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Is Left Ventricular Noncompaction a Trait, Phenotype, or Disease?: The Evidence Points to Phenotype [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 6, 2017 Category: Cardiology Authors: Hershberger, R. E., Morales, A., Cowan, J. Tags: Genetics, Cardiomyopathy Editorial Source Type: research

FLNC (Filamin-C): A New(er) Player in the Field of Genetic Cardiomyopathies [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 6, 2017 Category: Cardiology Authors: Brodehl, A., Gaertner-Rommel, A., Milting, H. Tags: Stem Cells, Translational Studies, Genetics, Cardiomyopathy, Heart Failure Editorial Source Type: research

Cardiovascular Risk and Matrix Metalloproteinase Polymorphisms: Not Just a Simple Substitution [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 6, 2017 Category: Cardiology Authors: Spinale, F. G., Sapp, A. A. Tags: Heart Failure Editorial Source Type: research

Genome-Wide Gene-Potassium Interaction Analyses on Blood Pressure: The GenSalt Study (Genetic Epidemiology Network of Salt Sensitivity) [Original Articles]
Conclusions— We identified 2 novel BP loci and 6 genes through the examination of single nucleotide polymorphism- and gene-based interactions with potassium. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 6, 2017 Category: Cardiology Authors: Li, C., He, J., Chen, J., Zhao, J., Gu, D., Hixson, J. E., Rao, D. C., Jaquish, C. E., Rice, T. K., Sung, Y. J., Kelly, T. N. Tags: Diet and Nutrition, Genetic, Association Studies, High Blood Pressure Original Articles Source Type: research

Novel Mutation in FLNC (Filamin C) Causes Familial Restrictive Cardiomyopathy [Original Articles]
Conclusion— We have identified a novel variant in FLNC as pathogenic variant for familial RCM—a finding that further expands on the genetic basis of this rare and morbid cardiomyopathy. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 6, 2017 Category: Cardiology Authors: Tucker, N. R., McLellan, M. A., Hu, D., Ye, J., Parsons, V. A., Mills, R. W., Clauss, S., Dolmatova, E., Shea, M. A., Milan, D. J., Scott, N. S., Lindsay, M., Lubitz, S. A., Domian, I. J., Stone, J. R., Lin, H., Ellinor, P. T. Tags: Contractile Function, Genetics, Cardiomyopathy Original Articles Source Type: research

Genetic Testing in Pediatric Left Ventricular Noncompaction [Original Articles]
Conclusions— Genetic testing should be considered in individuals with cardiomyopathy co-occurring with LVNC. These data do not suggest an indication for cardiomyopathy gene panel testing in individuals with isolated LVNC in the absence of a family history of cardiomyopathy. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 6, 2017 Category: Cardiology Authors: Miller, E. M., Hinton, R. B., Czosek, R., Lorts, A., Parrott, A., Shikany, A. R., Ittenbach, R. F., Ware, S. M. Tags: Pediatrics, Genetics, Cardiomyopathy Original Articles Source Type: research

Genetic Variants Contributing to Circulating Matrix Metalloproteinase 8 Levels and Their Association With Cardiovascular Diseases: A Genome-Wide Analysis [Original Articles]
Conclusions— According to our results, the activation of the alternative pathway of the complement system strongly contributes to serum MMP-8 concentration. Genetic polymorphism in S100A9–S100A12–S100A8 locus affects serum and plasma MMP-8 and shows a suggestive association with the risk of CVDs. Our results show that genetic variation determines a significant portion of circulating MMP-8 concentrations. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 6, 2017 Category: Cardiology Authors: Salminen, A., Vlachopoulou, E., Havulinna, A. S., Tervahartiala, T., Sattler, W., Lokki, M.-L., Nieminen, M. S., Perola, M., Salomaa, V., Sinisalo, J., Meri, S., Sorsa, T., Pussinen, P. J. Tags: Computational Biology, Biomarkers, Cardiovascular Disease, Genetic, Association Studies, Genetics Original Articles Source Type: research

Hypertrophic Cardiomyopathy Gene Testing: Go Big? [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 13, 2017 Category: Cardiology Authors: Puckelwartz, M. J., McNally, E. M. Tags: Genetics, Cardiomyopathy Editorial Source Type: research

Sex Determines Cardiac Myocyte Stretch and Relaxation [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 13, 2017 Category: Cardiology Authors: Coronado, M. J., Fairweather, D., Bruno, K. A. Tags: Animal Models of Human Disease, Basic Science Research, Contractile Function, Cardiovascular Disease Editorial Source Type: research

Blood Pressure Genome-Wide Association Studies, Missing Heritability, and Omnigenics [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 13, 2017 Category: Cardiology Authors: Morris, B. J. Tags: Genetic, Association Studies, Genetics, Functional Genomics, High Blood Pressure, Hypertension Editorial Source Type: research

A Smoking-Associated miRNA-mRNA Coexpression Network [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 13, 2017 Category: Cardiology Authors: Civelek, M. Tags: Pulmonary Biology, Biomarkers, Epidemiology, Lifestyle, Risk Factors Editorial Source Type: research

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals [Original Articles]
Conclusions— We report 4 novel loci associated with BP regulation, and 1 independent variant at an established BP locus. This analysis highlights several candidate genes with variation that alter protein function or gene expression for potential follow-up. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 13, 2017 Category: Cardiology Authors: Kraja, A. T., Cook, J. P., Warren, H. R., Surendran, P., Liu, C., Evangelou, E., Manning, A. K., Grarup, N., Drenos, F., Sim, X., Smith, A. V., Amin, N., Blakemore, A. I. F., Bork-Jensen, J., Brandslund, I., Farmaki, A.-E., Fava, C., Ferreira, T., Herzig, Tags: Gene Expression & Regulation, Genetic, Association Studies, Genetics, High Blood Pressure Original Articles Source Type: research

Transcriptome and Functional Profile of Cardiac Myocytes Is Influenced by Biological Sex [Original Articles]
Conclusions— These data support the notion that sex-specific gene expression differences at baseline influence cardiac function, particularly through the protein kinase A pathway, and could potentially be responsible for differences in cardiovascular disease presentation and outcomes. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - October 13, 2017 Category: Cardiology Authors: Trexler, C. L., Odell, A. T., Jeong, M. Y., Dowell, R. D., Leinwand, L. A. Tags: Myocardial Biology, Women, Gene Expression & Regulation Original Articles Source Type: research

A Comparison of Whole Genome Sequencing to Multigene Panel Testing in Hypertrophic Cardiomyopathy Patients [Original Articles]
Conclusions— WGS detected nearly all variants identified on panel testing, provided 1 new diagnostic finding, and allowed interrogation of posited disease genes. Several variants of uncertain clinical use and numerous secondary genetic findings were also identified. Whereas panel testing and WGS provided similar diagnostic yield, WGS offers the advantage of reanalysis over time to incorporate advances in knowledge, but requires expertise in genomic interpretation to appropriately incorporate WGS into clinical care. Clinical Trial Registration— URL: https://clinicaltrials.gov. Unique identifier: NCT01736566. (S...
Source: Circulation: Cardiovascular Genetics - October 13, 2017 Category: Cardiology Authors: Cirino, A. L., Lakdawala, N. K., McDonough, B., Conner, L., Adler, D., Weinfeld, M., OGara, P., Rehm, H. L., Machini, K., Lebo, M., Blout, C., Green, R. C., MacRae, C. A., Seidman, C. E., Ho, C. Y., for the MedSeq Project* Tags: Genetics, Functional Genomics, Cardiomyopathy Original Articles Source Type: research