Percutaneous Pericardial Resection: A Novel Potential Treatment for Heart Failure With Preserved Ejection Fraction [Original Articles]
Conclusions—
This proof of concept study demonstrates that pericardial resection through a minimally invasive percutaneous approach mitigates the elevation in LV filling pressures with volume loading in both normal animals and a pig model with diastolic dysfunction. Further study is warranted to determine whether this method is safe and produces similar acute and chronic hemodynamic benefits in people with heart failure and preserved ejection fraction. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 10, 2017 Category: Cardiology Authors: Borlaug, B. A., Carter, R. E., Melenovsky, V., DeSimone, C. V., Gaba, P., Killu, A., Naksuk, N., Lerman, L., Asirvatham, S. J. Tags: Hemodynamics, Pathophysiology, Heart Failure Original Articles Source Type: research
Percutaneous Transfemoral Tricuspid Valve Edge-to-Edge Repair: A Case Series [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 4, 2017 Category: Cardiology Authors: Muller, K., Jorbenadze, R., Walker, T., Schuler, R., Hammerstingl, C., Schlensak, C., Gawaz, M., Langer, H. F., Seizer, P. Tags: Valvular Heart Disease, Treatment Images and Case Reports in Heart Failure Source Type: research
Late Migration of a CardioMEMSTM Wireless Pulmonary Artery Hemodynamic Monitoring Sensor [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 4, 2017 Category: Cardiology Authors: Rali, A. S., Shah, Z., Sauer, A., Gupta, K. Tags: Cardiomyopathy, Heart Failure Images and Case Reports in Heart Failure Source Type: research
Association Between Use of Long-Acting Nitrates and Outcomes in Heart Failure With Preserved Ejection Fraction [Original Articles]
Conclusions—
In HFpEF, the use of nitrates was not associated with improvements in all-cause mortality or heart failure hospitalization. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 4, 2017 Category: Cardiology Authors: Lim, S. L., Benson, L., Dahlstrom, U., Lam, C. S. P., Lund, L. H. Tags: Heart Failure, Mortality/Survival Original Articles Source Type: research
Use of {beta}-Blockers in Pulmonary Hypertension [Advances in Heart Failure]
Contrasting with the major attention that left heart failure has received, right heart failure remains understudied both at the preclinical and clinical levels. However, right ventricle failure is a major predictor of outcomes in patients with precapillary pulmonary hypertension because of pulmonary arterial hypertension, and in patients with postcapillary pulmonary hypertension because of left heart disease. In pulmonary hypertension, the status of the right ventricle is one of the most important predictors of both morbidity and mortality. Paradoxically, there are currently no approved therapies targeting the right ventri...
Source: Circulation: Heart Failure - March 31, 2017 Category: Cardiology Authors: Perros, F., de Man, F. S., Bogaard, H. J., Antigny, F., Simonneau, G., Bonnet, S., Provencher, S., Galie, N., Humbert, M. Tags: Clinical Studies, Cardiovascular Disease, Heart Failure, Pulmonary Hypertension, Treatment Advances in Heart Failure Source Type: research
Effect of Intensive Blood Pressure Treatment on Heart Failure Events in the Systolic Blood Pressure Reduction Intervention Trial [Original Articles]
Conclusions—
Targeting a systolic BP<120 mm Hg, compared with <140 mm Hg, significantly reduced ADHF events, and the benefit was similar across all key, prespecified subgroups. Participants who developed ADHF had markedly increased risk for subsequent cardiovascular events and death, highlighting the importance of strategies aimed at prevention of ADHF, especially intensive BP reduction.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT01206062 (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 31, 2017 Category: Cardiology Authors: Upadhya, B., Rocco, M., Lewis, C. E., Oparil, S., Lovato, L. C., Cushman, W. C., Bates, J. T., Bello, N. A., Aurigemma, G., Fine, L. J., Johnson, K. C., Rodriguez, C. J., Raj, D. S., Rastogi, A., Tamariz, L., Wiggers, A., Kitzman, D. W., for the SPRINT Re Tags: Aging, Heart Failure, Hypertension Original Articles Source Type: research
Reassessing Phase II Heart Failure Clinical Trials: Consensus Recommendations [Development of Therapeutics for Heart Failure]
The increasing burden and the continued suboptimal outcomes for patients with heart failure underlines the importance of continued research to develop novel therapeutics for this disorder. This can only be accomplished with successful translation of basic science discoveries into direct human application through effective clinical trial design and execution that results in a substantially improved clinical course and outcomes. In this respect, phase II clinical trials play a pivotal role in determining which of the multitude of potential basic science discoveries should move to the large and expansive registration trials i...
Source: Circulation: Heart Failure - March 29, 2017 Category: Cardiology Authors: Butler, J., Hamo, C. E., Udelson, J. E., OConnor, C., Sabbah, H. N., Metra, M., Shah, S. J., Kitzman, D. W., Teerlink, J. R., Bernstein, H. S., Brooks, G., Depre, C., DeSouza, M. M., Dinh, W., Donovan, M., Frische-Danielson, R., Frost, R. J., Garza, D., G Tags: Heart Failure, Pharmacology, Treatment Development of Therapeutics for Heart Failure Source Type: research
Hospice Enrollment in Patients With Advanced Heart Failure Decreases Acute Medical Service Utilization [Forum for Early Career Clinical Investigation]
Conclusions—
Home health care Medicare beneficiaries with advanced HF who enrolled in hospice had lower acute medical service utilization after their enrollment. Their pattern of hospice use suggests that earlier referral and improved retention may benefit this population. Further research is necessary to understand hospice referral and palliative care needs of advanced HF patients. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 13, 2017 Category: Cardiology Authors: Yim, C. K., Barron, Y., Moore, S., Murtaugh, C., Lala, A., Aldridge, M., Goldstein, N., Gelfman, L. P. Tags: Heart Failure, Health Services, Quality and Outcomes Forum for Early Career Clinical Investigation Source Type: research
Circulating Biomarkers of Cardiac Fibrosis: Do We Have Any and What Use Are They? [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 12, 2017 Category: Cardiology Authors: Richards, A. M. Tags: Biomarkers, Fibrosis, Cardiomyopathy, Heart Failure, Inflammatory Heart Disease Editorial Source Type: research
Plasma and Cardiac Galectin-3 in Patients With Heart Failure Reflects Both Inflammation and Fibrosis: Implications for Its Use as a Biomarker [Original Article]
Conclusions—
The present study suggests that myocardial Gal-3 can be considered as a possible marker for both cardiac inflammation and fibrosis, depending on the pathogenesis of heart failure. However, circulating concentrations of Gal-3 do not seem to reflect endomyocardial Gal-3 levels or cardiac fibrosis. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 12, 2017 Category: Cardiology Authors: Besler, C., Lang, D., Urban, D., Rommel, K.-P., von Roeder, M., Fengler, K., Blazek, S., Kandolf, R., Klingel, K., Thiele, H., Linke, A., Schuler, G., Adams, V., Lurz, P. Tags: Biomarkers, Fibrosis, Cardiomyopathy, Heart Failure, Inflammatory Heart Disease Original Article Source Type: research
Validation of Noninvasive Measurement of Cardiac Output Using Inert Gas Rebreathing in a Cohort of Patients With Heart Failure and Reduced Ejection Fraction [Original Article]
Conclusions—
The IGR method is a simple, accurate, and reproducible noninvasive method for quantification of CO in patients with advanced heart failure. The prognostic value of this simple measurement needs to be studied prospectively. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 9, 2017 Category: Cardiology Authors: Hassan, M., Wagdy, K., Kharabish, A., Selwanos, P. P., Nabil, A., Elguindy, A., ElFaramawy, A., Elmahdy, M. F., Mahmoud, H., Yacoub, M. H. Tags: Heart Failure, Diagnostic Testing, Echocardiography, Exercise Testing, Functional Magnetic Resonance Imaging (fMRI) Original Article Source Type: research
Heart Failure Incidence and Mortality in the Southern Community Cohort Study [Original Article]
Conclusions—
In this low-income population, HF incidence was higher for all race–sex groups than previously reported in other cohorts. The SCCS is a unique resource to investigate determinants of HF risk in a segment of the population underrepresented in other existing cohorts. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 1, 2017 Category: Cardiology Authors: Akwo, E. A., Kabagambe, E. K., Wang, T. J., Harrell, F. E., Blot, W. J., Mumma, M., Gupta, D. K., Lipworth, L. Tags: Epidemiology, Race and Ethnicity, Heart Failure Original Article Source Type: research
Implantation of the HeartMate III Left Ventricular Assist Device in a Giant Left Ventricular Aneurysm: Is Left Ventricular Reconstruction Mandatory? [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - February 26, 2017 Category: Cardiology Authors: Spiliopoulos, S., Wasler, A., Fruehwald, F., Ablasser, K., Stoschitzky, G., Dapunt, O. Tags: Heart Failure, Cardiovascular Surgery Images and Case Reports in Heart Failure Source Type: research
Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure [Original Articles]
Conclusions—
CD4+ T lymphocytes are globally expanded and activated in chronic ischemic HF, with Th2 (versus Th1) and Th17 (versus Treg) predominance in failing hearts, and with expansion of memory T cells in the spleen. Cardiac and splenic T cells in HF are primed to induce cardiac injury and remodeling, and retain this memory on adoptive transfer. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - February 26, 2017 Category: Cardiology Authors: Bansal, S. S., Ismahil, M. A., Goel, M., Patel, B., Hamid, T., Rokosh, G., Prabhu, S. D. Tags: Inflammation, Heart Failure, Myocardial Infarction, Remodeling Original Articles Source Type: research
{alpha}-B Crystallin Reverses High Diastolic Stiffness of Failing Human Cardiomyocytes [Original Articles]
Conclusions—
High cardiomyocyte stiffness contributed to stiffness of failing human myocardium because of reduced titin distensibility. The latter resulted from an absent stiffness-lowering effect of baseline phosphorylation and from titin aggregation. High cardiomyocyte stiffness was corrected by α-B crystallin probably through relief of titin aggregation. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - February 26, 2017 Category: Cardiology Authors: Franssen, C., Kole, J., Musters, R., Hamdani, N., Paulus, W. J. Tags: Pathophysiology, Translational Studies, Heart Failure Original Articles Source Type: research
