Donation After Cardiac Death Heart Transplantation in America Is Clinically Necessary and Ethically Justified [On My Mind]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 16, 2018 Category: Cardiology Authors: Rajab, T. K., Singh, S. K. Tags: Transplantation On My Mind Source Type: research
Mechanical Circulatory Support Device Utilization and Heart Transplant Waitlist Outcomes in Patients With Restrictive and Hypertrophic Cardiomyopathy [Original Articles]
Conclusions:
Patients with RCM/HCM are less likely to receive MCSD but have similar waitlist mortality and slightly higher incidence of transplantation compared with other patients. The United Network for Organ Sharing RCM/HCM risk model can help identify patients who are at high risk for clinical deterioration and in need of expedited heart transplantation. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 16, 2018 Category: Cardiology Authors: Sridharan, L., Wayda, B., Truby, L. K., Latif, F., Restaino, S., Takeda, K., Takayama, H., Naka, Y., Colombo, P. C., Maurer, M., Farr, M. A., Topkara, V. K. Tags: Cardiomyopathy, Heart Failure, Transplantation, Mortality/Survival, Statements and Guidelines Original Articles Source Type: research
Racial Differences in Characteristics and Outcomes of Patients With Heart Failure and Preserved Ejection Fraction in the Treatment of Preserved Cardiac Function Heart Failure Trial [Original Articles]
Conclusions:
Black patients with HFpEF have a higher HF hospitalization risk than nonblack patients, but spironolactone is similarly effective and safe in both groups.
Clinical Trial Registration:
URL: https://www.clinicaltrials.gov. Unique identifier: NCT00094302. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 16, 2018 Category: Cardiology Authors: Lewis, E. F., Claggett, B., Shah, A. M., Liu, J., Shah, S. J., Anand, I., OMeara, E., Sweitzer, N. K., Rouleau, J. L., Fang, J. C., Desai, A. S., Retta, T. M., Solomon, S. D., Heitner, J. F., Stamos, T. D., Boineau, R., Pitt, B., Pfeffer, M. A. Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Clinical Studies, Cardiomyopathy, Heart Failure Original Articles Source Type: research
Longitudinal Assessment of Vascular Function With Sunitinib in Patients With Metastatic Renal Cell Carcinoma [Emerging Investigators]
Conclusions:
In patients with metastatic renal cell carcinoma, sunitinib resulted in early, significant increases in blood pressure, arterial stiffness, and resistive and pulsatile load within 3.5 weeks of treatment. Baseline vascular function parameters were associated with worsening diastolic but not systolic function. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 16, 2018 Category: Cardiology Authors: Catino, A. B., Hubbard, R. A., Chirinos, J. A., Townsend, R., Keefe, S., Haas, N. B., Puzanov, I., Fang, J. C., Agarwal, N., Hyman, D., Smith, A. M., Gordon, M., Plappert, T., Englefield, V., Narayan, V., Ewer, S., ElAmm, C., Lenihan, D., Ky, B. Tags: Heart Failure, Hypertension Emerging Investigators Source Type: research
Outcomes in Patients With Hypertrophic Cardiomyopathy Awaiting Heart Transplantation [Original Articles]
Conclusions:
The number of patients with HCM in need of HT is increasing. Although post-transplant survival in HCM is excellent, waitlist mortality is substantial and with minimal decline in the most recent era, despite the frequent use of listing status upgrade by exception in this patient cohort. Different strategies to improve the performance of the organ allocation system in patients with HCM are needed. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 16, 2018 Category: Cardiology Authors: Zuniga Cisneros, J., Stehlik, J., Selzman, C. H., Drakos, S. G., McKellar, S. H., Wever-Pinzon, O. Tags: Risk Factors, Cardiomyopathy, Heart Failure, Transplantation, Mortality/Survival Original Articles Source Type: research
Socioeconomic Disparities in Adherence and Outcomes After Heart Transplant: A UNOS (United Network for Organ Sharing) Registry Analysis [Original Articles]
Conclusions:
Racial and socioeconomic disparities exist in heart transplant outcomes, but the latter may be narrowing over time. These disparities are not explained by differences in clinical or graft characteristics. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 16, 2018 Category: Cardiology Authors: Wayda, B., Clemons, A., Givens, R. C., Takeda, K., Takayama, H., Latif, F., Restaino, S., Naka, Y., Farr, M. A., Colombo, P. C., Topkara, V. K. Tags: Race and Ethnicity, Risk Factors, Heart Failure, Ethics and Policy, Mortality/Survival Original Articles Source Type: research
Exploring New Cardiovascular Pathways: Are Soluble Guanylate Cyclase Stimulators the Right Direction? [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 15, 2018 Category: Cardiology Authors: Michalak, M., Armstrong, P. W. Tags: Heart Failure Editorial Source Type: research
Prevention of PKG-1{alpha} Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation [Original Articles]
Conclusions:
In the stressed heart and myocytes, PKG1α C42-disulfide formation contributes to PDE5 activation. This augments the pathological role of PDE5 and so in turn enhances the therapeutic impact from its inhibition. PKG1α oxidation does not change the benefits from sGC activation. This finding favors the use of sGC activators regardless of PKG1α oxidation and may help guide precision therapy leveraging the cyclic GMP/PKG pathway to treat heart disease. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 15, 2018 Category: Cardiology Authors: Nakamura, T., Zhu, G., Ranek, M. J., Kokkonen-Simon, K., Zhang, M., Kim, G. E., Tsujita, K., Kass, D. A. Tags: Myocardial Biology, Oxidant Stress, Heart Failure, Hypertrophy, Pharmacology Original Articles Source Type: research
Prevalence of Pathogenic Gene Mutations and Prognosis Do Not Differ in Isolated Left Ventricular Dysfunction Compared With Dilated Cardiomyopathy [Short Communications]
Conclusions:
Genetic evaluation is advised in LVdys patients and should not merely be restricted to DCM. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 14, 2018 Category: Cardiology Authors: Hazebroek, M. R., Krapels, I., Verdonschot, J., van den Wijngaard, A., Vanhoutte, E., Hoos, M., Snijders, L., van Montfort, L., Witjens, M., Dennert, R., Crijns, H. J. G. M., Brunner-La Rocca, H.-P., Brunner, H. G., Heymans, S. Tags: Genetics, Cardiomyopathy Short Communications Source Type: research
Outcomes After Continuous-Flow Left Ventricular Assist Device Implantation as Destination Therapy at Transplant Versus Nontransplant Centers [Original Articles]
Conclusions:
In a large, modern cohort of destination therapy LVAD recipients, outcomes after implantation were similar at transplant and nontransplant centers. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 14, 2018 Category: Cardiology Authors: Brinkley, D. M., DeNofrio, D., Ruthazer, R., Vest, A. R., Kapur, N. K., Couper, G. S., Kiernan, M. S. Tags: Heart Failure, Cardiovascular Surgery, Mortality/Survival, Quality and Outcomes Original Articles Source Type: research
Caloric Restriction as a Therapeutic Approach to Heart Failure: Can Less Be More in (Mice) and Men? [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 13, 2018 Category: Cardiology Authors: Sandesara, P. B., Sperling, L. S. Tags: Diet and Nutrition Editorial Source Type: research
Long-Term Caloric Restriction Improves Cardiac Function, Remodeling, Adrenergic Responsiveness, and Sympathetic Innervation in a Model of Postischemic Heart Failure [Original Articles]
Conclusions:
We demonstrate, for the first time, that chronic CR, when started after HF established, can ameliorate cardiac dysfunction and improve inotropic reserve. At the molecular level, we find that chronic CR diet significantly improves sympathetic cardiac innervation and β-adrenergic receptor levels in failing myocardium. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 13, 2018 Category: Cardiology Authors: de Lucia, C., Gambino, G., Petraglia, L., Elia, A., Komici, K., Femminella, G. D., DAmico, M. L., Formisano, R., Borghetti, G., Liccardo, D., Nolano, M., Houser, S. R., Leosco, D., Ferrara, N., Koch, W. J., Rengo, G. Tags: Autonomic Nervous System, Diet and Nutrition, Chronic Ischemic Heart Disease, Heart Failure, Remodeling Original Articles Source Type: research
Long-Term Cognitive Decline After Newly Diagnosed Heart Failure: Longitudinal Analysis in the CHS (Cardiovascular Health Study) [Original Articles]
Conclusions:
Decline in global cognitive ability tends to be faster after HF diagnosis than without HF. Clinical and public health implications of this finding warrant further attention. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 9, 2018 Category: Cardiology Authors: Hammond, C. A., Blades, N. J., Chaudhry, S. I., Dodson, J. A., Longstreth, W. T., Heckbert, S. R., Psaty, B. M., Arnold, A. M., Dublin, S., Sitlani, C. M., Gardin, J. M., Thielke, S. M., Nanna, M. G., Gottesman, R. F., Newman, A. B., Thacker, E. L. Tags: Clinical Studies, Epidemiology, Heart Failure Original Articles Source Type: research
Thirty-Day Readmissions After Left Ventricular Assist Device Implantation in the United States: Insights From the Nationwide Readmissions Database [Original Articles]
Conclusions:
Early readmissions are frequent after LVAD implantation even in contemporary times. Preimplant identification of high-risk patients, and a protocol-driven follow-up using a multidisciplinary approach will be needed to reduce readmissions and improve outcomes. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 8, 2018 Category: Cardiology Authors: Agrawal, S., Garg, L., Shah, M., Agarwal, M., Patel, B., Singh, A., Garg, A., Jorde, U. P., Kapur, N. K. Tags: Heart Failure, Quality and Outcomes Original Articles Source Type: research
Robotically Guided Left Ventricular Biopsy to Diagnose Cardiac Sarcoidosis: A Multidisciplinary Innovation Leading to First-in-Human Case [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 8, 2018 Category: Cardiology Authors: Bhimaraj, A., Trachtenberg, B., Valderrabano, M. Tags: Electrophysiology, Cardiomyopathy, Inflammatory Heart Disease Images and Case Reports in Heart Failure Source Type: research
