Melatonin secretion patterns are associated with cognitive vulnerability and brain structure in bipolar depression
Chronobiol Int. 2023 Oct 2:1-12. doi: 10.1080/07420528.2023.2262572. Online ahead of print.ABSTRACTCircadian rhythm disruption is a core symptom of bipolar disorder (BD), also reflected in altered patterns of melatonin release. Reductions of grey matter (GM) volumes are well documented in BD. We hypothesized that levels and timing of melatonin secretion in bipolar depression could be associated with depressive psychopathology and brain GM integrity. The onset of melatonin secretion under dim light conditions (DLMO) and the amount of time between DLMO and midsleep (i.e. phase angle difference; PAD) were used as circadian rh...
Source: Chronobiology International - October 2, 2023 Category: Biology Authors: Elisa M T Melloni Marco Paolini Sara Dallaspezia Cristina Lorenzi Sara Poletti Greta d'Orsi Takuya Yoshiike Raffaella Zanardi Cristina Colombo Francesco Benedetti Source Type: research
An < em > in silico < /em > investigation: Can melatonin serve as an adjuvant in NR1D1-linked chronotherapy for amyotrophic lateral sclerosis?
This study provides preliminary data and lays the groundwork for future investigations involving in vitro (laboratory-based) and in vivo (animal or human-based) research on chronotherapy. In summary, this research highlights the potential of clock gene-related therapy utilizing melatonin in conjunction with FDA-approved drugs for amyotrophic lateral sclerosis treatment, offering insights into novel treatment strategies. The findings underscore the need for further studies to explore the effectiveness of this hypothetical approach in experimental and clinical settings.PMID:37781884 | DOI:10.1080/07420528.2023.2265476 (Sourc...
Source: Chronobiology International - October 2, 2023 Category: Biology Authors: Emine Erdag Ismail Celil Haskologlu Merve Mercan Nurettin Abacioglu Ahmet Ozer Sehirli Source Type: research
Association between circadian body temperature rhythm during the first 24 hours of ICU stay and 28-day mortality in elderly critically ill patients: A retrospective cohort study
This study revealed that the augmented amplitude of the circadian rhythm of body temperature in the elderly patients constitutes a risk factor for the rise of 28-day mortality. Additionally, the circadian body temperature rhythm may facilitate the early detection of critically ill elderly patients.PMID:37781772 | DOI:10.1080/07420528.2023.2259994 (Source: Chronobiology International)
Source: Chronobiology International - October 2, 2023 Category: Biology Authors: Hongbin Deng Xianqiang Yu Yang Liu Weiqin Li Jiemei Fan Source Type: research
Circadian preference and physical and cognitive performance in adolescence: A scoping review
Chronobiol Int. 2023 Oct 2:1-36. doi: 10.1080/07420528.2023.2256901. Online ahead of print.ABSTRACTAdolescence is a crucial period of development which coincides with changes in circadian rhythmicity. This may augment the impact of circadian preference on performance in this group. We aimed to scope the literature available on chronotypes and their effect on physical and mental aspects of performance in adolescents. Studies were identified by systematically searching bibliographical databases and grey literature. The Morningness-Eveningness Questionnaire was the most frequently reported tool for circadian preference assess...
Source: Chronobiology International - October 2, 2023 Category: Biology Authors: Vanessa F Vidueira Josie N Booth David H Saunders John Sproule Anthony P Turner Source Type: research
The effect of circadian preference and sleep disturbances on depression in children 6 to 12 years of age
This study was conducted to determine sleep disturbances and circadian preferences and their possible associations with depression in healthy children 6 to 12 years of age. A total of 111 healthy children (mean age 7.5 years; 62.2% male) were included. Sleep disturbances and depression were determined by the Sleep Disturbance Scale for Children (SDSC) and the Children's Depression Inventory (CDI), respectively. Circadian preference was evaluated by the Morningness - Eveningness Stability Scale improved (MESSi). SDSC was correlated with CDI (r = 0.396, p < 0.001). Morning affect was inversely correlated with CDI (r = -0....
Source: Chronobiology International - October 2, 2023 Category: Biology Authors: Necla İpar Source Type: research
Night shift work and serum markers of bone turnover in male shift workers
In this study, we evaluated the serum levels of CTX, P1NP and 25-Hydroxy Vitamin D in 82 male subjects (42 daytime workers and 40 night shift workers) to assess the possible risk of osteoporosis in male shift workers. Serum levels of CTX and P1NP were found to be higher in night shift workers than in daytime workers. No significant difference was found in vitamin D levels between night shift and daytime workers. The increased CTX and P1NP levels reveal a higher rate of bone turnover in night shift workers and thus a possible increased risk of osteoporosis in this category of workers compared with daytime workers. In view o...
Source: Chronobiology International - October 2, 2023 Category: Biology Authors: Margherita Martelli Gianmaria Salvio Raffaella Lazzarini Marijana Milinkovic Alessandro Ciarloni Giancarlo Balercia Lory Santarelli Massimo Bracci Source Type: research
The associations between sleep timing and night sleep duration with dyslipidemia in a rural population: The Henan Rural Cohort Study
Chronobiol Int. 2023 Oct 2:1-9. doi: 10.1080/07420528.2023.2262565. Online ahead of print.ABSTRACTEvidence linking sleep timing and night sleep duration to dyslipidemia was limited and inconclusive, especially among low- and middle-income adults. The aims were to evaluate the associations between sleep timing, night sleep duration and dyslipidemia in a rural population. Based on the Henan Rural Cohort Study, a total of 37 164 participants were included. The Pittsburgh Sleep Quality Index was used to collect sleep information. Logistic regression and restrictive cubic splines were conducted to explore the associations. Of t...
Source: Chronobiology International - October 2, 2023 Category: Biology Authors: Ruifang Zhu Jing Yang Zhihan Zhai Hongfei Zhao Feng Jiang Chunyang Sun Xiaotian Liu Jian Hou Ping Dou Chongjian Wang Source Type: research
Melatonin secretion patterns are associated with cognitive vulnerability and brain structure in bipolar depression
Chronobiol Int. 2023 Oct 2:1-12. doi: 10.1080/07420528.2023.2262572. Online ahead of print.ABSTRACTCircadian rhythm disruption is a core symptom of bipolar disorder (BD), also reflected in altered patterns of melatonin release. Reductions of grey matter (GM) volumes are well documented in BD. We hypothesized that levels and timing of melatonin secretion in bipolar depression could be associated with depressive psychopathology and brain GM integrity. The onset of melatonin secretion under dim light conditions (DLMO) and the amount of time between DLMO and midsleep (i.e. phase angle difference; PAD) were used as circadian rh...
Source: Chronobiology International - October 2, 2023 Category: Biology Authors: Elisa M T Melloni Marco Paolini Sara Dallaspezia Cristina Lorenzi Sara Poletti Greta d'Orsi Takuya Yoshiike Raffaella Zanardi Cristina Colombo Francesco Benedetti Source Type: research
An < em > in silico < /em > investigation: Can melatonin serve as an adjuvant in NR1D1-linked chronotherapy for amyotrophic lateral sclerosis?
This study provides preliminary data and lays the groundwork for future investigations involving in vitro (laboratory-based) and in vivo (animal or human-based) research on chronotherapy. In summary, this research highlights the potential of clock gene-related therapy utilizing melatonin in conjunction with FDA-approved drugs for amyotrophic lateral sclerosis treatment, offering insights into novel treatment strategies. The findings underscore the need for further studies to explore the effectiveness of this hypothetical approach in experimental and clinical settings.PMID:37781884 | DOI:10.1080/07420528.2023.2265476 (Sourc...
Source: Chronobiology International - October 2, 2023 Category: Biology Authors: Emine Erdag Ismail Celil Haskologlu Merve Mercan Nurettin Abacioglu Ahmet Ozer Sehirli Source Type: research
Is implementing a post-lunch nap beneficial on evening performance, following two nights partial sleep restriction?
Chronobiol Int. 2023 Sep 18:1-18. doi: 10.1080/07420528.2023.2253908. Online ahead of print.ABSTRACTWe have investigated the effects that partial-sleep-restriction (PSR0, 4-h sleep retiring at 02:30 and waking at 06:30 h for two consecutive nights) have on 07:30 and 17:00 h cognitive and submaximal weightlifting; and whether this performance improves at 17:00 h following a 13:00 h powernap (0, 30 or 60-min). Fifteen resistance-trained males participated in this study. Prior to the experimental protocol, one repetition max (1RM) bench press and back squat, normative habitual sleep and food intake were recorded. Participants...
Source: Chronobiology International - September 18, 2023 Category: Biology Authors: Chloe Gallagher Chloe E Green Michael L Kenny Jessie R Evans Glenn D W McCullagh Samuel A Pullinger Ben J Edwards Source Type: research
Sensation seeking, drinking motives, and going out mediate the link between eveningness and alcohol use and problems in adolescence
Chronobiol Int. 2023 Sep 18:1-11. doi: 10.1080/07420528.2023.2256396. Online ahead of print.ABSTRACTThe present study was aimed at obtaining a more comprehensive understanding of the possible mediating factors in the morningness-eveningness → alcohol consumption relation. We explored the role of mediators such as sensation seeking, the frequency of going out in the evenings, and drinking motives. We tested the proposed mediation model via structural equation modeling based on cross-sectional research conducted among Hungarian adolescents and young adults (N = 1695, 42.5% male, Mage = 18.98, SDage = 1.89). The outcomes in...
Source: Chronobiology International - September 18, 2023 Category: Biology Authors: Adrien Rig ó Istv án Tóth-Király Anna Magi Andrea Eisinger Zsolt Demetrovics R óbert Urbán Source Type: research
Intraindividual variability in sleep duration and college degree attainment
The objective of the current study was to examine the relationship between sleep characteristics and college degree attainment. Participants were 968 college students (72% female; mean age 19.7 [1.7]). Participants completed a psychosocial and sleep questionnaire battery followed by one week of daily sleep diaries. Academic degree completion data was obtained from the university registrar 10 years later. Logistic regression examined whether mean and variability in sleep duration and sleep efficiency and insomnia symptoms predicted degree attainment, adjusting for age, gender, semester, grade point average (GPA), and percei...
Source: Chronobiology International - September 18, 2023 Category: Biology Authors: Jessica R Dietch Alisa Huskey Ian O Dadeboe Danica C Slavish Daniel J Taylor Source Type: research
Early-to-mid pregnancy sleep and circadian markers in relation to birth outcomes: An epigenetics pilot study
Chronobiol Int. 2023 Sep 18:1-11. doi: 10.1080/07420528.2023.2256854. Online ahead of print.ABSTRACTMaternal sleep and circadian health during pregnancy are emerging as important predictors of pregnancy outcomes, but examination of potential epigenetic mechanisms is rare. We investigated links between maternal leukocyte DNA methylation of circadian genes and birth outcomes within a pregnancy cohort. Women (n = 96) completed a questionnaire and provided a blood sample at least once during early-to-mid pregnancy (average gestation weeks = 14.2). Leukocyte DNA was isolated and DNA methylation (average percent of methylation) ...
Source: Chronobiology International - September 18, 2023 Category: Biology Authors: Erica C Jansen Kelvin Pengyuan Zhang Dana C Dolinoy Helen J Burgess Louise M O'Brien Elizabeth Langen Naquia Unwala Jessa Ehlinger Molly C Mulcahy Jaclyn M Goodrich Source Type: research
Association between circadian clock gene expressions and meal timing in young and older adults
In this study, we investigated the relationship between clock gene expression and meal timing in young and older adults. In this cross-sectional study, we enrolled 51 healthy young men and 35 healthy older men (age, mean±standard deviation: 24 ± 4 and 70 ± 4 y, respectively). Under daily living conditions, beard follicle cells were collected at 4-h intervals over a 24-h period to evaluate clock gene expression. Participants were asked to record the timing of habitual sleep and wake-up, breakfast, lunch, and dinner. From these data, we calculated "From bedtime to breakfast time," "From wake up to first meal time," and "F...
Source: Chronobiology International - September 18, 2023 Category: Biology Authors: Masaki Takahashi Mayuko Fukazawa Yu Tahara Hyeon-Ki Kim Kumpei Tanisawa Tomoko Ito Takashi Nakaoka Mitsuru Higuchi Shigenobu Shibata Source Type: research
Is implementing a post-lunch nap beneficial on evening performance, following two nights partial sleep restriction?
Chronobiol Int. 2023 Sep 18:1-18. doi: 10.1080/07420528.2023.2253908. Online ahead of print.ABSTRACTWe have investigated the effects that partial-sleep-restriction (PSR0, 4-h sleep retiring at 02:30 and waking at 06:30 h for two consecutive nights) have on 07:30 and 17:00 h cognitive and submaximal weightlifting; and whether this performance improves at 17:00 h following a 13:00 h powernap (0, 30 or 60-min). Fifteen resistance-trained males participated in this study. Prior to the experimental protocol, one repetition max (1RM) bench press and back squat, normative habitual sleep and food intake were recorded. Participants...
Source: Chronobiology International - September 18, 2023 Category: Biology Authors: Chloe Gallagher Chloe E Green Michael L Kenny Jessie R Evans Glenn D W McCullagh Samuel A Pullinger Ben J Edwards Source Type: research
