Indoor mold odor in the workplace increases the risk of Asthma-COPD Overlap Syndrome: a population-based incident case –control study
ConclusionsPresent results provide new evidence of the significant relation between workplace exposure to mold odor and adult-onset ACOS. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - January 14, 2020 Category: Allergy & Immunology Source Type: research
A meta-analysis of baseline characteristics in trials on mite allergen avoidance in asthmatics: room for improvement
This study updates and extends the existing Cochrane review by G øtzsche and Johansen (Cochrane Database of Systematic Reviews, 2008, Art. No: CD001187), with a focus on baseline asthma outcomes and allergen exposures.MethodsWe used the existing trials in the original Cochrane review and included newly published studies. The baseline data for the mite allergen load from the mattress, the standardized asthma symptom score (ASS), the forced expiratory volume in 1 s percentage of predicted (FEV1 %pred.), and the histamine provocative concentration causing a 20% drop in FEV1 (PC20) were extracted. First, the mean values of ...
Source: Clinical and Translational Allergy - January 5, 2020 Category: Allergy & Immunology Source Type: research
Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper
AbstractBecause of the inflammatory mechanisms of most chronic upper airway diseases such as rhinitis and chronic rhinosinusitis, systemic steroids have been used for their treatment for decades. However, it has been very well documented that —potentially severe—side-effects can occur with the accumulation of systemic steroid courses over the years. A consensus document summarizing the benefits of systemic steroids for each upper airway disease type, as well as highlighting the potential harms of this treatment is currently lacking. Therefore, a panel of international experts in the field of Rhinology reviewed the avai...
Source: Clinical and Translational Allergy - January 2, 2020 Category: Allergy & Immunology Source Type: research
House dust mite sensitisation and association with atopic dermatitis in Brunei
AbstractIgE sensitisation in tropical areas is under-reported. A 2 year retrospective cohort study of allergy data specific to aero and food allergens in Brunei demonstrated that specific IgE levels to house dust mite (Dermatophagoides pteronyssinus, D.farinae, Blomia tropicalis) were highest in this population and correlated with atopic dermatitis (p < 0.001). Shrimp and peanut were the most common food allergens. A dominance of house/storage mite sensitization is seen in Brunei which is consistent with other tropical countries. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - December 22, 2019 Category: Allergy & Immunology Source Type: research
Association between component-resolved diagnosis of house dust mite and efficacy of allergen immunotherapy in allergic rhinitis patients
AbstractData regarding clinical relevance of house dust mite (HDM) components over allergen immunotherapy (AIT) for allergic rhinitis (AR) are lacking. 18 adult AR patients receiving HDM-AIT for 52 weeks were followed up to assess serum levels of sIgE and sIgG4 to HDM components. The study showed that Der p1, p2, p23, Der f1 and f2, are important sensitizing components of HDM, of which Der p1 appears to be the most clinically relevant allergenic component for effective AIT. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - December 18, 2019 Category: Allergy & Immunology Source Type: research
Rhinovirus species and tonsillar immune responses
ConclusionsRhinovirus species associated differently with clinical characteristics and tonsillar cytokine responses. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - December 1, 2019 Category: Allergy & Immunology Source Type: research
Reduced expression of miR-146a in human bronchial epithelial cells alters neutrophil migration
ConclusionOur results suggest that decreased level of miR-146a in HBECs from patients with asthma may contribute to the development of neutrophilic phenotype of asthma. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 26, 2019 Category: Allergy & Immunology Source Type: research
Association of IKZF1 SNPs in cold medicine-related Stevens –Johnson syndrome in Thailand
ConclusionIn addition to the Japanese, Korean and Indian populations, Thai cases with CM-SJS/TEN and SOC were significantly associated withIKZF1 SNPs. With our previous report of the critical role ofIKZF1 in mucocutaneous inflammation, these results suggest thatIKZF1 is important in the pathogenesis of CM-SJS/TEN with SOC. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 21, 2019 Category: Allergy & Immunology Source Type: research
Highlights and recent developments in skin allergy and related diseases in EAACI journals (2018)
AbstractThe European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Paediatric Allergy and Immunology as well as Clinical and Translational Allergy. The major goals of EAACI include (i) supporting health promotion in which the prevention of allergy and asthma plays a critical role and (ii) disseminating the knowledge of allergy to all stakeholders including the EAACI junior members. Substantial progress was made in 2018 in the identification of basic mechanisms of atopic dermatitis and urticaria and the translation of t hese mechanisms into clinics. Many large epidemiologic studies a...
Source: Clinical and Translational Allergy - November 19, 2019 Category: Allergy & Immunology Source Type: research
Adherence to adrenaline autoinjector prescriptions in patients with anaphylaxis
This study evaluates adherence to adrenaline autoinjector prescriptions in a cohort of well-characterized anaphylaxis patients. The overall retrieval rate was 76% with the highest rate in patients with severe anaphylaxis. Special attention is needed in patients with unknown elicitors and in young adults, comprising the largest proportion of non-adherent patients.Trial registration No intervention performed. Retrospective data used with permission from the Danish Data Protection Agency and Regional Committees on Health Research Ethics (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 7, 2019 Category: Allergy & Immunology Source Type: research
Eliciting dose is associated with tolerance development in peanut and cow ’s milk allergic children
ConclusionApproximately 1 out of 4 children with DBPCFC confirmed peanut allergy developed tolerance, compared to more than half of the children with milk or egg allergy, respectively. Tolerance development in peanut and milk allergy is significantly associated with ED at initial DBPCFC. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 5, 2019 Category: Allergy & Immunology Source Type: research
Helsinki by nature: The Nature Step to Respiratory Health
ConclusionsIn Finland and elsewhere in Europe, successful programmes have been implemented to reduce the burden of respiratory disorders and other NCDs. Unhealthy behaviour can be changed by well-coordinated actions involving all stakeholders. The growing public health concern caused by NCDs in urban surroundings cannot be solved by health care alone; a multidisciplinary approach is mandatory. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 29, 2019 Category: Allergy & Immunology Source Type: research
Short-acting β2-agonists (SABA) bronchodilator sales and outdoor mould in central France
ConclusionsDaily SABA sales are positively associated withAlternaria spores in the general population of children and young adults. The association between daily SABA sales and temporal changes toAlternaria andAspergillus–Penicillium in male children indicate that outdoor moulds contribute to asthma morbidity. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 24, 2019 Category: Allergy & Immunology Source Type: research
The safety and tolerability profile of bilastine for chronic urticaria in children
ConclusionsIn line with the recent guideline recommendation for the use of second generation H1 antihistamines in children we have reviewed the safety and tolerability profile of bilastine in children with chronic urticaria. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 22, 2019 Category: Allergy & Immunology Source Type: research
Risk factors for severe systemic sting reactions in wasp ( Vespula spp.) and honeybee ( Apis mellifera ) venom allergic patients
ConclusionThe clinical history is essential for the allergological workup and therapeutic decision on Hymenoptera venom allergies. A short latency time and the absence of skin symptoms are indicators for severe systemic sting reactions, followed by the patient ’s age and baseline serum tryptase levels. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 10, 2019 Category: Allergy & Immunology Source Type: research
