Clinical and Experimental Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A comparison of TRECs and flow cytometry for naive T cell quantification
Summary Assessment of thymic output by measurement of naive T cells is carried out routinely in clinical diagnostic laboratories, predominantly using flow cytometry with a suitable panel of antibodies. Naive T cell measurements can also be made using molecular analyses to quantify T cell receptor excision circle (TRECs) levels in sorted cells from peripheral blood. In this study we have compared TRECs levels retrospectively with CD45RA+CD27+ T cells and also with CD45RA+CD31+ T cells in 134 patient samples at diagnosis or during follow‐up. Both panels provide naive T cell measurements that have a strongly positive corre...
Source: Clinical and Experimental Immunology - October 27, 2017 Category: Allergy & Immunology Authors: S. P. Adams, S. Kricke, E. Ralph, N. Gilmour, K. C. Gilmour Tags: Original Article Source Type: research

Combining multiple biomarkers differentiates between active SJIA, SJIA ‐MAS and EBV‐HLH
Summary Cytokine storm syndromes are a clinically heterogeneous group of conditions resulting from a maladaptive host response to an inflammatory trigger. These syndromes lead to rapid progression of immune‐mediated damage to healthy tissues resulting in life‐threatening multi‐system organ failure. Prompt recognition of disease and medical intervention to limit damage to healthy tissues is essential to prevent cytokine storm morbidity and mortality. However, the diagnosis of cytokine storm syndromes is challenging, given the clinical heterogeneity in disease presentations. Therefore, expeditious and readily available...
Source: Clinical and Experimental Immunology - October 26, 2017 Category: Allergy & Immunology Authors: L. K. Weaver Tags: Commentary Source Type: research

Detection of ABCB5 tumour antigen ‐specific CD8+ T cells in melanoma patients and implications for immunotherapy
Summary ATP binding cassette subfamily B member 5 (ABCB5) has been identified as a tumour‐initiating cell marker and is expressed in various malignancies, including melanoma. Moreover, treatment with anti‐ABCB5 monoclonal antibodies has been shown to inhibit tumour growth in xenotransplantation models. Therefore, ABCB5 represents a potential target for cancer immunotherapy. However, cellular immune responses against ABCB5 in humans have not been described so far. Here, we investigated whether ABCB5‐reactive T cells are present in human melanoma patients and tested the applicability of ABCB5‐derived peptides for exp...
Source: Clinical and Experimental Immunology - October 24, 2017 Category: Allergy & Immunology Authors: S. Borchers, C. Ma βlo, C. A. Müller, A. Tahedl, J. Volkind, Y. Nowak, V. Umansky, J. Esterlechner, M. H. Frank, C. Ganss, M. A. Kluth, J. Utikal Tags: Original Article Source Type: research

An increased CD25 ‐positive intestinal regulatory T lymphocyte population is dependent upon Cox‐2 activity in the Apcmin/+ model
We report dependence of an 'activated' intestinal regulatory T‐lymphocytes phenotype on stromal Cox‐2 activity in the Apc/Min+ mouse which develops intestinal adenomas. The absence of similar findings in unconnected lymph node raises the possibility of utilizing this as a selective therapeutic target, if similar findings are observed in human tumours. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - October 24, 2017 Category: Allergy & Immunology Authors: O. O. Faluyi, P. Fitch, S. E. M. Howie Tags: Original Article Source Type: research

Genetic immunization with mouse thyrotropin hormone receptor plasmid breaks self ‐tolerance for a murine model of autoimmune thyroid disease and Graves' orbitopathy
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - October 23, 2017 Category: Allergy & Immunology Authors: Anke Schl üter, Mareike Horstmann, Salvador Diaz‐Cano, Svenja Plöhn, Kerstin Stähr, Stefan Mattheis, Michael Oeverhaus, Stephan Lang, Ulrich Flögel, Utta Berchner‐Pfannschmidt, Anja Eckstein, J Paul Banga Tags: Original Article Source Type: research