Complicated Acute Aortic Syndromes Affecting the Descending Thoracic Aorta: Endovascular Treatment Compared With Open Repair
ConclusionsEndovascular treatment in patients with complicated acute thoracic aortic syndromes localized at the descending thoracic aorta is feasible and safe, with a lower rate of early complications and similar long‐term benefits when compared with surgical treatment. (Source: Clinical Cardiology)
Source: Clinical Cardiology - September 1, 2015 Category: Cardiology Authors: Guering Eid‐Lidt, Jorge Gaspar Hernández, Hector González‐Pacheco, Pablo Acevedo Gómez, Samuel Ramírez Marroquín, Valentín Herrera Alarcon, Jorge Cervantes Salazar, Marco Martínez‐Ríos Tags: Clinical Investigations Source Type: research

Predicting Bleeding Risk by Platelet Function Testing in Patients Undergoing Heart Surgery
ABSTRACT BackgroundPredicting bleeding events in patients with coronary artery bypass grafting (CABG) represents an unmet medical need that may improve CABG outcomes. HypotesisTo assess the potential link between platelet function testing and bleeding risk in patients undergoing CABG. MethodsPlatelet aggregation and clinical outcomes in 478 patients treated with aspirin and/or clopidogrel were retrospectively analyzed. Platelet activity was assessed prior to CABG with arachidonic acid (ASPI Test), and adenosine diphosphate(ADP Test) utilizing multiple‐electrode aggregometry. ResultsIn the study group of 478 patients, mea...
Source: Clinical Cardiology - September 1, 2015 Category: Cardiology Authors: Wiktor Kuliczkowski, Joanna Sliwka, Jacek Kaczmarski, Dorota Zysko, Michal Zembala, Damian Steter, Marian Zembala, Seth Fortmann, Victor Serebruany Tags: Clinical Investigations Source Type: research

Effect of High‐Dose Statin Pretreatment on the Incidence of Periprocedural Myocardial Infarction in Patients Undergoing Percutaneous Coronary Intervention: Grading the Evidence Through a Cumulative Meta‐analysis
ConclusionsHigh‐dose statin pretreatment can reduce the rate of PMI, irrespective of either the clinical presentation or previous statin‐treatment history. Importantly, the overall GRADE evidence quality was moderate. (Source: Clinical Cardiology)
Source: Clinical Cardiology - September 1, 2015 Category: Cardiology Authors: ChuanNan Zhai, HongLiang Cong, YuJie Liu, Ying Zhang, XianFeng Liu, Hao Zhang, ZhiJing Ren Tags: Clinical Investigations Source Type: research

The Prognostic Significance of Right Bundle Branch Block: A Meta‐analysis of Prospective Cohort Studies
ConclusionsRight bundle branch block is associated with an increased risk of mortality in general population and patients with heart disease. (Source: Clinical Cardiology)
Source: Clinical Cardiology - September 1, 2015 Category: Cardiology Authors: Yunyun Xiong, Lian Wang, Wenyan Liu, Graeme J. Hankey, Biao Xu, Shang Wang Tags: Clinical Investigations Source Type: research

Issue Information
(Source: Clinical Cardiology)
Source: Clinical Cardiology - August 18, 2015 Category: Cardiology Tags: Issue Information Source Type: research

Effect of Low‐Density Lipoprotein Cholesterol Lowering by Ezetimibe/Simvastatin on Outcome Incidence: Overview, Meta‐Analyses, and Meta‐Regression Analyses of Randomized Trials
ABSTRACT This analysis investigated the extent of different outcome reductions from low‐density lipoprotein cholesterol (LDL‐C) lowering following ezetimibe/simvastatin treatment and the proportionality of outcome to LDL‐C reductions. The authors searched PubMed between 1997 and mid‐June 2015 (any language) and the Cochrane Library to identify all randomized controlled trials comparing ezetimibe/simvastatin with placebo or less intensive LDL‐C lowering. Risk ratios (RR) and 95% confidence intervals (CIs), standardized to 20 mg/dL LDL‐C reduction, were calculated for 5 primary outcomes (fatal and nonfatal...
Source: Clinical Cardiology - August 18, 2015 Category: Cardiology Authors: Costas Thomopoulos, George Skalis, Helena Michalopoulou, Costas Tsioufis, Thomas Makris Tags: Review Source Type: research

Vitamin D Supplementation in the Treatment of Chronic Heart Failure: A Meta‐analysis of Randomized Controlled Trials
ABSTRACT BackgroundIn recent years, there has been growing evidence that vitamin D deficiency is associated with the development and progression of chronic heart failure (CHF). HypothesisAdditional supplementation of vitamin D may have protective effects in patients with CHF. MethodsWe searched PubMed, Embase, and Cochrane databases through June 2015 and included 7 randomized controlled trials that investigated the effects of vitamin D on cardiovascular outcomes in patients with CHF. Then, we performed a meta‐analysis of clinical trials to confirm whether vitamin D supplementation is beneficial in CHF patients. The weigh...
Source: Clinical Cardiology - August 1, 2015 Category: Cardiology Authors: Wei‐Long Jiang, Hai‐Bo Gu, Yu‐Feng Zhang, Qing‐Qing Xia, Jia Qi, Jian‐Chang Chen Tags: Review Source Type: research

The Effect of Remote Ischemic Conditioning and Glyceryl Trinitrate on Perioperative Myocardial Injury in Cardiac Bypass Surgery Patients: Rationale and Design of the ERIC‐GTN Study
ABSTRACT Remote ischemic conditioning (RIC) using transient limb ischemia/reperfusion has been reported to reduce perioperative myocardial injury in patients undergoing coronary artery bypass grafting and/or valve surgery. The role of intravenous glyceryl trinitrate (GTN) therapy administered during cardiac surgery as a cardioprotective agent and whether it interferes with RIC cardioprotection is not clear and is investigated in the ERIC‐GTN trial ( http://www.clinicaltrials.gov: NCT01864252). The ERIC‐GTN trial is a single‐site, double‐blind, randomized, placebo‐controlled study. Consenting adult patients (age&g...
Source: Clinical Cardiology - August 1, 2015 Category: Cardiology Authors: Ashraf Hamarneh, Vivek Sivaraman, Heerajnarain Bulluck, Hilary Shanahan, Bonnie Kyle, Manish Ramlall, Robin Chung, Claire Jarvis, Maria Xenou, Cono Ariti, Roger Cordery, Derek M. Yellon, Derek J. Hausenloy Tags: Trial Designs Source Type: research

The Safety and Efficacy of Absorb Bioresorbable Vascular Scaffold: A Systematic Review
ABSTRACT Bioresorbable stents are novel devices designed to overcome the long‐term limitations of permanent stent implantation. The Absorb bioresorbable vascular scaffold (BVS; Abbott Vascular, Santa Clara, CA) was the first bioresorbable stent with Conformité Européenne mark approval in coronary vessels and has been the subject of multiple clinical studies. Despite its potential advantages, the safety and efficacy of BVS remain unclear. To address this, we conducted a systematic review to examine the safety and efficacy of BVS. The MEDLINE, Embase, Current Index to Nursing & Allied Health Literature (C...
Source: Clinical Cardiology - August 1, 2015 Category: Cardiology Authors: Chang Lu, Kristian B. Filion, Mark J. Eisenberg Tags: Review Source Type: research

Incidence and Predictors of Left Ventricular Thrombus After Primary Percutaneous Coronary Intervention for Anterior ST‐Segment Elevation Myocardial Infarction
ConclusionsIn contemporary practice with primary PCI, definite LV thrombus following anterior STEMI with LV dysfunction is challenging to predict. Further investigation is needed to determine if there is a subset of patients that should be treated with prophylactic warfarin. (Source: Clinical Cardiology)
Source: Clinical Cardiology - August 1, 2015 Category: Cardiology Authors: Adam Driesman, Omar Hyder, Christopher Lang, Phillip Stockwell, Athena Poppas, J. Dawn Abbott Tags: Clinical Investigations Source Type: research

Conicity Index and Waist‐to‐Hip Ratio Are Superior Obesity Indices in Predicting 10‐Year Cardiovascular Risk Among Men and Women
ConclusionConicity index and WHR had a more discriminatory accuracy for 10‐year CV events compared with the other obesity indices. (Source: Clinical Cardiology)
Source: Clinical Cardiology - August 1, 2015 Category: Cardiology Authors: Nima Motamed, Dhaya Perumal, Farhad Zamani, Hossein Ashrafi, Majid Haghjoo, F.S. Saeedian, Mansooreh Maadi, Haleh Akhavan‐Niaki, Behnam Rabiee, Mohsen Asouri Tags: Clinical Investigations Source Type: research

Insights Into Statin Intolerance
(Source: Clinical Cardiology)
Source: Clinical Cardiology - August 1, 2015 Category: Cardiology Authors: Stephen Kopecky, Seth Baum, JoAnne M. Foody, Michael Koren, James McKenney, Laurence Sperling, Nathan D. Wong, Tags: Supplement Article Source Type: research

Multimodality Evaluation of the Right Ventricle: An Updated Review
ABSTRACT The assessment of the volumes, function, and mechanics of the right ventricle (RV) is very challenging because of the anatomical complexity of the RV. Because RV structure, function, and deformation are very important predictors of cardiovascular morbidity and mortality in patients with heart failure, pulmonary hypertension, congenital heart disease, or arrhythmogenic RV cardiomyopathy, it is of great importance to use an appropriate imaging modality that will provide all necessary information. In everyday clinical practice, 2‐dimensional echocardiography (2DE) represents a method of first choice in RV evaluatio...
Source: Clinical Cardiology - August 1, 2015 Category: Cardiology Authors: Marijana Tadic Tags: Review Source Type: research

Authors' Reply
(Source: Clinical Cardiology)
Source: Clinical Cardiology - July 27, 2015 Category: Cardiology Authors: Syed Wamique Yusuf, Smita I. Negi, Jose Banchs, Rahul G. Argula Tags: Letter to the Editor Source Type: research

Response to Role of a 12‐Lead Electrocardiogram in the Diagnosis of Cardiac Tamponade as Diagnosed by Transthoracic Echocardiography in Patients With Malignant Pericardial Effusion
(Source: Clinical Cardiology)
Source: Clinical Cardiology - July 27, 2015 Category: Cardiology Authors: Nauman Khalid, Lovely Chhabra, David H. Spodick Tags: Letter to the Editor Source Type: research

Authors' Reply
(Source: Clinical Cardiology)
Source: Clinical Cardiology - July 27, 2015 Category: Cardiology Authors: Grant W. Reed, Jianping Guo, Christopher P. Cannon, Amit Kumar, Sary Aranki, Prem Shekar, Arvind Agnihotri, Andrew O. Maree, Dalton S. McLean, Kenneth Rosenfield Tags: Letter to the Editor Source Type: research

Issue Information
(Source: Clinical Cardiology)
Source: Clinical Cardiology - July 27, 2015 Category: Cardiology Tags: Issue Information Source Type: research

Rationale, Design, and Baseline Characteristics of the EPICOR Asia Study (Long‐tErm follow‐uP of antithrombotic management patterns In Acute CORonary Syndrome patients in Asia)
ConclusionsEPICOR Asia will provide information regarding clinical management and AMPs for ACS patients in Asia. Impact of AMPs on clinical outcomes, healthcare resource use, and self‐reported health status both during hospitalization and up to 2 years after discharge will also be described. (Source: Clinical Cardiology)
Source: Clinical Cardiology - July 24, 2015 Category: Cardiology Authors: Yong Huo, Stephen W.‐L. Lee, Jitendra P. S. Sawhney, Hyo‐Soo Kim, Rungroj Krittayaphong, Vo T. Nhan, Angeles Alonso‐Garcia, Ya Ling Han, Junbo Ge, Chee Tang Chin, Tiong K. Ong, Stephen Jan, Yohji Itoh, Ana Maria Vega, Stuart Pocock Tags: Trial Designs Source Type: research

Is Heart Rate Variability Related to Season of Birth?
ConclusionsSeason of birth is related to both parasympathetic and sympathetic activity among school‐age children, especially boys. Temperature and humidity are potential causes of this SOB phenomenon. (Source: Clinical Cardiology)
Source: Clinical Cardiology - July 24, 2015 Category: Cardiology Authors: Wei‐Lieh Huang, Be‐Tau Hwang, Chun‐Ting Lai, Jia‐Yi Li, Terry B.J. Kuo, Cheryl C.H. Yang Tags: Clinical Investigations Source Type: research

Non–Vitamin K Antagonist Oral Anticoagulant Use in Patients With Atrial Fibrillation and Associated Intracranial Hemorrhage: A Focused Review
ABSTRACT Atrial fibrillation (AF) is the most common cardiac arrhythmia and predisposes patients to an increased risk of embolic stroke. After nearly 60 years, warfarin is no longer the only effective therapeutic option for patients with AF. Large randomized trials have consistently shown that non–vitamin K oral anticoagulants (NOACs) including dabigatran, rivaroxaban, apixaban, and edoxaban significantly reduce from the risk of intracranial hemorrhage (ICH) compared with warfarin. We provide a focused review regarding the NOACs and ICH in AF patients by summarizing findings of these large clinical trials, mechanisms...
Source: Clinical Cardiology - July 14, 2015 Category: Cardiology Authors: Boris Arbit, Jonathan C. Hsu Tags: Review Source Type: research

Markers of Myocardial Ischemia in Patients With Coronary Artery Disease and Obstructive Sleep Apnea: Effect of Continuous Positive Airway Pressure Therapy
ConclusionsCPAP significantly reduced NT‐proBNP in patients suffering from severe OSA and coexisting CAD. Repeated nocturnal myocardial ischemia did not cause myocyte necrosis evidenced by elevated hs‐TropT or ST‐segment depression. (Source: Clinical Cardiology)
Source: Clinical Cardiology - July 14, 2015 Category: Cardiology Authors: Misa Valo, Annette Wons, Albert Moeller, Claudius Teupe Tags: Clinical Investigations Source Type: research

Overview of the Acetylcholine Spasm Provocation Test
Abstract The acetylcholine (ACh) spasm provocation test proposed by Yasue, Okumura et al more than a quarter‐century ago has become a popular method for induction of coronary spasm. This test is safe and has a low rate of complications. However, it may be limited in its ability to document attacks in daily life because previously it was the gold‐standard method for diagnosing active variant angina. There may be some clinical issues to modify for the next generation of cardiologists. A maximal ACh dose of 50/100 µg in the right coronary artery/left coronary artery is recommended in the Japanese Circulation ...
Source: Clinical Cardiology - July 14, 2015 Category: Cardiology Authors: Shozo Sueda, Hiroaki Kohno, Takaaki Ochi, Tadao Uraoka Tags: Reviews Source Type: research

Detect Long‐term Complications After ICD Replacement (DECODE): Rationale and Study Design of a Multicenter Italian Registry
ABSTRACT The replacement of implantable cardioverter‐defibrillators (ICDs) may give rise to considerable clinical consequences, the importance of which is underrated by the medical community. Replacement‐related adverse events are difficult to identify and require monitoring of both short‐term complications and long‐term patient outcome. The aim of this study is to perform a structured evaluation of both short‐ and long‐term adverse events and a cost analysis of consecutive ICD replacement procedures. Detect Long‐term Complications After ICD Replacement (DECODE) is a prospective, single‐arm, multicenter coh...
Source: Clinical Cardiology - July 1, 2015 Category: Cardiology Authors: Igor Diemberger, Quintino Parisi, Paolo De Filippo, Maria Lucia Narducci, Francesco Zanon, Domenico Rosario Potenza, Gianfranco Ciaramitaro, Maurizio Malacrida, Giuseppe Boriani, Mauro Biffi Tags: Trial Designs Source Type: research

Tocopherols in the Prevention and Treatment of Atherosclerosis and Related Cardiovascular Disease
ABSTRACT Oxidants/antioxidants play an important role in cellular homeostasis. The human body has endogenous molecules that work as antioxidants, such as glutathione, superoxide dismutase, peroxidases, and catalase. Exogenous substances in the diet, such as β‐carotene, ascorbate, and vitamin E, are vital antioxidants. Of these, vitamin E is likely the most important antioxidant in the human diet, and many studies have been performed to elucidate its role in health and disease. Vitamin E is a family of several compounds, of which α‐tocopherol is the most widely known analog. α‐Tocopherol exhibits anti...
Source: Clinical Cardiology - July 1, 2015 Category: Cardiology Authors: Pankaj Mathur, Zufeng Ding, Tom Saldeen, Jawahar L. Mehta Tags: Review Source Type: research

Benefit of Anticoagulation Therapy in Hyperthyroidism‐Related Atrial Fibrillation
ABSTRACT BackgroundExisting data on the risk of ischemic stroke in hyperthyroidism‐related atrial fibrillation (AF) and the impact of long‐term anticoagulation in these patients, particularly those with self‐limiting AF, remain inconclusive. HypothesisRisk of stroke in hyperthyroidism‐related AF is the same as nonhyperthyroid counterparts. MethodsThis was a single‐center observational study of 9727 Chinese patients with nonvalvular AF from July 1997 to December 2011. Patients with AF diagnosed concomitantly with hyperthyroidism were identified. Primary and secondary endpoints were defined as hospitalization with ...
Source: Clinical Cardiology - July 1, 2015 Category: Cardiology Authors: Pak‐Hei Chan, Jojo Hai, Chun‐Yip Yeung, Gregory Y.H. Lip, Karen Siu‐Ling Lam, Hung‐Fat Tse, Chung‐Wah Siu Tags: Clinical Investigations Source Type: research

Single vs Dual Antiplatelet Therapy Following Transcatheter Aortic Valve Implantation: A Systematic Review
The objective of this review was to evaluate published and unpublished reports regarding the efficacy and safety of dual antiplatelet therapy (DAPT) compared with a single antiplatelet agent in patients undergoing TAVI. We searched MEDLINE, CENTRAL, Embase, and unpublished sources of literature from inception to December 2014 using terms synonymous with TAVI and DAPT. We included randomized controlled trials (RCTs) and cohort or case‐control studies that compared DAPT with a single antiplatelet agent post‐TAVI. Four articles met the inclusion criteria (2 RCTs, 2 cohort studies), of which all were deemed to be at high r...
Source: Clinical Cardiology - July 1, 2015 Category: Cardiology Authors: Ricky D. Turgeon, Arden R. Barry Tags: Review Source Type: research

Issue Information
(Source: Clinical Cardiology)
Source: Clinical Cardiology - June 19, 2015 Category: Cardiology Tags: Issue Information Source Type: research

Renal Denervation for the Treatment of Hypertension: Making a New Start, Getting It Right
(Source: Clinical Cardiology)
Source: Clinical Cardiology - June 1, 2015 Category: Cardiology Authors: Michael A. Weber, Ajay Kirtane, Laura Mauri, Raymond R. Townsend, David E. Kandzari, Martin B. Leon Tags: Editorial Source Type: research

Cognitive and Physical Function by Statin Exposure in Elderly Individuals Following Acute Myocardial Infarction
ABSTRACT Despite beneficial effects on morbidity and mortality after acute myocardial infarction (AMI), concerns remain about the safety of statin therapy, particularly their potential effects on cognitive and physical function, in elderly individuals. Among statin‐naive AMI patients age ≥65 years in a multicenter US registry, we examined the association between statin prescription at discharge and change in cognition (via Modified Telephone Interview for Cognitive Status [TICS‐M]) assessed at 1 and 6 months after AMI. Short Form‐12 Physical Component score, hand grip, walk time, and chair‐rise tests were...
Source: Clinical Cardiology - June 1, 2015 Category: Cardiology Authors: Kristopher J. Swiger, Seth S. Martin, Fengming Tang, Michael J. Blaha, Roger S. Blumenthal, Karen P. Alexander, Suzanne V. Arnold, John A. Spertus Tags: Quality and Outcomes Source Type: research

Management of Arrhythmias in Cardiac Sarcoidosis
ABSTRACT The prevalence of cardiac involvement in sarcoidosis is under‐recognized and is associated with multiple complications, including conduction block, arrhythmias, and sudden death. The comparative roles of common therapies have been inadequately studied. The purpose of this review is to examine the literature regarding treatments utilized to manage arrhythmias associated with cardiac sarcoidosis. (Source: Clinical Cardiology)
Source: Clinical Cardiology - June 1, 2015 Category: Cardiology Authors: David G. Rosenthal, Paco E. Bravo, Kristen K. Patton, Zachary D. Goldberger Tags: Review Source Type: research

Burden of First and Recurrent Cardiovascular Events Among Patients With Hyperlipidemia
ConclusionsPatients with recurrent CV events had higher total health care costs during 24‐month follow‐up for each type of CV event. Total health care costs among patients with a CV event were higher for the initial as well as subsequent events. Statins and lipid‐modifying medications were significantly underutilized in all cohorts, despite the presence of CVD. (Source: Clinical Cardiology)
Source: Clinical Cardiology - June 1, 2015 Category: Cardiology Authors: Rajeshwari S. Punekar, Kathleen M. Fox, Akshara Richhariya, Maxine D. Fisher, Mark Cziraky, Shravanthi R. Gandra, Peter P. Toth Tags: Clinical Investigations Source Type: research

The Epidemiology, Clinical Manifestations, and Management of Chagas Heart Disease
ABSTRACT Chagas disease results from infection by the protozoan parasite Trypanosoma cruzi and is endemic in Latin America. T cruzi is most commonly transmitted through the feces of an infected triatomine, but can also be congenital, via contaminated blood transfusion or through direct oral contact. In the acute phase, the disease can cause cardiac derangements such as myocarditis, conduction system abnormalities, and/or pericarditis. If left untreated, the disease advances to the chronic phase. Up to one‐half of these patients will develop a cardiomyopathy, which can lead to cardiac failure and/or ventricular arrhythmia...
Source: Clinical Cardiology - May 21, 2015 Category: Cardiology Authors: Lindsey H. Malik, Gagan D. Singh, Ezra A. Amsterdam Tags: Reviews Source Type: research

Mineralocorticoid Receptor Antagonist Pretreatment to MINIMISE Reperfusion Injury After ST‐Elevation Myocardial Infarction (The MINIMISE STEMI Trial): Rationale and Study Design
ABSTRACT Novel therapies capable of reducing myocardial infarct (MI) size when administered prior to reperfusion are required to prevent the onset of heart failure in ST‐segment elevation myocardial infarction (STEMI) patients treated by primary percutaneous coronary intervention (PPCI). Experimental animal studies have demonstrated that mineralocorticoid receptor antagonist (MRA) therapy administered prior to reperfusion can reduce MI size, and MRA therapy prevents adverse left ventricular (LV) remodeling in post‐MI patients with LV impairment. With these 2 benefits in mind, we hypothesize that initiating MRA therapy ...
Source: Clinical Cardiology - May 19, 2015 Category: Cardiology Authors: Heerajnarain Bulluck, Georg M. Fröhlich, Shah Mohdnazri, Reto A. Gamma, John R. Davies, Gerald J. Clesham, Jeremy W. Sayer, Rajesh K. Aggarwal, Kare H. Tang, Paul A. Kelly, Rohan Jagathesan, Alamgir Kabir, Nicholas M. Robinson, Alex Sirker, Anthony Mathu Tags: Trial Designs Source Type: research

Issue Information
(Source: Clinical Cardiology)
Source: Clinical Cardiology - May 19, 2015 Category: Cardiology Tags: Issue Information Source Type: research

Electrocardiographic Versus Echocardiographic Left Ventricular Hypertrophy in Prediction of Congestive Heart Failure in the Elderly
ConclusionsBoth LVH‐ECG and echo‐LVH are equally predictive of incident HF and can be used interchangeably in HF risk‐prediction models. (Source: Clinical Cardiology)
Source: Clinical Cardiology - May 12, 2015 Category: Cardiology Authors: Mohamed Faher Almahmoud, Wesley T. O'Neal, Waqas Qureshi, Elsayed Z. Soliman Tags: Clinical Investigations Source Type: research

Comparative Effectiveness of Medical Therapy, Supervised Exercise, and Revascularization for Patients With Intermittent Claudication: A Network Meta‐analysis
ConclusionsEvidence is insufficient to determine treatment superiority for improving quality of life and walking parameters in IC patients. Further studies with attention to study design, standardized efficacy and safety endpoints, and appropriate subgroup reporting are necessary to determine comparative effectiveness. (Source: Clinical Cardiology)
Source: Clinical Cardiology - May 12, 2015 Category: Cardiology Authors: Sreekanth Vemulapalli, Rowena J. Dolor, Vic Hasselblad, Sumeet Subherwal, Kristine M. Schmit, Brooke L. Heidenfelder, Manesh R. Patel, W. Schuyler Jones Tags: Clinical Investigations Source Type: research

A Review of the Use of Iloprost, A Synthetic Prostacyclin, in the Prevention of Radiocontrast Nephropathy in Patients Undergoing Coronary Angiography and Intervention
ABSTRACT Iloprost, a prostacyclin analogue, has been effective in preventing renal dysfunction among transplant patients. We hypothesized that iloprost is protective against renal dysfunction in different settings, in which similar underlying mechanisms of nephrotoxicity occur. We conducted a literature review, and discuss the application of iloprost in reducing acute renal insufficiency and the pathophysiological mechanisms of contrast‐induced nephropathy (CIN). One proposed mechanism of CIN is prolonged renal arterial vasoconstriction, causing renal hypoperfusion, ischemia, and release of free radicals. Iloprost is an ...
Source: Clinical Cardiology - May 12, 2015 Category: Cardiology Authors: Hayah M. Kassis, Kristopher D. Minsinger, Peter A. McCullough, Clay A. Block, Mandeep S. Sidhu, Jeremiah R. Brown Tags: Reviews Source Type: research

Antithrombotic Regimens for Patients Taking Oral Anticoagulation After Coronary Intervention: A Meta‐analysis of 16 Clinical Trials and 9185 Patients
This study sought to compare efficacy and safety outcomes of triple therapy (OAC, aspirin, and clopidogrel) vs dual therapy (clopidogrel with aspirin or OAC) in these patients. We hypothesize OAC plus clopidogrel could be the optimal regimen for patients with indications for OAC receiving stent implantation. Medline, the Cochrane Library, and other Internet sources were searched for clinical trials comparing the efficacy and safety of triple vs dual therapy for patients taking OAC after coronary stenting. Sixteen eligible trials including 9185 patients were identified. The risks of major adverse cardiac events (odds ratio ...
Source: Clinical Cardiology - May 12, 2015 Category: Cardiology Authors: Xiao‐Fei Gao, Yan Chen, Zhong‐Guo Fan, Xiao‐Min Jiang, Zhi‐Mei Wang, Bing Li, Wen‐Xing Mao, Jun‐Jie Zhang, Shao‐Liang Chen Tags: Reviews Source Type: research

Enhanced External Counterpulsation Is Cost‐Effective in Reducing Hospital Costs in Refractory Angina Patients
ConclusionsTreatment of refractory angina patients with EECP resulted in improvement in angina and functional class accompanied by a sustained reduction in health care costs over 1 year of follow‐up. (Source: Clinical Cardiology)
Source: Clinical Cardiology - May 11, 2015 Category: Cardiology Authors: William E. Lawson, John C.K. Hui, Elizabeth D. Kennard, Georgiann Linnemeier, Tags: Clinical Investigations Source Type: research

Carotid Intima‐Media Thickness Measurement Promises to Improve Cardiovascular Risk Evaluation in Head and Neck Cancer Patients
ConclusionsCarotid IMT identified a much greater percentage of radiation‐treated HNC patients at high CV risk compared with standard CV‐risk calculators. By more accurately identifying the patients at high risk, this may lead to more effective prevention, and therefore a reduction in CV events. (Source: Clinical Cardiology)
Source: Clinical Cardiology - May 11, 2015 Category: Cardiology Authors: Douglas Jacoby, Jihane Hajj, Ali Javaheri, Emil deGoma, Alexander Lin, Peter Ahn, Harry Quon Tags: Clinical Investigations Source Type: research

Quality of Anticoagulation With Vitamin K Antagonists
ConclusionsPatients who receive VKA to prevent stroke for AF spend less than half the time within therapeutic range. (Source: Clinical Cardiology)
Source: Clinical Cardiology - May 11, 2015 Category: Cardiology Authors: Vicente Bertomeu‐González, Manuel Anguita, José Moreno‐Arribas, Ángel Cequier, Javier Muñiz, Jesús Castillo‐Castillo, Juan Sanchis, Inmaculada Roldán, Francisco Marin, Vicente Bertomeu‐Martínez, Tags: Clinical Investigations Source Type: research

High‐Sensitivity Cardiac Troponin T in Stable Patients Undergoing Pharmacological Stress Testing
Abstract BackgroundAcute changes in high‐sensitivity troponin T (hs‐TnT) are induced by myocardial ischemia during exercise stress testing, but there are no reports of pharmacological stress testing. HypothesisThe pattern of troponin release by myocardial ischemia–induced pharmacological stress testing differs according to the ischemic burden in stable patients. MethodsIn total, 250 patients with suspected coronary artery disease underwent pharmacological stress magnetic resonance imaging (MRI). The amount and degree of myocardial ischemia on MRI and ischemic outcomes at 6 months were determined. hs‐TnT levels ...
Source: Clinical Cardiology - May 8, 2015 Category: Cardiology Authors: Nattawut Wongpraparut, Sudarat Piyophirapong, Adisak Maneesai, Kosit Sribhen, Rungroj Krittayaphong, Rungtiwa Pongakasira, Harvey D. White Tags: Clinical Investigations Source Type: research

Impact of Insurance Carrier, Prior Authorization, and Socioeconomic Status on Appropriate Use of SPECT Myocardial Perfusion Imaging in Private Community‐Based Office Practice
ABSTRACT BackgroundThe impact of health insurance carrier and socioeconomic status (SES) on the adherence to appropriate use criteria (AUC) for radionuclide myocardial perfusion imaging (MPI) is unknown. HypothesisHealth insurance carrier's prior authorization and patient's SES impact adherence to AUC for MPI in a fee‐for‐service setting. MethodsWe conducted a prospective cohort study of 1511 consecutive patients who underwent outpatient MPI in a multi‐site, office‐based, fee‐for‐service setting. The patients were stratified according to the 2009 AUC into appropriate/uncertain appropriateness and inappropriate ...
Source: Clinical Cardiology - May 8, 2015 Category: Cardiology Authors: Rami Doukky, Kathleen Hayes, Nathan Frogge, Noreen T. Nazir, Fareed M. Collado, Kim A. Williams Tags: Clinical Investigations Source Type: research

Brugada Syndrome, Exercise, and Exercise Testing
Abstract There are few data on the risk of exercise and the role of exercise stress testing in Brugada syndrome. We sought to address this deficiency using a systematic literature review. We identified 98 English‐language articles possibly addressing exercise in Brugada syndrome by searching PubMed and Google Scholar from January 1990 through November 2013 using the keywords “Brugada syndrome,” “exercise,” “exercise testing,” and “syncope” alone and in combinations. Abstracts were reviewed, and those articles pertaining to Brugada syndrome and exercise were reviewed in full...
Source: Clinical Cardiology - May 8, 2015 Category: Cardiology Authors: Shihab Masrur, Sarfaraz Memon, Paul D. Thompson Tags: Reviews Source Type: research

How Do Noninvasive Imaging Facilities Perceive the Accreditation Process? Results of an Intersocietal Accreditation Commission Survey
The objective of this study was to examine the perception of laboratory accreditation from those who had undergone the process. An electronic survey request was sent to all facilities that had received IAC accreditation at least once. Demographic information, as well as opinions on the perceived value of accreditation as it relates to 15 quality metrics was acquired. Responses were obtained from 2782 facilities. Of the 15 quality metrics examined, the process was perceived as leading to improvements by a majority of respondents for 10 (67%) metrics including: report standardization, adherence to guidelines, test standardiz...
Source: Clinical Cardiology - May 1, 2015 Category: Cardiology Authors: Warren J. Manning, Mary B. Farrell, Louis I. Bezold, John Y. Choi, Kevin M. Cockroft, Heather L. Gornik, Scott D. Jerome, Sandra L. Katanick, Gary V. Heller Tags: Quality and Outcomes Source Type: research

Assessing the Quality of Care for Patients With Acute Myocardial Infarction in China
ABSTRACT There is a wide practice gap between optimal care and actual care for patients with acute myocardial infarction (AMI) in China. Indicators of quality of care for AMI patients have already been developed by a modified Delphi process. Our aim was to assess the association between those indicators and in‐hospital mortality in AMI patients. We hypothesized that an association exists between quality‐of‐care indicators and in‐hospital mortality in AMI patients. Based on the data of 2128 AMI patients at 20 tertiary hospitals in Heilongjiang Province from January 1, 2009 to October 31, 2010, we estimated the compl...
Source: Clinical Cardiology - May 1, 2015 Category: Cardiology Authors: Yupeng Wang, Rong Fu, Zhiqiang Wang, Han Bao, Yongjie Chen, Fengjuan Yang, Xiao Luo, Meina Liu Tags: Quality and Outcomes Source Type: research

Clinical Diagnosis and Management of Hypertension Compared With the Joint National Committee 8 Panelists' Recommendations
ConclusionsOur study found that clinical practice does not correlate well with the new blood‐pressure goal recommendations published by the Joint National Committee 8 panelists, particularly in patients age>60 years. Practitioners are likely to follow the recommendations in regard to pharmacologic management. (Source: Clinical Cardiology)
Source: Clinical Cardiology - May 1, 2015 Category: Cardiology Authors: David Snipelisky, Oral Waldo, M. Caroline Burton Tags: Clinical Investigations Source Type: research

Effects of Ranolazine in Patients With Chronic Angina in Patients With and Without Percutaneous Coronary Intervention for Acute Coronary Syndrome: Observations From the MERLIN‐TIMI 36 Trial
ConclusionsIn patients with chronic angina, ranolazine reduced recurrent ischemic events, regardless of whether patients did or did not receive PCI within 30 days of a non‐ST‐segment ACS. (Source: Clinical Cardiology)
Source: Clinical Cardiology - May 1, 2015 Category: Cardiology Authors: Jorge A. Gutierrez, Ewa Karwatowska‐Prokopczuk, Sabina A. Murphy, Luiz Belardinelli, Ramin Farzaneh‐Far, Gennyne Walker, David A. Morrow, Benjamin M. Scirica Tags: Clinical Investigations Source Type: research

Platelet Function Testing and Prediction of Bleeding in Patients Exposed to Clopidogrel Undergoing Coronary Artery Surgery
(Source: Clinical Cardiology)
Source: Clinical Cardiology - May 1, 2015 Category: Cardiology Authors: Mate Petricevic, Bojan Biocina, Davor Milicic, Cecilija Rotim, Marko Boban Tags: Letters to the Editor Source Type: research

Assessment of American Heart Association's Ideal Cardiovascular Health Metrics Among Employees of a Large Healthcare Organization: The Baptist Health South Florida Employee Study
ConclusionsA combination of HRAs and wellness examinations can provide useful insights into the cardiovascular health status of an employee population. Future tracking of the CV health metrics will provide critical feedback on the impact of system wide wellness efforts as well as identifying proactive programs to assist in making substantial progress toward the AHA 2020 Impact Goal. (Source: Clinical Cardiology)
Source: Clinical Cardiology - May 1, 2015 Category: Cardiology Authors: Oluseye Ogunmoroti, Adnan Younus, Maribeth Rouseff, Erica S. Spatz, Sankalp Das, Don Parris, Ehimen Aneni, Leah Holzwarth, Henry Guzman, Thinh Tran, Lara Roberson, Shozab S. Ali, Arthur Agatston, Wasim Maziak, Theodore Feldman, Emir Veledar, Khurram Nasir Tags: Clinical Investigations Source Type: research