Circulating soluble corin as a potential biomarker for cardiovascular diseases: A translational review
Publication date: October 2018 Source:Clinica Chimica Acta, Volume 485 Author(s): Rong Yu, Xuebin Han, Xun Zhang, Yun Wang, Tong Wang Corin is a type II transmembrane serine protease that is highly expressed in the heart and plays a physiological role in the activation of natriuretic peptides. Corin is expressed primarily in myocytes, and it can enter the circulation. Circulating soluble corin has been found to be associated with various cardiovascular diseases, such as hypertension, heart failure, myocardial infarction, preeclampsia, and stroke. All these findings indicate that circulating soluble corin has the potential...
Source: Clinica Chimica Acta - June 28, 2018 Category: Laboratory Medicine Source Type: research

Lipophilic antioxidants in neurodegenerative diseases
Publication date: October 2018 Source:Clinica Chimica Acta, Volume 485 Author(s): Kuo-Hsuan Chang, Mei-Ling Cheng, Mu-Chun Chiang, Chiung-Mei Chen Oxidative stress is commonly involved in the pathogenesis of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis. Therefore, lipophilic antioxidants, such as vitamin A, carotinoids, vitamin E, coenzyme Q10, docosahexaenoic acid and eicosapentaenoic acid, have received increasing attention as therapeutic and preventive intervention for neurodegenerative diseases. Although d...
Source: Clinica Chimica Acta - June 28, 2018 Category: Laboratory Medicine Source Type: research

Prognostic value of ribonucleotide reductase subunit M1 (RRM1) in non-small cell lung cancer: A meta-analysis
Conclusion In meta-analysis of studies which used gemcitabine-based therapies, higher RRM1 expression is found to associated with shorter OS but not PFS. HR depicting relationship between RRM1 expression and OS/PFS/treatment response could not demonstrate a prognostic role of RRM1 in NSCLC patients. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 28, 2018 Category: Laboratory Medicine Source Type: research

Effects of liver-targeted drugs on expression of immune-related proteins in hepatocellular carcinoma cells
Conclusion Lenvatinib and regorafenib affected the expression of PD-L1 in the process of anti-HCC. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 28, 2018 Category: Laboratory Medicine Source Type: research

Simultaneous determination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in human serum by ultra performance liquid chromatography: An economical and validated method with bovine serum albumin
Publication date: October 2018 Source:Clinica Chimica Acta, Volume 485 Author(s): Siok-Fong Chin, Junaida Osman, Rahman Jamal A simple and economical method has been developed for simultaneous determination of human serum 25-hydroxyvitamin D2 (25OHD2) and 25-hydroxyvitamin D3 (25OHD3) using Ultra Performance Liquid Chromatography (UPLC). Non-human matrix of 4% BSA was used to construct the calibration curve and in quality control samples’ preparation to avoid interference of the endogenous 25-hydroxyvitamin D (25OHD) present in the human serum. 25OHD2, 25OHD3 and dodecanophenone (internal standard, IS) were separate...
Source: Clinica Chimica Acta - June 27, 2018 Category: Laboratory Medicine Source Type: research

Prognostic value of neutrophil to lymphocyte ratio in heart failure patients
Conclusions The meta-analysis demonstrates that NLR is a predictor of all-cause mortality in patients with heart failure. Because the quality of the included studies varies, further well-designed studies are needed to confirm this association. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 27, 2018 Category: Laboratory Medicine Source Type: research

Kr üppel-like factor 4 expression in solid tumor prognosis: A meta-analysis
Conclusion KLF4 might be a potential marker to predict prognosis in solid cancer patients. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 27, 2018 Category: Laboratory Medicine Source Type: research

The new WHO list of essential diagnostic tests: A clinical chemist's perspective
Publication date: October 2018 Source:Clinica Chimica Acta, Volume 485 Author(s): Joris R. Delanghe, Marc L. De Buyzere (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 23, 2018 Category: Laboratory Medicine Source Type: research

MiR-139 in digestive system tumor diagnosis and detection: Bioinformatics and meta-analysis
Conclusion miR-139 could be a potential biomarker for diagnosis of digestive system tumors especially colorectal cancer. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 21, 2018 Category: Laboratory Medicine Source Type: research

The prognostic value of preoperative neutrophil-to-lymphocyte ratio in patients with upper tract urothelial carcinoma
Conclusions Preoperative elevated NLR was associated with worse outcomes in patients with UTUC. Subgroup analysis affirmed that NLR was a useful predictor in patients with high-grade disease, but not in those with low-grade UTUC. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 20, 2018 Category: Laboratory Medicine Source Type: research

Serum GDNF levels and anxiety disorders in a population-based study of young adults
Conclusion In this paper, we observed increased serum levels of GDNF in individuals with anxiety disorders, suggesting that this biomarker can be used as a putative marker for AD's. The knowledge of the physiological changes related to anxiety disorders can provide a better understanding of AD's pathogenesis, as well as, mechanisms involved in the progression of this condition. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 20, 2018 Category: Laboratory Medicine Source Type: research

Assessment of diagnostic methods for the detection of anticardiolipin and anti- βeta2 glycoprotein I antibodies in patients under routine evaluation for antiphospholipid syndrome
Conclusions With inclusion of LAC, the ELISA and CIA show comparable performance for the diagnosis of APS. However, correlations of APS-specific manifestations were dependent on method of detecting the aPL antibodies suggesting platforms may not be used interchangeable. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 19, 2018 Category: Laboratory Medicine Source Type: research

Assessing the stability of Cd, Mn, Pb, Se, and total Hg in whole human blood by ICP-DRC-MS as a function of temperature and time
Conclusions Storage temperatures of −20 °C and 4 °C are equivalent to −70 °C for stability of Cd, Mn, Pb, Se, and Hg in human whole blood for at least 36 months when blood is stored in sealed polypropylene vials. Increasing the sample storage temperature from −70 °C to −20 °C or 4 °C can lead to large energy savings. The best analytical results are obtained when storage time at higher temperature conditions (e.g. 23 °C and 37 °C) is minimized because recovery of Se and Hg is reduced. Blood samples stored in polypropylene cryovials also lose volume ov...
Source: Clinica Chimica Acta - June 19, 2018 Category: Laboratory Medicine Source Type: research

The utility of long non-coding RNA ZEB1-AS1 as a prognostic biomarker in human solid tumors: A meta-analysis
Conclusion High expression level of ZEB1-AS1 was associated with unfavorable survival outcome for cancer patients, and ZEB1-AS1 could be used as a prognostic predictor for cancers. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 19, 2018 Category: Laboratory Medicine Source Type: research

Prognostic value of serum bilirubin in southern Chinese patients with advanced nasopharyngeal carcinoma
Conclusions Pretreatment IBIL and DBIL are potentially independent prognostic factors for patients with advanced NPC. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 16, 2018 Category: Laboratory Medicine Source Type: research

Serum uric acid and metabolic components with special reference to diabetes mellitus
Publication date: September 2018 Source:Clinica Chimica Acta, Volume 484 Author(s): Tomoyuki Kawada (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 15, 2018 Category: Laboratory Medicine Source Type: research

Inflammatory and oxidative stress parameters as potential early biomarkers for silicosis
Publication date: September 2018 Source:Clinica Chimica Acta, Volume 484 Author(s): Jessica Nardi, Sabrina Nascimento, Gabriela Göethel, Bruna Gauer, Elisa Sauer, Nuryan Fão, Larissa Cestonaro, Caroline Peruzzi, Jorge Souza, Solange Cristina Garcia Workers involved in mining activities are exposed to crystalline silica, which leads to constant pulmonary inflammatory reactions and severe oxidative damage, resulting in silicosis. In this work, we aimed to evaluate inflammatory and oxidative stress parameters as potential early biomarkers of effect to assess crystalline silica toxicity in workers who had occupati...
Source: Clinica Chimica Acta - June 14, 2018 Category: Laboratory Medicine Source Type: research

The rate of neonatal respiratory distress syndrome/transient tachypnea in the newborn and the amniotic lamellar body count in twin pregnancies compared with singleton pregnancies
Conclusions We showed that twin fetuses experience more rapid lung maturation and lung fluid absorption than singleton fetuses, as confirmed by the higher LBC values in twin fetuses. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 13, 2018 Category: Laboratory Medicine Source Type: research

Glycophagy: An emerging target in pathology
Publication date: September 2018 Source:Clinica Chimica Acta, Volume 484 Author(s): Hong Zhao, Mingzhu Tang, Meiqing Liu, Linxi Chen Autophagy, a highly conserved self-digestion process, is initially regarded as non-selectively sequestering and degradation cytoplasmic contents. Nowadays, many kinds of selective autophagy have been found in response to various physiological cues such as mitophagy, reticulophagy and glycophagy. Glycophagy, as a selective autophagy, plays a crucial role in maintaining glucose homeostasis in many tissues including heart, liver and skeletal muscles. Moreover, glycophagy is highly regulated by ...
Source: Clinica Chimica Acta - June 13, 2018 Category: Laboratory Medicine Source Type: research

MiRNA-221/222 in thyroid cancer: A meta-analysis
Conclusion Differences in expression levels of miRNA-221/222 can provide clues for exploring the etiology of thyroid cancer. In addition, miRNA-221/222 were promising molecular biomarkers that may significantly improve the diagnostic accuracy of thyroid cancer. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 13, 2018 Category: Laboratory Medicine Source Type: research

Objective clinical pain analysis using serum cyclooxygenase-2 and inducible nitric oxide synthase in American patients
Conclusions The findings support the requirement of further studies to use COX-2 and iNOS as prognostic biomarkers for objective quantification of pain at the clinical level. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 12, 2018 Category: Laboratory Medicine Source Type: research

Preoperative increased systemic immune-inflammation index predicts poor prognosis in patients with operable non-small cell lung cancer
Conclusions Preoperative SII was a powerful prognostic biomarker for predicting outcome in patients with operable NSCLC. Preoperative SII may assist clinicians treatment strategy making and individual treatment choice. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 12, 2018 Category: Laboratory Medicine Source Type: research

LncRNA ZEB1-AS1 expression in cancer prognosis: Review and meta-analysis
Conclusions High expression of lncRNA ZEB1-AS1 was an unfavorable predictor of cancer prognosis in terms of OS, DFS, RFS, tumor differentiation, depth of invasion, clinical stage, organ metastasis and lymph node metastasis. Therefore, the expression of lncRNA ZEB1-AS1 might be used as a promising prognostic biomarker for cancer. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 12, 2018 Category: Laboratory Medicine Source Type: research

The 90-day prognostic value of serum cyclophilin A in traumatic brain injury
Conclusions Increased serum cyclophilin A concentrations could reflect trauma severity and unfavorable outcome after head trauma, substantializing cyclophilin A as a potential biomarker for prognostic prediction of TBI. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 10, 2018 Category: Laboratory Medicine Source Type: research

Uric acid in aortic dissection: A meta-analysis
Conclusions This meta-analysis provides evidence that SUA levels are significantly higher among patients with aortic dissection than those in controls. Elevated SUA levels may contribute to the pathogenesis of aortic dissection. Further large clinical studies to investigate whether SUA levels are an independently risk factor for aortic dissection are warranted. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 10, 2018 Category: Laboratory Medicine Source Type: research

Independent and combined effects of resting heart rate and pulse pressure with metabolic syndrome in Chinese rural population: The Henan Rural Cohort study
Conclusion Increased resting heart rate and pulse pressure are associated with the higher risk of metabolic syndrome as well as the influences of resting heart rate with pulse pressure might cumulatively increase the risk of metabolic syndrome. However, the potential clinical application remains to be determined. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 9, 2018 Category: Laboratory Medicine Source Type: research

Predictive value of serum cyclophilin A concentrations after acute pancreatitis
Conclusions Increased serum CypA concentrations have close relation to the severity, inflammation and prognosis, substantializing CypA as a potential prognostic biomarker of AP. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 8, 2018 Category: Laboratory Medicine Source Type: research

Establishing age and sex dependent upper reference limits for the plasma lipoprotein (a) in a Chinese health check-up population and according to its relative risk of primary myocardial infarction
Conclusions We proposed Lp (a) < 170 mg/l after rounding as cut-off values for Chinese Han ethnicity. Effects of age and sex on Lp (a) concentrations were also noted. Prospective validation of these cutoff values is critically important in Chinese Han ethnicity. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 8, 2018 Category: Laboratory Medicine Source Type: research

Molecular characterization of MPS IIIA, MPS IIIB and MPS IIIC in Tunisian patients
Publication date: September 2018 Source:Clinica Chimica Acta, Volume 484 Author(s): A.C. Deden, M.A. van Slegtenhorst, G.J.G. Ruijter, G.C. Schoonderwoerd, H.H. Huidekoper, E. Oussoren, A.S. Brooks, S. Demirdas (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 7, 2018 Category: Laboratory Medicine Source Type: research

Urinary N-terminal fragment of titin is a marker to diagnose muscular dystrophy in patients with cardiomyopathy
Publication date: September 2018 Source:Clinica Chimica Acta, Volume 484 Author(s): Akiomi Yoshihisa, Takatoyo Kiko, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Yasuchika Takeishi The differential diagnosis of cardiomyopathy is important. It has been recently reported that urinary titin N (U-TN) is increased in patients with muscular dystrophy (MD), and is associated with muscular damage. We aimed to clarify whether U-TN is useful as a diagnostic tool for distinguishing MD from various cardiomyopathies [e.g. dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM)]. We measured and compared the U-TN/creatin...
Source: Clinica Chimica Acta - June 7, 2018 Category: Laboratory Medicine Source Type: research

Do metabolites account for higher serum steroid hormone levels measured by RIA compared to mass spectrometry?
This study aimed to determine which estradiol metabolites may contribute to this effect. LC-MS/MS analysis was performed on 70 serum samples from premenopausal women, after purification by extraction and Celite column partition chromatography as would be used prior to conventional RIA for estradiol. The metabolites estrone and 2-methoxyestradiol accounted for 6.9% and 2.1% of the estradiol fractions in the purified samples overall, but the extent of contamination with these metabolites was greater in the samples containing <50 pg/mL estradiol (14.6% and 3.8% respectively) than in those containing >50 pg/m...
Source: Clinica Chimica Acta - June 7, 2018 Category: Laboratory Medicine Source Type: research

Critically low sodium levels due to concentration gradients formed in patient samples after undergoing a freeze-thaw cycle
Conclusions Large hospitals that have a central core lab and receive patient samples from satellite clinics need to be aware of this phenomena, which can contribute to erroneous lab results being posted in a patient's electronic medical record, resulting in a misdiagnosis. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 7, 2018 Category: Laboratory Medicine Source Type: research

Human epididymis protein 4 concentration is not associated with liver fibrosis and cirrhosis in a case control study
Conclusions Serum HE4 level does not appear to be associated with fibrotic and cirrhotic liver, suggesting that HE4 may not serve as a valuable clinical biomarker for liver fibrosis and cirrhosis. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 6, 2018 Category: Laboratory Medicine Source Type: research

Prognostic value of DNA methylation for bladder cancer
Conclusions DNA methylation was negatively correlated with the prognosis of BC patients and might become a promising biomarker. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 6, 2018 Category: Laboratory Medicine Source Type: research

Effect of uremic toxin-indoxyl sulfate on the skeletal system
Publication date: September 2018 Source:Clinica Chimica Acta, Volume 484 Author(s): Wen-Chih Liu, Chia-Chao Wu, Paik-Seong Lim, Shiaw-Wen Chien, Yi-Chou Hou, Cai-Mei Zheng, Jia-Fwu Shyu, Yuh-Feng Lin, Kuo-Cheng Lu Chronic kidney disease-mineral bone disorders (CKD-MBD) exhibit abnormalities in the circulating mineral levels, vitamin D metabolism, and parathyroid function that contribute to the formation of a bone lesion. The uremic toxin, indoxyl sulfate (IS), accumulates in the blood in cases of renal failure and leads to bone loss. The bone and renal responses to the action of the parathyroid hormone (PTH) are progressi...
Source: Clinica Chimica Acta - June 6, 2018 Category: Laboratory Medicine Source Type: research

The impact of fertility treatment on the neonatal respiratory outcomes and amniotic lamellar body counts in twin pregnancies
Conclusions None of the individual types of fertility treatment had a direct impact on respiratory disorders such as RDS and TTN in twin infants. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 5, 2018 Category: Laboratory Medicine Source Type: research

Evaluation of the new Sysmex UF-5000 fluorescence flow cytometry analyser for ruling out bacterial urinary tract infection and for prediction of Gram negative bacteria in urine cultures
Conclusion: The new Sysmex UF-5000 showed high diagnostic accuracy in UTI-screening with a very low rate of false negatives. The instrument is capable of predicting Gram negatives with a good SE and a high agreement with the culture, even if this performance needs further evaluation. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 2, 2018 Category: Laboratory Medicine Source Type: research

Plasma concentration of diamine oxidase (DAO) predicts 1-month mortality of acute-on-chronic hepatitis B liver failure
Conclusions The plasma DAO level plus MELD > 0.07 predicts poor 1-month mortality of ACHBLF. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 2, 2018 Category: Laboratory Medicine Source Type: research

Role of nutritional vitamin D in osteoporosis treatment
This article emphasizes the role of nutritional vitamin D replacement in different turnover status (high or low bone turnover disorders) of osteoporosis together with either anti-resorptive (Bisphosphonate, Denosumab et.) or anabolic (Teriparatide) agents when osteoporosis persists. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 2, 2018 Category: Laboratory Medicine Source Type: research

Uric acid and cardiovascular disease
Publication date: September 2018 Source:Clinica Chimica Acta, Volume 484 Author(s): Gjin Ndrepepa Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in humans. When present in cytoplasm of the cells or in acidic/hydrophobic milieu in atherosclerotic plaques, UA converts into a pro-oxidant agent and promotes oxidative stress and through this mechanism participates in the pathophysiology of human disease including cardiovascular disease (CVD). Most epidemiological studies but not all of them ...
Source: Clinica Chimica Acta - June 2, 2018 Category: Laboratory Medicine Source Type: research

Other very rare and poorly known uric acid crystals for the first time also shown by polarized light and definitively identified by infrared spectroscopy
Publication date: September 2018 Source:Clinica Chimica Acta, Volume 484 Author(s): C. Covarelli, A. Primiano, G. Garigali, E. Caselli, J. Gervasoni, S. Baroni, G.B. Fogazzi (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 1, 2018 Category: Laboratory Medicine Source Type: research

Genotype-phenotype correlation among Malaysian patients with osteogenesis imperfecta
Conclusion Majority of our OI patients have mutations in collagen genes, similar to other OI populations worldwide. Genotype-phenotype analysis revealed that qualitative mutations had more severe clinical characteristics compared to quantitative mutations. It is crucial to identify the causative mutations and the clinical severity of OI patients may be predicted based on the types of mutations. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 1, 2018 Category: Laboratory Medicine Source Type: research

Evaluation of the serum ionic fluoride concentration as a biomarker of bone metabolism post-spinal fusion surgery
Conclusions An SIF concentration that is higher postoperatively than preoperatively may indicate unstable bone union, whereas a lower SIF concentration postoperatively than preoperatively may indicate stable bone union. We concluded that the SIF concentration may be useful for diagnosing bone union. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 1, 2018 Category: Laboratory Medicine Source Type: research

Prognostic significance of pretreatment neutrophil-to-lymphocyte ratio in melanoma patients: A meta-analysis
Conclusion Our findings suggest that elevated pretreatment NLR was associated with poor prognosis in melanoma patients, suggesting NLR might be a prognostic factor in patients with melanoma. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - June 1, 2018 Category: Laboratory Medicine Source Type: research

Properties and units in the clinical laboratory sciences part XXIV. Properties and units in clinical molecular genetics (technical report 2017)
Publication date: September 2018 Source:Clinica Chimica Acta, Volume 484 Author(s): Ulla M. Petersen, Ariadna Padró-Miquel, Graham Taylor, Jens Michael Hertz, Rebecca Ceder, Xavier Fuentes-Arderiu, Johan T. den Dunnen This document describes the application of the syntax, semantic rules, and format of the Nomenclature for Properties and Units (NPU) terminology for coded dedicated kinds-of-property in the subject field of clinical molecular genetics. A vocabulary for NPU definitions in this field, based on international terminology and nomenclature, is introduced; examples of actual NPU definitions for different typ...
Source: Clinica Chimica Acta - May 31, 2018 Category: Laboratory Medicine Source Type: research

Associations of body mass index with glycated albumin and glycated albumin/glycated hemoglobin A1c ratio in Chinese diabetic and non-diabetic populations
Conclusions In both diabetic and non-diabetic populations, GA and GA/HbA1c levels are independently and negatively associated with BMI. For every 1 kg/m2 increment in BMI, the absolute value of GA decreases approximately .13%. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 31, 2018 Category: Laboratory Medicine Source Type: research

Incidence of amplification failure in DMPK allele due to allelic dropout event in a diagnostic laboratory
Conclusions Allele dropout could be considered as a potentially important problem in DM1 diagnosis that may lead to the attribution of a wrong genotype with long-term consequences for both proband and family. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 31, 2018 Category: Laboratory Medicine Source Type: research

Circulating microRNAs as novel biomarkers of Alzheimer's disease
Publication date: September 2018 Source:Clinica Chimica Acta, Volume 484 Author(s): Mustapha Zendjabil Alzheimer's disease (AD) is the most common neurodegenerative disorder. Biomarkers could help identify patients at risk and define stages of this disease. Furthermore, biomarkers can be used to evaluate the efficiency of therapeutic agents under testing and thus accelerate the therapeutic discovery process. Biological exploration of AD is currently based on the measurement of β amyloid peptides, tau and phospho-Tau proteins in cerebrospinal fluid. However, these tests have many limitations. So, the search for new bi...
Source: Clinica Chimica Acta - May 30, 2018 Category: Laboratory Medicine Source Type: research

The first-trimester maternal serum cyclophilin A concentrations in women with complicated pregnancy as preeeclampsia
Conclusions Serum CyPA might be utilized as a potential inflammatory biomarker for complicated pregnancy and assessment of serum CyPA might aid in the prediction of complicated pregnancy. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 29, 2018 Category: Laboratory Medicine Source Type: research

Carbohydrate intake and the risk of prostate cancer
Conclusions Our meta-analysis shows no association between carbohydrate intake and prostate cancer risk. Nor is association detected about carbohydrate intake with advanced or non-advanced Pca risk. More studies are needed for a further dose-response meta-analysis. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 29, 2018 Category: Laboratory Medicine Source Type: research