Reduced Myocardial Flow Reserve by Positron Emission Tomography Predicts Cardiovascular Events After Cardiac Transplantation [Emerging Investigators]
Conclusions:
MFR assessed by cardiac rubidium-82 PET imaging is a predictor of cardiovascular events after orthotopic heart transplant and is associated with cardiac allograft vasculopathy severity. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 11, 2018 Category: Cardiology Authors: Konerman, M. C., Lazarus, J. J., Weinberg, R. L., Shah, R. V., Ghannam, M., Hummel, S. L., Corbett, J. R., Ficaro, E. P., Aaronson, K. D., Colvin, M. M., Koelling, T. M., Murthy, V. L. Tags: Nuclear Cardiology and PET, Transplantation, Mortality/Survival Emerging Investigators Source Type: research
Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy [Original Articles]
Conclusions:
Female patients with HCM are older at the time of myectomy and show greater impairment of diastolic function. Furthermore, left ventricular and left atrial remodeling is increased in women when corrected for body surface area. At a cellular level, HCM women showed increased compliant titin and a larger degree of interstitial fibrosis. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 31, 2018 Category: Cardiology Authors: Nijenkamp, L. L. A. M., Bollen, I. A. E., van Velzen, H. G., Regan, J. A., van Slegtenhorst, M., Niessen, H. W. M., Schinkel, A. F. L., Kruger, M., Poggesi, C., Ho, C. Y., Kuster, D. W. D., Michels, M., van der Velden, J. Tags: Contractile Function, Pathophysiology, Translational Studies, Cardiomyopathy Original Articles Source Type: research
Eosinophilic Myocarditis With Rapid Progression to Cardiogenic Shock, Managed With Mechanical Support and High-Dose Corticosteroids [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 30, 2018 Category: Cardiology Authors: Tandan, S., Meltzer, S. N., Davila, C. D., Konstam, M. A., LeWinter, M. M. Tags: Cardiopulmonary Resuscitation and Emergency Cardiac Care, Inflammatory Heart Disease Images and Case Reports in Heart Failure Source Type: research
Intake of Different Dietary Proteins and Risk of Heart Failure in Men: The Kuopio Ischaemic Heart Disease Risk Factor Study [Original Articles]
Conclusions:
In middle-aged men, higher protein intake was marginally associated with increased risk of HF.
CLINICAL TRIAL REGISTRATION:
URL: https://www.clinicaltrials.gov. Unique identifier: NCT03221127 (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 29, 2018 Category: Cardiology Authors: Virtanen, H. E. K., Voutilainen, S., Koskinen, T. T., Mursu, J., Tuomainen, T.-P., Virtanen, J. K. Tags: Diet and Nutrition, Epidemiology, Risk Factors, Heart Failure Original Articles Source Type: research
Trends in Noncardiovascular Comorbidities Among Patients Hospitalized for Heart Failure: Insights From the Get With The Guidelines-Heart Failure Registry [Original Articles]
Conclusions:
Patients admitted in hospital for HF have an increasing number of noncardiovascular comorbidities over time, which are associated with worse outcomes. Strategies addressing the growing burden of noncardiovascular comorbidities may represent an avenue to improve outcomes and should be included in the delivery of in-hospital HF care. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 23, 2018 Category: Cardiology Authors: Sharma, A., Zhao, X., Hammill, B. G., Hernandez, A. F., Fonarow, G. C., Felker, G. M., Yancy, C. W., Heidenreich, P. A., Ezekowitz, J. A., DeVore, A. D. Tags: Heart Failure, Mortality/Survival Original Articles Source Type: research
Prognostic Significance of Creatinine Increases During an Acute Heart Failure Admission in Patients With and Without Residual Congestion: A Post Hoc Analysis of the PROTECT Data [Original Articles]
Conclusions:
In patients admitted for acute heart failure, WRF defined as a creatinine increase of ≥0.3 mg/dL was associated with longer length of hospital stay, and worse 30- and 90-day outcomes. However, effects were largely driven by patients who had residual congestion at the time of renal function assessment.
Clinical Trial Registration
: URL: https://www.clinicaltrials.gov. Unique identifiers: NCT00328692 and NCT00354458. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 10, 2018 Category: Cardiology Authors: Metra, M., Cotter, G., Senger, S., Edwards, C., Cleland, J. G., Ponikowski, P., Cursack, G. C., Milo, O., Teerlink, J. R., Givertz, M. M., OConnor, C. M., Dittrich, H. C., Bloomfield, D. M., Voors, A. A., Davison, B. A. Tags: Heart Failure Original Articles Source Type: research
Independent Prognostic Value of Serum Soluble ST2 Measurements in Patients With Heart Failure and a Reduced Ejection Fraction in the PARADIGM-HF Trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) [Original Articles]
Conclusions:
Sacubitril/valsartan resulted in greater reductions and less increases in sST2 levels than enalapril. No specific threshold was associated with risk, as linear relationships between baseline sST2 and outcomes were observed. Changes in sST2 from baseline to 1 month were independently associated with the risk of outcomes.
Clinical Trial Registration
: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01035255. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 10, 2018 Category: Cardiology Authors: OMeara, E., Prescott, M. F., Claggett, B., Rouleau, J. L., Chiang, L.-M., Solomon, S. D., Packer, M., McMurray, J. J. V., Zile, M. R. Tags: Biomarkers, Clinical Studies, Fibrosis, Heart Failure, Prognosis Original Articles Source Type: research
Dog Model Holds Promise for Early Mechanical Unloading in Patients With Acute Myocardial Infarction [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 8, 2018 Category: Cardiology Authors: Guerrero-Miranda, C. Y., Hall, S. A. Tags: Cardiomyopathy, Heart Failure, Myocardial Infarction, Remodeling, Treatment Editorial Source Type: research
Left Ventricular Mechanical Unloading by Total Support of Impella in Myocardial Infarction Reduces Infarct Size, Preserves Left Ventricular Function, and Prevents Subsequent Heart Failure in Dogs [Original Article]
Conclusions:
LV mechanical unloading by the total support of Impella during the acute phase of myocardial infarction reduced infarct size and prevented subsequent heart failure in dogs. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 8, 2018 Category: Cardiology Authors: Saku, K., Kakino, T., Arimura, T., Sunagawa, G., Nishikawa, T., Sakamoto, T., Kishi, T., Tsutsui, H., Sunagawa, K. Tags: Basic Science Research, Hemodynamics, Ischemia, Heart Failure Original Article Source Type: research
Coronary Artery Remodeling and Fibrosis With Continuous-Flow Left Ventricular Assist Device Support [Emerging Investigators]
Conclusions:
Among patients supported with CF-LVADs, the coronary arteries develop marked remodeling with increased adventitial fibrosis. The physiological consequences of these structural changes are unknown, but it is possible that arterial contractility may be impaired, thus limiting coronary flow reserve and promoting myocardial ischemia. This may contribute to CF-LVAD complications, such as ventricular arrhythmias and right ventricular failure. As more patients receive CF-LVADs and new pump technology attempts to modulate flow profiles and pulsatility, further research is needed to understand the mechanisms and long-t...
Source: Circulation: Heart Failure - May 3, 2018 Category: Cardiology Authors: Ambardekar, A. V., Weiser-Evans, M. C. M., Li, M., Purohit, S. N., Aftab, M., Reece, T. B., Moulton, K. S. Tags: Coronary Circulation, Translational Studies, Vascular Biology, Heart Failure, Transplantation Emerging Investigators Source Type: research
Risk Factor Burden, Heart Failure, and Survival in Women of Different Ethnic Groups: Insights From the Womens Health Initiative [Original Articles]
Conclusions:
Among diverse racial/ethnic groups, an increase in the number of baseline RFs was associated with higher risk of HF and death before HF but was not associated with death after HF. Early RF prevention may reduce the burden of HF across multiple racial/ethnic groups. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 1, 2018 Category: Cardiology Authors: Breathett, K., Leng, I., Foraker, R. E., Abraham, W. T., Coker, L., Whitfield, K. E., Shumaker, S., Manson, J. E., Eaton, C. B., Howard, B. V., Ijioma, N., Cene, C. W., Martin, L. W., Johnson, K. C., Klein, L. Tags: Race and Ethnicity, Risk Factors, Women, Heart Failure, Mortality/Survival Original Articles Source Type: research
Load-Dependent Changes in Left Ventricular Structure and Function in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure [Original Articles]
Conclusions:
Hemodynamic unloading of a pathophysiologically relevant mouse model of HF results in normalization of LV structure, incomplete recovery of LV function, and incomplete reversal of the HF transcriptional program. The HF-DB mouse model may provide novel insights into mechanisms of reverse LV remodeling. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 1, 2018 Category: Cardiology Authors: Weinheimer, C. J., Kovacs, A., Evans, S., Matkovich, S. J., Barger, P. M., Mann, D. L. Tags: Contractile Function, Fibrosis, Hemodynamics, Cardiomyopathy, Remodeling Original Articles Source Type: research
Internal Versus External Compression of a Left Ventricular Assist Device Outflow Graft: Diagnosis With Intravascular Ultrasound and Treatment With Stenting [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 25, 2018 Category: Cardiology Authors: Trankle, C. R., Quader, M. A., Grizzard, J. D., Tang, D. G., Shah, K. B., Paris, K., Shepard, C. K., Gertz, Z. M. Tags: Heart Failure, Stent Images and Case Reports in Heart Failure Source Type: research
Pulmonary Capillary Wedge Pressure Patterns During Exercise Predict Exercise Capacity and Incident Heart Failure [Original Articles]
Conclusions:
Elevated PCWP/CO slope during exercise (>2 mm Hg/L/min) is common in DOE-nlrW and predicts exercise capacity and heart failure outcomes. These findings suggest that current definitions of HFpEF based on single measures during rest are insufficient and that assessment of exercise PCWP/CO slope may refine early HFpEF diagnosis. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 25, 2018 Category: Cardiology Authors: Eisman, A. S., Shah, R. V., Dhakal, B. P., Pappagianopoulos, P. P., Wooster, L., Bailey, C., Cunningham, T. F., Hardin,, K. M., Baggish, A. L., Ho, J. E., Malhotra, R., Lewis, G. D. Tags: Heart Failure Original Articles Source Type: research
Correction to: 2017 ACC/AHA/HFSA/ISHLT/ACP Advanced Training Statement on Advanced Heart Failure and Transplant Cardiology (Revision of the ACCF/AHA/ACP/HFSA/ISHLT 2010 Clinical Competence Statement on Management of Patients With Advanced Heart Failure and Cardiac Transplant): A Report of the ACC Competency Management Committee [Correction]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 24, 2018 Category: Cardiology Tags: Correction Source Type: research
