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Alk5/Runx1 signaling mediated by extracellular vesicles promotes vascular repair in acute respiratory distress syndrome
Pulmonary endothelial cells ’ (ECs) injury and apoptotic death are necessary and sufficient for the pathogenesis of the acute respiratory distress syndrome (ARDS), regardless of epithelial damage. Interaction o... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - June 22, 2018 Category: Internal Medicine Authors: Trushil Shah, Shanshan Qin, Mona Vashi, Dan N. Predescu, Niranjan Jeganathan, Cristina Bardita, Balaji Ganesh, Salvatore diBartolo, Louis F. Fogg, Robert A. Balk and Sanda A. Predescu Tags: Research Source Type: research

Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator
Airway fibrin casts are clinically important complications of severe inhalational smoke-induced acute lung injury (ISIALI) for which reliable evidence-based therapy is lacking. Nebulized anticoagulants or a ti... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - June 18, 2018 Category: Internal Medicine Authors: Satoshi Fukuda, Perenlei Enkhbaatar, Christina Nelson, Robert A. Cox, Marla R. Wolfson, Thomas H. Shaffer, Robert O. Williams III, Soraya Hengsawas Surasarang, Sahakijpijarn Sawittree, Galina Florova, Andrey A. Komissarov, Kathleen Koenig, Krishna Sarva, Tags: Research Source Type: research

Potential important roles and signaling mechanisms of YPEL4 in pulmonary diseases
Human Yippee-like-4 (YPEL4) is a member of the YPEL gene family. This family has been characterized as the first highly conserved family of genes coding for proteins that contain putative zinc-finger-like meta... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - June 11, 2018 Category: Internal Medicine Authors: Lillian Truong, Yun-Min Zheng, Tengyao Song, Yi Tang and Yong-Xiao Wang Tags: Review Source Type: research

The impact of modifiable risk factor reduction on childhood asthma development
Childhood asthma is responsible for significant morbidity and health care expenditures in the United States. The incidence of asthma is greatest in early childhood, and the prevalence is projected to continue ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - June 11, 2018 Category: Internal Medicine Authors: Andrew Abreo, Tebeb Gebretsadik, Cosby A. Stone and Tina V. Hartert Tags: Review Source Type: research

Extracellular vesicles as circulating cancer biomarkers: opportunities and challenges
Extracellular vesicles (EVs) are small, lipid-bound particles containing nucleic acid and protein cargo which are excreted from cells under a variety of normal and pathological conditions. EVs have garnered su... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 31, 2018 Category: Internal Medicine Authors: R. E. Lane, D. Korbie, M. M. Hill and M. Trau Tags: Review Source Type: research

Comparison of paired human nasal and bronchial airway epithelial cell responses to rhinovirus infection and IL-13 treatment
Because of its advantage as a minimally invasive procedure, nasal brushings have been increasingly used and proposed as a valuable approach to study lower airway diseases in lieu of bronchial epithelial cells.... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 2, 2018 Category: Internal Medicine Authors: Nicole Roberts, Reem Al Mubarak, David Francisco, Monica Kraft and Hong Wei Chu Tags: Research Source Type: research

Clinical lipidomics: a new way to diagnose human diseases
Lipidomics is a measurement of a large scale of lipid species to understand roles of their carbon atoms, dual bonds, or isomerism in the lipid molecule. Clinical lipidomics was recently defined “as a new integ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 27, 2018 Category: Internal Medicine Authors: Jiapei Lv, Linlin Zhang, Furong Yan and Xiangdong Wang Tags: Commentary Source Type: research

The IRB structure and medical research reform
Optimal Independent Review Board (IRB) structure encompasses ongoing process improvement, ethics policies and continuous relationship building, all sound in evidence. With optimal IRB structure, a global resea... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 2, 2018 Category: Internal Medicine Authors: Julie Babyar Tags: Commentary Source Type: research

Correlation analysis of monocyte subsets and insulin resistance considering fetuin-A involvement in patients with type 2 diabetes
Fetuin-A is a multifunctional circulating glycoprotein that can induce insulin resistance. Lately, adipose tissue has gained prominence as an effector site of fetuin-A. Although fetuin-A —induced proinflammator... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 27, 2018 Category: Internal Medicine Authors: Saori Maruo, Katsuhito Mori, Koka Motoyama, Miyuki Nakamura, Reina Kawarabayashi, Yoshinori Kakutani, Yuko Yamazaki, Tomoaki Morioka, Tetsuo Shoji, Masaaki Inaba and Masanori Emoto Tags: Research Source Type: research

Correction to: A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors
In this Correction, the authors would like to acknowledge that the original publication of the article “A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in th... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 2, 2018 Category: Internal Medicine Authors: Md Maksudul Alam, Sneha Lal, Keely E. FitzGerald and Li Zhang Tags: Correction Source Type: research

Analyses of repeated failures in cancer therapy for solid tumors: poor tumor-selective drug delivery, low therapeutic efficacy and unsustainable costs
For over six decades reductionist approaches to cancer chemotherapies including recent immunotherapy for solid tumors produced outcome failure-rates of 90% ( ±5) according to governmental agencies and industry.... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 1, 2018 Category: Internal Medicine Authors: Hiroshi Maeda and Mahin Khatami Tags: Perspective Source Type: research

Merging perspectives: genotype-directed molecular therapy for hereditary diffuse gastric cancer (HDGC) and E-cadherin –EGFR crosstalk
Hereditary diffuse gastric cancer is a cancer predisposition syndrome associated with germline mutations of the E-cadherin gene (CDH1; NM_004360). Male CDH1 germline mutation carriers have by the age of 80 yea... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 22, 2018 Category: Internal Medicine Authors: Dandan Li, Winifred Lo and Udo Rudloff Tags: Perspective Source Type: research

Recent advances in hyaluronic acid based therapy for osteoarthritis
Osteoarthritis is a debilitating disease that has increased in prevalence across the world due to the aging population. Currently, physicians use a plethora of treatment strategies to try and slow down the pro... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 16, 2018 Category: Internal Medicine Authors: Steven Bowman, Mohamed E. Awad, Mark W. Hamrick, Monte Hunter and Sadanand Fulzele Tags: Review Source Type: research

The ratio of ADSCs to HSC-progenitors in adipose tissue derived SVF may provide the key to predict the outcome of stem-cell therapy
Stromal vascular fraction (SVF) represents an attractive source of adult stem cells and progenitors, holding great promise for numerous cell therapy approaches. In 2017, it was reported that 1524 patients rece... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 7, 2018 Category: Internal Medicine Authors: Mehmet Okyay Kilinc, Antonio Santidrian, Ivelina Minev, Robert Toth, Dobrin Draganov, Duong Nguyen, Elliot Lander, Mark Berman, Boris Minev and Aladar A. Szalay Tags: Research Source Type: research

Lipidomics unveils the complexity of the lipidome in metabolic diseases
Dysregulation of lipid metabolism is responsible for pathologies of human diseases including metabolic diseases. Recent advances in lipidomics analysis allow for the targeted and untargeted identification of l... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 26, 2018 Category: Internal Medicine Authors: Todd A. Lydic and Young-Hwa Goo Tags: Review Source Type: research