early and Sensitive Diagnostic Biomarkers of Disease [Proteomics and Protein Markers]
CONCLUSIONS:
Our results suggest TFF3 is a valuable diagnostic marker for early CKD in dysglycemic populations and acts as a proof of concept for the application of this novel MR technique to identify diagnostic biomarkers for other chronic diseases.
ClinicalTrials.gov Identifier:
NCT00069784 (Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Mohammadi-Shemirani, P., Sjaarda, J., Gerstein, H. C., Treleaven, D. J., Walsh, M., Mann, J. F., McQueen, M. J., Hess, S., Pare, G. Tags: Proteomics and Protein Markers Source Type: research
Quality Monitoring of a FIT-Based Colorectal Cancer Screening Program [General Clinical Chemistry]
CONCLUSIONS:
Variations were observed in positivity and detection rates between collection devices and reagents, but there was no detected variation in PPV. Although the overall population effect of these variations on the screened population is expected to be modest, there is room for improvement. (Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Toes-Zoutendijk, E., Bonfrer, J. M. G., Ramakers, C., Thelen, M., Spaander, M. C. W., Dekker, E., van der Meulen, M. P., Buskermolen, M., van Vuuren, A. J., Kuipers, E. J., van Kemenade, F. J., van Velthuysen, M.-L. F., Thomeer, M. G. J., van Veldhuizen, Tags: General Clinical Chemistry Source Type: research
Validation of a Metabolite Panel for a More Accurate Estimation of Glomerular Filtration Rate Using Quantitative LC-MS/MS [General Clinical Chemistry]
CONCLUSIONS:
The new eGFRmet equation could serve as a confirmatory test for GFR estimation. (Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Freed, T. A., Coresh, J., Inker, L. A., Toal, D. R., Perichon, R., Chen, J., Goodman, K. D., Zhang, Q., Conner, J. K., Hauser, D. M., Vroom, K. E. T., Oyaski, M. L., Wulff, J. E., Eiriksdottir, G., Gudnason, V., Torres, V. E., Ford, L. A., Levey, A. S. Tags: Other Areas of Clinical Chemistry General Clinical Chemistry Source Type: research
Implications of Monoclonal Antibody Therapeutics Use for Clinical Laboratory Testing [Reviews]
BACKGROUND:
Monoclonal antibody therapeutics (MATs) represent a rapidly expanding class of biological drugs used to treat a variety of diseases. The widespread use of MATs increasingly affects clinical laboratory medicine.
CONTENT:
This review provides an overview of MATs currently approved for clinical use in the US, starting from basic biology of antibodies to the engineering, pharmacokinetic and pharmacodynamic properties, nomenclature, and production of MATs. Immunogenicity and the production of antidrug antibodies (ADAs) play a major role in loss of therapeutic response and the development of treatment failure to cer...
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Lazar-Molnar, E., Delgado, J. C. Tags: Drug Monitoring and Toxicology Reviews Source Type: research
Next-Generation Sequencing for Biodefense: Biothreat Detection, Forensics, and the Clinic [Reviews]
BACKGROUND:
Next-generation sequencing (NGS) is revolutionizing a variety of molecular biology fields including bioforensics, biosurveillance, and infectious disease diagnostics. For pathogen detection, the ability to sequence all nucleic acids in a sample allows near limitless multiplexability, free from a priori knowledge regarding an etiologic agent as is typically required for targeted molecular assays such as real-time PCR. Furthermore, sequencing capabilities can generate in depth genomic information, allowing detailed molecular epidemiological studies and bioforensics analysis, which is critical for source agent ide...
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Minogue, T. D., Koehler, J. W., Stefan, C. P., Conrad, T. A. Tags: Molecular Diagnostics and Genetics Reviews Source Type: research
Commentary [Clinical Case Study]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Stevens-Hernandez, C. J., Bradbury, W. H., Oakes, R., Bruce, L. J. Tags: Clinical Case Study Source Type: research
