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ST-Elevation Magnitude Correlates With Right Ventricular Outflow Tract Conduction Delay in Type I Brugada ECG [Original Articles]
Conclusions: Magnitude of ST (J point) elevation in the type I BrS pattern is attributed to degree of conduction delay in the RVOT and not prolongation in repolarization time. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - October 16, 2017 Category: Cardiology Authors: Leong, K. M. W., Ng, F. S., Yao, C., Roney, C., Taraborrelli, P., Linton, N. W. F., Whinnett, Z. I., Lefroy, D. C., Davies, D. W., Boon Lim, P., Harding, S. E., Peters, N. S., Kanagaratnam, P., Varnava, A. M. Tags: Electrophysiology, Mechanisms, Pathophysiology, Electrocardiology (ECG) Original Articles Source Type: research

Influence of Intramyocardial Adipose Tissue on the Accuracy of Endocardial Contact Mapping of the Chronic Myocardial Infarction Substrate [Original Articles]
Conclusions: These novel findings enhance our understanding of the confounding influence of IMAT on endocardial scar mapping. Combined bipolar and unipolar voltage mapping using optimal thresholds may be useful for delineating IMAT dense regions of myocardium, in postinfarct cardiomyopathy. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - October 16, 2017 Category: Cardiology Authors: Samanta, R., Kumar, S., Chik, W., Qian, P., Barry, M. A., Al Raisi, S., Bhaskaran, A., Farraha, M., Nadri, F., Kizana, E., Thiagalingam, A., Kovoor, P., Pouliopoulos, J. Tags: Arrhythmias, Electrophysiology, Animal Models of Human Disease Original Articles Source Type: research

Right Ventricular Pacing: Can More of a Bad Thing Be Good? [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - October 13, 2017 Category: Cardiology Authors: Zarraga, I. G. E., Jessel, P. M., Raitt, M. H. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator Editorial Source Type: research

Risk Stratification for Sudden Cardiac Death in Individuals Without Structural Disease: Implications From Studies of Rare Genetic Arrhythmic Disorders [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - October 13, 2017 Category: Cardiology Authors: Goldenberg, I., Moss, A. J. Tags: Biomarkers Editorial Source Type: research

Association Between QT-Interval Components and Sudden Cardiac Death: The ARIC Study (Atherosclerosis Risk in Communities) [Original Articles]
Conclusions: The risk of SCD with the QT interval is driven by prolongation of the T-wave onset to T-peak component. This suggests that shifting the focus from the overall QT interval to its individual components will refine SCD prediction in the community. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - October 13, 2017 Category: Cardiology Authors: ONeal, W. T., Singleton, M. J., Roberts, J. D., Tereshchenko, L. G., Sotoodehnia, N., Chen, L. Y., Marcus, G. M., Soliman, E. Z. Tags: Sudden Cardiac Death Original Articles Source Type: research

Right Ventricular Pacing Increases Risk of Appropriate Implantable Cardioverter-Defibrillator Shocks Asymmetrically: An Analysis of the ALTITUDE Database [Original Articles]
Conclusions: Increasing frequency of RVP is associated with a progressively increased risk of appropriate ICD shocks until ≥98% RVP. RVP may have ventricular proarrhythmia because of competition of paced and intrinsic rhythm in ICD patients. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - October 13, 2017 Category: Cardiology Authors: Cronin, E. M., Jones, P., Seth, M. C., Varma, N. Tags: Arrhythmias, Atrial Fibrillation, Heart Failure, Pacemaker, Quality and Outcomes Original Articles Source Type: research

Cl-/HCO3- Exchanger slc26a6: A pH Regulator Shapes the Cardiac Action Potential [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - October 12, 2017 Category: Cardiology Authors: Aiello, E. A., Casey, J. R., Alvarez, B. V. Tags: Arrhythmias, Electrophysiology, Myocardial Biology, Physiology Editorial Source Type: research

Low Adrenomedullin and Endothelin-1 Predict Cardioinhibitory Response During Vasovagal Reflex in Adults Over 40 Years of Age [Research Letter]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - October 12, 2017 Category: Cardiology Authors: Hamrefors, V., Nilsson, D., Melander, O., Sutton, R., Fedorowski, A. Tags: Arrhythmias, Autonomic Nervous System, Pacemaker Research Letter Source Type: research

Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6 [Original Articles]
Conclusions Our study provides mechanistic insights into Slc26a6, a unique cardiac electrogenic Cl–/HCO3– transporter in ventricular myocytes, linking the critical roles of Slc26a6 in regulation of pHi, excitability, and contractility. pHi is a critical regulator of other membrane and contractile proteins. Future studies are needed to investigate possible changes in these proteins in Slc26a6–/– mice. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - October 12, 2017 Category: Cardiology Authors: Sirish, P., Ledford, H. A., Timofeyev, V., Thai, P. N., Ren, L., Kim, H. J., Park, S., Lee, J. H., Dai, G., Moshref, M., Sihn, C.-R., Chen, W. C., Timofeyeva, M. V., Jian, Z., Shimkunas, R., Izu, L. T., Chiamvimonvat, N., Chen-Izu, Y., Yamoah, E. N., Zhan Tags: Arrhythmias, Electrophysiology, Basic Science Research, Contractile Function, Ion Channels/Membrane Transport Original Articles Source Type: research

Alternative Approach for Ablation of the Mitral Isthmus [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - October 10, 2017 Category: Cardiology Authors: Liu, Y., Shehata, M., Wang, X. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology Editorial Source Type: research

Inhibition of Small-Conductance Ca2+-Activated K+ Channels: The Long-Awaited Breakthrough for Antiarrhythmic Drug Therapy of Atrial Fibrillation? [Editorial]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - October 10, 2017 Category: Cardiology Authors: Heijman, J., Dobrev, D. Tags: Electrophysiology, Atrial Fibrillation, Ion Channels/Membrane Transport Editorial Source Type: research

Hybrid Atrial Fibrillation Ablation: Current Status and a Look Ahead [Advances in Arrhythmia and Electrophysiology]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - October 10, 2017 Category: Cardiology Authors: Khoynezhad, A., Ellenbogen, K. A., Al-Atassi, T., Wang, P. J., Kasirajan, V., Wang, X., Edgerton, J. R. Tags: Arrhythmias, Atrial Fibrillation, Cardiovascular Surgery, Treatment, Complications Advances in Arrhythmia and Electrophysiology Source Type: research

Catheter Ablation of the Superolateral Mitral Isthmus Line: A Novel Approach to Reduce the Need for Epicardial Ablation [Original Articles]
Conclusions The superolateral MIL is associated with a high acute success rate to achieve bidirectional block using endocardial ablation only with minimal need for epicardial ablation from within the coronary sinus. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - October 10, 2017 Category: Cardiology Authors: Maurer, T., Metzner, A., Ho, S. Y., Wohlmuth, P., Reissmann, B., Heeger, C., Lemes, C., Hayashi, K., Saguner, A. M., Riedl, J., Sohns, C., Mathew, S., Kuck, K.-H., Wissner, E., Ouyang, F. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology Original Articles Source Type: research

Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs [Original Articles]
Conclusions SK currents play a role in porcine atrial repolarization, and pharmacological inhibition of these with AP14145 demonstrates antiarrhythmic effects in a vernakalant-resistant porcine model of AF. These results suggest SK channel blockers as potentially interesting anti-AF drugs. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - October 10, 2017 Category: Cardiology Authors: Diness, J. G., Skibsbye, L., Simo-Vicens, R., Santos, J. L., Lundegaard, P., Citerni, C., Sauter, D. R. P., Bomholtz, S. H., Svendsen, J. H., Olesen, S.-P., Sorensen, U. S., Jespersen, T., Grunnet, M., Bentzen, B. H. Tags: Arrhythmias, Electrophysiology, Animal Models of Human Disease, Ion Channels/Membrane Transport, Remodeling Original Articles Source Type: research

In This Issue: September [In This Issue: September]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - September 19, 2017 Category: Cardiology Tags: In This Issue: September Source Type: research