IL4 ‐10 fusion protein: a novel immunoregulatory drug combining activities of interleukin 4 and interleukin 10
The objective of this study was to test the capacity of a newly developed fusion protein of interleukin 4 (IL ‐4) and IL‐10 [IL4‐10 fusion protein (FP)] to shift multiple pro‐inflammatory pathways towards immune regulation, and to inhibit pro‐inflammatory activity in arthritis models. The effects of IL4‐10 FP in comparison with IL‐4, IL‐10 and IL‐4 plus IL‐10 on pro‐ and anti‐inflamm atory mediators, T cells and immunoglobulin (Ig) receptors in favour of immunoregulatory activity were studied. In addition, the capacity of IL4‐10 FP to inhibit pro‐inflammatory activity inex ‐vivo andin ‐vivo ...
Source: Clinical and Experimental Immunology - November 11, 2018 Category: Allergy & Immunology Authors: C. Steen ‐Louws, S. A. Y. Hartgring, J. Popov‐Celeketic, A. P. Lopes, M. B. M. de Smet, N. Eijkelkamp, F. P. J. G. Lafeber, C. E. Hack, J. A. G. van Roon Tags: Original Article Source Type: research

Monocytes show immunoregulatory capacity on CD4+ T ‐cells in a human in vitro model of extracorporeal photopheresis
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 8, 2018 Category: Allergy & Immunology Authors: Franziska Wiese, Katharina Reinhardt ‐Heller, Mareike Volz, Christian Gille, Natascha Köstlin, Heiko Billing, Rupert Handgretinger, Ursula Holzer Tags: Original Article Source Type: research

CCR6 defines a subset of activated memory T cells of Th 17 potential in immune thrombocytopenia
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 7, 2018 Category: Allergy & Immunology Authors: Mingen Lyu, Yang Li, Yating Hao, Cuicui Lyu, Yueting Huang, Boyang Sun, Huiyuan Li, Feng Xue, Xiaofan Liu, Renchi Yang Tags: Original Article Source Type: research

Phenotypical heterogeneity in RAG ‐deficient patients from a highly consanguineous population
Clinical&Experimental Immunology, EarlyView. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - November 5, 2018 Category: Allergy & Immunology Authors: S. S. Meshaal, R. E. El Hawary, D. S. Abd Elaziz, A. Eldash, R. Alkady, S. Lotfy, A. A. Mauracher, L. Opitz, J. Pachlopnik Schmid, M. van der Burg, J. Chou, N. M. Galal, J. A. Boutros, R. Geha, A. M. Elmarsafy Source Type: research

21 ‐hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - October 29, 2018 Category: Allergy & Immunology Authors: Agnethe Berglund, Line Cleemann, Bergithe E. Oftedal, Kirsten Holm, Eystein S. Husebye, Claus H. Gravholt Source Type: research

A predominant Th1 polarization is present in synovial fluid of end ‐stage osteoarthritic knee joints – analysis of peripheral blood, synovial fluid & synovial membrane
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - October 28, 2018 Category: Allergy & Immunology Authors: Nils Rosshirt, S ébastien Hagmann, Elena Tripel, Tobias Gotterbarm, Johannes Kirsch, Felix Zeifang, Hanns‐Martin Lorenz, Theresa Tretter, Babak Moradi Source Type: research

Anti ‐β2‐glycoprotein I antibody with DNA binding activity enters living monocytes via cell surface DNA & induces tissue factor expression
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - October 28, 2018 Category: Allergy & Immunology Authors: S Virachith, M Saito, Y Watanabe, K Inoue, O Hoshi, T Kubota Source Type: research

Altered metabolic pathways regulate synovial inflammation in Rheumatoid Arthritis
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Ursula Fearon, Megan M. Hanlon, Sarah M Wade, Jean Fletcher Source Type: research

AID and TET2 cooperation modulates FANCA expression by active demethylation in diffuse large B cell lymphoma
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - October 25, 2018 Category: Allergy & Immunology Authors: J Jiao, Y. Jin, M. Zheng, H. Zhang, M. Yuan, Z. Lv, W. Odhiambo, X. Yu, P. Zhang, C. Li, Y. Ma, Y. Ji Source Type: research

Recruitment of Activated Neutrophils Correlates with Disease Severity in Adult Crohn's Disease
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - October 22, 2018 Category: Allergy & Immunology Authors: Amelie Therrien, Laurence Chapuy, Marwa Bsat, Manuel Rubio, Gabriel Bernard, Elizabeth Arslanian, Katarzyna Orlicka, Audrey Weber, Benoit ‐Pierre Panzini, Judy Dorais, Edmond‐Jean Bernard, Genevieve Soucy, Mickael Bouin, Marika Sarfati Source Type: research

Clinical and laboratory features of seventy ‐eight UK patients with Good’s syndrome (thymoma and hypogammaglobulinaemia)
Clinical&Experimental Immunology, EarlyView. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - October 22, 2018 Category: Allergy & Immunology Authors: M. Zaman, A. Huissoon, M. Buckland, S. Patel, H. Alachkar, J. D. Edgar, M. Thomas, G. Arumugakani, H. Baxendale, S. Burns, A. P. Williams, S. Jolles, R. Herriot, R. B. Sargur, P. D. Arkwright Source Type: research

Issue Information
Clinical&Experimental Immunology,Volume 194, Issue 2, November 2018. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - October 19, 2018 Category: Allergy & Immunology Source Type: research

Th17 responses to pneumococcus in blood and adenoidal cells in children
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - October 16, 2018 Category: Allergy & Immunology Authors: Elizabeth Oliver, Caroline Pope, Ed Clarke, Claire Langton Hewer, Abiodun D. Ogunniyi, James C. Paton, Tim Mitchell, Richard Malley, Adam Finn Source Type: research

The Sj ögren’s syndrome‐associated autoantigen Ro52/TRIM21 modulates follicular B cell homeostasis and immunoglobulin production
Clinical&Experimental Immunology, EarlyView. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - October 16, 2018 Category: Allergy & Immunology Authors: S. Brauner, M. Ivanchenko, G. E. Thorlacius, A. Ambrosi, M. Wahren ‐Herlenius Source Type: research

Erratum
Clinical&Experimental Immunology, EarlyView. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - October 16, 2018 Category: Allergy & Immunology Source Type: research