Computer Modeling: The Future of Cardiac Resynchronization Therapy Patient Selection? [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - January 11, 2018 Category: Cardiology Authors: Cobb, D. B., Gold, M. R. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Mortality/Survival Editorial Source Type: research

Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias [Original Articles]
Conclusions Kir2.x isoforms have a unique intracellular pattern of distribution in association with specific Cav3 domains and that critically depends on interaction with N-terminal Kir2.x Cav3-binding motifs. Long-QT syndrome-9-CAV3 mutation differentially regulates current density and cell surface expression of Kir2.x homomeric and heteromeric channels. Mathematical Purkinje cell model incorporating experimental findings suggests delayed after-depolarization–type triggered activity as a possible arrhythmia mechanism. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - January 11, 2018 Category: Cardiology Authors: Vaidyanathan, R., Van Ert, H., Haq, K. T., Morotti, S., Esch, S., McCune, E. C., Grandi, E., Eckhardt, L. L. Tags: Arrhythmias, Electrophysiology, Basic Science Research, Ion Channels/Membrane Transport, Translational Studies Original Articles Source Type: research

Machine Learning Algorithm Predicts Cardiac Resynchronization Therapy Outcomes: Lessons From the COMPANION Trial [Original Articles]
Conclusions In the COMPANION trial, a machine learning algorithm produced a model that predicted clinical outcomes after CRT. Applied before device implant, this model may better differentiate outcomes over current clinical discriminators and improve shared decision-making with patients. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - January 11, 2018 Category: Cardiology Authors: Kalscheur, M. M., Kipp, R. T., Tattersall, M. C., Mei, C., Buhr, K. A., DeMets, D. L., Field, M. E., Eckhardt, L. L., Page, C. D. Tags: Heart Failure Original Articles Source Type: research

Idiopathic Ventricular Arrhythmias Originating From the Vicinity of the Communicating Vein of Cardiac Venous Systems at the Left Ventricular Summit [Original Articles]
Conclusions The myocardium near the summit CV can be the source of idiopathic VAs. Direct monitoring of the summit CV is helpful for identifying the site of origin and provides a landmark of the ablation target, which may facilitate ablation through adjacent structures. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - January 11, 2018 Category: Cardiology Authors: Komatsu, Y., Nogami, A., Shinoda, Y., Masuda, K., Machino, T., Kuroki, K., Yamasaki, H., Sekiguchi, Y., Aonuma, K. Tags: Arrhythmias, Electrophysiology Original Articles Source Type: research

Cardiac Implantable Electronic Device Infections and Lead Extraction: Are Patients With Renal Insufficiency Special? [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - January 10, 2018 Category: Cardiology Authors: Chrispin, J., Love, C. J. Tags: Mortality/Survival, Quality and Outcomes Editorial Source Type: research

Transvenous Lead Extraction in Chronic Kidney Disease and Dialysis Patients With Infected Cardiac Devices [Original Articles]
Conclusions: In patients with cardiac implantable electronic device infection, dialysis status did not seem to add complexity to transvenous lead extraction but was independently associated with increased mortality at 1 and 6 months. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - January 10, 2018 Category: Cardiology Authors: Barakat, A. F., Wazni, O. M., Tarakji, K. G., Callahan, T., Nimri, N., Saliba, W. I., Shah, S., Abdur Rehman, K., Rickard, J., Brunner, M. P., Martin, D. O., Kanj, M., Baranowski, B., Cantillon, D., Niebauer, M., Dresing, T., Lindsay, B. D., Wilkoff, B. L Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Pacemaker, Complications, Mortality/Survival Original Articles Source Type: research

Mortality After Magnetic Resonance Imaging of the Brain in Patients With Cardiovascular Implantable Devices [Original Articles]
Conclusions: Brain MRI in patients with CIEDs does not carry an increased mortality risk compared with brain CT and can be performed with adherence to appropriate procedural protocols. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - January 10, 2018 Category: Cardiology Authors: Padmanabhan, D., Jondal, M. L., Hodge, D. O., Mehta, R. A., Acker, N. G., Dalzell, C. M., Kapa, S., Asirvatham, S. J., Cha, Y.-M., Felmlee, J. P., Watson, R. E., Friedman, P. A. Tags: Arrhythmias, Imaging, Magnetic Resonance Imaging (MRI), Mortality/Survival, Quality and Outcomes Original Articles Source Type: research

January 8th Question [Challenge of the Week]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - January 8, 2018 Category: Cardiology Authors: Noheria, A. Tags: Atrial Fibrillation, Pacemaker Challenge of the Week Source Type: research

Differential Expression and Remodeling of Transient Outward Potassium Currents in Human Left Ventricles [Original Articles]
Conclusions Ito,f and Ito,s are differentially expressed in nonfailing human LV, contributing to regional heterogeneities in AP waveforms. Ito,f regulates notch and plateau potentials and modulates the time course and amplitude of ICa. Slowing Ito,f inactivation results in dramatic AP shortening. Remodeling of Ito,f in failing human LV subepicardial myocytes attenuates transmural differences in AP waveforms. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - January 8, 2018 Category: Cardiology Authors: Johnson, E. K., Springer, S. J., Wang, W., Dranoff, E. J., Zhang, Y., Kanter, E. M., Yamada, K. A., Nerbonne, J. M. Tags: Arrhythmias, Electrophysiology, Ion Channels/Membrane Transport, Heart Failure, Remodeling Original Articles Source Type: research

Effect of Baseline Antiarrhythmic Drug on Outcomes With Ablation in Ischemic Ventricular Tachycardia: A VANISH Substudy (Ventricular Tachycardia Ablation Versus Escalated Antiarrhythmic Drug Therapy in Ischemic Heart Disease) [Original Articles]
Conclusions Patients with amio-refractory VT have a higher rate of ventricular arrhythmia and mortality than those with sotalol-refractory VT and derive greater benefit of catheter ablation than for patients with sotalol-refractory VT who are switched to amiodarone. CLINICAL TRIAL REGISTRATION URL: https://clinicaltrials.gov. Unique identifier: NCT00905853. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - January 5, 2018 Category: Cardiology Authors: Parkash, R., Nault, I., Rivard, L., Gula, L., Essebag, V., Nery, P., Tung, S., Raymond, J.-M., Sterns, L., Doucette, S., Wells, G., Tang, A. S. L., Stevenson, W. G., Sapp, J. L. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Clinical Studies Original Articles Source Type: research

Quantification of the Arrhythmogenic Effects of Spontaneous Atrial Extrasystole Using High-Resolution Epicardial Mapping [Original Articles]
Conclusions Intraoperative high-resolution epicardial mapping showed that conduction disorders are mainly provoked by prematurely aberrant AES, particularly in patients with left atrial dilation and diabetes mellitus or emerging as epicardial breakthrough. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - December 21, 2017 Category: Cardiology Authors: Teuwen, C. P., Kik, C., van der Does, L. J. M. E., Lanters, E. A. H., Knops, P., Mouws, E. M. J. P., Bogers, A. J. J. C., de Groot, N. M. S. Tags: Arrhythmias, Electrophysiology, Atrial Fibrillation, Etiology Original Articles Source Type: research

In This Issue: December [In This Issue: December]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - December 19, 2017 Category: Cardiology Tags: In This Issue: December Source Type: research

Rotational Drivers in Atrial Fibrillation: Are Multiple Techniques Circling Similar Mechanisms? [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - December 18, 2017 Category: Cardiology Authors: Zaman, J. A. B., Rogers, A. J., Narayan, S. M. Tags: Arrhythmias, Atrial Fibrillation, Computational Biology Editorial Source Type: research

Ventricular Tachycardia Ablation: Are We in a New Age? [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - December 18, 2017 Category: Cardiology Authors: Kanagasundram, A. N., Lugo, R. M., Michaud, G. F. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Complications, Quality and Outcomes Editorial Source Type: research

Ablation of Rotor Domains Effectively Modulates Dynamics of Human: Long-Standing Persistent Atrial Fibrillation [Original Articles]
Conclusions: Rotor domains appropriately explain long-standing persistent atrial fibrillation physiology at its frequency content. Their ablation effectively modifies dynamics on restricted ablation. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - December 18, 2017 Category: Cardiology Authors: Calvo, D., Rubin, J., Perez, D., Moris, C. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Atrial Fibrillation Original Articles Source Type: research