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Outcomes and Management of Patients With Severe Pulmonary Vein Stenosis From Prior Atrial Fibrillation Ablation [Original Articles]
Conclusions: The incidence of severe PV stenosis is low but remains associated with significant morbidity. In patients with recurrent arrhythmia, conduction recovery at the stenosed or stented veins is common. Care must be taken to ablate antrally to avoid stenosis progression. In patients with prior PV stents, we suggest to avoid using Lasso. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 11, 2018 Category: Cardiology Authors: Raeisi-Giglou, P., Wazni, O. M., Saliba, W. I., Barakat, A., Tarakji, K. G., Rickard, J., Cantillon, D., Baranowski, B., Tchou, P. J., Bhargava, M., Dresing, T. J., Callahan, T. D., Kanj, M., Lindsay, B. D., Hussein, A. A. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Atrial Fibrillation Original Articles Source Type: research

Effects of Prolonged Spaceflight on Atrial Size, Atrial Electrophysiology, and Risk of Atrial Fibrillation [Original Articles]
Conclusions: Six months of spaceflight may be sufficient to cause transient changes in left atrial structure and atrial electrophysiology that increase the risk of AF. However, there was no definite evidence of increased supraventricular arrhythmias and no identified episodes of AF. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 11, 2018 Category: Cardiology Authors: Khine, H. W., Steding-Ehrenborg, K., Hastings, J. L., Kowal, J., Daniels, J. D., Page, R. L., Goldberger, J. J., Ng, J., Adams-Huet, B., Bungo, M. W., Levine, B. D. Tags: Arrhythmias, Electrophysiology, Atrial Fibrillation, Magnetic Resonance Imaging (MRI) Original Articles Source Type: research

Functional Invalidation of Putative Sudden Infant Death Syndrome-Associated Variants in the KCNH2-Encoded Kv11.1 Channel [Original Articles]
Conclusions: We conclude that these rare Kv11.1 missense variants are not long-QT syndrome subtype 2–causative variants and therefore do not represent the pathogenic substrate for sudden infant death syndrome in the variant-positive infants. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 11, 2018 Category: Cardiology Authors: Smith, J. L., Tester, D. J., Hall, A. R., Burgess, D. E., Hsu, C.-C., Claude Elayi, S., Anderson, C. L., January, C. T., Luo, J. Z., Hartzel, D. N., Mirshahi, U. L., Murray, M. F., Mirshahi, T., Ackerman, M. J., Delisle, B. P. Tags: Arrhythmias, Sudden Cardiac Death, Ventricular Fibrillation, Ion Channels/Membrane Transport, Functional Genomics Original Articles Source Type: research

Minimally Invasive Delivery of Hydrogel-Encapsulated Amiodarone to the Epicardium Reduces Atrial Fibrillation [Original Articles]
Conclusions: The pericardium is an underutilized therapeutic site and may be a new treatment strategy for AF and other cardiovascular diseases. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 10, 2018 Category: Cardiology Authors: Garcia, J. R., Campbell, P. F., Kumar, G., Langberg, J. J., Cesar, L., Deppen, J. N., Shin, E. Y., Bhatia, N. K., Wang, L., Xu, K., Schneider, F., Robinson, B., Garcia, A. J., Levit, R. D. Tags: Arrhythmias, Electrophysiology, Atrial Fibrillation, Animal Models of Human Disease, Treatment Original Articles Source Type: research

Interleukin 10 Treatment Ameliorates High-Fat Diet-Induced Inflammatory Atrial Remodeling and Fibrillation [Original Articles]
Conclusions: Our results highlight IL-10 treatment as a potential therapeutic approach to limit the progression of HFD-induced obesity-caused atrial fibrillation. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 10, 2018 Category: Cardiology Authors: Kondo, H., Abe, I., Gotoh, K., Fukui, A., Takanari, H., Ishii, Y., Ikebe, Y., Kira, S., Oniki, T., Saito, S., Aoki, K., Tanino, T., Mitarai, K., Kawano, K., Miyoshi, M., Fujinami, M., Yoshimura, S., Ayabe, R., Okada, N., Nagano, Y., Akioka, H., Shinohara, Tags: Atrial Fibrillation, Animal Models of Human Disease, Fibrosis, Inflammation, Obesity Original Articles Source Type: research

Does High-Intensity Endurance Training Increase the Risk of Atrial Fibrillation?: A Longitudinal Study of Left Atrial Structure and Function [Original Articles]
Conclusions: Changes in LA structure, LA mechanical function, and left ventricular remodeling occurred after 10 months of exercise but without significant change in atrial electrical activity. A longer duration of training may be required to induce electrical changes thought to cause atrial fibrillation in middle-aged endurance athletes. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique Identifier: NCT02039154. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 10, 2018 Category: Cardiology Authors: Opondo, M. A., Aiad, N., Cain, M. A., Sarma, S., Howden, E., Stoller, D. A., Ng, J., van Rijckevorsel, P., Hieda, M., Tarumi, T., Palmer, M. D., Levine, B. D. Tags: Arrhythmias, Atrial Fibrillation, Exercise, Risk Factors, Remodeling Original Articles Source Type: research

Clinical Implications of Ablation of Drivers for Atrial Fibrillation: A Systematic Review and Meta-Analysis [Original Articles]
Conclusions: In controlled studies, the addition of AF driver ablation to PVI supports the possible benefit of a combined approach of AF driver ablation and PVI in improving single-procedure freedom from all arrhythmias. However, most studies are uncontrolled and are limited by substantial heterogeneity in outcomes. Large multicenter randomized trials are needed to precisely define the benefits of adding driver ablation to PVI. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 9, 2018 Category: Cardiology Authors: Baykaner, T., Rogers, A. J., Meckler, G. L., Zaman, J., Navara, R., Rodrigo, M., Alhusseini, M., Kowalewski, C. A. B., Viswanathan, M. N., Narayan, S. M., Clopton, P., Wang, P. J., Heidenreich, P. A. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Atrial Fibrillation Original Articles Source Type: research

Ventricular Electrical Activation Delay and High-Frequency Electrocardiograms: Hype or Hope? [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 26, 2018 Category: Cardiology Authors: Killu, A. M., Cha, Y.-M. Tags: Arrhythmias Editorial Source Type: research

Impact of Female Sex on Clinical Outcomes in the FIRE AND ICE Trial of Catheter Ablation for Atrial Fibrillation [Original Articles]
Conclusions: After catheter ablation of paroxysmal AF, female sex was associated with an almost 40% increase in the risks of primary efficacy failure and cardiovascular rehospitalization. Primary efficacy failure was also adversely impacted by a history of direct current cardioversion, whereas hypertension had a negative impact on cardiovascular rehospitalization. History of AF was the only predictor of repeat ablation. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01490814. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 26, 2018 Category: Cardiology Authors: Kuck, K.-H., Brugada, J., Furnkranz, A., Chun, K. R. J., Metzner, A., Ouyang, F., Schluter, M., Elvan, A., Braegelmann, K. M., Kueffer, F. J., Arentz, T., Albenque, J.-P., Kuhne, M., Sticherling, C., Tondo, C., on behalf of the FIRE AND ICE Investigators Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Atrial Fibrillation Original Articles Source Type: research

How Accurate Is Inverse Electrocardiographic Mapping?: A Systematic In Vivo Evaluation [Original Articles]
Conclusions: Inverse potential mapping provides useful information on the origin and spread of epicardial activation. However the spatio-temporal variability of recovered electrograms limit resolution and must constrain the accuracy with which arrhythmia circuits can be identified independently using this approach. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 26, 2018 Category: Cardiology Authors: Bear, L. R., LeGrice, I. J., Sands, G. B., Lever, N. A., Loiselle, D. S., Paterson, D. J., Cheng, L. K., Smaill, B. H. Tags: Arrhythmias, Electrophysiology, Electrocardiology (ECG) Original Articles Source Type: research

Ablation of the Ligament of Marshall and Left Stellate Ganglion Similarly Reduces Ventricular Arrhythmias During Acute Myocardial Infarction [Original Articles]
Conclusions: LOMLSPV ablation prevented acute myocardial infarction–induced VAs with the same efficiency as LSG ablation, potentially by blocking the sympathetic pathway from the LSG to the heart. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 26, 2018 Category: Cardiology Authors: Liu, S., Yu, X., Luo, D., Qin, Z., Wang, X., He, W., Ma, R., Hu, H., Xie, J., He, B., Lu, Z., Jiang, H. Tags: Arrhythmias, Electrophysiology, Ventricular Fibrillation Original Articles Source Type: research

Hot Balloon Versus Cryoballoon Ablation for Atrial Fibrillation: Lesion Characteristics and Middle-Term Outcomes [Original Articles]
Conclusions: Although HBA lesions appear to be smaller than CBA lesions, middle-term outcomes are not statistically different between these balloon modalities. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 26, 2018 Category: Cardiology Authors: Nagashima, K., Okumura, Y., Watanabe, I., Nakahara, S., Hori, Y., Iso, K., Watanabe, R., Arai, M., Wakamatsu, Y., Kurokawa, S., Mano, H., Nakai, T., Ohkubo, K., Hirayama, A. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Atrial Fibrillation Original Articles Source Type: research

Ventricular Electrical Delay Measured From Body Surface ECGs Is Associated With Cardiac Resynchronization Therapy Response in Left Bundle Branch Block Patients From the MADIT-CRT Trial (Multicenter Automatic Defibrillator Implantation-Cardiac Resynchronization Therapy) [Original Articles]
Conclusions: Left bundle branch block patients with a high baseline VED value benefited most from CRT, whereas left bundle branch block patients with low VED did not show CRT benefits. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 26, 2018 Category: Cardiology Authors: Plesinger, F., Jurak, P., Halamek, J., Nejedly, P., Leinveber, P., Viscor, I., Vondra, V., McNitt, S., Polonsky, B., Moss, A. J., Zareba, W., Couderc, J.-P. Tags: Electrophysiology, Heart Failure, Electrocardiology (ECG), Prognosis, Pacemaker Original Articles Source Type: research

In This Issue: April [In This Issue: April]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 17, 2018 Category: Cardiology Tags: In This Issue: April Source Type: research

April 16th Question [Challenge of the Week]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - April 16, 2018 Category: Cardiology Authors: Noheria, A. Tags: Arrhythmias, Electrophysiology, Atrial Fibrillation Challenge of the Week Source Type: research