Issue Information
(Source: Clinical Cardiology)
Source: Clinical Cardiology - April 22, 2015 Category: Cardiology Tags: Issue Information Source Type: research

Feasibility of Extended Ambulatory Electrocardiogram Monitoring to Identify Silent Atrial Fibrillation in High‐risk Patients: The Screening Study for Undiagnosed Atrial Fibrillation (STUDY‐AF)
ConclusionsOutpatient extended ECG screening for asymptomatic AF is feasible, with AF identified in 1 in 20 subjects and sustained AT/AF identified in 1 in 9 subjects, respectively. We also found a high prevalence of asymptomatic AT and frequent supraventricular ectopic complexes, which may be relevant to development of AF or stroke. If confirmed in a larger study, primary screening for AF could have a significant impact on public health. (Source: Clinical Cardiology)
Source: Clinical Cardiology - April 14, 2015 Category: Cardiology Authors: Mintu P. Turakhia, Aditya J. Ullal, Donald D. Hoang, Claire T. Than, Jared D. Miller, Karen J. Friday, Marco V. Perez, James V. Freeman, Paul J. Wang, Paul A. Heidenreich Tags: Clinical Investigations Source Type: research

Preoperative Cerebrovascular Evaluation in Patients With Infective Endocarditis
This article addresses these issues based on the available evidence. (Source: Clinical Cardiology)
Source: Clinical Cardiology - April 14, 2015 Category: Cardiology Authors: Réza Behrouz Tags: Reviews Source Type: research

Metrics of Quality Care in Veterans: Correlation Between Primary‐Care Performance Measures and Inappropriate Myocardial Perfusion Imaging
ConclusionsInappropriate MPI is not associated with performance on metrics of quality care. If an association exists, it may be between inappropriate MPI and overly aggressive care. Most clinicians document a plan of care to address failure of quality metrics, suggesting awareness of the problem. (Source: Clinical Cardiology)
Source: Clinical Cardiology - April 13, 2015 Category: Cardiology Authors: David E. Winchester, Andrew Kitchen, John C. Brandt, Raman S. Dusaj, Salim S. Virani, Steven M. Bradley, Leslee J. Shaw, Rebecca J. Beyth Tags: Quality and Outcomes Source Type: research

Increased Transforming Growth Factor‐β Levels Associated With Cardiac Adverse Events in Hypertrophic Cardiomyopathy
ABSTRACT BackgroundHypertrophic cardiomyopathy (HCM) is a common genetic heart disease characterized by ventricular hypertrophy, myocardial fibrosis, and impaired ventricular relaxation. The exact mechanisms by which fibrosis is caused remain unknown. HypothesisCirculating TGF‐β is related to poor prognosis in HCM. MethodsWe compared TGF‐β levels of 49 HCM patients with those of 40 non‐HCM patients. We followed the patients with HCM for 18 months and divided them into 2 groups: low TGF‐β (≤4877 pg/mL) and high TGF‐β (>4877 pg/mL). We compared the 2 groups in terms of brain natriuretic pe...
Source: Clinical Cardiology - April 1, 2015 Category: Cardiology Authors: Burak Ayça, Irfan Sahin, Suat Hayri Kucuk, Fatih Akin, Didem Kafadar, Murat Avşar, Ilker Ilhan Avci, Barış Gungor, Ertugrul Okuyan, Mustafa Hakan Dinckal Tags: Clinical Investigations Source Type: research

Beneficial Effects of Positive Airway Pressure Therapy for Sleep‐Disordered Breathing in Heart Failure Patients With Preserved Left Ventricular Ejection Fraction
ABSTRACT BackgroundRight‐heart dysfunction is associated with poor prognosis in heart failure with preserved left ventricular ejection fraction (HFpEF). It remains unclear whether sleep‐disordered breathing (SDB) treatment using positive airway pressure (PAP) improves right‐heart and pulmonary function and exercise capacity and reduces mortality rates of HFpEF patients. HypothesisPAP may improve right‐heart and pulmonary function, exercise capacity and prognosis in HFpEF patients with SDB. MethodsOne hundred nine consecutive patients with HFpEF (left ventricular ejection fraction>50%) and moderate to severe SDB ...
Source: Clinical Cardiology - April 1, 2015 Category: Cardiology Authors: Akiomi Yoshihisa, Satoshi Suzuki, Hiroyuki Yamauchi, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu‐Ichi Saitoh, Yasuchika Takeishi Tags: Clinical Investigations Source Type: research

Contemporary Trends of Optimal Evidence‐Based Medical Therapy at Discharge for Patients Surviving Acute Myocardial Infarction From the Korea Acute Myocardial Infarction Registry
We examined discharge medications of 17,578 post‐MI patients who had no documented contraindications to antiplatelet agents, β‐blockers, angiotensin‐converting enzyme inhibitors, or statins across a 6‐year period (divided into subperiods of November 2005 to December 2006 [period 1], 2007 [period 2], 2008 [period 3], 2009 [period 4], 2010 [period 5], and January to June 2011 [period 6]) in the Korean AMI Registry. OMT was defined as use of all 4 indicated medications. ResultsMarked increases in OMT (48.6% to 63.2%) were seen irrespective of age and sex, mainly attributed to marked increases in the use of β...
Source: Clinical Cardiology - April 1, 2015 Category: Cardiology Authors: Jang Hoon Lee, Myung Hwan Bae, Dong Heon Yang, Hun Sik Park, Yongkeun Cho, Myung Ho Jeong, Young Jo Kim, Kee‐Sik Kim, Seung Ho Hur, In Whan Seong, Myeong Chan Cho, Chong Jin Kim, Shung Chull Chae, Tags: Clinical Investigations Source Type: research

Stem‐Cell Angiogenesis and Regeneration of the Heart: Review of a Saga of 2 Decades
ABSTRACT Advances in the novel approach to control ischemic heart disease and heart failure using stem cells or progenitor cells from bone marrow, mesenchyme, or myocardial tissue itself have demonstrated efficacy for increasing left ventricular function, decreasing infarct scar tissue, improving exercise tolerance and heart failure symptoms, and, in some studies, decreasing mortality and reducing rehospitalization for intractable angina or subsequent myocardial infarction. The most common techniques utilize injections of cells into the coronary vasculature or directly into specific areas of vulnerable myocardium. Although...
Source: Clinical Cardiology - April 1, 2015 Category: Cardiology Authors: Philip R. Liebson Tags: Reviews Source Type: research

Impact of Metabolic Syndrome on Development of Contrast‐Induced Nephropathy After Elective Percutaneous Coronary Intervention Among Nondiabetic Patients
ABSTRACT BackgroundIdentifying patients who are vulnerable to development of contrast‐induced nephropathy (CIN) is essential because of its association with prolonged hospitalization, increased cost, and increased in‐hospital and long‐term mortality rates. HypothesisIndividual components of metabolic syndrome (MetS) are well‐established risk factors for kidney injury. Nondiabetic patients diagnosed with MetS might be at an increased risk of developing CIN after elective percutaneous coronary intervention (PCI). MethodsA total of 599 nondiabetic patients were enrolled, of whom 313 met the MetS criteria and 286 were ...
Source: Clinical Cardiology - March 19, 2015 Category: Cardiology Authors: Ozgur Ulas Ozcan, Hacer Adanir Er, Sadi Gulec, Elif Ezgi Ustun, Demet Menekse Gerede, Huseyin Goksuluk, Cansin Tulunay Kaya, Cetin Erol Tags: Clinical Investigation Source Type: research

Issue Information
(Source: Clinical Cardiology)
Source: Clinical Cardiology - March 19, 2015 Category: Cardiology Tags: Issue Information Source Type: research

Deeply Reinverted T Wave at 14 Days After the Onset of First Anterior Acute Myocardial Infarction Predicts Improved Left Ventricular Function at 6 Months
Abstract BackgroundChanges in electrocardiogram (ECG), especially in the ST segment and T wave, have been recognized as a noninvasive diagnostic tool for coronary flow or myocardial injury. HypothesisA deeply inverted T wave at 14 days after successful percutaneous coronary intervention (PCI) in patients with ST‐segment elevation acute myocardial infarction (STEMI) predicts improved left ventricular (LV) function at 6 months. MethodsWe enrolled 112 consecutive patients (88 men, 63 ± 11 years) with first anterior STEMI who underwent successful PCI. A 12‐lead ECG was recorded everyday from adm...
Source: Clinical Cardiology - March 10, 2015 Category: Cardiology Authors: Hiroaki Yokoyama, Hirofumi Tomita, Fumie Nishizaki, Kenji Hanada, Shuji Shibutani, Masahiro Yamada, Naoki Abe, Takumi Higuma, Tomohiro Osanai, Ken Okumura Tags: Clinical Investigations Source Type: research

Atrial Septostomy: A Contemporary Review
This article aims to detail the history, indications, contraindications, procedural techniques, and outcomes of atrial septostomy. We will also shed light on some of the newer interventions, inspired by the same physiological concept, that are being evaluated as potential palliative modalities in patients with PAH. (Source: Clinical Cardiology)
Source: Clinical Cardiology - March 2, 2015 Category: Cardiology Authors: Hayan Al Maluli, Christine M. DeStephan, René J. Alvarez, Julio Sandoval Tags: Reviews Source Type: research

A Risk Score for No Reflow in Patients With ST‐Segment Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention
ConclusionsIn patients with STEMI treated by primary PCI, incidence of NRF phenomenon may be predicted with an acceptable accuracy based on a 7‐item simplified risk score. (Source: Clinical Cardiology)
Source: Clinical Cardiology - March 1, 2015 Category: Cardiology Authors: Jin‐Wen Wang, Zi‐Qiang Zhou, Yun‐Dai Chen, Chang‐Hua Wang, Xiao‐ling Zhu Tags: Clinical Investigations Source Type: research

Reducing Cardiovascular and Cancer Risk: How to Address Global Primary Prevention in Clinical Practice
Abstract Emerging evidence suggesting the possibility that interventions able to prevent cardiovascular disease (CVD) may also be effective in the prevention of cancer have recently stimulated great interest in the medical community. In particular, data from both experimental and observational studies have demonstrated that aspirin may play a role in preventing different types of cancer. Although the use of aspirin in the secondary prevention of CVD is well established, aspirin in primary prevention is not systematically recommended because the absolute cardiovascular event reduction is similar to the absolute excess in ma...
Source: Clinical Cardiology - March 1, 2015 Category: Cardiology Authors: Allegra Battistoni, Vittoria Mastromarino, Massimo Volpe Tags: Reviews Source Type: research

Cholesterol, Statins, and Dementia: What the Cardiologist Should Know
Abstract Alzheimer dementia (AD) is an important clinical problem that appears to be closely tied to comorbid cardiovascular disease, making it a relevant topic for the clinical cardiologist. Determinants of cardiovascular health, especially midlife dyslipidemia, are associated with an increased risk of dementia based on molecular and epidemiologic data. Given the potential role of dyslipidemia in the development of dementia, statins have been investigated as potential therapeutic options to slow or prevent disease. This review discusses the role of dyslipidemia and other cardiovascular risk factors in the pathogenesis of ...
Source: Clinical Cardiology - March 1, 2015 Category: Cardiology Authors: Brett L. Wanamaker, Kristopher J. Swiger, Roger S. Blumenthal, Seth S. Martin Tags: Reviews Source Type: research

Association Between Electrocardiographic Findings, Right Heart Strain, and Short‐Term Adverse Clinical Events in Patients With Acute Pulmonary Embolism
ConclusionsA simple ECG (TwiST) score can identify patients likely or not likely to have RHS with>80% specificity and sensitivity and may assist in identifying patients with acute PE at risk for adverse clinical events before pursuing other advanced imaging tests. (Source: Clinical Cardiology)
Source: Clinical Cardiology - March 1, 2015 Category: Cardiology Authors: Praveen Hariharan, David M. Dudzinski, Ikenna Okechukwu, James Kimo Takayesu, Yuchiao Chang, Christopher Kabrhel Tags: Clinical Investigations Source Type: research

Diabetes and Ischemic Heart Disease Death in People Age 25–54: A Multiple‐Cause‐of‐Death Analysis Based on Over 400 000 Deaths From 1990 to 2008 in New York City
Abstract BackgroundOver the past decade, ischemic heart disease (IHD) mortality trends have been less favorable among adults age 25–54 than age ≥55 years. HypothesisDisorders associated with IHD such as diabetes, chronic inflammatory and infectious diseases, and cocaine use are important contributors to premature IHD mortality. MethodsMultiple‐cause‐of‐death analysis was performed using the New York City (NYC) Vital Statistics database. Frequencies of selected contributing causes on death records with IHD as the underlying cause for decedents age ≥25 were assessed (n = 418,151; 1990&n...
Source: Clinical Cardiology - February 25, 2015 Category: Cardiology Authors: Adriana Quinones, Iryna Lobach, Gil A. Maduro, Nathaniel R. Smilowitz, Harmony R. Reynolds Tags: Clinical Investigation Source Type: research

Issue Information
(Source: Clinical Cardiology)
Source: Clinical Cardiology - February 25, 2015 Category: Cardiology Tags: Issue Information Source Type: research

Variation of Ventilation Practices With Center Volume After Pediatric Heart Surgery
This study was designed to evaluate the odds of mechanical ventilation and duration of mechanical ventilation after pediatric cardiac surgery across centers of varying center volume using the Virtual PICU Systems database. HypothesisChildren receiving cardiac surgery at high‐volume centers will be associated with lower odds of mechanical ventilation and shorter duration of mechanical ventilation, compared with low‐volume centers. MethodsPatients age
Source: Clinical Cardiology - February 23, 2015 Category: Cardiology Authors: Punkaj Gupta, Xinyu Tang, Jeffrey M. Gossett, Christine M. Gall, Casey Lauer, Tom B. Rice, Randall C. Wetzel Tags: Clinical Investigations Source Type: research

Left Ventricular Diastolic Dysfunction and E/E′ Ratio as the Strongest Echocardiographic Predictors of Reduced Exercise Capacity After Acute Myocardial Infarction
Abstract BackgroundThe mechanisms that determine reduced exercise capacity after acute myocardial infarction (AMI) are not fully understood, especially the relative role of left ventricular diastolic and systolic function. HypothesisTo evaluate the role of different diastolic and systolic function echocardiographic parameters as predictors of reduced functional capacity in patients after AMI. MethodsOne month after AMI, 225 patients (84% male; mean age, 55.1 ± 10.9 years) were enrolled and underwent detailed echocardiography and cardiopulmonary exercise test on the same day. Systolic and diastol...
Source: Clinical Cardiology - February 23, 2015 Category: Cardiology Authors: Ricardo Fontes‐Carvalho, Francisco Sampaio, Madalena Teixeira, Francisco Rocha‐Gonçalves, Vasco Gama, Ana Azevedo, Adelino Leite‐Moreira Tags: Clinical Investigations Source Type: research

Serious Cardiac Complications in Coronary Spasm Provocation Tests Using Acetylcholine or Ergonovine: Analysis of 21 512 Patients From the Diagnosis Procedure Combination Database in Japan
ABSTRACT BackgroundPrevious studies on complications with coronary spasm provocation tests were based on small sample sizes or were limited to high‐volume centers. The risk of provocation tests using acetylcholine (ACH) or ergonovine (ER) remains to be fully examined by a large‐scale multicenter study. HypothesisACH provocation tests are associated with a higher rate of serious cardiac complications than ER tests. MethodsUsing the Diagnosis Procedure Combination database in Japan, we identified patients aged ≥20 years who underwent a pharmacological provocation test during coronary angiography. We assessed the compo...
Source: Clinical Cardiology - February 18, 2015 Category: Cardiology Authors: Toshiaki Isogai, Hideo Yasunaga, Hiroki Matsui, Hiroyuki Tanaka, Tetsuro Ueda, Hiromasa Horiguchi, Kiyohide Fushimi Tags: Clinical Investigations Source Type: research

Role of a 12‐Lead Electrocardiogram in the Diagnosis of Cardiac Tamponade as Diagnosed by Transthoracic Echocardiography in Patients With Malignant Pericardial Effusion
ConclusionsIn malignant PE, combination of ECG abnormalities can supplement clinical examination in the diagnosis of echocardiographic cardiac tamponade. Due to its low NPV, 12‐lead ECG cannot be used as a screening tool to exclude cardiac tamponade with malignant PE. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 18, 2015 Category: Cardiology Authors: Rahul G. Argula, Smita I. Negi, Jose Banchs, Syed Wamique Yusuf Tags: Clinical Investigations Source Type: research

The 2014 American College of Cardiology ACC/American Heart Association Guideline for the Management of Patients With Non–ST‐Elevation Acute Coronary Syndromes
(Source: Clinical Cardiology)
Source: Clinical Cardiology - February 3, 2015 Category: Cardiology Authors: Ezra A. Amsterdam, Nanette K. Wenger Tags: Review Source Type: research

The 2014 American College of CardiologyACC/American Heart Association Guideline for the Management of Patients With Non–ST‐Elevation Acute Coronary Syndromes
(Source: Clinical Cardiology)
Source: Clinical Cardiology - February 3, 2015 Category: Cardiology Authors: Ezra A. Amsterdam, Nanette K. Wenger Tags: Reviews Source Type: research

Echocardiographic and Biohumoral Characteristics in Patients With AL and TTR Amyloidosis at Diagnosis
ConclusionsOur data show that at time of first diagnosis, TTR patients have a more advanced amyloidotic involvement of the heart, despite less severe symptoms and biohumoral signs of heart failure. We can hypothesize that we observed different diseases at different stages. In fact, AL amyloidosis is a multiorgan disease with quick progression rate, that becomes rapidly symptomatic, whereas TTR amyloidosis might have a slow progression rate and might remain poorly symptomatic for a greater amount of time. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 2, 2015 Category: Cardiology Authors: Francesco Cappelli, Samuele Baldasseroni, Franco Bergesio, Stefano Perlini, Francesco Salinaro, Luigi Padeletti, Paola Attanà, Alessandro Paoletti Perini, Alberto Moggi Pignone, Elisa Grifoni, Alessia Fabbri, Niccolò Marchionni, Gian Franco Gensini, Fed Tags: Clinical Investigations Source Type: research

Sinus of Valsalva Aneurysms: Review of the Literature and an Update on Management
We report here 4 incidental SOVA cases and review the current literature. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 1, 2015 Category: Cardiology Authors: Michael Weinreich, Pey‐Jen Yu, Biana Trost Tags: Reviews Source Type: research

Midterm Follow‐up After Retrievable Inferior Vena Cava Filter Placement in Venous Thromboembolism Patients With or Without Malignancy
This study was designed to evaluate the efficacy and disadvantages of the retrievable IVCF use particularly in venous thromboembolism (VTE) patients with malignancy. HypothesisRetrievable IVCFs might be safe and useful in VTE patients with malignancy. MethodsThe study population consisted of 56 consecutive patients undergoing IVCF placement at our institution from January 1, 2008 to December 31, 2011. Prognostic data were retrospectively reviewed in April 2013. ResultsMean follow‐up period was 584.6 (range, 1–1857) days. Twenty‐six of the 56 patients had a malignancy. In 16 of the 30 patients without malignancy, ...
Source: Clinical Cardiology - February 1, 2015 Category: Cardiology Authors: Masahiro Myojo, Masao Takahashi, Tomofumi Tanaka, Yasutomi Higashikuni, Arihiro Kiyosue, Jiro Ando, Hideo Fujita, Issei Komuro, Yasunobu Hirata Tags: Clinical Investigations Source Type: research

Prognostic Implications of Low Level Cardiac Troponin Elevation Using High‐Sensitivity Cardiac Troponin T
ABSTRACT BackgroundHigh‐sensitivity cardiac troponin T (hsTnT) is used in many countries, but is not available in the United States. Prior evidence has been viewed as inconclusive as to whether low cardiac troponin T (cTnT) concentrations detected with hsTnT are prognostically meaningful compared with fourth‐generation cTnT. HypothesisThe aim of this study was to assess the prognostic performance of low‐level cTnT elevations using the hsTnT assay compared with the assay (fourth‐generation) currently available in the United States. MethodsWe measured serum cTnT in 4160 patients with non–ST‐elevation acute co...
Source: Clinical Cardiology - February 1, 2015 Category: Cardiology Authors: Jonathan Grinstein, Marc P. Bonaca, Petr Jarolim, Michael J. Conrad, Erin Bohula‐May, Naveen Deenadayalu, Eugene Braunwald, Robert P. Giugliano, L. Kristin Newby, Marc S. Sabatine, David A. Morrow Tags: Clinical Investigations Source Type: research

Treatment of Heart Failure in Real‐World Clinical Practice: Findings From the REFLECT‐HF Registry in Patients With NYHA Class II Symptoms and a Reduced Ejection Fraction
ConclusionsGiven the high proportion of patients with reduced left ventricular systolic function but only minor symptoms, HF‐REF appears to be underdiagnosed, and a higher proportion of patients than are currently recognized could potentially be candidates for OMT. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 1, 2015 Category: Cardiology Authors: Michael Böhm, Carsten Tschöpe, Jost Henner Wirtz, Jan Lokies, Eva Turgonyi, Peter Bramlage, Katharina Lins, Anke M. Strunz, Ulrich Tebbe Tags: Clinical Investigations Source Type: research

Gender‐Related Mortality and In‐Hospital Complications Following ST‐Segment Elevation Myocardial Infarction: Data From a Primary Percutaneous Coronary Intervention Cohort
ABSTRACT BackgroundThe increased mortality related to female gender in ST‐segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PPCI) has been reported from various patient cohorts and treatment strategies with controversial results. In the present work, we evaluated the impact of female gender on mortality and in‐hospital complications among a specific subset of consecutive STEMI patients managed solely by PPCI. HypothesisFemale gender is not an independent predicor for mortality among STEMI patients. MethodsWe performed a retrospective, single‐center obser...
Source: Clinical Cardiology - February 1, 2015 Category: Cardiology Authors: Michal Laufer‐Perl, Yacov Shacham, Sivan Letourneau‐Shesaf, Ofir Priesler, Gad Keren, Arie Roth, Arie Steinvil Tags: Clinical Investigations Source Type: research

Impact of Hypertension on Global Cardiovascular Risk Stratification: Analysis of a Large Cohort of Outpatient Population in Italy
ABSTRACT BackgroundControl of hypertension remains a major unmet need, worldwide. HypothesisTo test whether the presence of hypertension may improve global cardiovascular (CV) risk stratification and achievement of therapeutic targets for CV risk factors in adult outpatients in Italy. MethodsPhysicians were asked to submit data covering the first 10 consecutive adult outpatients. All data were centrally analyzed for global CV risk assessment and rates of control of major CV risk factors, mostly blood pressure (BP) levels, in different high‐risk subgroups of hypertensive patients. ResultsOverall, 1078 physicians collected...
Source: Clinical Cardiology - January 27, 2015 Category: Cardiology Authors: Giuliano Tocci, Allegra Battistoni, Michela D'Agostino, Francesca Palano, Jasmine Passerini, Pietro Francia, Andrea Ferrucci, Massimo Volpe, Tags: Clinical Investigation Source Type: research

Usefulness and Safety of Intracoronary Administration of Nicorandil for Evaluating Fractional Flow Reserve in Japanese Patients
ABSTRACT BackgroundFractional flow reserve (FFR) is useful for determining the functional significance of epicardial coronary stenosis and may facilitate clinical decision making in patients with an equivocal coronary stenosis for coronary revascularization. Therefore, determining an efficient and safe method to achieve hyperemia is important for evaluating FFR. We investigated the usefulness and safety of intracoronary bolus administration of nicorandil compared with intravenous administration of adenosine triphosphate (ATP) for evaluating FFR in Japanese patients with suspected angina pectoris. MethodsFirst, we evaluated...
Source: Clinical Cardiology - January 27, 2015 Category: Cardiology Authors: Nobukiyo Tanaka, Yuya Takahashi, Hiroki Ishihara, Tohru Kawakami, Hiroyoshi Ono Tags: Clinical Investigation Source Type: research

Issue Information
(Source: Clinical Cardiology)
Source: Clinical Cardiology - January 27, 2015 Category: Cardiology Tags: Issue Information Source Type: research

Some Thoughts About Patient Ownership
(Source: Clinical Cardiology)
Source: Clinical Cardiology - January 7, 2015 Category: Cardiology Authors: C. Richard Conti Tags: Editorial Source Type: research

The Value of Magnetic Resonance Imaging in Catheter Ablation of Atrial Fibrillation
Abstract Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. Catheter ablation is now a recognized treatment for those with symptomatic AF refractory to drug therapy. Innovations in magnetic resonance imaging (MRI) have empowered clinicians to improve ablation efficacy while reducing the risk of complications. It is demonstrated that late gadolinium enhancement MRI has additional advantages over modalities such as echocardiography and computed tomography, due to its ability to assess the structural remodeling directly. As a result, MRI has become an indispensable imaging tool to persona...
Source: Clinical Cardiology - January 5, 2015 Category: Cardiology Authors: Jun Gu, Wei Hu, Xu Liu Tags: Reviews Source Type: research

Commonly Consumed Beverages in Daily Life: Do They Cause Atrial Fibrillation?
Abstract Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in the United States and worldwide. Caffeine, alcohol, and, more recently, energy drinks are the most commonly consumed beverages in daily living, especially by young individuals. Several questions have been raised about the implications of caffeine, alcohol, and energy drinks in cardiovascular health, especially in triggering AF. This review focuses on the role of these commonly consumed beverages as a cause of AF, with special emphasis of potential mechanisms and studies addressing this issue. (Source: Clinical Cardiology)
Source: Clinical Cardiology - January 1, 2015 Category: Cardiology Authors: Mohit K. Turagam, Poonam Velagapudi, Abraham G. Kocheril, Martin A. Alpert Tags: Reviews Source Type: research

Mortality and Readmission Rates in Patients Hospitalized for Acute Decompensated Heart Failure: A Comparison Between Cardiology and General‐Medicine Service Outcomes in an Underserved Population
ConclusionsIn this cohort of ADHF patients from the Bronx, New York, involvement of a cardiologist resulted in improved short‐term mortality and readmission outcomes compared with treatment by general internal medicine. (Source: Clinical Cardiology)
Source: Clinical Cardiology - January 1, 2015 Category: Cardiology Authors: Ahmed M. Selim, Jeremy A. Mazurek, Muhammad Iqbal, Dan Wang, Abdissa Negassa, Ronald Zolty Tags: Quality and Outcomes Source Type: research

Pretransplant Coagulopathy and In‐hospital Outcomes Among Heart Transplant Recipients: A Propensity‐Matched Nationwide Inpatient Sample Study
ABSTRACT BackgroundThe prevalence and contemporary trends of pre–heart transplantation (HT) coagulopathy and associated clinical outcomes have not been studied from a national database. HypothesisPre‐HT coagulopathy is associated with increased in‐hospital mortality. MethodsAmong 2454 adult HT recipients from the 2003 to 2010 Nationwide Inpatient Sample databases, 707 (29%) had pre‐HT coagulopathy (defined as a comorbidity variable, based on International Classification of Diseases, Ninthe Revision, Clinical Modification and Diagnosis Related Group codes). We used propensity scores for coagulopathy to assemble ...
Source: Clinical Cardiology - January 1, 2015 Category: Cardiology Authors: Marjan Mujib, Neel Khanna, Nabila K. Mazumder, Wilbert S. Aronow, Dhaval Kolte, Sahil Khera, Chandrasekar Palaniswamy, Diwakar Jain, Gregg M. Lanier, Sachin Sule, Ali Ahmed, Wayne C. Levy, Sumanth D. Prabhu, Howard A. Cooper, Julio A. Panza, Alan L. Gass, Tags: Clinical Investigations Source Type: research

Premature Ventricular Contraction–Induced Cardiomyopathy
Abstract Premature ventricular contractions are of common occurrence in routine clinical practice. Though generally perceived as of benign consequence in healthy people in the absence of heart disease, their presence can be a harbinger of fatal ventricular tachyarrhythmia in individuals with structural heart disease. With some of the latest insights into the treatment of ventricular tachyarrhythmia, especially with the advent of catheter ablation, there has been renewed interest in premature ventricular contractions, not only as a predictor of arrhythmia, but also for their potential etiological association with cardiomyop...
Source: Clinical Cardiology - January 1, 2015 Category: Cardiology Authors: Alok Saurav, Aiman Smer, Ahmed Abuzaid, Ojas Bansal, Hussam Abuissa Tags: Reviews Source Type: research

Cystatin C–based CKD‐EPI Equations and N‐Terminal Pro‐B‐Type Natriuretic Peptide for Predicting Outcomes in Acutely Decompensated Heart Failure
ABSTRACT BackgroundIn patients with acute decompensated heart failure (ADHF), both natriuretic peptides and renal impairment predict adverse outcomes. Our aim was to evaluate the complementary prognosis role of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) and the newly developed Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) equations based on cystatin C (CysC) for glomerular filtration rate (GFR) estimation in ADHF patients. HypothesisRenal impairment assessed by CysC‐based CKD‐EPI equations and natriuretic peptides have complementary prognostic value in ADHF patients. MethodsThe study ...
Source: Clinical Cardiology - January 1, 2015 Category: Cardiology Authors: Pedro J. Flores‐Blanco, Sergio Manzano‐Fernández, Juan I. Pérez‐Calvo, Francisco J. Pastor‐Pérez, Francisco J. Ruiz‐Ruiz, Francisco J. Carrasco‐Sánchez, José L. Morales‐Rull, Domingo Pascual‐Figal, Luis Galisteo‐Almeda, James L. Jan Tags: Clinical Investigations Source Type: research

Point‐of‐Care Platelet Function Testing Predicts Bleeding in Patients Exposed to Clopidogrel Undergoing Coronary Artery Bypass Grafting: Verify Pre‐Op TIMI 45—A Pilot Study
Abstract BackgroundGuidelines recommend delaying coronary artery bypass grafting (CABG) for 5 days after discontinuing clopidogrel. However, platelet function may recover quicker in certain individuals. HypothesisWe hypothesized that perioperative measurement of platelet function with a point‐of‐care P2Y12 inhibitor assay could predict bleeding during CABG in patients exposed to clopidogrel. MethodsVerify Pre‐Op TIMI 45 was a prospective pilot study of 39 patients on clopidogrel who subsequently underwent CABG. Preoperative on‐treatment platelet reactivity was assessed with VerifyNow P2Y12 Reaction Units (PRU), wit...
Source: Clinical Cardiology - January 1, 2015 Category: Cardiology Authors: Grant W. Reed, Amit Kumar, Jianping Guo, Sary Aranki, Prem Shekar, Arvind Agnihotri, Andrew O. Maree, Dalton S. McLean, Kenneth Rosenfield, Christopher P. Cannon Tags: Clinical Investigations Source Type: research

Late Percutaneous Coronary Intervention Prevents Left Ventricular Remodeling and Improves Clinical Outcomes in Patients With ST‐Elevation Myocardial Infarction
Abstract BackgroundThe optimal strategy for treating late presenters of ST‐elevation myocardial infarction (STEMI) remains uncertain. Hypothesispercutaneous coronary intervention (PCI) has a favorable effect on left ventricular (LV) remodeling and clinical outcomes in late presenters of STEMI. MethodsPatients with STEMI who were hospitalized between 2009 and 2011 at 7 PCI‐capable hospitals in China were selected. Cardiac characteristics were reassessed by echocardiography between August 2013 and January 2014. The clinical endpoints were evaluated during a median follow‐up period of 36 months. Results1090 patients who...
Source: Clinical Cardiology - January 1, 2015 Category: Cardiology Authors: Yan Fan, Xiaojun Bai, Yuewu Chen, Guidong Shen, Qun Lu, Zhaofei Wan, Dong Zhou, Yuan Shen, Aiqun Ma Tags: Clinical Investigations Source Type: research

The Obesity Paradox in Patients Undergoing Transcatheter Aortic Valve Implantation
ConclusionsIn our single‐center study, obesity and overweight were independently associated with better outcome, supporting the obesity paradox in the TAVI population. (Source: Clinical Cardiology)
Source: Clinical Cardiology - January 1, 2015 Category: Cardiology Authors: Maayan Konigstein, Ofer Havakuk, Yaron Arbel, Ariel Finkelstein, Eyal Ben‐Assa, Eran Leshem Rubinow, Yigal Abramowitz, Gad Keren, Shmuel Banai Tags: Clinical Investigations Source Type: research

Relation of In‐hospital Serum Creatinine Change Patterns and Outcomes Among ST‐Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
Abstract BackgroundThe worsening of serum creatinine (sCr) level is a frequent finding among ST‐segment elevation MI (STEMI) patients undergoing primary percutaneous coronary intervention (PCI), associated with adverse short‐term and long‐term outcomes. No information is present, however, regarding the incidence and prognostic implications associated with an improvement in sCr levels throughout hospitalization, as compared with admission levels. HypothesisReversible renal impairment prior to PCI is not associated with adverse outcomes. MethodsWe retrospectively studied 1260 STEMI patients undergoing primary PCI. The ...
Source: Clinical Cardiology - January 1, 2015 Category: Cardiology Authors: Yacov Shacham, Eran Leshem‐Rubinow, Amir Gal‐Oz, Eyal Ben‐Assa, Arie Steinvil, Gad Keren, Arie Roth, Yaron Arbel Tags: Clinical Investigations Source Type: research

Issue Information
(Source: Clinical Cardiology)
Source: Clinical Cardiology - December 22, 2014 Category: Cardiology Tags: Issue Information Source Type: research

Characterizing Major Bleeding in Patients With Nonvalvular Atrial Fibrillation: A Pharmacovigilance Study of 27 467 Patients Taking Rivaroxaban
ConclusionsIn this large observational study, the MB rate was generally consistent with the registration trial results, and fatal bleeds were rare. (Source: Clinical Cardiology)
Source: Clinical Cardiology - December 1, 2014 Category: Cardiology Authors: Sally Tamayo, W. Frank Peacock, Manesh Patel, Nicholas Sicignano, Kathleen P. Hopf, Larry E. Fields, Troy Sarich, Shujian Wu, Daniel Yannicelli, Zhong Yuan Tags: Quality and Outcomes Source Type: research

Hospital Volume and Cardiac Complications of Endomyocardial Biopsy: A Retrospective Cohort Study of 9508 Adult Patients Using a Nationwide Inpatient Database in Japan
ABSTRACT BackgroundRecent research on complications with endomyocardial biopsy (EMB) has been based on single‐center or 2‐center studies in high‐volume cardiovascular centers. No study has examined the association between hospital volume and the complication rate after EMB. HypothesisHospital volume is inversely associated with cardiac complication rate after EMB. MethodsUsing the Diagnosis Procedure Combination database in Japan, we identified inpatients aged ≥20 years who underwent EMB under fluoroscopic guidance. We assessed cardiac complications requiring the following urgent procedures on the day of EM...
Source: Clinical Cardiology - December 1, 2014 Category: Cardiology Authors: Toshiaki Isogai, Hideo Yasunaga, Hiroki Matsui, Tetsuro Ueda, Hiroyuki Tanaka, Hiromasa Horiguchi, Kiyohide Fushimi Tags: Clinical Investigations Source Type: research

Evaluation of Synergistic Effects of Resynchronization Therapy and a β‐Blocker Up‐titration Strategy Based on a Predefined Patient‐Management Program: The RESTORE Study
This study might provide important information about the benefit of a predefined management program for β‐blocker up‐titration in patients receiving CRT. Moreover, assessment of health‐care utilization and the consumption of resources will allow estimating the potential utility of remote monitoring by means of an automated telemedicine system in facilitating the titration of β‐blockers in comparison with a standard in‐hospital approach. (Source: Clinical Cardiology)
Source: Clinical Cardiology - December 1, 2014 Category: Cardiology Authors: Pietro Palmisano, Ernesto Ammendola, Antonio D'Onofrio, Michele Accogli, Leonardo Calò, Antonio Ruocco, Antonio Rapacciuolo, Giuseppe Del Giorno, Valter Bianchi, Maurizio Malacrida, Sergio Valsecchi, Edoardo Gronda Tags: Trial Designs Source Type: research

Applying the Ideal Cardiovascular Health Metrics to Couples: A Cross‐Sectional Study in Primary Care
Abstract BackgroundThere is little research on overall cardiovascular (CV) health among couples. Our aim was to examine concordance levels for CV health among couples, using the American Heart Association ideal health metrics, and to investigate if the CV health of an individual is associated with that of his or her partner. HypothesisThere is a positive association between the overall cardiovascular health of an individual and that of his/her partner. MethodsThe Mitchelstown Study is a community‐based cohort study of middle‐aged Irish adults. Potential couples were identified as 2 study participants living at the same...
Source: Clinical Cardiology - December 1, 2014 Category: Cardiology Authors: Anne Marie O'Flynn, Sheena M. McHugh, Jamie M. Madden, Janas M. Harrington, Ivan J. Perry, Patricia M. Kearney Tags: Clinical Investigations Source Type: research

Outcomes Associated With Preoperative Use of Extracorporeal Membrane Oxygenation in Children Undergoing Heart Operation for Congenital Heart Disease: A Multi‐institutional Analysis
This study was designed to evaluate this association using the Pediatric Health Information System (PHIS) database. HypothesisWe hypothesize that patients receiving ECMO prior to heart operation will have worse outcomes, including mortality, compared with patients receiving ECMO after heart operation. MethodsPatients age ≤18 years receiving ECMO before or after pediatric heart operation (with or without cardiopulmonary bypass) at a PHIS‐participating hospital from 2004 to 2013 were included. Multivariable logistic regression or Cox proportional‐hazards models were fitted to study the effect of timing of ECMO ...
Source: Clinical Cardiology - December 1, 2014 Category: Cardiology Authors: Punkaj Gupta, Michael J. Robertson, Brandon W. Beam, Mallikarjuna Rettiganti Tags: Clinical Investigations Source Type: research