Chinese Journal of Natural Medicines This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Identification of constituents in Gui-Zhi-Jia-Ge-Gen-Tang by LC-IT-MS combined with LC-Q-TOF-MS and elucidation of their metabolic networks in rat plasma after oral administration
Publication date: November 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 11Author(s): Lu-Lin CHEN, Can-Hui CHEN, Xing-Xian ZHANG, Yi WANG, Shu-Fang WANGAbstractGui-Zhi-Jia-Ge-Gen-Tang (GZJGGT) is a traditional Chinese medicine (TCM) prescription commonly used to treat cervical spondylopathy, scapulohumeral periarthritis, etc. Though it is widely applied in clinical practice, the effective constituents of GZJGGT remain unclear. This was the first report on the identification of the chemical constituents from GZJGGT in vitro and in vivo using LC-IT-MS combined with LC-Q-TOF-MS. A total of 141 constituent...
Source: Chinese Journal of Natural Medicines - December 10, 2019 Category: Complementary Medicine Source Type: research

Systematic analysis of the metabolites of Angelol B by UPLC-Q-TOF-MS after oral administration to rats
Publication date: November 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 11Author(s): Mei-Qi WAN, You-Bo ZHANG, Xiao-Yan LIU, Ke-Ming LI, Ling-Yun JIA, Xiu-Wei YANGAbstractAngelicae Pubescentis Radix (APR), a widely used traditional Chinese medicine (TCM), is mainly used to treat rheumatism and headache diseases. Angelol B is one of the bioactive constituents of APR with significant anti-inflammatory activity. This paper is aimed to illustrate the metabolites of angelol B in vivo. To achieve this objective, a metabolomics approach based on a rapid and accurate UPLC-Q-TOF-MS method was used to detect th...
Source: Chinese Journal of Natural Medicines - December 10, 2019 Category: Complementary Medicine Source Type: research

Akkermansia muciniphila: a promising target for the therapy of metabolic syndrome and related diseases
Publication date: November 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 11Author(s): Ji-Chao ZHOU, Xiao-Wei ZHANGAbstractThe probiotic Akkermansia muciniphila (A. muciniphila) is an intestinal bacterium that was first identified in human feces in 2004. Its specialization in mucin degradation makes it a key microorganism that maintains intestinal mucosal barrier function. As an unique representative strain of the phylum Verrucomicrobia that can be cultured in vitro, A. muciniphila is much easier to detect by metagenomic analysis of intestinal flora. In the past few years, A. muciniphila has been gettin...
Source: Chinese Journal of Natural Medicines - December 10, 2019 Category: Complementary Medicine Source Type: research

Profiling the metabolites of astrapterocarpan in rat hepatic 9000g supernatant
In conclusion, this is the first report on the metabolism of a pure pterocarpan in animal tissues, and these findings will provide a solid basis for further studies on the metabolism of other pterocarpans. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - December 10, 2019 Category: Complementary Medicine Source Type: research

Interactions of drug-metabolizing enzymes with the Chinese herb Psoraleae Fructus
This article reviews the interactions between human drug-metabolizing enzymes and the constituents of Psoraleae Fructus; the major constituents in Psoraleae Fructus, along with their chemical structures and metabolic pathways are summarized, and the inhibitory and inductive effects of the constituents in Psoraleae Fructus on human drug-metabolizing enzymes (DMEs), including target enzyme(s), its modulatory potency, and mechanisms of action are presented. Collectively, this review summarizes current knowledge of the interactions between the Chinese herb Psoraleae Fructus and therapeutic drugs in an effort to facilitate its ...
Source: Chinese Journal of Natural Medicines - December 10, 2019 Category: Complementary Medicine Source Type: research

Comparative pharmacodynamic, pharmacokinetic and tissue distribution of Dahuang-Gancao decoction in normal and experimental constipation mice
Publication date: November 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 11Author(s): Yan-Yan CHEN, Yu-Jie CAO, Yu-Ping TANG, Shi-Jun YUE, Jin-Ao DUANAbstractDahuang-Gancao decoction (DGD) is a classical formula, which is commonly used for reliving constipation in Chinese clinic. The aim of this study was to investigate the pharmacodynamic, pharmacokinetic and tissue distribution alternations of DGD in normal and constipation mice. DGD exhibited stronger purgative effect in constipation mice by the increased fecal excretion and reduced first defection time compared with normal mice. The Cmax, AUC0-t an...
Source: Chinese Journal of Natural Medicines - December 10, 2019 Category: Complementary Medicine Source Type: research

Therapeutic effects of garlic in cardiovascular atherosclerotic disease
Publication date: October 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 10Author(s): Igor A. Sobenin, Veronika A. Myasoedova, Maria I. Iltchuk, Dong-Wei ZHANG, Alexander N. OrekhovABSTRACTGarlic (Allium sativum) is a widely known medicinal plant, potential of which remains to be fully evaluated. Its wide-range beneficial effects appear to be relevant for treatment and prevention of atherosclerosis and related diseases. It is generally believed that garlic-based preparations are able to improve lipid profile in humans, inhibit cholesterol biosynthesis, suppress low density lipoprotein oxidation, modulat...
Source: Chinese Journal of Natural Medicines - November 6, 2019 Category: Complementary Medicine Source Type: research

The prognostic impact of traditional Chinese medicine monomers on tumor-associated macrophages in non-small cell lung cancer
Publication date: October 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 10Author(s): Liang-Qin WAN, Yan TAN, Miao JIANG, Qian HUAABSTRACTNon-small cell lung cancer (NSCLC) accounts for 80%–85% of all lung malignancies and good diagnosis and prognosis of NSCLC are critical to the increase of its survival rate. Tumor-associated macrophages (TAM) abundantly present in numerous cancer types, and the role of TAMs in tumor biology and their prognostic value in cancer become major topics of interest. After various stimulations in the tumor microenvironment, TAMs develop into a M1 (tumor-inhibitory) phenotyp...
Source: Chinese Journal of Natural Medicines - November 6, 2019 Category: Complementary Medicine Source Type: research

DNA barcoding and rapid identification of the precious herb Herba Anoectochili
Publication date: October 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 10Author(s): Shuai-Jun HU, Hao-Yu HU, Han GAO, Xia LIU, Shi-Lin CHENABSTRACTHerba Anoectochili is a commonly used medicinal material. However, its adulteration is a serious concern. Due to the similar morphological characteristics of Herba Anoectochili and its adulterants, traditional identification techniques often fail to distinguish between them accurately, which is not conducive to the circulation management and safety of the medicinal materials. To improve the distinction between Herba Anoectochili and its adulterants accurate...
Source: Chinese Journal of Natural Medicines - November 6, 2019 Category: Complementary Medicine Source Type: research

YQWY decoction reverses cardiac hypertrophy induced by TAC through inhibiting GATA4 phosphorylation and MAPKs
Publication date: October 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 10Author(s): Jing-Jing HUANG, Yong XIE, He LI, Xiao-Xiao ZHANG, Qing HUANG, Yao ZHU, Ping GU, Wei-Min JIANGABSTRACTTo investigate the effect of Yiqi Wenyang (YQWY) decoction on reversing cardiac hypertrophy induced by the transverse aortic constriction (TAC). Wistar rats aged 7–8 weeks were subjected to TAC surgery and then randomly divided into 4 groups (n = 5/group): Sham group, TAC group, low-dose group and high dose group. After 16-week intragastric administration of YQWY decoction, the effect of YQWY decoction on alleviating...
Source: Chinese Journal of Natural Medicines - November 6, 2019 Category: Complementary Medicine Source Type: research

Pilose antler aqueous extract promotes the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells by stimulating the BMP-2/Smad1, 5/Runx2 signaling pathway
In conclusion, PAAE activates the BMP-2/Smad1, 5/Runx2 pathway to induce osteoblastic differentiation and mineralization in BMSCs and can inhibit OVX-induced bone loss. These mechanisms are likely responsible for its therapeutic effect on postmenopausal osteoporosis. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - November 6, 2019 Category: Complementary Medicine Source Type: research

Inhibitory effects of polyphyllins I and VII on human cisplatin-resistant NSCLC via p53 upregulation and CIP2A/AKT/mTOR signaling axis inhibition
Publication date: October 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 10Author(s): Fei-Fei FENG, Peng CHENG, Chao SUN, Hui WANG, Wei WANGABSTRACTCancerous inhibitor of protein phosphatase 2A (CIP2A) is a human oncoprotein that is overexpressed in multiple kinds of cancers including non-small cell lung cancer (NSCLC). CIP2A plays an ‘oncogenic nexus’ to participate in the tumorigenesis and chemoresistance in several cancer types. AKT and mTORC1 overactivation are detected in NSCLC and many other cancers. Previous studies found that the CIP2A/AKT/mTOR pathway controls cell growth, apoptosis, autoph...
Source: Chinese Journal of Natural Medicines - November 6, 2019 Category: Complementary Medicine Source Type: research

Steroidal constituents from Helleborus thibetanus and their cytotoxicities
In this study, compounds 2–13 were evaluated for their cytotoxic activities against HCT116, A549 and HepG2 tumor cell lines in vitro. Among them, compound 8 (thibetanoside C) showed cytotoxicities against A549 cells(IC50 39.6 ± 1.9 μmol·L−1) and HepG2 cells(IC50 41.5 ± 1.1 μmol·L−1), respectively. Compound 9 (23S, 24S)-24-[(O-β-D-fucopyranosyl)oxy]-3β, 23-dihydroxy-spirosta-5, 25(27)-diene-1β-ylO-(4-O-acetyl- α-L-rhamnopyranosyl)-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-α-L-arabinopyranoside) showed cytotoxicity against HCT116 cells(IC50 33.6 ± 2.1 μmol·L−1). (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - November 6, 2019 Category: Complementary Medicine Source Type: research

Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica
Publication date: October 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 10Author(s): Abilova Zhamilya, Jie YUAN, Jenis Janar, Chun-Ping TANG, Yang YEABSTRACTOne new dimeric (1) and two monomeric sesquiterpene lactones (5 and 13), together with 10 known compounds (2–4, 6–12), were isolated from Artemisia heptapotamica collected in Almaty region of Kazakhstan. All compounds were isolated from this plant for the first time. The structures of the new compounds were mainly achieved by extensive analysis of MS, 1D and 2D NMR spectroscopic data, and ECD spectrum as well. The inhibitory activities of all i...
Source: Chinese Journal of Natural Medicines - November 6, 2019 Category: Complementary Medicine Source Type: research

Purification, structure characterization and antioxidant activity of polysaccharides from Saposhnikovia divaricata
Publication date: October 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 10Author(s): Yao MENG, Lin YI, Lei CHEN, Jie HAO, Du-Xin LI, Jie XUE, Nai-Yu XU, Zhen-Qing ZHANGABSTRACTPolysaccharide from traditional Chinese herb, Saposhnikovia divaricata (Turcz.) Schischk. (SD) was extracted, fractionated and characterized in this work. Four fractions were prepared. Their molecular weight, monosaccharide compositions, linkage modes and structural properties were characterized with SEC-MALS-RI, HPAEC-PAD, GC-MS and NMR. SDP1 was assigned as a 1, 4-α-glucan with small amount of O-6 linked branches. SDP2 contain...
Source: Chinese Journal of Natural Medicines - November 6, 2019 Category: Complementary Medicine Source Type: research