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Clinical Cardiology,Volume 41, Issue 2, Page 211-216, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 27, 2018 Category: Cardiology Source Type: research

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Clinical Cardiology,Volume 41, Issue 2, Page 228-231, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 27, 2018 Category: Cardiology Source Type: research

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Clinical Cardiology,Volume 41, Issue 2, Page 173-178, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 27, 2018 Category: Cardiology Source Type: research

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Clinical Cardiology,Volume 41, Issue 2, Page 220-227, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 27, 2018 Category: Cardiology Source Type: research

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Clinical Cardiology,Volume 41, Issue 2, Page 269-273, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 27, 2018 Category: Cardiology Source Type: research

Transcatheter aortic valve replacement in women
This review examines the treatment options for women with severe aortic stenosis. It is known that female sex is associated with poorer outcomes after surgical aortic valve replacement. With the introduction and adoption of transcatheter aortic valve replacement as an alternative to surgical aortic valve replacement, there are emerging data about the potential impact of female sex‐specific characteristics on clinical outcomes after transcatheter aortic valve replacement. These data provide an insight into female‐specific aspects of the treatment of aortic stenosis. The data can help guide patient selection, choice of i...
Source: Clinical Cardiology - February 27, 2018 Category: Cardiology Authors: Dipti Itchhaporia Tags: REVIEW Source Type: research

Women as leaders in cardiovascular medicine
Cardiology remains a specialty that is dominated by men. Even though half of all medical students and over 40% of internal medicine residents are women, the number of women in the field of cardiology remains low. The reasons for the persistent lack of increase in cardiology trainees are not well understood and are likely multifactorial. Despite this under‐representation, women cardiologists are increasingly visible in leadership roles, including those in research science, health systems administration, professional societies, and clinical practice. This review will highlight the various leadership roles and paths taken o...
Source: Clinical Cardiology - February 27, 2018 Category: Cardiology Authors: Mary Norine Walsh Tags: REVIEW Source Type: research

Hypertension in pregnancy: Taking cues from pathophysiology for clinical practice
Pregnancy‐related hypertension (PHTN) syndromes are a frequent and potentially deadly complication of pregnancy, while also negatively impacting the lifelong health of the mother and child. PHTN appears in women likely to develop hypertension later in life, with the stress of pregnancy unmasking a subclinical hypertensive phenotype. However, distinguishing between PHTN and chronic hypertension is essential for optimal management. Preeclampsia (PE) is linked to potentially severe outcomes and lacks effective treatments due to poorly understood mechanisms. Inadequate remodeling of spiral uterine arteries (SUAs), the corner...
Source: Clinical Cardiology - February 27, 2018 Category: Cardiology Authors: Ruxandra I. Sava, Keith L. March, Carl J. Pepine Tags: REVIEW Source Type: research

The ramifications of recent health policy actions for cardiovascular care of women: Progress, threats, and opportunities
Women's health and well‐being are shaped by a combination of healthcare policies that impact the type of health insurance coverage they benefit from, as well as access to preventive, screening, and treatment services. Furthermore, more distal policies, such as those that pertain to housing, education, and employment, as well as social determinants of health, such as issues of socioeconomic status and women's status in society, also impact their cardiac health. Before the passage of the Affordable Care Act in 2010, women were at greater risk of facing barriers to coverage, reflecting gender rating and the higher likelihoo...
Source: Clinical Cardiology - February 27, 2018 Category: Cardiology Authors: Claire D. Brindis, Karen M. Freund Tags: REVIEW Source Type: research

NT ‐proBNP is associated with mortality and adverse cardiac events in patients with atrial fibrillation presenting to the emergency department
Clinical Cardiology, EarlyView. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Source Type: research

Predictive risk factors for recurrent atrial fibrillation after modified endoscopic ablation: A 2 ‐year follow‐up
Clinical Cardiology, EarlyView. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Source Type: research

Elevated lipoprotein(a) and familial hypercholesterolemia in the coronary care unit: Between Scylla and Charybdis
Clinical Cardiology, EarlyView. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Source Type: research

Atherosclerotic vascular disease in the autoimmune rheumatologic woman
Clinical Cardiology,Volume 41, Issue 2, Page 258-263, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Source Type: research

How do we attract and retain women in cardiology?
Clinical Cardiology,Volume 41, Issue 2, Page 264-268, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Source Type: research

Taking cardiology clinical trials to the next level: A call to action
Clinical Cardiology,Volume 41, Issue 2, Page 179-184, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Source Type: research

Cardiac implantable electrical devices in women
Clinical Cardiology,Volume 41, Issue 2, Page 232-238, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Source Type: research

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Clinical Cardiology, Ahead of Print. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Source Type: research

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Clinical Cardiology,Volume 41, Issue 2, Page 258-263, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Source Type: research

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Clinical Cardiology,Volume 41, Issue 2, Page 264-268, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Source Type: research

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Clinical Cardiology,Volume 41, Issue 2, Page 179-184, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Source Type: research

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Clinical Cardiology,Volume 41, Issue 2, Page 232-238, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Source Type: research

Taking cardiology clinical trials to the next level: A call to action
Physicians previously perceived heart disease to be a man's disease; yet, since 1984, more women have died of ischemic heart disease. Because women who develop obstructive coronary heart disease and heart failure tend to do so 10 years later than men, cardiology clinical trials that use arbitrary age cutoffs or exclusion criteria based on comorbidities and polypharmacy often limit the pool of potential participants to a greater extent for women. Issues related to trial design and insufficient accounting for female‐predominant disease patterns have contributed to low rates of enrollment of women in certain domains ...
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Authors: Janine A. Clayton, Matthew E. Arnegard Tags: REVIEW Source Type: research

Predictive risk factors for recurrent atrial fibrillation after modified endoscopic ablation: A 2 ‐year follow‐up
ConclusionsOur 2‐year follow‐up study suggested that low LAAEF, long AF duration, and large LAD might be potential predictive risk factors for AF recurrence. Patients with PAF and non‐PAF had a similar AF recurrence rate after modified endoscopic ablation. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Authors: Kang An, Jiaquan Zhu, Nan Ma, Min Tang, Ju Mei Tags: CLINICAL INVESTIGATIONS Source Type: research

Elevated lipoprotein(a) and familial hypercholesterolemia in the coronary care unit: Between Scylla and Charybdis
BackgroundElevated lipoprotein(a) (Lp[a]) and familial hypercholesterolemia (FH) are inherited lipid disorders. Their frequencies, coexistence, and associations with premature coronary artery disease (CAD) in patients admitted to the coronary care unit (CCU) remain to be defined. HypothesisElevated Lp(a) and FH are commonly encountered among CCU patients and independently associated with increased premature CAD risk. MethodsPlasma Lp(a) concentrations were measured in consecutive patients admitted to the CCU with an acute coronary syndrome (ACS) or prior history of CAD for 6.5 months. Elevated Lp(a) was defined as c...
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Authors: Katrina L. Ellis, Jing Pang, David Chieng, Damon A. Bell, John R. Burnett, Carl J. Schultz, Graham S. Hillis, Gerald F. Watts Tags: CLINICAL INVESTIGATIONS Source Type: research

Cardiac implantable electrical devices in women
Clinical trials have demonstrated the benefits of cardiac implantable electrical devices, which include pacemakers, implantable cardioverter‐defibrillators (ICDs), and cardiac resynchronization therapy (CRT), with respect to key clinical outcomes and survival. Women more often require permanent pacing for sick sinus syndrome, whereas atrioventricular block is more common in men. Women appear to have a higher incidence of complications with pacemaker implantation, as well as with ICD and CRT implantation. The indications for ICDs and CRT do not have any distinctions based on sex, and outcomes are comparable in men and wom...
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Authors: Kalaimani Elango, Anne B. Curtis Tags: REVIEW Source Type: research

NT ‐proBNP is associated with mortality and adverse cardiac events in patients with atrial fibrillation presenting to the emergency department
BackgroundAtrial fibrillation (AF) is the most common cardiac arrhythmia in the emergency department. The CHA2DS2‐VASc score helps to predict thromboembolic risk; however, the rate of other adverse cardiac events is more difficult to predict. HypothesisThe biomarker N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) has prognostic value in patients presenting to the emergency department with AF. MethodsDuring a 1.5‐year period, a prospective study was performed in consecutive patients presenting to the emergency department with AF on the presenting electrocardiogram. At baseline, NT‐proBNP was measured. The p...
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Authors: Marijn J. Holl, Ewout J. van den Bos, Ron T. van Domburg, Michael A. Fouraux, Marcel J. Kofflard Tags: CLINICAL INVESTIGATIONS Source Type: research

Atherosclerotic vascular disease in the autoimmune rheumatologic woman
Autoimmune rheumatologic conditions have increased cardiovascular morbidity and mortality compared to the general population. Many of these diseases occur more commonly in women, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis, and Sjogren's. Most of the literature that has identified the link between autoimmune diseases and atherosclerotic cardiovascular disease (ASCVD) has been regarding patients with RA and SLE. The reason for the increased ASCVD is related to both traditional risk factors for atherosclerosis and nontraditional risk factors such as the burden of inflammation. Pr...
Source: Clinical Cardiology - February 26, 2018 Category: Cardiology Authors: Reto Daniel Kurmann, Rekha Mankad Tags: REVIEW Source Type: research

Type I Wenckebach second ‐degree AV block: A matter of definition
Clinical Cardiology, EarlyView. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 20, 2018 Category: Cardiology Source Type: research

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Clinical Cardiology, Ahead of Print. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 20, 2018 Category: Cardiology Source Type: research

Effect of type D personality on smoking status and their combined impact on outcome after acute myocardial infarction
Clinical Cardiology, EarlyView. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 19, 2018 Category: Cardiology Source Type: research

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Clinical Cardiology, Ahead of Print. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 19, 2018 Category: Cardiology Source Type: research

Peripartum cardiomyopathy: Status 2018
Clinical Cardiology,Volume 41, Issue 2, Page 217-219, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 16, 2018 Category: Cardiology Source Type: research

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Clinical Cardiology,Volume 41, Issue 2, Page 217-219, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 16, 2018 Category: Cardiology Source Type: research

You've come a long way, baby
Clinical Cardiology,Volume 41, Issue 2, Page 171-172, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 15, 2018 Category: Cardiology Source Type: research

Adverse pregnancy outcomes and future maternal cardiovascular disease
Clinical Cardiology,Volume 41, Issue 2, Page 239-246, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 15, 2018 Category: Cardiology Source Type: research

The connection between the breast and heart in a woman: Breast cancer and cardiovascular disease
Clinical Cardiology,Volume 41, Issue 2, Page 253-257, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 15, 2018 Category: Cardiology Source Type: research

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Clinical Cardiology,Volume 41, Issue 2, Page 171-172, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 15, 2018 Category: Cardiology Source Type: research

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Clinical Cardiology,Volume 41, Issue 2, Page 239-246, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 15, 2018 Category: Cardiology Source Type: research

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Clinical Cardiology,Volume 41, Issue 2, Page 253-257, February 2018. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 15, 2018 Category: Cardiology Source Type: research

The connection between the breast and heart in a woman: Breast cancer and cardiovascular disease
Cardiovascular disease remains the leading cause of death in women in the United States and is a major public health issue for all women, but it is of increasing concern to breast cancer survivors. Advancements in early detection and breast cancer therapy have resulted in over 90% of women surviving 5 years past their diagnosis of breast cancer. Nonetheless, with increased survivorship from breast cancer, there has been an increase in cardiovascular disease in these women. The consequences of the treatments for breast cancer may increase the risk for cardiovascular disease. Additionally, there is an overlap of risk factors...
Source: Clinical Cardiology - February 15, 2018 Category: Cardiology Authors: Martha Gulati, Sharon L. Mulvagh Tags: REVIEW Source Type: research

Adverse pregnancy outcomes and future maternal cardiovascular disease
Cardiovascular disease (CVD) remains the leading cause of death in women. Although traditional risk factors increase later‐life CVD, pregnancy‐associated complications additionally influence future CVD risk in women. Recent guidelines for the prevention of CVD in women have added adverse pregnancy outcomes as major CVD risk factors. Studies have shown that women with a history of preeclampsia, gestational diabetes, preterm delivery, and delivery of a small‐for‐gestational‐age infant have an increased risk of developing cardiometabolic risk factors and subsequent CVD. A history of multiple adverse pregnancy outcom...
Source: Clinical Cardiology - February 15, 2018 Category: Cardiology Authors: Alisse Hauspurg, Wendy Ying, Carl A. Hubel, Erin D. Michos, Pamela Ouyang Tags: REVIEW Source Type: research

Issue Information
(Source: Clinical Cardiology)
Source: Clinical Cardiology - February 8, 2018 Category: Cardiology Tags: ISSUE INFORMATION Source Type: research

Stroke prevention strategies in North American patients with atrial fibrillation: the GLORIA ‐AF registry program
ConclusionsIn GLORIA‐AF, 20% of the population comprising males with CHA2DS2‐VASc ≥1 and females with CHA2DS2‐VASc ≥2 did not receive oral anticoagulation therapy. Patient characteristics associated with a lower likelihood of OAC prescription were use of antiplatelet drugs, paroxysmal pattern of AF, a history of falls, and prior bleeding. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 1, 2018 Category: Cardiology Authors: William F. McIntyre, David Conen, Brian Olshansky, Jonathan L. Halperin, Emil Hayek, Menno V. Huisman, Gregory Y.H. Lip, Shihai Lu, Jeff S. Healey Tags: CLINICAL INVESTIGATIONS Source Type: research

Initial Apixaban Dosing in Patients with Atrial Fibrillation
BackgroundApixaban is a non‐vitamin K oral anticoagulant and has been approved for prevention of stroke and systemic embolism in patients with non‐valvular atrial fibrillation (AF). Current labelling recommends dose reduction based on patients age, weight and renal function. ObjectivesThe aim of this study was to analyze adherence to current labeling instructions concerning initial apixaban dosing in clinical practice and to identify factors associated with inappropriate dose reduction. MethodsPatients with AF initiated on apixaban in 2016, were identified in the Heart Center Leipzig database. Health records were scree...
Source: Clinical Cardiology - February 1, 2018 Category: Cardiology Authors: Alexander Buchholz, Laura Ueberham, Kaja Gorczynska, Borislav Dinov, Sebastian Hilbert, Nikolaos Dagres, Daniela Husser, Gerhard Hindricks, Andreas Bollmann Tags: CLINICAL INVESTIGATIONS Source Type: research

Association between transthoracic impedance and electrical cardioversion success with biphasic defibrillators: an analysis of 1,055 shocks for atrial fibrillation and flutter
Summary BackgroundThe relevance of transthoracic impedance (TTI) to electrical cardioversion (ECV) success for atrial tachyarrhythmias when using biphasic waveform defibrillators is unknown. HypothesisTTI is predictive of ECV success with contemporary defibrillators. MethodsDe‐identified data stored in biphasic defibrillator memory cards from ECV attempts for atrial fibrillation (AF) or atrial flutter (AFL) over a two‐year period at our center were evaluated. ECV success, defined as arrhythmia termination and at least one sinus beat, was adjudicated by two blinded cardiac electrophysiologists. The association between T...
Source: Clinical Cardiology - February 1, 2018 Category: Cardiology Authors: Mouhannad M. Sadek, Varsha Chaugai, Mark J. Cleland, Timothy J. Zakutney, David H. Birnie, F. Daniel Ramirez Tags: CLINICAL INVESTIGATIONS Source Type: research

Subvalvular aortic stenosis: a review of current literature
Subvalvular aortic stenosis (SAS) is one of the common adult congenital heart diseases, with a prevalence of 6.5%. It is usually diagnosed in the first decade of life. Echocardiography is the test of choice to diagnose SAS. Surgical correction is the best treatment modality, and the prognosis is usually excellent. In this review, we describe the pathophysiology, diagnosis, prognosis, and management of SAS with a focus on different pathophysiologic mechanisms, diagnostic approach, and prognosis of the disease by reviewing the current literature. (Source: Clinical Cardiology)
Source: Clinical Cardiology - January 29, 2018 Category: Cardiology Authors: Subodh R. Devabhaktuni, Eyas Chakfeh, Ali O. Malik, Joshua A. Pengson, Jibran Rana, Chowdhury H. Ahsan Tags: REVIEW Source Type: research

Safety and efficacy of second ‐generation drug‐eluting stents compared with bare‐metal stents: An updated meta‐analysis and regression of 9 randomized clinical trials
The efficacy of second‐generation drug‐eluting stents (DES; eg, everolimus and zotarolimus) compared with bare‐metal stents (BMS) in patients undergoing percutaneous coronary intervention was challenged recently by new evidence from large clinical trials. Thus, we aimed to conduct an updated systematic review and meta‐analysis of randomized clinical trials (RCTs) evaluating the efficacy and safety of second‐generation DES compared with BMS. Electronic databases were systematically searched for all RCTs comparing second‐generation DES with BMS and reporting clinical outcomes. The primary efficacy outcome was maj...
Source: Clinical Cardiology - January 25, 2018 Category: Cardiology Authors: Ahmed N. Mahmoud, Nikhil H. Shah, Islam Y. Elgendy, Nayan Agarwal, Akram Y. Elgendy, Amgad Mentias, Amr F. Barakat, Dhruv Mahtta, R. David Anderson, Anthony A. Bavry Tags: REVIEW Source Type: research

Growth differentiation factor 15 is associated with left atrial/left atrial appendage thrombus in patients with nonvalvular atrial fibrillation
BackgroundThere is evidence suggesting that growth differentiation factor 15 (GDF‐15) appears to be associated with stroke in patients with atrial fibrillation (AF). AF‐related thromboembolic stroke is predominantly attributed to the thrombus from the left atrium (LA) or left atrial appendage (LAA). HypothesisGDF‐15 is related to LA/LAA thrombus in nonvalvular AF (NVAF) patients. MethodsA total of 894 patients with NVAF without anticoagulation therapy were included in this study. All patients routinely underwent transesophageal echocardiography for detection of LA/LAA thrombus. GDF‐15 was measured by enzyme‐linke...
Source: Clinical Cardiology - January 24, 2018 Category: Cardiology Authors: Xiao Feng Hu, Rui Zhan, Shanhu Xu, Junjun Wang, Jiong Wu, Xiaoli Liu, Yaguo Li, Linhui Chen Tags: CLINICAL INVESTIGATIONS Source Type: research