Correction to: ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle
Following publication of the original article [1], the authors reported that one of the authors ’ names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. In the author list of this Correction article, only the correct name of the affected author and the corresponding author are presented. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 9, 2019 Category: Allergy & Immunology Source Type: research
Correction to: MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence
Following publication of the original article [1], the authors reported that one of the collaborators ’ names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. In the author list of this Correction article, only the corresponding author and institutional author are presented. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 8, 2019 Category: Allergy & Immunology Source Type: research
Correction to: Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma
Following publication of the original article [1], the authors reported that one of the collaborators ’ names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. In the author list of this Correction article, only the corresponding author and institutional author are presented. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 8, 2019 Category: Allergy & Immunology Source Type: research
Clinically relevant effect of rupatadine 20 mg and 10 mg in seasonal allergic rhinitis: a pooled responder analysis
ConclusionsThis responder analysis confirms the superior efficacy of rupatadine vs placebo to treat SAR. Rupatadine promoted higher proportions of responders according to stringent response criteria and in a dose-dependent manner, with faster and higher response rates in the 20 mg group. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 8, 2019 Category: Allergy & Immunology Source Type: research
Histamine H4 receptor regulates IL-6 and INF- γ secretion in native monocytes from healthy subjects and patients with allergic rhinitis
AbstractHistamine H1 receptor (H1R) and histamine H4 receptor (H4R) are essential in allergic inflammation. The roles of H4R have been characterized in T cell subsets, whereas the functional properties of H4R in monocytes remain unclear. In the current study, the responses of H4R in peripheral monocytes from patients with allergic rhinitis (AR) were investigated. The results confirmed that H4R has the functional effects of mediating cytokine production (i.e., down-regulating IFN- γ and up-regulating IL-6) in cells from a monocyte cell line following challenge with histamine. We demonstrated that when monocytes from AR pat...
Source: Clinical and Translational Allergy - September 29, 2019 Category: Allergy & Immunology Source Type: research
Is chronic urticaria more than skin deep?
AbstractChronic urticaria is a disease characterized by the appearance of weals, angioedema or both longer than 6 weeks. Degranulation of cutaneous or submucosal mast cells leads to release of mediators including histamine resulting in redness, swelling and itch. Because mast cells are widely distributed throughout the body, the question is why they are not activated systemically or does systemic activation o ccur without overt end organ dysfunction? We have conducted an exploratory literature search for reports that have evidence of organ-specific dysfunction in chronic urticaria that might justify prospective observati...
Source: Clinical and Translational Allergy - September 24, 2019 Category: Allergy & Immunology Source Type: research
High oral corticosteroid exposure and overuse of short-acting beta-2-agonists were associated with insufficient prescribing of controller medication: a nationwide electronic prescribing and dispensing database analysis
ConclusionsExposure to high-dose of OCS (101 per 100,000 patients) and SABA over-use (24 per 100,000) were frequent, and were associated with a low maintenance-to-total prescription ratio but not with primary non-adherence. These results suggest there is a need for initiatives to reduce OCS and SABA inappropriate prescribing. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 22, 2019 Category: Allergy & Immunology Source Type: research
Milk- and wheat protein drinks for double blind placebo controlled food challenge in adults: a simple tool for diagnosis
(Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 17, 2019 Category: Allergy & Immunology Source Type: research
Contraindications to immunotherapy: a global approach
ConclusionAs new data arise, revisions might soon be needed allowing AIT in the cases of patients treated with ACE inhibitors and beta-blockers, in elderly patients and in patients with concomitant autoimmune diseases and neoplasias in remission. The decision to prescribe AIT is always tailor-made, balancing risk vs benefit. Creating globally accepted guidelines would help Allergologists in their decision making. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 10, 2019 Category: Allergy & Immunology Source Type: research
Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases
ConclusionIn 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 8, 2019 Category: Allergy & Immunology Source Type: research
The prevalence of asthma in adult population of southwestern Iran and its association with chronic rhinosinusitis: a GA 2 LEN study
ConclusionThis large population study conducted in the southwestern part of Iran suggests that the prevalence of asthma is high. Moreover, the result of this study showed a strong association of asthma with CRS; also after adjusting for sex, age, educational level, and smoking. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - August 29, 2019 Category: Allergy & Immunology Source Type: research
Psychiatric comorbidity in chronic urticaria patients: a systematic review and meta-analysis
ConclusionsPatients with CU frequently experience psychiatric disorders. This highlights the need for a multidisciplinary therapeutic approach involving prompt recognition and management of any potential psychiatric disorder in addition to urticaria treatment. Further studies are needed to assess whether psychiatric disorders coexist with CU independently or follow urticaria onset and whether any psychological or psychiatric intervention may help in CU control. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - August 22, 2019 Category: Allergy & Immunology Source Type: research
Association of elevated fractional exhaled nitric oxide concentration and blood eosinophil count with severe asthma exacerbations
ConclusionThe combination of high FeNO and high BEC was associated with significantly increased severe exacerbation rates in the year preceding FeNO reading, suggesting that combining FeNO and BEC measurements in primary care may identify asthma patients at risk of exacerbations. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - August 20, 2019 Category: Allergy & Immunology Source Type: research
An update to the Milk Allergy in Primary Care guideline
AbstractThe Milk Allergy in Primary (MAP) Care guideline was first published in 2013 in this journal. MAP aimed to provide simple and accessible algorithms for UK clinicians in primary care, detailing all the steps between initial presentation, through diagnosis, management and tolerance development. Despite its UK focus, it soon became clear that MAP was being accessed internationally and thus an updated International Milk Allergy in Primary Care (iMAP) guideline was published in 2017. Both guidelines used existing international consensus guidelines to develop accessible algorithms accompanied by patient information leafl...
Source: Clinical and Translational Allergy - August 11, 2019 Category: Allergy & Immunology Source Type: research
Gene expression of TMEM178 , which encodes a negative regulator of NFATc1, decreases with the progression of asthma severity
AbstractIn two independent microarray studies involving primary airway epithelial cells, the relative gene expression ofTMEM178 decreases with the progression of asthma severity. Our manuscript creates a paradigm for future studies dissecting the role of Tmem178 in the pathogenesis of severe asthma. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - August 7, 2019 Category: Allergy & Immunology Source Type: research
