Chinese Journal of Natural Medicines This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Cimicifuga heracleifolia is therapeutically similar to black cohosh in relieving menopausal symptoms: evidence from pharmacological and metabolomics studies
In conclusion, these results demonstrated that CH is therapeutically similar to CR in relieving menopausal symptoms and CH could be considered as a promising alternative to CR instead of an adulterant in the market of botanical dietary supplements. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - June 29, 2019 Category: Complementary Medicine Source Type: research

Vitellaria paradoxa nutshells from seven sub-Saharan countries as potential herbal medicines for treating diabetes based on chemical compositions, HPLC fingerprints and bioactivity evaluation
Publication date: June 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 6Author(s): Da LI, Jian-Qi XIAO, Wen-Yuan LIU, Chao-Feng ZHANG, Toshihiro AKIHISA, Masahiko ABE, Eliot-T. MASTERS, Wei-Wei ZHAI, Feng FENG, Jie ZHANGAbstractThe aim of the study was to determine the feasibility of the Vitellaria paradoxa nutshell as a new medicinal resource for treating diabetes. A total of forty-one compounds were identified by HPLC-DAD-Q-TOF-MS and phytochemical methods in V. paradoxa nutshell methanol extract. Based on HPLC fingerprints, four characteristic constituents were quantified and the origin of twenty-eigh...
Source: Chinese Journal of Natural Medicines - June 29, 2019 Category: Complementary Medicine Source Type: research

Cardamine komarovii flower extract reduces lipopolysaccharide-induced acute lung injury by inhibiting MyD88/TRIF signaling pathways
In conclusion, our results suggest that CKF inhibits LPS-induced inflammatory response by inhibiting the MyD88/TRIF signaling pathways, thereby protecting mice from LPS-induced ALI. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - June 29, 2019 Category: Complementary Medicine Source Type: research

Withaminimas A—F, six withanolides with potential anti-inflammatory activity from Physalis minima
Publication date: June 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 6Author(s): Shan-Shan WEI, Cai-Yun GAO, Rui-Jun LI, Ling-Yi KONG, Jun LUOAbstractWithaminimas A—F (1—6), six new withaphysalin-type withanolides were isolated from the aerial parts of Physalis minima L.. The structures of these compounds were elucidated through a variety of spectroscopic techniques including HR-MS, NMR, and ECD. Compound 1 belongs to rare 18-norwithanolides, and 2—3 were 13/14-secowithanolides. According to the traditional usage of P. minima, inhibitory effects on nitric oxide (NO) production in lipopolysaccarid...
Source: Chinese Journal of Natural Medicines - June 29, 2019 Category: Complementary Medicine Source Type: research

Bioactive phenazines from an earwig-associated Streptomyces sp.
Publication date: June 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 6Author(s): Hao HAN, Zhi-Kai GUO, Bo ZHANG, Mei ZHANG, Jing SHI, Wei LI, Rui-Hua JIAO, Ren-Xiang TAN, Hui-Ming GEAbstractThree new phenazine-type compounds, named phenazines SA—SC (1—3), together with four new natural products (4—7), were isolated from the fermentation broth of an earwig-associated Streptomyces sp. NA04227. The structures of these compounds were determined by extensive analyses of NMR, high resolution mass spectroscopic data, as well as single-crystal X-ray diffraction measurement. Sequencing and analysis of the...
Source: Chinese Journal of Natural Medicines - June 29, 2019 Category: Complementary Medicine Source Type: research

Metabolomics and its application in the treatment of coronary heart disease with traditional Chinese medicine
This article summarized the application of metabolomics in the early diagnosis, the discovery of biomarkers and the treatment of TCM in CAD. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - June 4, 2019 Category: Complementary Medicine Source Type: research

A brief history of artemisinin: Modes of action and mechanisms of resistance
Publication date: 20 May 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 5Author(s): Feng LU, Xin-Long HE, Culleton Richard, Jun CAOAbstractThe cornerstone of antimalarial treatment, artemisinin, has reduced malaria associated morbidity and mortality worldwide. However, Plasmodium falciparum parasites with reduced sensitivity to artemisinin have emerged, and this threatens malaria control and elimination efforts. In this minireview, we describe the initial development of artemisinin as an antimalarial drug, its use both historically and currently, and our current understanding of its mode of action and t...
Source: Chinese Journal of Natural Medicines - June 4, 2019 Category: Complementary Medicine Source Type: research

Rapid identification of Dendrobium officinale using Loop-Mediated Isothermal Amplification (LAMP) method
In this study, we developed a rapid identification protocol for D. officinale using the loop-mediated isothermal amplification (LAMP) method. A set of primers were specifically designed to detect a modified internal transcribed spacer region of D. officinale at 65 °C within 40 min after adding SYBR® Green I, which was used for the detection of D. officinale. Unlike commonly used adulterants, reaction mixtures containing D. officinale DNA changed from orange to green, and this color change was easily observed with the naked eye. Thus, this methodology can be used to accurately differentiate D. officinale from other Dendro...
Source: Chinese Journal of Natural Medicines - June 4, 2019 Category: Complementary Medicine Source Type: research

Umbelliferone ameliorates renal function in diabetic nephropathy rats through regulating inflammation and TLR/NF-κB pathway
Publication date: 20 May 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 5Author(s): Han-Qing WANG, Sha-Sha WANG, Kuok Chiufai, Qi WANG, Xiao-Lan CHENGAbstractDiabetic nephropathy (DN) is a leading cause of renal failure, contributing to severe morbidity and mortality in diabetic patients. Umbelliferae (Umb) has been well characterized to exert protective effects in diabetes. However, the action and mechanism of Umb in DN remains unclear. In this work, we studied the effect of Umb in a streptozotocin (STZ)-induced DN rat model and explore its underlying mechanism. DN rats were treated withUmb (20, 40 mgÂ...
Source: Chinese Journal of Natural Medicines - June 4, 2019 Category: Complementary Medicine Source Type: research

Modified Da-chai-hu Decoction regulates the expression of occludin and NF-κB to alleviate organ injury in severe acute pancreatitis rats
Publication date: 20 May 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 5Author(s): Guang ZHAO, Yu-Zhen ZHUO, Li-Hua CUI, Cai-Xia LI, Sha-Yan CHEN, Dan LI, Jun-Hong LIU, Di-Hua LI, Nai-Qiang CUI, Shu-Kun ZHANGAbstractModified Da-chai-hu Decoction (MDD), a traditional Chinese medicinal formulation, which was empirically generated from Da-chai-hu decoction, has been utilized to treat severe acute pancreatitis (SAP) for decades. The aim of the present study was to explore its potential organprotective mechanism in SAP. In the present study, rat SAP model was induced by retrograde injection of 3.5% sodium t...
Source: Chinese Journal of Natural Medicines - June 4, 2019 Category: Complementary Medicine Source Type: research

5, 7, 2’, 4’, 5’-Pentamethoxyflavanone regulates M1/M2 macrophage phenotype and protects the septic mice
Publication date: 20 May 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 5Author(s): Li-Li FENG, Li-Sha XU, Meng-Meng GUO, Wei HUANG, Jia-Zhen ZHU, Ling-Dong KONG, Xu-Dong WU, Qiang XUAbstractFlavonoids have been reported to exert protective effect against many inflammatory diseases, while the underlying cellular mechanisms are still not completely known. In the present study, we explored the anti-inflammation activity of 5, 7, 2’, 4’, 5’-pentamethoxyflavanone (abbreviated as Pen.), a kind of polymethoxylated flavonoid, both in vitro and in vivo experiments. Pen. was showed no obvious toxicity in m...
Source: Chinese Journal of Natural Medicines - June 4, 2019 Category: Complementary Medicine Source Type: research

Broussonin E suppresses LPS-induced inflammatory response in macrophages via inhibiting MAPK pathway and enhancing JAK2-STAT3 pathway
Publication date: 20 May 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 5Author(s): Shao-Peng HUANG, Xin GUAN, Guo-Yin KAI, Ya-Zhou XU, Yuan XU, Hao-Jie WANG, Tao PANG, Lu-Yong ZHANG, Ying LIUAbstractMacrophages play an important role in inflammation, and excessive and chronic activation of macrophages leads to systemic inflammatory diseases, such as atherosclerosis and rheumatoid arthritis. In this paper, we explored the anti-inflammatory effect of broussonin E, a novel phenolic compound isolated from the barks ofBroussonetia kanzinoki, and its underlying molecular mechanisms. We discovered that Brouss...
Source: Chinese Journal of Natural Medicines - June 4, 2019 Category: Complementary Medicine Source Type: research

Prenylated stilbenes and flavonoids from the leaves of Cajanus cajan
Publication date: 20 May 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 5Author(s): Gui-Yun WU, Xiao ZHANG, Xue-Ying GUO, Lu-Qiong HUO, Hong-Xin LIU, Xiao-Ling SHEN, Sheng-Xiang QIU, Ying-Jie HU, Hai-Bo TANAbstractThree new prenylated stilbenes, named as cajanusins A-C (1-3), and one new natural product cajanusin D (4), along with six known derivatives (5-10) were isolated from the leaves of Cajanus cajan. Their structures were fully elucidated by means of extensive spectroscopic methods and comparison with data in the reported literatures. The new compounds of 1 and 2 were evaluated for in vitro cytoto...
Source: Chinese Journal of Natural Medicines - June 4, 2019 Category: Complementary Medicine Source Type: research

Dalestones A and B, two anti-inflammatory cyclopentenones from Daldinia eschscholzii with an edited strong promoter for the global regulator LaeA-like gene
Publication date: 20 May 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 5Author(s): Zhen-Zhen ZHOU, Hong-Jie ZHU, Cheng-Long YANG, Yan-Jun LIU, Nan JIANG, Yong-Sheng XIAO, Li-Yun SHI, Rui-Hua JIAO, Hui-Ming GE, Ren-Xiang TANAbstractReplacement of the native promoter of theglobal regulator LaeA-like gene of Daldinia eschscholzii by a strong gpdA promoter led to the generation of two novel cyclopentenone metabolites, named dalestones A and B, whose structures were assigned by a combination of spectroscopic analysis, modified Mosher’s reaction, and electronic circular dichroism (ECD). Dalestones A and B ...
Source: Chinese Journal of Natural Medicines - June 4, 2019 Category: Complementary Medicine Source Type: research

Six new monacolin analogs from red yeast rice
Publication date: 20 May 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 5Author(s): Bing-Yu LIU, Fei XU, Jian BAI, Dao-Jiang YAN, Le ZHANG, Dan ZHANG, You-Cai HUAbstractSix novel monacolin analogs, monacolins V1–V6 (1–6), together with seven known ones (7–13), were isolated from the ethyl acetate extract of red yeast rice. Their structures and absolute configurations were determined by spectroscopic methods, especially 2D NMR (1H-1HCOSY, HSQC, HMBC, and NOESY/ROESY) and CD spectroscopic analyses as well as chemical derivation. Monacolins V2 (2) and V3 (3) represent the first examples of monacolins...
Source: Chinese Journal of Natural Medicines - June 4, 2019 Category: Complementary Medicine Source Type: research