Retraction Note to: Partially hydrolysed, prebiotic supplemented whey formula for the prevention of allergic manifestations in high risk infants: a multicentre double-blind randomised controlled trial
An amendment to this paper has been published and can be accessed via the original article. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 9, 2020 Category: Allergy & Immunology Source Type: research
The role of antifungals in the management of patients with severe asthma
AbstractIn patients with asthma, the inhalation of elevated amounts of fungal spores and hyphae may precipitate the onset of asthma or worsen control to the extent of being life-threatening. Sensitisation to fungi, especiallyAspergillus fumigatus, is found in 15% to 48% of asthmatics in secondary care and is linked to worse asthma control, hospitalisation, bronchiectasis and fixed airflow obstruction, irrespective of whether allergic bronchopulmonary aspergillosis (ABPA) is diagnosed. ABPA represents a florid response to the presence ofAspergillus spp. but up to 70% of patients with severe asthma exhibit sensitisation to d...
Source: Clinical and Translational Allergy - November 6, 2020 Category: Allergy & Immunology Source Type: research
Anomalous asthma and chronic obstructive pulmonary disease Google Trends patterns during the COVID-19 pandemic
ConclusionsDuring March 2020, there was a peak in searches on asthma and COPD, which was probably mostly driven by media coverage, as suggested by their simultaneity in several countries with different epidemiological situations. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 2, 2020 Category: Allergy & Immunology Source Type: research
Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa
AbstractGenome wide association studies (GWASs) have revealed several airway disease-associated risk loci. Their role in the onset of asthma, allergic rhinitis (AR) or chronic rhinosinusitis (CRS), however, is not yet fully understood. The aim of this review is to evaluate the airway relevance of loci and genes identified in GWAS studies. GWASs were searched from databases, and a list of loci associating significantly (p < 10–8) with asthma, AR and CRS was created. This yielded a total of 267 significantly asthma/AR –associated loci from 31 GWASs. No significant CRS -associated loci were found in this search. ...
Source: Clinical and Translational Allergy - October 28, 2020 Category: Allergy & Immunology Source Type: research
Correction to: Is diet partly responsible for differences in COVID-19 death rates between and within countries?
An amendment to this paper has been published and can be accessed via the original article. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 26, 2020 Category: Allergy & Immunology Source Type: research
Validation of the DECA criteria for allergic conjunctivitis severity and control
ConclusionsValidation of the DECA criteria for severity and control of AC suggested that it can be useful in the evaluation of eye symptoms and follow-up of therapies. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 23, 2020 Category: Allergy & Immunology Source Type: research
Fungal and bacterial microbiome dysbiosis and imbalance of trans-kingdom network in asthma
ConclusionWe showed mycobiome and bacteriome dysbiosis in asthma featured by alterations in biodiversity, community composition, inter-kingdom and intra-kingdom network. We also observed several functional genes associated with asthma. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 22, 2020 Category: Allergy & Immunology Source Type: research
Unravelling the expression of interleukin-9 in chronic rhinosinusitis: A possible role for Staphylococcus aureus
AbstractChronic rhinosinusitis with nasal polyps (CRSwNP) is a Th2 biased inflammation, associated with nasal colonization ofStaphylococcus (S.)aureus. Interleukin (IL)-9 is a pro-inflammatory Th2 cytokine with a pivotal role in asthma, allergy and chronic obstructive pulmonary disease (COPD), but is less studied in CRSwNP. We aimed to characterize the expression and cellular source of IL-9 and examinedS. aureus as potential local trigger in CRSwNP. We showed increased numbers of interleukin-9 producing neutrophils and mononuclear cells in the tissue of CRSwNP patients. This interleukin-9 production was stimulated byS. aur...
Source: Clinical and Translational Allergy - October 19, 2020 Category: Allergy & Immunology Source Type: research
Current transition management of adolescents and young adults with allergy and asthma: a European survey
ConclusionAlthough there was agreement that transition is important for AYA with allergy and asthma, there are crucial limitations and variations in the current provision of transition services across Europe. Standardisation of AYA management and specific training are required. This should improve management and continuity of care during adolescence and into adulthood to achieve the best healthcare outcomes. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 6, 2020 Category: Allergy & Immunology Source Type: research
Primary non-adherence to inhaled medications measured with e-prescription data from Poland
ConclusionsOut of e-prescriptions for inhaled medications issued in 2018 in Poland, 15.3% were not redeemed. The degree of primary non-adherence was influenced by age, but not gender. Significant differences between MDIs and DPIs and between inhalers with/without a dosage counter were observed. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 6, 2020 Category: Allergy & Immunology Source Type: research
Correction to: Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper
An amendment to this paper has been published and can be accessed via the original article. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 27, 2020 Category: Allergy & Immunology Source Type: research
Correction to: Highlights and recent developments in skin allergy and related diseases in EAACI journals (2018)
An amendment to this paper has been published and can be accessed via the original article. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 14, 2020 Category: Allergy & Immunology Source Type: research
Initiating pollen sensitization – complex source, complex mechanisms
AbstractThe mechanisms involved in the induction of allergic sensitization by pollen are not fully understood. Within the last few decades, findings from epidemiological and experimental studies support the notion that allergic sensitization is not only dependent on the genetics of the host and environmental factors, but also on intrinsic features of the allergenic source itself. In this review, we summarize the current concepts and newest advances in research focusing on the initial mechanisms inducing pollen sensitization. Pollen allergens are embedded in a complex and heterogeneous matrix composed of a myriad of bioacti...
Source: Clinical and Translational Allergy - August 30, 2020 Category: Allergy & Immunology Source Type: research
The association between airborne pollen monitoring and sensitization in the hot desert climate
ConclusionsThis is the first study to monitor airborne pollen in the state of Qatar. The main pollen detected were Amaranthaceae and Poaceae. Pollen may represent a possible exacerbating factor in adult patients with allergic diseases such as asthma and allergic rhinitis. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - August 9, 2020 Category: Allergy & Immunology Source Type: research
IgE autoantibodies and autoreactive T cells and their role in children and adults with atopic dermatitis
AbstractThe pathophysiology of atopic dermatitis (AD) is highly complex and understanding of disease endotypes may improve disease management. Immunoglobulins E (IgE) against human skin epitopes (IgE autoantibodies) are thought to play a role in disease progression and prolongation. These antibodies have been described in patients with severe and chronic AD, suggesting a progression from allergic inflammation to severe autoimmune processes against the skin. This review provides a summary of the current knowledge and gaps on IgE autoreactivity and self-reactive T cells in children and adults with AD based on a systematic se...
Source: Clinical and Translational Allergy - August 2, 2020 Category: Allergy & Immunology Source Type: research
