Cell-Free SHOX2 DNA Methylation in Blood as a Molecular Staging Parameter for Risk Stratification in Renal Cell Carcinoma Patients: A Prospective Observational Cohort Study [Cancer Diagnostics]
CONCLUSIONS:
Pretherapeutic SHOX2 ccfDNA methylation testing allows for the identification of RCC patients at high risk of death after nephrectomy. These patients might benefit from an adjuvant treatment or early initiation of a palliative treatment. (Source: Clinical Chemistry)
Source: Clinical Chemistry - March 27, 2019 Category: Chemistry Authors: Jung, M., Ellinger, J., Gevensleben, H., Syring, I., Luders, C., de Vos, L., Putzer, S., Bootz, F., Landsberg, J., Kristiansen, G., Dietrich, D. Tags: Molecular Diagnostics and Genetics Cancer Diagnostics Source Type: research
Label-Free Enrichment and Molecular Characterization of Viable Circulating Tumor Cells from Diagnostic Leukapheresis Products [Cancer Diagnostics]
CONCLUSIONS:
The increased CTC numbers from fresh or cryopreserved DLA products facilitate multiple functional and molecular analyses and, thus, could improve our knowledge of their biology. (Source: Clinical Chemistry)
Source: Clinical Chemistry - March 27, 2019 Category: Chemistry Authors: Franken, A., Driemel, C., Behrens, B., Meier-Stiegen, F., Endris, V., Stenzinger, A., Niederacher, D., Fischer, J. C., Stoecklein, N. H., Ruckhaeberle, E., Fehm, T., Neubauer, H. Tags: Cancer Diagnostics (since 2002) Source Type: research
Independent Validation of a Diagnostic Noninvasive 3-MicroRNA Ratio Model (uCaP) for Prostate Cancer in Cell-Free Urine [Cancer Diagnostics]
CONCLUSIONS:
We successfully validated a urine-based diagnostic 3-miRNA signature for PC (uCaP) in 3 independent patient cohorts from 2 countries. In the future, the simple and noninvasive uCaP test may be used to help more accurately select patients for prostate biopsy. Prospective clinical validation is warranted. (Source: Clinical Chemistry)
Source: Clinical Chemistry - March 27, 2019 Category: Chemistry Authors: Fredsoe, J., Rasmussen, A. K. I., Laursen, E. B., Cai, Y., Howard, K. A., Pedersen, B. G., Borre, M., Mouritzen, P., Orntoft, T., Sorensen, K. D. Tags: Cancer Diagnostics (since 2002) Source Type: research
A Comprehensive LC-QTOF-MS Metabolic Phenotyping Strategy: Application to Alkaptonuria [Endocrinology and Metabolism]
CONCLUSIONS:
The comprehensive targeted profiling strategy described here has the potential of enabling discovery of novel pathways associated with pathogenesis and management of AKU. (Source: Clinical Chemistry)
Source: Clinical Chemistry - March 27, 2019 Category: Chemistry Authors: Norman, B. P., Davison, A. S., Ross, G. A., Milan, A. M., Hughes, A. T., Sutherland, H., Jarvis, J. C., Roberts, N. B., Gallagher, J. A., Ranganath, L. R. Tags: Endocrinology and Metabolism Source Type: research
Immunotherapy Using Chimeric Antigen Receptor-Engineered T Cells: A Novel Cellular Therapy with Important Implications for the Clinical Laboratory [Review]
BACKGROUND:
We have entered a new era of cancer therapy, with a number of immune-based therapies already used clinically as a standard of care. Adoptive cellular immunotherapy using T cells genetically modified with chimeric antigen receptors (CAR-T cells) represents a novel therapeutic approach. CAR-T cells have produced clinical responses in B-cell malignancies that are otherwise refractory to conventional therapies. Two CAR-T cell therapies obtained regulatory approval in 2017, with many more of these therapies under clinical development.
CONTENT:
This review focuses on the current state of adoptive cellular immunother...
Source: Clinical Chemistry - March 27, 2019 Category: Chemistry Authors: Thibodeaux, S. R., Milone, M. C. Tags: Cancer Diagnostics (since 2002) Review Source Type: research
Commentary [Clinical Case Study]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - March 27, 2019 Category: Chemistry Authors: Hoenig, M. P. Tags: Pediatric Clinical Chemistry Clinical Case Study Source Type: research
An Unusual Cause of Metabolic Alkalosis and Hypocalcemia in Childhood [Clinical Case Study]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - March 27, 2019 Category: Chemistry Authors: Huynh, T., Wilgen, U. Tags: Pediatric Clinical Chemistry, Clinical Case Studies Clinical Case Study Source Type: research
Mass Spectrometry-Based Tissue Imaging: The Next Frontier in Clinical Diagnostics? [Q&A]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - March 27, 2019 Category: Chemistry Authors: Leung, F., Eberlin, L. S., Schwamborn, K., Heeren, R. M. A., Winograd, N., Cooks, R. G. Tags: Molecular Diagnostics and Genetics Q & amp;A Source Type: research
Advancing Point-of-Care Diagnostics of Metabolites Through Engineering Semisynthetic Proteins [Perspective]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - March 27, 2019 Category: Chemistry Authors: Zhang, J., Lu, Y. Tags: Point-of-Care Testing, Perspective Source Type: research
Patrick Bossuyt [Inspiring Minds]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - March 27, 2019 Category: Chemistry Authors: Landau, M. Tags: Other Areas of Clinical Chemistry, Inspiring Minds Source Type: research
A Woman and a Coffee Cup [Unveiling the Right Side]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Dominiczak, M. H. Tags: Unveiling the Right Side Source Type: research
The Curious Case of an Isolated Positive Hepatitis B Surface Antigen Result [What Is Your Guess?]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Nerenz, R. D., Felty, C. C., Cervinski, M. A. Tags: What Is Your Guess? Source Type: research
Is This as Straightforward as It Looks? [What Is Your Guess?]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Authors: Hayden, J. A., Rossi, A., Harris, R. M. Tags: Cancer Diagnostics (since 2002) What Is Your Guess? Source Type: research
Correction [Correction]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - February 28, 2019 Category: Chemistry Tags: Other Areas of Clinical Chemistry Correction Source Type: research
