A nomogram integrating hepatic reserve and tumor characteristics for hepatocellular carcinoma following curative liver resection
ConclusionsThe nomogram integrating hepatic reserve and tumor characteristics provided a highly accurate estimation of OS in patients with HCC after curative liver resection, contributing to assess patient prognosis. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Urinary Syndecan-1 and acute kidney injury after pediatric cardiac surgery
ConclusionUrinary syndecan-1 predicts severe AKI after pediatric cardiac surgery. Moreover, it appears to add capacity to predict severe AKI into a clinical model. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

The sample that would not clot
ConclusionThis case displays the importance of genetic testing prior to warfarin dosing and the role antibiotics play in the coagulation cascade. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

5th generation cardiac troponin I and T assays in clinical routine – A head-to-head comparison with data from the Linz troponin (LITROP) study
Publication date: Available online 27 June 2018Source: Clinica Chimica ActaAuthor(s): Thomas Mueller, Margot Egger, Evi Peer, Benjamin DieplingerAbstractBackgroundIn Europe, clinicians use so called high-sensitivity assays for the measurement of cardiac troponin I and T (i.e., hs-cTnI and hs-cTnT assays, also termed 5th generation assays) since several years. We aimed at performing a head-to-head comparison of two 5th generation assays in “real life use”.MethodsWe studied 3588 consecutive patients presenting to an emergency department. We used both, a hs-cTnI assay from Abbott and a hs-cTnT assay from Roche in ...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Determination of serum carbohydrate-deficient transferrin by a nephelometric immunoassay for differential diagnosis of alcoholic and non-alcoholic liver diseases
ConclusionThis simple carbohydrate-deficient transferrin immunoassay is useful to detect so-called gamma glutamyl transferase non-responding drinkers and also to exclude the possible role of excessive drinking in apparently non-alcoholic liver diseases. A large-scale prospective study is needed to further confirm the diagnostic utility of carbohydrate-deficient transferrin. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Optimization and application of an HPLC method for quantification of Inosine-5′-monophosphate dehydrogenase activity as a pharmacodynamic biomarker of mycophenolic acid in Chinese renal transplant patients
ConclusionA bioanalytical assay for IMPDH quantification was optimized and evaluated. The differences in the pharmacodynamics of MPA between Asians and Caucasians may provide some evidence for dosing differences among ethnicities. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Tumor necrosis factor-α and diabetic retinopathy: Review and meta-analysis
ConclusionThe results this meta-analysis indicated that the level of TNF-α in DR patients was significantly different from that in the healthy controls, so TNF-α represents a candidate biomarker for DR. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Soluble CD14 is associated with the structural failure of bioprostheses
Publication date: Available online 30 June 2018Source: Clinica Chimica ActaAuthor(s): Mohamed J. Nsaibia, Marie-Chloé Boulanger, Rihab Bouchareb, Ghada Mkannez, Abdellaziz Dahou, Erwan Salaun, Yohan Bossé, Marie-Annick Clavel, Benoit J. Arsenault, Philippe Pibarot, Patrick MathieuAbstractIntroductionAortic valve bioprostheses, which do not mandate chronic anticoagulation, are prone to structural valve degeneration (SVD). The processes involved in SVD are likely multifactorial. We hypothesized that inflammation and macrophage activation could be involved in SVD.MethodsIn 203 patients with an aortic valve biopr...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Whole genome sequencing identifies a de novo 2.1 Mb balanced paracentric inversion disrupting FOXP1 and leading to severe intellectual disability
Publication date: Available online 30 June 2018Source: Clinica Chimica ActaAuthor(s): M.-L. Vuillaume, B. Cogné, M. Jeanne, Anne Boland, D.C. Ung, D. Quinquis, T. Besnard, J.-F. Deleuze, R. Redon, S. Bezieau, F. Laumonnier, A. ToutainAbstractThe FOXP1 gene, located on chromosome 3p13, encodes the Forkhead-box protein P1, one of the four forkhead transcription factors which repress transcription by forming active homo- and heterodimers and regulate distinct patterns of gene expression crucial for embryogenesis and normal development. FOXP1 mutations, mostly truncating, have been described in patients with mild to mod...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Software updates of Tosoh HPLC analyzers can cause and resolve interference of Hb-variants for HbA1c
Publication date: Available online 30 June 2018Source: Clinica Chimica ActaAuthor(s): Erna Lenters-Westra (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Serum bikunin is a biomarker of linkeropathies
Publication date: Available online 30 June 2018Source: Clinica Chimica ActaAuthor(s): Arnaud Bruneel, Johanne Dubail, Charles Roseau, Pierre Prada, Walid Haouari, Céline Huber, Thierry Dupré, Christian Poüs, Valérie Cormier-Daire, Nathalie Seta (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Triglyceride to high density lipoprotein cholesterol ratio may serve as a useful predictor of major adverse coronary event in female revascularized ST-elevation myocardial infarction
We examined the association between TG/HDL-C ratio and clinical outcome of revascularized STEMI patients in the Chinese population.Methods464 STEMI patients who underwent successful revascularization were enrolled to determine the relationship between TG/HDL-C ratio and major adverse coronary events(MACEs) with a 30-month follow-up. The Kaplan-Meier analysis and Cox regression proportional hazard model were applied to assess the prognostic value of TG/HDL-C ratio.ResultsTG/HDL-C ratio was found to be significantly associated with age (p = 0.017), history of diabetes(p = 0.017), heart rate(p = 0.011), TG(p 
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Point-of-care identification of organophosphates in gastric juice by ambient mass spectrometry in emergency settings
ConclusionsThe results suggested that TD-ESI/MS is promising in promptly providing toxicological information to assist succeeding medical management in an emergency room. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

The development of autoverification rules applied to urinalysis performed on the AutionMAX-SediMAX platform
ConclusionsReview rules applied to the algorithm for routine practice enhance workflow efficiency and optimize sample screening. Revision is not necessary for samples not flagged by the rules. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

LncRNA HOXA-AS2 and its molecular mechanisms in human cancer
Publication date: Available online 4 July 2018Source: Clinica Chimica ActaAuthor(s): Jicai Wang, Zhilei Su, Shounan Lu, Wen Fu, Zhifa Liu, Xingming Jiang, Sheng TaiAbstractLong non-coding RNAs (lncRNAs), are a novel class of noncoding RNAs, and are commonly defined as RNA molecules greater more than 200 nucleotides in length. Emerging research has indicated that lncRNA played a vital role in the pathophysiology of human tumorigenesis and progression by serving as tumor oncogenes or suppressors either oncogenes or tumor suppressor genes. LncRNA has been shown to get involved in participate various biological processes, such...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Validation model of a laboratory-developed method for the ISO15189 accreditation: The example of salivary cortisol determination
ConclusionsA high competence is required for laboratory professionals in order to guarantee that the validated quality specifications have a positive impact on patients' management. The ISO 15189 accreditation is an important tool that allows demonstrating the value of a medical laboratory in the clinical context. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Preoperative lymphocyte-to-monocyte ratio predicts breast cancer outcome: A meta-analysis
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Ru-jin Hu, Qin Liu, Jian-ying Ma, Jing Zhou, Gang LiuAbstractAimTo assess the prognostic value of the preoperative lymphocyte-to-monocyte ratio (LMR) in patients with breast cancer (BC).MethodsRelevant studies were systematically retrieved from the online Cochrane, MEDLINE, EMBASE and CNKI databases published until February 2018. The end points were overall survival (OS), disease-free survival (DFS), and clinicopathological parameters. Meta-analysis was performed using hazard ratios (HRs) or odds ratios (ORs) and their 95% confidence interva...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Prognostic and clinicopathological value of CXCL12/SDF1 expression in breast cancer: A meta-analysis
ConclusionsThis present meta-analysis suggests that CXCL12/SDF1 protein expression is a good prognostic biomarker in breast cancer. In addition, the over-expression of CXCL12/SDF1 protein was associated with positive ER status, negative HER2 status and small tumor size. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Methylation of NBPF1 as a novel marker for the detection of plasma cell-free DNA of breast cancer patients
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Dandan Li, Pengchang Li, Jie Wu, Jie Yi, Yaling Dou, Xiuzhi Guo, Yicong Yin, Danchen Wang, Chaochao Ma, Ling QiuAbstractBackgroundRecent studies revealed that tumor-specific gene methylation can be detected in the circulating cell-free DNA (cfDNA) of cancer patients; therefore, methylated cfDNA is considered a promising biomarker. Human neuroblastoma breakpoint family member 1 (NBPF1) was originally identified in a neuroblastoma (NB) patient. The present study is the first to evaluate the presence of NBPF1 gene methylation in cfDNA in plasma...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Human platelet antigens in disease
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Ying-hao Wen, Ding-Ping ChenAbstractPlatelets have various functions and participate in primary hemostasis, inflammation, and immune responses. Human platelet antigens (HPAs) are alloantigens expressed on the platelet membrane. Each HPA represent one of six platelet glycoproteins GPIIb, GPIIIa, GPIa, GPIbα, GPIbβ, and CD109, and six biallelic systems are grouped. A single nucleotide polymorphism (SNP) in the gene sequence causes a single amino acid substitution of relevant platelet glycoprotein with the exception of HPA-14bw. High...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

The clinicopathological and prognostic value of long non-coding RNA ZEB1-AS1 in solid tumors: A meta-analysis
ConclusionHigh expression of ZEB1-AS1 was associated with advanced clinicopathological characteristics, and ZEB1-AS1overexpression may be a potential prognostic biomarker in human cancer. However, more studies involving various tumor types and large sample size are needed. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Circulating microRNAs as novel biomarkers of Alzheimer's disease
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Mustapha ZendjabilAbstractAlzheimer's disease (AD) is the most common neurodegenerative disorder. Biomarkers could help identify patients at risk and define stages of this disease. Furthermore, biomarkers can be used to evaluate the efficiency of therapeutic agents under testing and thus accelerate the therapeutic discovery process. Biological exploration of AD is currently based on the measurement of β amyloid peptides, tau and phospho-Tau proteins in cerebrospinal fluid. However, these tests have many limitations. So, the search for n...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Prognostic significance of pretreatment neutrophil-to-lymphocyte ratio in melanoma patients: A meta-analysis
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Hui Zhan, Jian-Ying Ma, Qi-Chao JianAbstractIntroductionRecently, the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) has been widely evaluated in many cancers. Here we assessed the prognostic value of pretreatment NLR in melanoma.MethodsA range of online databases was systematically searched up to March,2018 for identify available studies which assessed the prognostic significance of NLR. Data from studies reporting a hazard ratio (HR) and 95% confidence interval (CI) were weighted by generic inverse-variance and pooled in rand...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Uric acid and cardiovascular disease
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Gjin NdrepepaAbstractUric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in humans. When present in cytoplasm of the cells or in acidic/hydrophobic milieu in atherosclerotic plaques, UA converts into a pro-oxidant agent and promotes oxidative stress and through this mechanism participates in the pathophysiology of human disease including cardiovascular disease (CVD). Most epidemiological studies but not all of ...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Role of nutritional vitamin D in osteoporosis treatment
This article emphasizes the role of nutritional vitamin D replacement in different turnover status (high or low bone turnover disorders) of osteoporosis together with either anti-resorptive (Bisphosphonate, Denosumab et.) or anabolic (Teriparatide) agents when osteoporosis persists. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Effect of uremic toxin-indoxyl sulfate on the skeletal system
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Wen-Chih Liu, Chia-Chao Wu, Paik-Seong Lim, Shiaw-Wen Chien, Yi-Chou Hou, Cai-Mei Zheng, Jia-Fwu Shyu, Yuh-Feng Lin, Kuo-Cheng LuAbstractChronic kidney disease-mineral bone disorders (CKD-MBD) exhibit abnormalities in the circulating mineral levels, vitamin D metabolism, and parathyroid function that contribute to the formation of a bone lesion. The uremic toxin, indoxyl sulfate (IS), accumulates in the blood in cases of renal failure and leads to bone loss. The bone and renal responses to the action of the parathyroid hormone (PTH) are prog...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Prognostic value of DNA methylation for bladder cancer
ConclusionsDNA methylation was negatively correlated with the prognosis of BC patients and might become a promising biomarker. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Uric acid in aortic dissection: A meta-analysis
ConclusionsThis meta-analysis provides evidence that SUA levels are significantly higher among patients with aortic dissection than those in controls. Elevated SUA levels may contribute to the pathogenesis of aortic dissection. Further large clinical studies to investigate whether SUA levels are an independently risk factor for aortic dissection are warranted. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

LncRNA ZEB1-AS1 expression in cancer prognosis: Review and meta-analysis
This study aimed to summarize the prognostic value of lncRNA ZEB1-AS1 in cancer.MethodsPubMed, Web of Science, Embase and Cochrane Library were thoroughly searched. All relevant studies satisfying the inclusion criteria were enrolled. The endpoints used in this study included overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS) and various clinical parameters.Results11 studies containing 891 cancer patients were finally included into this study. The results showed that, compared to the patients with low expression of lncRNA ZEB1-AS1, the patients with high ZEB1-AS1expression tended to have sho...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

MiRNA-221/222 in thyroid cancer: A meta-analysis
ConclusionDifferences in expression levels of miRNA-221/222 can provide clues for exploring the etiology of thyroid cancer. In addition, miRNA-221/222 were promising molecular biomarkers that may significantly improve the diagnostic accuracy of thyroid cancer. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Glycophagy: An emerging target in pathology
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Hong Zhao, Mingzhu Tang, Meiqing Liu, Linxi ChenAbstractAutophagy, a highly conserved self-digestion process, is initially regarded as non-selectively sequestering and degradation cytoplasmic contents. Nowadays, many kinds of selective autophagy have been found in response to various physiological cues such as mitophagy, reticulophagy and glycophagy. Glycophagy, as a selective autophagy, plays a crucial role in maintaining glucose homeostasis in many tissues including heart, liver and skeletal muscles. Moreover, glycophagy is highly regulate...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Inflammatory and oxidative stress parameters as potential early biomarkers for silicosis
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Jessica Nardi, Sabrina Nascimento, Gabriela Göethel, Bruna Gauer, Elisa Sauer, Nuryan Fão, Larissa Cestonaro, Caroline Peruzzi, Jorge Souza, Solange Cristina GarciaAbstractWorkers involved in mining activities are exposed to crystalline silica, which leads to constant pulmonary inflammatory reactions and severe oxidative damage, resulting in silicosis. In this work, we aimed to evaluate inflammatory and oxidative stress parameters as potential early biomarkers of effect to assess crystalline silica toxicity in workers who had occ...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

A monoclonal antibody sandwich ELISA for vitamin D-binding protein (VDBP) is unaffected by Gc-globulin phenotype peptides and actin and demonstrates reduced levels in sepsis and non-sepsis intensive care patients
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Katrina Hong, Christopher M. Florkowski, Matthew P. Doogue, Peter A. Elder, John G. LewisAbstractThe measurement of vitamin D-binding protein (VDBP) by immunoassay has been confounded by variable antibody recognition of the Gc1s, Gc1F and Gc2 phenotypes. This has led to spurious conclusions regarding vitamin D status in different ethnic groups. In order to overcome these problems there is a requirement for VDBP antibodies that are unaffected by phenotype status. Here we report the generation and testing of three monoclonal antibodies to VDBP...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Association between klotho expression and malignancies risk and progression: A meta-analysis
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Song Mao, Xiaopeng Wang, Liangxia Wu, Dou Zang, Wenjing ShiAbstractBackgroundWe assessed the association between tissue klotho protein expression and the risk and progression of malignancies.MethodsWe searched the electronic databases for the studies regarding the relationship between tissue klotho protein expression and risk/progression of malignancies through January 2018. We calculated the pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) to evaluate the impact of tissue klotho protein expression on malignancies. A...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Increase in insulin secretion and decrease in muscle degradation by fat-free milk intake are attenuated by physical exercise
ConclusionsBCAA-rich fat-free milk intake enhanced insulin secretion and suppressed muscle protein degradation, but these effects are attenuated by exercise accompanied with increase in catecholamine secretion. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Proteomic approach to profiling immune complex antigens in cerebrospinal fluid samples from patients with central nervous system autoimmune diseases
ConclusionsThis report is the first to comprehensively identify the antigens incorporated into ICs in CSF. There was limited overlap between the antigens we identified and the CSF proteome or the plasma proteome; therefore, our method can be distinguished from the conventional CSF proteome analysis. Although the sensitivity of disease-specific IC-antigens detected in immune complexome analysis screening, the sensitivity may be improved by developing an ELISA method specifically for detecting the ICs. Immune complexome analysis of CSF may be a new and promising path to biomarker discovery for diagnosis and study for CNS aut...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Serum CA125 levels predict outcome of interval debulking surgery after neoadjuvant chemotherapy in patients with advanced ovarian cancer
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Dan Zhang, Yu-xia Jiang, Shu-juan Luo, Rong Zhou, Qing-xiu Jiang, Hua LinghuAbstractObjectiveTo evaluate the correlation between the changes of serum CA125 level and the outcome of interval debulking surgery (IDS) after neoadjuvant chemotherapy (NACT) in patients with advanced epithelial ovarian cancer (EOC).MethodsA retrospective review for 62 patients with FIGO stage III or IV EOC treated with NACT-IDS was conducted. Demographic data, clinical characters, pathological features and prognosis were collected. Continuous variables were evaluat...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Urinary mitochondrial DNA level in non-diabetic chronic kidney diseases
ConclusionMitochondrial DNA is readily detectable in the urinary supernatant of non-diabetic CKD, and its level correlates with the rate of renal function decline and predicts the risk of doubling of serum creatinine or need of dialysis. Further studies are needed to determine the value of urinary supernatant mtDNA level as a prognostic indicator of non-diabetic CKD (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Paraoxonase 1 (PON1)-L55M among common variants in the coding region of the paraoxonase gene family may contribute to the glycemic control in type 2 diabetes
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Abdolkarim Mahrooz, Mohammad Bagher Hashemi-Soteh, Masoud Heydari, Ruzbeh Boorank, Fatemeh Ramazani, Ali Mahmoudi, Anvarsadat Kianmehr, Ahad AlizadehAbstractObjectiveGenome studies have shown that the genes encoding paraoxonase 1 (PON1) and PON2 are associated with glucose metabolism. The goal of this study was to simultaneously evaluate the association between functional variants in PON1 and PON2 genes and susceptibility for type 2 diabetes (T2D) and determine whether they can affect glycemic control.MethodsWe performed a case-control study...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Association between hippuric acid and left ventricular hypertrophy in maintenance hemodialysis patients
ConclusionsHA was significantly associated with LVH. HA could be a novel biomarker of left ventricular overload, which is closely associated with an increased risk of death in HD patients. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

The prognostic value of long noncoding RNA Sox2ot expression in various cancers: A systematic review and meta-analysis
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Xiaoyang Song, Hongyan Yao, Jinlin Liu, Qiang WangAbstractBackgroundSeveral investigations have explored the prognostic value of long noncoding RNA Sox2 overlapping transcript (lncRNA Sox2ot) expression in human cancers, however, with inconsistent results. The aim of this study was to evaluate the prognostic role of lncRNA Sox2ot expression in various cancers.MethodsPubMed, Web of Science, Embase, and Cochrane Library were comprehensively searched to retrieve relevant studies. The relationships between lncRNA Sox2ot expression and prognostic...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Carbohydrate intake and the risk of prostate cancer
ConclusionsOur meta-analysis shows no association between carbohydrate intake and prostate cancer risk. Nor is association detected about carbohydrate intake with advanced or non-advanced Pca risk. More studies are needed for a further dose-response meta-analysis. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

The first-trimester maternal serum cyclophilin A concentrations in women with complicated pregnancy as preeeclampsia
ConclusionsSerum CyPA might be utilized as a potential inflammatory biomarker for complicated pregnancy and assessment of serum CyPA might aid in the prediction of complicated pregnancy. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Incidence of amplification failure in DMPK allele due to allelic dropout event in a diagnostic laboratory
ConclusionsAllele dropout could be considered as a potentially important problem in DM1 diagnosis that may lead to the attribution of a wrong genotype with long-term consequences for both proband and family. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Associations of body mass index with glycated albumin and glycated albumin/glycated hemoglobin A1c ratio in Chinese diabetic and non-diabetic populations
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Xingxing He, Yifei Mo, Xiaojing Ma, Lingwen Ying, Wei Zhu, Yufei Wang, Yuqian Bao, Jian ZhouAbstractBackgroundRecent studies have discussed the relationship between body mass index (BMI) and glycated albumin (GA) level. However, the extent of the influence of BMI on GA remains uncertain. We investigated the associations between BMI and GA, glycated hemoglobin A1c (HbA1c) and GA/HbA1c, and to analyze the influence of obesity on GA, HbA1c, and GA/HbA1c in both Chinese diabetic and non-diabetic populations.MethodsA total of 2562 participants, i...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Properties and units in the clinical laboratory sciences part XXIV. Properties and units in clinical molecular genetics (technical report 2017)
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Ulla M. Petersen, Ariadna Padró-Miquel, Graham Taylor, Jens Michael Hertz, Rebecca Ceder, Xavier Fuentes-Arderiu, Johan T. den DunnenAbstractThis document describes the application of the syntax, semantic rules, and format of the Nomenclature for Properties and Units (NPU) terminology for coded dedicated kinds-of-property in the subject field of clinical molecular genetics. A vocabulary for NPU definitions in this field, based on international terminology and nomenclature, is introduced; examples of actual NPU definitions for differen...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Evaluation of the serum ionic fluoride concentration as a biomarker of bone metabolism post-spinal fusion surgery
ConclusionsAn SIF concentration that is higher postoperatively than preoperatively may indicate unstable bone union, whereas a lower SIF concentration postoperatively than preoperatively may indicate stable bone union. We concluded that the SIF concentration may be useful for diagnosing bone union. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Genotype-phenotype correlation among Malaysian patients with osteogenesis imperfecta
ConclusionMajority of our OI patients have mutations in collagen genes, similar to other OI populations worldwide. Genotype-phenotype analysis revealed that qualitative mutations had more severe clinical characteristics compared to quantitative mutations. It is crucial to identify the causative mutations and the clinical severity of OI patients may be predicted based on the types of mutations. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Plasma concentration of diamine oxidase (DAO) predicts 1-month mortality of acute-on-chronic hepatitis B liver failure
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Feng-Cai Li, Yue-Kai Li, Yu-Chen Fan, Kai WangAbstractBackgroundAcute-on-chronic hepatitis B liver failure (ACHBLF) has high 1-month mortality but it is difficult to predict. This present study was aimed to determine the diagnostic value of plasma diamine oxidase (DAO) in predicting the 1-month mortality of ACHBLF.MethodsA total of 106 consecutive newly diagnosed ACHBLF patients were retrospectively collected. The plasma expression of DAO was determined using enzyme-linked immunosorbent assay (ELISA).ResultsThe plasma DAO level of survivals ...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

The impact of fertility treatment on the neonatal respiratory outcomes and amniotic lamellar body counts in twin pregnancies
ConclusionsNone of the individual types of fertility treatment had a direct impact on respiratory disorders such as RDS and TTN in twin infants. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research