Human Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue as a Sensitive Test System for QT Prolongation and Arrhythmic Triggers [Original Articles]
Conclusions: EHT from hiPSC-CMs shows a lower repolarization reserve than human LV working myocardium and could thereby serve as a sensitive and specific human-based model for repolarization studies and arrhythmia, similar to Purkinje fibers. In both human LV and EHT, IKs only contributed to repolarization under adrenergic stimulation. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 20, 2018 Category: Cardiology Authors: Lemoine, M. D., Krause, T., Koivumaki, J. T., Prondzynski, M., Schulze, M. L., Girdauskas, E., Willems, S., Hansen, A., Eschenhagen, T., Christ, T. Tags: Arrhythmias, Electrophysiology, Basic Science Research, Ion Channels/Membrane Transport, Stem Cells Original Articles Source Type: research

Catheter Ablation of Atrial Fibrillation: A Life or Death Situation? [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 8, 2018 Category: Cardiology Authors: Terricabras, M., Verma, A. Tags: Arrhythmias, Atrial Fibrillation Editorial Source Type: research

Interaction of Localized Drivers and Disorganized Activation in Persistent Atrial Fibrillation: Reconciling Putative Mechanisms Using Multiple Mapping Techniques [Original Articles]
Conclusions: Sites at which persistent AF terminated by ablation show organized activation that fluctuate over time, because of collision from concurrent organized zones or fibrillatory waves, yet recur in conserved spatial regions. Results were similar by 2 mapping methods. This network of competing mechanisms should be reconciled with existing disorganized or driver mechanisms for AF, to improve clinical mapping and ablation of persistent AF. Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT02997254. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 8, 2018 Category: Cardiology Authors: Kowalewski, C. A. B., Shenasa, F., Rodrigo, M., Clopton, P., Meckler, G., Alhusseini, M. I., Swerdlow, M. A., Joshi, V., Hossainy, S., Zaman, J. A. B., Baykaner, T., Rogers, A. J., Brachmann, J., Miller, J. M., Krummen, D. E., Sauer, W. H., Peters, N. S., Tags: Electrophysiology, Atrial Fibrillation, Computational Biology, Mechanisms Original Articles Source Type: research

CAABL-AF (California Study of Ablation for Atrial Fibrillation): Mortality and Stroke, 2005 to 2013 [Original Articles]
Conclusions: In this large population-based study of hospitalized patients with nonvalvular AF, ablation was associated with lower mortality, ischemic stroke, and hemorrhagic stroke compared with controls. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 8, 2018 Category: Cardiology Authors: Srivatsa, U. N., Danielsen, B., Amsterdam, E. A., Pezeshkian, N., Yang, Y., Nordsieck, E., Fan, D., Chiamvimonvat, N., White, R. H. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Atrial Fibrillation, Cerebrovascular Disease/Stroke Original Articles Source Type: research

Role of 3-Dimensional Architecture of Scar and Surviving Tissue in Ventricular Tachycardia: Insights From High-Resolution Ex Vivo Porcine Models [Original Articles]
Conclusions: The combination of high-resolution imaging data and ventricular simulations revealed the 3-dimensional distribution of surviving tissue surrounding the scar and demonstrated its involvement in VT pathways. The new knowledge obtained in this study contributes toward a better understanding of infarct-related VT. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 7, 2018 Category: Cardiology Authors: Pashakhanloo, F., Herzka, D. A., Halperin, H., McVeigh, E. R., Trayanova, N. A. Tags: Arrhythmias, Electrophysiology, Mechanisms, Myocardial Infarction, Magnetic Resonance Imaging (MRI) Original Articles Source Type: research

Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4 [Original Articles]
Conclusions: Basal cardiac pacemaker function is regulated by concurrent PDE3+PDE4 activation which operates in a synergistic manner via decrease in cAMP/PKA phosphorylation, suppression of LCR parameters, and prolongation of the LCR period and spontaneous SANC cycle length. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 7, 2018 Category: Cardiology Authors: Vinogradova, T. M., Sirenko, S., Lukyanenko, Y. O., Yang, D., Tarasov, K. V., Lyashkov, A. E., Varghese, N. J., Li, Y., Chakir, K., Ziman, B., Lakatta, E. G. Tags: Calcium Cycling/Excitation-Contraction Coupling, Cell Signaling/Signal Transduction, Ion Channels/Membrane Transport Original Articles Source Type: research

Atrial Tachycardias After Atrial Fibrillation Ablation: What Matters for Identification of the Region of Interest? [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 1, 2018 Category: Cardiology Authors: Liu, Y., Shehata, M., Wang, X. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology Editorial Source Type: research

Coronary Sinus Activation and ECG Characteristics of Roof-Dependent Left Atrial Flutter After Pulmonary Vein Isolation [Original Articles]
Conclusions: Roof-dependent flutter around right PVs is more common than around left PVs. The ECG pattern for roof-dependent flutter around right PVs is similar to MA flutter with frontal plane axis dictated by septal activation. Roof-dependent flutter can be distinguished from MA flutter by more simultaneous rather than sequential coronary sinus activation. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 1, 2018 Category: Cardiology Authors: Casado Arroyo, R., Laţcu, D. G., Maeda, S., Kubala, M., Santangeli, P., Garcia, F. C., Enache, B., Eljamili, M., Hayashi, T., Zado, E. S., Saoudi, N., Marchlinski, F. E. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Atrial Fibrillation Original Articles Source Type: research

Unraveling the Underlying Arrhythmia Mechanism in Persistent Atrial Fibrillation: Results From the STARLIGHT Study [Original Articles]
Conclusions: No sustained rotors or localized drivers were detected, and instead, the mechanism of arrhythmia maintenance was consistent with the multiple wavelet hypothesis, with passive activation of short-lived rotational activity. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01765075. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 1, 2018 Category: Cardiology Authors: Child, N., Clayton, R. H., Roney, C. R., Laughner, J. I., Shuros, A., Neuzil, P., Petru, J., Jackson, T., Porter, B., Bostock, J., Niederer, S. A., Razavi, R. S., Rinaldi, C. A., Taggart, P., Wright, M. J., Gill, J. Tags: Arrhythmias, Electrophysiology, Atrial Fibrillation, Mechanisms Original Articles Source Type: research

Nationwide Study of Sudden Cardiac Death in People With Congenital Heart Defects Aged 0 to 35 Years [Original Articles]
Conclusions: The proportion of SCD-CHD in the young was 11%, which is higher than previously reported. Physical activity–related SCD-CHD was a rare event among patients with CHD. We observed an 4-fold lower incidence of SCD-CHD among infants born after implementation of nationwide screening. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 1, 2018 Category: Cardiology Authors: Lynge, T. H., Jeppesen, A. G., Winkel, B. G., Glinge, C., Schmidt, M. R., Sondergaard, L., Risgaard, B., Tfelt-Hansen, J. Tags: Arrhythmias, Sudden Cardiac Death, Epidemiology, Congenital Heart Disease, Echocardiography Original Articles Source Type: research

Circulating MicroRNA-21 Correlates With Left Atrial Low-Voltage Areas and Is Associated With Procedure Outcome in Patients Undergoing Atrial Fibrillation Ablation [Original Articles]
Conclusions: Circulating miR-21 correlates with left atrial LVAs and is associated with procedure outcome in patients with persistent AF undergoing ablation. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 30, 2018 Category: Cardiology Authors: Zhou, Q., Maleck, C., von Ungern-Sternberg, S. N. I., Neupane, B., Heinzmann, D., Marquardt, J., Duckheim, M., Scheckenbach, C., Stimpfle, F., Gawaz, M., Schreieck, J., Seizer, P., Gramlich, M. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Atrial Fibrillation, Biomarkers, Fibrosis Original Articles Source Type: research

Right Ventricular Dysfunction and Long-Term Risk of Sudden Cardiac Death in Patients With and Without Severe Left Ventricular Dysfunction [Original Articles]
Conclusions: Presence of RVD in patients with a history of preexisting cardiac disease is an independent predictor of SCD irrespective of left ventricular ejection fraction. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 16, 2018 Category: Cardiology Authors: Naksuk, N., Tan, N., Padmanabhan, D., Kancharla, K., Makkar, N., Yogeswaran, V., Gaba, P., Kaginele, P., Riley, D. C., Sugrue, A. M., Rosenbaum, A. N., El-Harasis, M. A., Asirvatham, S. J., Kapa, S., McLeod, C. J. Tags: Sudden Cardiac Death, Cardiomyopathy Original Articles Source Type: research

Comprehensive Multicenter Study of the Common Isthmus in Post-Atrial Fibrillation Ablation Multiple-Loop Atrial Tachycardia [Original Articles]
Conclusions: Multiple-loop ATs are complex, frequently including anatomic circuits. They have specific characteristics determined by the combination of AMAT and non-AMAT. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 16, 2018 Category: Cardiology Authors: Takigawa, M., Derval, N., Maury, P., Martin, R., Denis, A., Miyazaki, S., Yamashita, S., Frontera, A., Vlachos, K., Kitamura, T., Cheniti, G., Massoulliee, G., Thompson, N., Martin, C. A., Wolf, M., Pillois, X., Duchateau, J., Klotz, N., Duparc, A., Rolli Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Atrial Fibrillation Original Articles Source Type: research

Transient Outward K+ Current (Ito) Underlies the Right Ventricular Initiation of Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long-QT Syndrome Type 1 [Original Articles]
Conclusions: Ito heterogeneity creates both triggers and an arrhythmogenic substrate in LQT1. In the absence of IKs, Ito interactions with ICa,L and IKr promote EADs in the RV while prolonging action potential duration in the left ventricle. This heterogeneity of action potential enhances dispersion of refractoriness and facilitates conduction blocks that initiate pVTs. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 16, 2018 Category: Cardiology Authors: Choi, B.-R., Li, W., Terentyev, D., Kabakov, A. Y., Zhong, M., Rees, C. M., Terentyeva, R., Kim, T. Y., Qu, Z., Peng, X., Karma, A., Koren, G. Tags: Arrhythmias, Electrophysiology, Basic Science Research, Mechanisms Original Articles Source Type: research

Pulmonary Vein Stenosis After Atrial Fibrillation Ablation: An Iatrogenic Problem Larger Than the Primary Problem [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 11, 2018 Category: Cardiology Authors: Padala, S. K., Ellenbogen, K. A. Tags: Atrial Fibrillation Editorial Source Type: research