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Combination therapy to checkmate Glioblastoma: clinical challenges and advances
Combination therapy is increasingly becoming the cornerstone of current day antitumor therapy. Glioblastoma multiforme is an aggressive brain tumor with a dismal median survival post diagnosis and a high rate ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 16, 2018 Category: Internal Medicine Authors: Debarati Ghosh, Saikat Nandi and Sonali Bhattacharjee Tags: Review Source Type: research

Combination systemic therapies with immune checkpoint inhibitors in pancreatic cancer: overcoming resistance to single-agent checkpoint blockade
Immune checkpoint inhibitors have demonstrated broad single-agent antitumor activity and a favorable safety profile that render them attractive agents to combine with other systemic anticancer therapies. Pancr... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 8, 2018 Category: Internal Medicine Authors: Jun Gong, Andrew Hendifar, Richard Tuli, Jeremy Chuang, May Cho, Vincent Chung, Daneng Li and Ravi Salgia Tags: Review Source Type: research

Application of metabolomics to drug discovery and understanding the mechanisms of action of medicinal plants with anti-tuberculosis activity
Human tuberculosis (TB) is amongst the oldest and deadliest human bacterial diseases that pose major health, social and economic burden at a global level. Current regimens for TB treatment are lengthy, expensi... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 1, 2018 Category: Internal Medicine Authors: Naasson Tuyiringire, Deusdedit Tusubira, Jean-Pierre Munyampundu, Casim Umba Tolo, Claude M. Muvunyi and Patrick Engeu Ogwang Tags: Review Source Type: research

Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis
Research in the field of relation between microbes and colorectal carcinogenesis has gained increasing interest in past years. Recently, link between microbial biofilm and carcinogenesis in colon was demonstra... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - September 17, 2018 Category: Internal Medicine Authors: Hans Raskov, Kasper N ørskov Kragh, Thomas Bjarnsholt, Mahdi Alamili and Ismail Gögenur Tags: Case report Source Type: research

Retraction Note: Purified umbilical cord derived mesenchymal stem cell treatment in a case of systemic lupus erythematosus
The Editor-in-Chief is retracting this article because the authors have not obtained consent to publish from the patient whose details are described in this case report. The article has been removed to protect... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - September 14, 2018 Category: Internal Medicine Authors: Christopher D. Phillips, Pornpatcharin Wongsaisri, Thein Htut and Terry Grossman Tags: Retraction Note Source Type: research

HIV-exposed uninfected infants: elevated cord blood Interleukin 8 (IL-8) is significantly associated with maternal HIV infection and systemic IL-8 in a Kenyan cohort
In low and middle income countries, human immunodeficiency virus (HIV) exposed, uninfected (HEU) infants demonstrate higher morbidity and mortality than their unexposed counterparts. To determine possible immu... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - September 10, 2018 Category: Internal Medicine Authors: Barbara Lohman-Payne, Benjamin Gabriel, Sangshin Park, Dalton Wamalwa, Elizabeth Maleche-Obimbo, Carey Farquhar, Rose Kerubo Bosire and Grace John-Stewart Tags: Research Source Type: research

Cytokines, breast cancer stem cells (BCSCs) and chemoresistance
Chemotherapy resistance of breast cancer poses a great challenge to the survival of patients. During breast cancer treatment, the development of intrinsic and acquired drug resistance tends to further induce a... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - September 3, 2018 Category: Internal Medicine Authors: Weilong Chen, Yuanyuan Qin and Suling Liu Tags: Review Source Type: research

Viral antigens detectable in CSF exosomes from patients with retrovirus associated neurologic disease: functional role of exosomes
HTLV-1 infects over 20 million people worldwide and causes a progressive neuroinflammatory disorder in a subset of infected individuals called HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - August 27, 2018 Category: Internal Medicine Authors: Monique R. Anderson, Michelle L. Pleet, Yoshimi Enose-Akahata, James Erickson, Maria Chiara Monaco, Yao Akpamagbo, Ashley Velluci, Yuetsu Tanaka, Shila Azodi, Ben Lepene, Jennifer Jones, Fatah Kashanchi and Steven Jacobson Tags: Research Source Type: research

Biobank integration of large-scale clinical and histopathology melanoma studies within the European Cancer Moonshot Lund Center
We present the Cancer Moonshot clinical project located at the European center in Lund. Here, tissue and blood samples have been collected and stored in a large-scale biobank. Multiple clinical centers around ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - August 20, 2018 Category: Internal Medicine Authors: Johan Malm, Yutaka Sugihara, Marcell Szasz, Ho Jeong Kwon, Henrik Lindberg, Roger Appelqvist and Gy örgy Marko-Varga Tags: Research Source Type: research

Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms
Yes-associated protein (YAP) and its paralog WW domain containing transcription regulator 1 (TAZ) are important regulators of multiple cellular functions such as proliferation, differentiation, and survival. O... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - August 13, 2018 Category: Internal Medicine Authors: Oleg Dobrokhotov, Mikhail Samsonov, Masahiro Sokabe and Hiroaki Hirata Tags: Review Source Type: research

Endogenous expression mapping of malignant melanoma by mass spectrometry imaging
Currently, only a limited number of molecular biomarkers for malignant melanoma exist. This is the case for both diagnosing the disease, staging, and efficiently measuring the response to therapy by tracing th... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - August 6, 2018 Category: Internal Medicine Authors: Yutaka Sugihara, Daniel Rivas, Johan Malm, Marcell Szasz, HoJeong Kwon, Bo Baldetorp, H åkan Olsson, Christian Ingvar, Melinda Rezeli, Thomas E. Fehniger and György Marko-Varga Tags: Research Source Type: research

Lipidomics: a promising cancer biomarker
The prevention, diagnosis and targeted therapies of cancer are important in cancer controlling and treatment. The present challenge about cancer biomarker still remains in identifying the special biomarkers fo... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - July 30, 2018 Category: Internal Medicine Authors: Furong Yan, Hong Zhao and Yiming Zeng Tags: Commentary Source Type: research

The frequency of post-traumatic stress disorder symptoms in athletes with and without sports related concussion
Purpose of this study is to investigate the presence and frequency of post-traumatic stress disorder (PTSD) symptoms in post-concussed (PC) athletes compared to a group of healthy control (HC) athletes. (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - July 23, 2018 Category: Internal Medicine Authors: Heather E. Brassil and Anthony P. Salvatore Tags: Research Source Type: research

The role of CD133 in cancer: a concise review
Despite the abundant ongoing research efforts, cancer remains one of the most challenging diseases to treat globally. Due to the heterogenous nature of cancer, one of the major clinical challenges in therapeut... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - July 9, 2018 Category: Internal Medicine Authors: Paige M. Glumac and Aaron M. LeBeau Tags: Review Source Type: research

Cancer; an induced disease of twentieth century! Induction of tolerance, increased entropy and ‘Dark Energy’: loss of biorhythms (Anabolism v. Catabolism)
Maintenance of health involves a synchronized network of catabolic and anabolic signals among organs/tissues/cells that requires differential bioenergetics from mitochondria and glycolysis (biological laws or ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - July 2, 2018 Category: Internal Medicine Authors: Mahin Khatami Tags: Perspective Source Type: research