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Circulation: Genomic and Precision Medicine Editors and Editorial Board [Circulation: Genomic and Precision Medicine Masthead]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 16, 2018 Category: Cardiology Tags: Circulation: Genomic and Precision Medicine Masthead Source Type: research

Coagulation Factors in Ischemic Heart Disease: Answers From a Mendelian Randomization Study Inspire Further Questions [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 12, 2018 Category: Cardiology Authors: Aslibekyan, S., Lawler, P. R. Tags: Cardiovascular Disease, Epidemiology, Genetic, Association Studies, Genetics, Thrombosis Editorial Source Type: research

Road to Unravel Gene-Environment Interactions on Cardiovascular Complex Diseases [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 12, 2018 Category: Cardiology Authors: Elosua, R. Tags: Epidemiology, Primary Prevention, Risk Factors, Genetic, Association Studies, Coronary Artery Disease Editorial Source Type: research

Coagulation Factors and the Risk of Ischemic Heart Disease: A Mendelian Randomization Study [Original Articles]
Conclusions: ETP may affect IHD. Assessing the role of its drivers in more precisely phenotyped studies of IHD could be worthwhile. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 12, 2018 Category: Cardiology Authors: Zhao, J. V., Schooling, C. M. Tags: Cardiovascular Disease, Epidemiology Original Articles Source Type: research

Polygenic Risk Score for Coronary Heart Disease Modifies the Elevated Risk by Cigarette Smoking for Disease Incidence [Original Articles]
Conclusions: Genetic predisposition to CHD modifies the associated increased CHD risk by smoking. The PRS has a better predictive use among never smokers compared with smokers. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 12, 2018 Category: Cardiology Authors: Hindy, G., Wiberg, F., Almgren, P., Melander, O., Orho-Melander, M. Tags: Epidemiology, Lifestyle, Genetic, Association Studies, Coronary Artery Disease Original Articles Source Type: research

Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling and Precision Medicine: A Scientific Statement From the American Heart Association [AHA Scientific Statement]
Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human physiology and disease at the cellular level. They also have the potential to be leveraged in the practice of precision medicine, for example, personalized drug testing. This statement comprehensively describes the provenance of iPSC lines, their use for cardiovascular disease modeling, their use for precision medicine, and strategies through which to promote their wider use for biomedical applications. Human iPSCs exhibit properties that render them uniquely qualified as model systems for studying human diseases: they are of human or...
Source: Circulation: Cardiovascular Genetics - January 12, 2018 Category: Cardiology Authors: Musunuru, K., Sheikh, F., Gupta, R. M., Houser, S. R., Maher, K. O., Milan, D. J., Terzic, A., Wu, J. C., On behalf of the American Heart Association Council on Functional Genomics and Translational Biology; Council on Cardiovascular Disease in the Young; Tags: Statements and Guidelines AHA Scientific Statement Source Type: research

Decoding Dysfunction in Duchenne Muscular Dystrophy Cardiomyopathy [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 11, 2018 Category: Cardiology Authors: Reza, N., Owens, A. T. Tags: Genetics, Cardiomyopathy, Echocardiography, Magnetic Resonance Imaging (MRI) Editorial Source Type: research

Cardiac Ion Channelopathies and Stillbirth [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 11, 2018 Category: Cardiology Authors: Chatterjee, N. A. Tags: Arrhythmias, Electrophysiology, Sudden Cardiac Death, Genetics Editorial Source Type: research

Unraveling the Puzzle of the Role of Heritability in the Variability of the QT Interval Using Exome Array Analysis [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 11, 2018 Category: Cardiology Authors: Bos, J. M., Pereira, N. L. Tags: Genetic, Association Studies, Electrocardiology (ECG), Meta Analysis Editorial Source Type: research

Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths [Original Articles]
Conclusions Although a causative link is unclear, 1 putative pathogenic and variants of uncertain significance variant resulting in cardiac channelopathies was identified in some cases of otherwise unexplained stillbirth, and these variants may have a role in fetal demise. Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT01120886. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 11, 2018 Category: Cardiology Authors: Munroe, P. B., Addison, S., Abrams, D. J., Sebire, N. J., Cartwright, J., Donaldson, I., Cohen, M. M., Mein, C., Tinker, A., Harmer, S. C., Aziz, Q., Terry, A., Struebig, M., Warren, H. R., Vadgama, B., Fowler, D. J., Peebles, D., Taylor, A. M., Lally, P. Tags: Arrhythmias, Sudden Cardiac Death, Genetic, Association Studies, Genetics Original Articles Source Type: research

Cardiac Dysfunction in Duchenne Muscular Dystrophy Is Less Frequent in Patients With Mutations in the Dystrophin Dp116 Coding Region Than in Other Regions [Original Articles]
Conclusions Left ventricular ejection fraction in DMD declined stepwise with age. Cardiac dysfunction was less frequent in Dp116-deficient than other patients with DMD. Dp116 transcript was identified in human cardiac muscle for the first time. These results indicate that Dp116 is associated with cardiac involvement in DMD. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 11, 2018 Category: Cardiology Authors: Yamamoto, T., Awano, H., Zhang, Z., Sakuma, M., Kitaaki, S., Matsumoto, M., Nagai, M., Sato, I., Imanishi, T., Hayashi, N., Matsuo, M., Iijima, K., Saegusa, J. Tags: Echocardiography Original Articles Source Type: research

ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals [Original Articles]
Conclusions Our analyses show a role for myocyte internal structure and interconnections in modulating QT interval duration, adding to previous known roles of potassium, sodium, and calcium ion regulation, as well as autonomic control. We anticipate that these discoveries will open new paths to the goal of making novel remedies for the prevention of lethal ventricular arrhythmias and sudden cardiac arrest. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 11, 2018 Category: Cardiology Authors: Bihlmeyer, N. A., Brody, J. A., Smith, A. V., Warren, H. R., Lin, H., Isaacs, A., Liu, C.-T., Marten, J., Radmanesh, F., Hall, L. M., Grarup, N., Mei, H., Muller-Nurasyid, M., Huffman, J. E., Verweij, N., Guo, X., Yao, J., Li-Gao, R., van den Berg, M., We Tags: Electrophysiology, Genetic, Association Studies Original Articles Source Type: research

Whole-Exome Sequencing Reveals GATA4 and PTEN Mutations as a Potential Digenic Cause of Left Ventricular Noncompaction [Clinical Vignettes]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 10, 2018 Category: Cardiology Authors: Tang, V. T., Arscott, P., Helms, A. S., Day, S. M. Tags: Myocardial Biology, Gene Expression & Regulation, Genetics, Functional Genomics, Cardiomyopathy Clinical Vignettes Source Type: research

Chemotherapy-Related Cardiac Dysfunction: A Systematic Review of Genetic Variants Modulating Individual Risk [Review]
Chemotherapy-related cardiac dysfunction is a significant side effect of anticancer treatment. Risk stratification is based on clinical- and treatment-related risk factors that do not adequately explain individual susceptibility. The addition of genetic variants may improve risk assessment. We conducted a systematic literature search in PubMed and Embase, to identify studies investigating genetic risk factors for chemotherapy-related cardiac dysfunction. Included were articles describing genetic variants in humans altering susceptibility to chemotherapy-related cardiac dysfunction. The validity of identified studies was as...
Source: Circulation: Cardiovascular Genetics - January 10, 2018 Category: Cardiology Authors: Linschoten, M., Teske, A. J., Cramer, M. J., van der Wall, E., Asselbergs, F. W. Tags: Pathophysiology, Risk Factors, Genetics, Cardiomyopathy, Heart Failure Review Source Type: research

Genetic Risk Scores in Premature Coronary Artery Disease: Still Only One Piece of the Prevention Puzzle [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - January 8, 2018 Category: Cardiology Authors: Assimes, T. L., Herrington, D. M. Tags: Genetic, Association Studies, Coronary Artery Disease Editorial Source Type: research