Higher sympathetic transduction is independently associated with greater very short-term diastolic blood pressure variability in young healthy males and females
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - May 27, 2023 Category: Research Source Type: research
Familial dysautonomia
AbstractFamilial dysautonomia (FD) is an autosomal recessive hereditary sensory and autonomic neuropathy (HSAN, type 3) expressed at birth with profound sensory loss and early death. The FD founder mutation in theELP1 gene arose within the Ashkenazi Jews in the sixteenth century and is present in 1:30 Jews of European ancestry. The mutation yield a tissue-specific skipping of exon 20 and a loss of function of the elongator-1 protein (ELP1), which is essential for the development and survival of neurons. Patients with FD produce variable amounts of ELP1 in different tissues, with the brain producing mostly mutant transcript...
Source: Clinical Autonomic Research - May 19, 2023 Category: Research Source Type: research
Cancer in pathologically confirmed multiple system atrophy
ConclusionThe evidence from this retrospective cohort found no significant clinical association of MSA with breast cancer or other cancers. These results do not exclude the possibility that knowledge about synuclein pathology at the molecular level in cancer may lead to future discoveries and potential therapeutic targets for MSA. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - May 13, 2023 Category: Research Source Type: research
Low- and high-frequency spinal cord stimulation and arterial blood pressure in patients with chronic pain and hypertension: a retrospective study
ConclusionThese findings confirm previous studies showing reduced BP following implantation of LF-SCS in patients with chronic pain and hypertension and provide novel data regarding reduced BP following implantation of newer generation HF-SCS devices. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - May 12, 2023 Category: Research Source Type: research
Autonomic control of ventricular function in health and disease: current state of the art
ConclusionsAlthough our understanding of autonomic imbalance in cardiovascular diseases has significantly increased, specific, pivotal mediators of this imbalance and the recognition and implementation of available autonomic parameters and neuromodulatory therapies are still lagging. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - May 11, 2023 Category: Research Source Type: research
Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD): a collaborative review of the current understanding
ConclusionROHHAD is a poorly understood, complex, and potentially devastating disorder. The search for its cause intertwines with the search for causes of obesity and autonomic dysregulation. The care for the patient with ROHHAD necessitates collaborative international efforts to advance our knowledge and, thereby, treatment, to decrease the disease burden and eventually to stop, and/or reverse the unfolding of the phenotype. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - May 10, 2023 Category: Research Source Type: research
Exaggerated blood pressure response to standing in young-to-middle-age subjects: prevalence and factors involved
ConclusionAn orthostatic systolic BP reaction ≥ 20 mmHg is rare in young adults. However, even lower BP increases may be clinically relevant. The BP level, the supine BP decline over repeated measurement, and the white-coat effect can influence the estimate of the BP response to standing and should be considered in clinical and pathogen etic studies. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - April 29, 2023 Category: Research Source Type: research
A systematic review of the effects of transcutaneous auricular vagus nerve stimulation on baroreflex sensitivity and heart rate variability in healthy subjects
ConclusionThe results were mixed, which may be mainly attributable to the heterogeneity of the study designs and stimulation delivery dosages. Thus, future studies with comparable designs are required to determine the optimal stimulation parameters and clarify the significance of autonomic indices as a reliable marker of neuromodulation responsiveness.Graphical abstract (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - April 29, 2023 Category: Research Source Type: research
Exaggerated blood pressure response to standing in young-to-middle-age subjects: prevalence and factors involved
ConclusionAn orthostatic systolic BP reaction ≥ 20 mmHg is rare in young adults. However, even lower BP increases may be clinically relevant. The BP level, the supine BP decline over repeated measurement, and the white-coat effect can influence the estimate of the BP response to standing and should be considered in clinical and pathogen etic studies. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - April 29, 2023 Category: Research Source Type: research
