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APOL1 Nephropathy Risk Variants and Incident Cardiovascular Disease Events in Community-Dwelling Black Adults [Original Articles]
Conclusions: APOL1 high-risk status is associated with CVD events in community-dwelling Black adults without diabetes mellitus. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 13, 2018 Category: Cardiology Authors: Gutierrez, O. M., Irvin, M. R., Chaudhary, N. S., Cushman, M., Zakai, N. A., David, V. A., Limou, S., Pamir, N., Reiner, A. P., Naik, R. P., Sale, M. M., Safford, M. M., Hyacinth, H. I., Judd, S. E., Kopp, J. B., Winkler, C. A. Tags: Cardiovascular Disease, Race and Ethnicity, Risk Factors, Genetic, Association Studies, Ischemic Stroke Original Articles Source Type: research

Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future [Review]
Type 2 diabetes mellitus (T2D) and obesity already represent 2 of the most prominent risk factors for cardiovascular disease, and are destined to increase in importance given the global changes in lifestyle. Ten years have passed since the first round of genome-wide association studies for T2D and obesity. During this decade, we have witnessed remarkable developments in human genetics. We have graduated from the despair of candidate gene-based studies that generated few consistently replicated genotype-phenotype associations, to the excitement of an exponential harvest of loci robustly associated with medical outcomes thro...
Source: Circulation: Cardiovascular Genetics - June 13, 2018 Category: Cardiology Authors: Ingelsson, E., McCarthy, M. I. Tags: Diabetes, Type 2, Obesity, Genetic, Association Studies, Genetics, Functional Genomics Review Source Type: research

1986 American Heart Association Bugher Program Pivotal to Current Management and Research of Heart Disease [Perspective]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 6, 2018 Category: Cardiology Authors: Roberts, R. Tags: Cardiovascular Disease, Catheter-Based Coronary and Valvular Interventions, Coronary Artery Disease Perspective Source Type: research

Identification of Pathological FBN1 Variants Is Not Straightforward [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 6, 2018 Category: Cardiology Authors: West, M., Summers, K. Tags: Clinical Studies, Gene Expression & Regulation, Genetics Editorial Source Type: research

Low Birth Weight: A Novel Cardiovascular Risk Factor? [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 6, 2018 Category: Cardiology Authors: Laina, A., Stellos, K. Tags: Diabetes, Type 2, Epidemiology, Risk Factors, Genetic, Association Studies, Coronary Artery Disease Editorial Source Type: research

Birthweight, Type 2 Diabetes Mellitus, and Cardiovascular Disease: Addressing the Barker Hypothesis With Mendelian Randomization [Original Articles]
Conclusions: Our study indicates that lower birthweight, used as a proxy for intrauterine growth retardation, is causally related with increased susceptibility to coronary artery disease and T2D. This causal relationship is not mediated by adult obesity or hypertension. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 6, 2018 Category: Cardiology Authors: Zanetti, D., Tikkanen, E., Gustafsson, S., Priest, J. R., Burgess, S., Ingelsson, E. Tags: Genetics Original Articles Source Type: research

Tailoring the American College of Medical Genetics and Genomics and the Association for Molecular Pathology Guidelines for the Interpretation of Sequenced Variants in the FBN1 Gene for Marfan Syndrome: Proposal for a Disease- and Gene-Specific Guideline [Original Articles]
Conclusions: Our study shows that classification of variants remains challenging and may change over time. Currently, a higher level of evidence is necessary to classify a variant as pathogenic. Gene-specific guidelines may be useful to allow a more precise and uniform interpretation of the variants to accurately support clinical decision-making. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 6, 2018 Category: Cardiology Authors: Muino-Mosquera, L., Steijns, F., Audenaert, T., Meerschaut, I., De Paepe, A., Steyaert, W., Symoens, S., Coucke, P., Callewaert, B., Renard, M., De Backer, J. Tags: Genetics, Aneurysm, Aortic Dissection Original Articles Source Type: research

Looking for the Missing Links: Challenges in the Search for Genotype-Phenotype Correlation in Marfan Syndrome [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - May 30, 2018 Category: Cardiology Authors: De Backer, J., Campens, L., Muino Mosquera, L. Tags: Genetics, Aneurysm, Aortic Dissection Editorial Source Type: research

Variants of Uncertain Significance: Should We Revisit How They Are Evaluated and Disclosed? [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - May 30, 2018 Category: Cardiology Authors: Morales, A., Hershberger, R. E. Tags: Cardiovascular Disease, Risk Factors, Genetics, Ethics and Policy Editorial Source Type: research

Impact of Pathogenic FBN1 Variant Types on the Progression of Aortic Disease in Patients With Marfan Syndrome [Original Articles]
Conclusions: DN-CD+HI patients should be monitored more carefully than DN-nonCD patients for rapid development of aortic root aneurysms. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - May 30, 2018 Category: Cardiology Authors: Takeda, N., Inuzuka, R., Maemura, S., Morita, H., Nawata, K., Fujita, D., Taniguchi, Y., Yamauchi, H., Yagi, H., Kato, M., Nishimura, H., Hirata, Y., Ikeda, Y., Kumagai, H., Amiya, E., Hara, H., Fujiwara, T., Akazawa, H., Suzuki, J.-i., Imai, Y., Nagai, R Tags: Genetic, Association Studies, Aneurysm, Aortic Dissection Original Articles Source Type: research

Ability of Patients to Distinguish Among Cardiac Genomic Variant Subclassifications [Original Articles]
Conclusions: Participants are better able to distinguish pathogenicity subclassifications when presented with multiple categories. Individuals who receive a single uncertain result in a cardiovascular disease gene may benefit from interventions to decrease worry, calibrate risk perceptions, and motivate variant-appropriate behaviors. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - May 30, 2018 Category: Cardiology Authors: Hellwig, L. D., Biesecker, B. B., Lewis, K. L., Biesecker, L. G., James, C. A., Klein, W. M. P. Tags: Cardiovascular Disease, Genetics, Diagnostic Testing, Behavioral/Psychosocial Treatment, Health Services Original Articles Source Type: research

Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association [AHA Scientific Statement]
The completion of the Human Genome Project has unleashed a wealth of human genomics information, but it remains unclear how best to implement this information for the benefit of patients. The standard approach of biomedical research, with researchers pursuing advances in knowledge in the laboratory and, separately, clinicians translating research findings into the clinic as much as decades later, will need to give way to new interdisciplinary models for research in genomic medicine. These models should include scientists and clinicians actively working as teams to study patients and populations recruited in clinical settin...
Source: Circulation: Cardiovascular Genetics - May 29, 2018 Category: Cardiology Authors: Musunuru, K., Arora, P., Cooke, J. P., Ferguson, J. F., Hershberger, R. E., Hickey, K. T., Lee, J.-M., Lima, J. A. C., Loscalzo, J., Pereira, N. L., Russell, M. W., Shah, S. H., Sheikh, F., Wang, T. J., MacRae, C. A., On behalf of the American Heart Assoc Tags: Statements and Guidelines AHA Scientific Statement Source Type: research

In This Issue: May [In This Issue: May]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - May 15, 2018 Category: Cardiology Tags: In This Issue: May Source Type: research

Response by Kapplinger et al to Letter Regarding Article, "Yield of the RYR2 Genetic Test in Suspected Catecholaminergic Polymorphic Ventricular Tachycardia and Implications for Test Interpretation" [Correspondence]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - May 11, 2018 Category: Cardiology Authors: Kapplinger, J. D., Tester, D. J., Ackerman, M. J. Tags: Arrhythmias, Sudden Cardiac Death, Genetics Correspondence Source Type: research

SCN10A-Dependent Late INa Current: Never Too Late for Cardiac Conduction? [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - May 11, 2018 Category: Cardiology Authors: Maier, L. S., Sossalla, S., Schulze-Bahr, E. Tags: Arrhythmias, Electrophysiology, Ion Channels/Membrane Transport Editorial Source Type: research