Clinical and Experimental Immunology 
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Clinical&Experimental Immunology, Ahead of Print. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - March 12, 2018 Category: Allergy & Immunology Source Type: research
Separation of plasma ‐derived exosomes into CD3(+) and CD3(–) fractions allows for association of immune cell and tumour cell markers with disease activity in HNSCC patients
Summary
Head and neck squamous cell carcinoma (HNSCC) is a highly immunosuppressive malignancy. Exosomes in HNSCC patients' plasma are enriched in inhibitory cargo and mediate immunosuppression. As these exosomes are products of various cells, the cellular origin of immunoregulatory proteins they carry is unknown. To test whether tumour‐ or T cell‐derived exosomes in patients' plasma are immunosuppressive and impact upon disease activity, we separated CD3(–) from CD3(+) exosomes by immunocapture using anti‐CD3 antibodies. The exosome protein cargo was evaluated for immunoregulatory proteins using on‐bead flow cyt...
Source: Clinical and Experimental Immunology - March 12, 2018 Category: Allergy & Immunology Authors: M. ‐N. Theodoraki, T. K. Hoffmann, T. L. Whiteside Tags: Original Article Source Type: research
Correction of T cell deficiency in ZAP ‐70 knock‐out mice by simple intraperitoneal adoptive transfer of thymocytes
Summary
The tyrosine kinase zeta chain‐associated protein of 70 kDa (ZAP‐70) plays a key role in T cell development and signalling. In the absence of ZAP‐70, T cell development is arrested in the CD4+CD8+ double‐positive stage, thus ZAP‐70 homozygous knockout (ZAP‐70–/–) mice have no mature T cells in their peripheral lymphoid organs and blood, causing severe immunodeficiency. We investigated the early kinetics and long‐term effects of wild‐type thymocyte transfer on T cell repopulation in ZAP‐70–/– mice. We used a single intraperitoneal (i.p.) injection to deliver donor thymocytes to the recipien...
Source: Clinical and Experimental Immunology - March 12, 2018 Category: Allergy & Immunology Authors: R. Kugyelka, Z. Kohl, K. Olasz, L. Prenek, T. Berki, P. Balogh, F. Boldizs ár Tags: Original Article Source Type: research
IL ‐27: a double agent in the IL‐6 family
Clinical&Experimental Immunology, EarlyView. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - March 9, 2018 Category: Allergy & Immunology Source Type: research
The CDK inhibitor purvalanol A induces neutrophil apoptosis and increases the turnover rate of Mcl ‐1: potential role of p38‐MAPK in regulation of Mcl‐1 turnover
Clinical&Experimental Immunology, EarlyView. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - March 9, 2018 Category: Allergy & Immunology Source Type: research
A triglyceride ‐rich lipoprotein environment exacerbates renal injury in the accelerated nephrotoxic nephritis model
Clinical&Experimental Immunology, EarlyView. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - March 9, 2018 Category: Allergy & Immunology Source Type: research
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Clinical&Experimental Immunology, Ahead of Print. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - March 9, 2018 Category: Allergy & Immunology Source Type: research
IL ‐27: a double agent in the IL‐6 family
Summary
The cytokine interleukin (IL)‐6 is a major therapeutic target for the treatment of various inflammatory and autoimmune diseases. While IL‐6 receives considerable attention in studies of innate and adaptive immunity, the IL‐6‐related family member IL‐27 is recognized increasingly for its effects on cellular proliferation, differentiation and leucocyte effector functions. Both cytokines activate responses in myeloid and stromal tissue cells, where they direct the transition from innate to adaptive immunity. However, they are identified frequently as lymphokines that control responses in T cells and B cells....
Source: Clinical and Experimental Immunology - March 9, 2018 Category: Allergy & Immunology Authors: G. W. Jones, D. G. Hill, A. Cardus, S. A. Jones Tags: Review Article Source Type: research
The induced RNA ‐binding protein, HuR, targets 3′‐UTR region of IL‐6 mRNA and enhances its stabilization in periodontitis
Clinical&Experimental Immunology, EarlyView. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - March 8, 2018 Category: Allergy & Immunology Source Type: research
Corrigendum
Clinical&Experimental Immunology,Volume 192, Issue 1, Page 138-138, April 2018. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - March 8, 2018 Category: Allergy & Immunology Source Type: research
Issue Information
Clinical&Experimental Immunology,Volume 192, Issue 1, April 2018. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - March 8, 2018 Category: Allergy & Immunology Source Type: research
