Relaxation and the Role of Calcium in Isolated Contracting Myocardium From Patients With Hypertensive Heart Disease and Heart Failure With Preserved Ejection Fraction [Original Articles]
Conclusions
Contraction and relaxation are prolonged in isolated myocardium from patients with HHD and HHD+HFpEF. This leads to incomplete relaxation at higher rates. Elevated calcium levels in HFpEF are neither a result of an impaired Na+ gradient nor expression changes in key ion transporters and regulatory proteins. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 7, 2017 Category: Cardiology Authors: Runte, K. E., Bell, S. P., Selby, D. E., Haussler, T. N., Ashikaga, T., LeWinter, M. M., Palmer, B. M., Meyer, M. Tags: Heart Failure, Hypertrophy, Remodeling Original Articles Source Type: research
Health-Related Quality of Life Outcomes in PARADIGM-HF [Original Articles]
Conclusions
Change scores in KCCQ clinical summary scores and KCCQ overall summary scores were better in patients treated with sacubitril/valsartan compared with those treated with enalapril, with consistency in most domains, and persist during follow-up beyond 8 months. These findings demonstrate that sacubitril/valsartan leads to better HRQL in surviving patients with heart failure.
Clinical Trial Registration
URL: http://www.clinicaltrials.gov. Unique identifier: NCT01035255. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 7, 2017 Category: Cardiology Authors: Lewis, E. F., Claggett, B. L., McMurray, J. J. V., Packer, M., Lefkowitz, M. P., Rouleau, J. L., Liu, J., Shi, V. C., Zile, M. R., Desai, A. S., Solomon, S. D., Swedberg, K. Tags: Heart Failure Original Articles Source Type: research
Who Should Deliver Medical Therapy for Patients With Chronic Heart Failure?: An Immediate Call for Action to Implement a Community-Based Collaborative Solution [On My Mind]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 3, 2017 Category: Cardiology Authors: Packer, M. Tags: Heart Failure On My Mind Source Type: research
Association of Concentric Left Ventricular Hypertrophy With Subsequent Change in Left Ventricular End-Diastolic Volume: The Dallas Heart Study [Original Articles]
Conclusions
In the absence of interval myocardial infarction, concentric hypertrophy was associated with a small, but significantly greater, increase in LVEDV after 7-year follow-up. However, the degree of LV enlargement was minimal, and few participants developed a dilated LV. These data suggest that if concentric hypertrophy does progress to a dilated cardiomyopathy, such a transition would occur over a much longer timeframe (eg, decades) and may be less common than previously thought.
Clinical Trial Registration
URL: http://www.clinicaltrials.gov. Unique identifier: NCT00344903. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 3, 2017 Category: Cardiology Authors: Garg, S., de Lemos, J. A., Matulevicius, S. A., Ayers, C., Pandey, A., Neeland, I. J., Berry, J. D., McColl, R., Maroules, C., Peshock, R. M., Drazner, M. H. Tags: Heart Failure, Hypertrophy, Remodeling, Magnetic Resonance Imaging (MRI) Original Articles Source Type: research
Isolated Fourth Heart Sound [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 1, 2017 Category: Cardiology Authors: Yokota, S., Mori, S., Kanazawa, F., Toh, H., Shinkura, Y., Takuma, Y., Imada, H., Fukuzawa, K., Hirata, K.-i. Tags: Arrhythmias, Cardiomyopathy, Heart Failure Images and Case Reports in Heart Failure Source Type: research
Heart Failure Increases the Risk of Adverse Renal Outcomes in Patients With Normal Kidney Function [Original Articles]
Conclusions
HF is associated with significantly higher risk of incident CKD, incident CKD or mortality, and rapid eGFR decline. Early diagnosis and management of HF could help reduce the risk of long-term renal complications. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 1, 2017 Category: Cardiology Authors: George, L. K., Koshy, S. K. G., Molnar, M. Z., Thomas, F., Lu, J. L., Kalantar-Zadeh, K., Kovesdy, C. P. Tags: Heart Failure, Quality and Outcomes Original Articles Source Type: research
Editors Perspective [Editor's Perspective]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 13, 2017 Category: Cardiology Authors: Sweitzer, N. K. Tags: Heart Failure Editor ' s Perspective Source Type: research
Making the Case for Skeletal Muscle Myopathy and Its Contribution to Exercise Intolerance in Heart Failure With Preserved Ejection Fraction [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 13, 2017 Category: Cardiology Authors: Kitzman, D. W., Haykowsky, M. J., Tomczak, C. R. Tags: Heart Failure, Exercise Testing, Functional Magnetic Resonance Imaging (fMRI) Editorial Source Type: research
Fatigability, Exercise Intolerance, and Abnormal Skeletal Muscle Energetics in Heart Failure [Original Articles]
Conclusions
Symptomatic fatigue during plantar flexion exercise occurs at a common energetic limit in all subjects. HFrEF and HFpEF patients with EI and increased fatigability manifest early, rapid exercise-induced declines in SM high-energy phosphates and reduced oxidative capacity compared with healthy and low-fatigability HF patients, suggesting that SM metabolism is a potentially important target for future HF treatment strategies. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 13, 2017 Category: Cardiology Authors: Weiss, K., Schar, M., Panjrath, G. S., Zhang, Y., Sharma, K., Bottomley, P. A., Golozar, A., Steinberg, A., Gerstenblith, G., Russell, S. D., Weiss, R. G. Tags: Metabolism, Heart Failure, Exercise Testing, Magnetic Resonance Imaging (MRI) Original Articles Source Type: research
Inpatient Mortality Risk Scores and Postdischarge Events in Hospitalized Heart Failure Patients: A Community-Based Study [Original Articles]
Conclusions
The simple ADHERE and GWTG scores stratify hospitalized HF patients for both inpatient and early postdischarge mortality risk, allowing comprehensive risk assessment on admission. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 12, 2017 Category: Cardiology Authors: Win, S., Hussain, I., Hebl, V. B., Dunlay, S. M., Redfield, M. M. Tags: Risk Factors, Heart Failure, Health Services, Mortality/Survival Original Articles Source Type: research
Floating Clots in the Descending Aorta: A Rare Complication of Femoral Venoarterial Extracorporeal Membrane Oxygenation Combined With Microaxial Pump for Cardiogenic Shock [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 10, 2017 Category: Cardiology Authors: Ando, M., Garan, A. R., Axom, K. M., Takeda, K. Tags: Heart Failure, Myocardial Infarction, Cardiovascular Surgery, Complications, Thrombosis Images and Case Reports in Heart Failure Source Type: research
Atrial Septostomy to Treat Stiff Left Atrium Syndrome [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 10, 2017 Category: Cardiology Authors: Chandrashekar, P., Park, J. Y., Al-Hijji, M. A., Reddy, Y. N. V., Zack, C. J., Reeder, G. S., Rea, R. F., Borlaug, B. A. Tags: Hemodynamics, Pathophysiology, Heart Failure, Catheter-Based Coronary and Valvular Interventions, Treatment Images and Case Reports in Heart Failure Source Type: research
Peripheral Venous Pressure Measurements in Patients With Acute Decompensated Heart Failure (PVP-HF) [Original Articles]
Conclusions
In patients with acute heart failure syndromes, a simple assessment of PVP demonstrates a high correlation with CVP. These findings suggest that PVP may be useful in the standard bedside clinical assessment of volume status in these patients to help guide decongestive therapy. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 10, 2017 Category: Cardiology Authors: Sperry, B. W., Campbell, J., Yanavitski, M., Kapadia, S., Tang, W. H. W., Hanna, M. Tags: Hemodynamics, Cardiomyopathy, Heart Failure Original Articles Source Type: research
Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure [Original Articles]
Conclusions
Myocardial CTSD upregulation induced by myocardial infarction protects against cardiac remodeling and malfunction, which is at least in part through promoting myocardial autophagic flux. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 10, 2017 Category: Cardiology Authors: Wu, P., Yuan, X., Li, F., Zhang, J., Zhu, W., Wei, M., Li, J., Wang, X. Tags: Basic Science Research, Myocardial Biology, Chronic Ischemic Heart Disease, Heart Failure, Myocardial Infarction Original Articles Source Type: research
Editors Note [Editor's Note]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 14, 2017 Category: Cardiology Authors: Udelson, J. E. Tags: Heart Failure Editor ' s Note Source Type: research
