Correction to: Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort
Following publication of the original article [1], the authors reported that one of the authors ’ name was spelled incorrectly. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - April 3, 2019 Category: Allergy & Immunology Source Type: research
Prevalence of food hypersensitivity in relation to IgE sensitisation to common food allergens among the general adult population in West Sweden
ConclusionsThe prevalence of self-reported food hypersensitivity in West Sweden indicates a rising trend. The correspondence between self-reported symptoms and IgE-sensitisation to foods is generally poor, except for hazelnut and almond which exhibit moderate or fair correlation. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 31, 2019 Category: Allergy & Immunology Source Type: research
Quality standards in respiratory real-life effectiveness research: the REal Life EVidence AssessmeNt Tool (RELEVANT): report from the Respiratory Effectiveness Group —European Academy of Allergy and Clinical Immunology Task Force
ConclusionsUsing such quality appraisal tools is mandatory to assess whether specific observational real-life effectiveness studies can be used to inform guideline development and/or decision-making in clinical practice. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 26, 2019 Category: Allergy & Immunology Source Type: research
The REal Life EVidence AssessmeNt Tool (RELEVANT): development of a novel quality assurance asset to rate observational comparative effectiveness research studies
ConclusionsRELEVANT is the first quality checklist to assist in the appraisal of published observational CER developed through iterative feedback derived from pilot implementation and inter-rater agreement evaluation. Developed for a REG-EAACI Task Force quality appraisal of recent asthma CER, RELEVANT also has wider utility to support appraisal of CER literature in general (including pre-publication). It may also assist in manuscript development and in educating relevant stakeholders about key quality markers in observational CER. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 26, 2019 Category: Allergy & Immunology Source Type: research
Cofactors of wheat-dependent exercise-induced anaphylaxis do not increase highly individual gliadin absorption in healthy volunteers
ConclusionThe adsorption of gliadin in the gut in healthy volunteers is less dependent on cofactors than has been hypothesized. Patients with WDEIA may have a predisposition needed for the additional effect of cofactors, e.g., hyperresponsive or damaged intestinal epithelium. Alternatively, other mechanisms, such as cofactor-induced blood flow redistribution, increased activity of tissue transglutaminase, or increases in plasma osmolality and acidosis inducing basophil and mast cell histamine release may play the major role in WDEIA. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 24, 2019 Category: Allergy & Immunology Source Type: research
Adverse drug reaction classification by health professionals: appropriate discrimination between allergy and intolerance?
ConclusionsHealth professionals have suboptimal understanding of classification of ADRs. Strategies are required to strictly avoid re-exposure of patients to drugs which carry an increased risk of inducing a dangerous reaction, whilst minimising the avoidance of drugs which are of minimal risk or allowing the use of low-risk drugs where the benefits may be significant. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 18, 2019 Category: Allergy & Immunology Source Type: research
Comparison of hypothesis- and data-driven asthma phenotypes in NHANES 2007 –2012: the importance of comprehensive data availability
ConclusionBoth data- and hypothesis-driven approaches using clinical and physiological variables commonly used to characterize asthma are suboptimal to identify asthma phenotypes among adults from the general population. Further studies based on more comprehensive disease features are required to identify asthma phenotypes in population-based studies. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 12, 2019 Category: Allergy & Immunology Source Type: research
Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma
AbstractAimsMobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurred by the disease and to improve the digital transformation of health and care. The ultimate goal is to change the management strategy in chronic diseases.MethodsMASK implements ICT technologies for individualized and predictive medicine to develop novel care pathways by a ...
Source: Clinical and Translational Allergy - March 10, 2019 Category: Allergy & Immunology Source Type: research
Cosmetics for neonates and infants: haptens in products ’ composition
AbstractCosmetics and skin care products for neonates and infants are considered as ‘‘hypoallergenic’’, “tested” or ‘‘safe’’. Nevertheless, the prevalence of haptens in these products is a matter of concern, since allergic contact dermatitis in children is gaining an importance. We aimed to assess the prevalence of haptens in cosmetics designed for children youn ger than 1 year. To identify haptens, the components of the cosmetics listed on packaging were compared with substances from European baseline series, Cosmetics series and Fragrance series. Survey comprised 212 cosmetics among which 186 (87.7%)...
Source: Clinical and Translational Allergy - March 7, 2019 Category: Allergy & Immunology Source Type: research
Two grass pollen tablets commercially available for allergy immunotherapy display different IgE epitope repertoires
ConclusionsCompared to the 1-grass tablet, the 5-grass tablet generally covers better the sensitization profiles of European patients, especially patients from Southern Europe, in principle less exposed to pollen from Timothy than from other grasses. The 5-grass tablet is therefore expected to elicit larger spectra of blocking antibodies, which might have implications in light of the generally accepted mechanisms of allergy immunotherapy. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 27, 2019 Category: Allergy & Immunology Source Type: research
Evaluation of major mite allergens from European standardized commercial extracts for in vivo diagnosis: addressing the need for precision medicine
ConclusionsCertain naturalD. pteronyssinus andB. tropicalis extracts lack important allergens showing a considerable variability in composition and content. A closer collaboration among clinicians, allergen manufacturing companies and regulatory agencies to improve the quality and consistency ofD. pteronyssinus andB. tropicalis extracts is warranted to achieve a more precise diagnosis and treatment of house dust mite allergy. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 25, 2019 Category: Allergy & Immunology Source Type: research
Characterization of a subgroup of non-type 2 asthma with cow ’s milk hypersensitivity in young subjects
ConclusionIn a subgroup of non-atopic young asthmatics with perceived cow ’s milk hypersensitivity we observed poor asthma-related quality of life, airway hyperresponsiveness, and clinically relevant non-type 2 inflammation. MMP-1 was elevated in this group, which deserves further studies. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 22, 2019 Category: Allergy & Immunology Source Type: research
Evaluation of basophil activation caused by transgenic rice seeds expressing whole T cell epitopes of the major Japanese cedar pollen allergens
ConclusionsThe results will contribute to the safety of Tg-rice seeds in terms of allergies. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 20, 2019 Category: Allergy & Immunology Source Type: research
Sensitivity and specificity of standardised allergen extracts in skin prick test for diagnoses of IgE-mediated respiratory allergies
ConclusionIn this study, with a large number of patients, it was demonstrated that clinical case history, previous SPT and specific IgE measurement could all be used as reference methods for the assessment of sensitivity/specificity of SPT solutions. The comparison of SPT with specific IgE resulted in the largest AUC. The highest sensitivity was observed for the SPT solution of 50,000 SU/mL.Trial registration EudraCT: 2006-005304-14. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 18, 2019 Category: Allergy & Immunology Source Type: research
Identification of the recently described plasminogen gene mutation p.Lys330Glu in a family from Northern Germany with hereditary angioedema
We report a family from Northern Germany with six individuals suffering from recurrent swellings, indicating HAE. Laboratory tests and genetic diagnostics of the genesSERPING1, encoding C1 esterase inhibitor (C1-INH), andF12, encoding coagulation factor XII, were unremarkable. In three affected and one yet unaffected member of the family, we were then able to identify the c.988A > G (also termed c.1100A > G) mutation in theplasminogen (PLG) gene, which has recently been described in several families with HAE. This mutation leads to a missense mutation with an amino acid exchange p.Lys330Glu in the kringle ...
Source: Clinical and Translational Allergy - February 14, 2019 Category: Allergy & Immunology Source Type: research
