Genetic polymorphisms of autophagy-related gene 5 (ATG5) rs473543 predict different disease-free survivals of triple-negative breast cancer patients receiving anthracycline- and/or taxane-based adjuvant chemotherapy.
CONCLUSION: ATG5 rs473543 genotypes may serve as a potential marker for predicting recurrence of early-stage TNBC patients who received anthracycline-and/or taxane-based regimens as adjuvant chemotherapy. PMID: 29382381 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - February 1, 2018 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Computed tomography and magnetic resonance imaging evaluation of pelvic lymph node metastasis in bladder cancer.
In this study, we aimed to evaluate the diagnostic accuracy of computed tomography (CT) and magnetic resonance imaging (MRI) for metastatic lymph nodes in BCa and establish criteria of imaging diagnosis. METHODS: We retrospectively assessed the imaging characteristics of 191 BCa patients who underwent radical cystectomy. The data regarding size, shape, density, and diffusion of the lymph nodes on CT and/or MRI were obtained and analyzed using Kruskal-Wallis test and χ2 test. The optimal cutoff value for the size of metastatic node was determined using the receiver operating characteristic (ROC) curve analysis. ...
Source: Chinese Journal of Cancer - January 28, 2018 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma.
In this study, we aimed to characterize the role of FSTL1 in the development of ccRCC. METHODS: The effects of FSTL1 on cell activity and cell cycle were investigated in ccRCC cell lines with altered FSTL1 expression. Gene expression microarray assays were performed to identify the major signaling pathways affected by FSTL1 knockdown. The expression of FSTL1 in ccRCC and its effect on postoperative prognosis were estimated in a cohort with 89 patients. RESULTS: FSTL1 knockdown promoted anchorage-independent growth, migration, invasion, and cell cycle of ccRCC cell lines, whereas FSTL1 overexpression attenuated cell...
Source: Chinese Journal of Cancer - January 25, 2018 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

The 150 most important questions in cancer research and clinical oncology series: questions 86-93 : Edited by Chinese Journal of Cancer.
Authors: Chinese Journal of Cancer Abstract Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which spark diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 8 more questions are presented as follows. Question 86. In which circumstances is good supportive care associated with a survival advantage in patients with cancer? Question 87. Can we develop animal models to mimic immunotherapy response of cancer patients? Question 88. What are the mechanis...
Source: Chinese Journal of Cancer - January 25, 2018 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein-Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma.
This study aimed to evaluate the prognostic values of gross tumor volume of metastatic regional lymph node (GTVnd) and pretreatment serum copy number of Epstein-Barr virus (EBV) DNA in predicting distant metastasis of patients with N1 NPC, and to develop an integrated prognostic model that incorporates GTVnd and EBV DNA copy number for this group of patients. METHODS: The medical records of 787 newly diagnosed patients with nonmetastatic, histologically proven N1 NPC who were treated at Sun Yat-sen University Cancer Center between November 2009 and February 2012 were analyzed. Computed tomography-derived GTVnd was meas...
Source: Chinese Journal of Cancer - December 31, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Famitinib versus placebo in the treatment of refractory metastatic colorectal cancer: a multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial.
CONCLUSION: Famitinib prolonged PFS in refractory mCRC patients with acceptable tolerability. Trial registration This study was registered on ClinicalTrials.gov (NCT01762293) and was orally presented in the 2015 ASCO-Gastrointestinal Symposium. PMID: 29273089 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 25, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Prognostic value of preoperative prognostic nutritional index and its associations with systemic inflammatory response markers in patients with stage III colon cancer.
This study aimed to investigate the prognostic value of PNI in patients with stage III colon cancer. METHODS: Medical records of 274 consecutive patients with stage III colon cancer undergoing curative tumor resection followed by adjuvant chemotherapy with oxaliplatin and capecitabine between December 2007 and December 2013 were reviewed. The optimal PNI cutoff value was determined using receiver operating characteristic (ROC) curve analysis. The associations of PNI with systemic inflammatory response markers, including lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte rat...
Source: Chinese Journal of Cancer - December 23, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Significant value of 18F-FDG-PET/CT in diagnosing small cervical lymph node metastases in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy.
Authors: Peng H, Chen L, Tang LL, Li WF, Mao YP, Guo R, Zhang Y, Liu LZ, Tian L, Zhang X, Lin XP, Guo Y, Sun Y, Ma J Abstract BACKGROUND: Little is known about the nature of metastasis to small cervical lymph nodes (SCLNs) in the patients with nasopharyngeal carcinoma (NPC) examined by using 18-fluoro-2-deoxy-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). The present study aimed to evaluate the diagnostic values of PET/CT in identifying metastasis in SCLNs in NPC patients. METHODS: Magnetic resonance images (MRI) and PET/CT scans for 470 patients with newly diagnosed, non-distant m...
Source: Chinese Journal of Cancer - December 22, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Expression and clinical value of programmed cell death-ligand 1 (PD-L1) in diffuse large B cell lymphoma: a retrospective study.
Authors: Hu LY, Xu XL, Rao HL, Chen J, Lai RC, Huang HQ, Jiang WQ, Lin TY, Xia ZJ, Cai QQ Abstract BACKGROUND: The programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway inhibits the activation of T cells and plays a crucial role in the negative regulation of cellular and humoral immune responses. Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy in adults. In the present study, we aimed to detect the expression of PD-L1 in DLBCL and to analyze its relationship with prognosis. METHODS: We reviewed medical records of 204 newly diagnosed DLBCL patients in Sun Yat-...
Source: Chinese Journal of Cancer - December 19, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Survival and prognostic factors of non-small cell lung cancer patients with postoperative locoregional recurrence treated with radical radiotherapy.
CONCLUSIONS: Radical radiotherapy is effective and well-tolerated in NSCLC patients with postoperative locoregional recurrence. High BED is a predictor for long LRFS, and the presence of wild-type EGFR is a predictor for long DMFS. PMID: 29228994 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 13, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

International Szent-Gy örgyi Prize for Progress in Cancer Research: basic and translational research recognition : Mary-Claire King received the 2016 Prize for her pioneering research that demonstrated the first evidence of genetic predisposition to breast cancer.
International Szent-Györgyi Prize for Progress in Cancer Research: basic and translational research recognition : Mary-Claire King received the 2016 Prize for her pioneering research that demonstrated the first evidence of genetic predisposition to breast cancer. Chin J Cancer. 2017 Nov 21;36(1):92 Authors: Hartmann H, Zhao J, Ba S Abstract The Szent-Györgyi Prize for Progress in Cancer Research is a prestigious scientific award sponsored by the National Foundation for Cancer Research (NFCR)-a leading cancer research charitable organization in the United States that supports innovative cancer...
Source: Chinese Journal of Cancer - November 23, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

The 150 most important questions in cancer research and clinical oncology series: questions 76-85 : Edited by Chinese Journal of Cancer.
Authors: Editorial Office of Chinese Journal of Cancer Abstract Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology to promote cancer research and accelerate collaborations. In this article, 10 questions are presented as followed. Question 76. How to develop effective therapeutics for cancer cachexia? Question 77. How can we develop preclinical animal models to recapitulate clinical situations of cancer patients for more effective anti-cancer drug development? Question 78. How can we develop novel effective therapeutics for pa...
Source: Chinese Journal of Cancer - November 22, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Nasopharyngeal carcinoma incidence and mortality in China, 2013.
CONCLUSIONS: These results demonstrated that NPC incidence and mortality in China in 2013 were also at high levels worldwide, which suggested that its control and prevention should be enhanced. PMID: 29122009 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - November 12, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Expression of voltage-gated sodium channel Nav1.5 in non-metastatic colon cancer and its associations with estrogen receptor (ER)- β expression and clinical outcomes.
Expression of voltage-gated sodium channel Nav1.5 in non-metastatic colon cancer and its associations with estrogen receptor (ER)-β expression and clinical outcomes. Chin J Cancer. 2017 Nov 09;36(1):89 Authors: Peng J, Ou Q, Wu X, Zhang R, Zhao Q, Jiang W, Lu Z, Wan D, Pan Z, Fang Y Abstract BACKGROUND: Voltage-gated sodium channel 1.5 (Nav1.5) potentially promotes the migratory and invasive behaviors of colon cancer cells. Hitherto, the prognostic significance of Nav1.5 expression remains undetermined. The present study aimed to explore the associations of Nav1.5 expression with clinical outcomes...
Source: Chinese Journal of Cancer - November 12, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Prognostic value of plasma Epstein-Barr virus DNA level during posttreatment follow-up in the patients with nasopharyngeal carcinoma having undergone intensity-modulated radiotherapy.
Authors: Li WF, Zhang Y, Huang XB, Du XJ, Tang LL, Chen L, Peng H, Guo R, Sun Y, Ma J Abstract BACKGROUND: The value of Epstein-Barr virus (EBV) DNA assay during posttreatment follow-up of the patients with nasopharyngeal carcinoma (NPC) presenting with different pretreatment plasma EBV DNA levels remains unclear. In the present study, we aimed to evaluate the prognostic value of plasma EBV DNA assay during posttreatment follow-up in the patients with NPC who have undergone intensity-modulated radiotherapy. METHODS: The medical records of 385 NPC patients treated with intensity-modulated radiotherapy between No...
Source: Chinese Journal of Cancer - November 9, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Systematic analyses of glutamine and glutamate metabolisms across different cancer types.
CONCLUSIONS: We comprehensively predicted the roles of glutamine and glutamate metabolisms in selected metabolic pathways in cancer tissues versus control tissues, which may lead to novel approaches to therapeutic development targeted at glutamine and/or glutamate metabolism. However, our predictions need further functional validation. PMID: 29116024 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - November 9, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

The 150 most important questions in cancer research and clinical oncology series: questions 67-75 : Edited by Chinese Journal of Cancer.
Authors: Chinese Journal of Cancer Abstract Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 9 more questions are presented as followed. Question 67. How could we overcome the resistance of hepatocellular carcinoma against chemotherapeutics? Question 68. Is pursuit of non-covalent small-molecule binders of RAS proteins viable as a strategy of cancer drug discovery? Question 69. In ...
Source: Chinese Journal of Cancer - November 3, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Conditional survival in patients with gallbladder cancer.
CONCLUSIONS: T and M categories were significant prognostic factors even 5 years after the initial diagnosis, whereas local treatments at the time of diagnosis were not, suggesting that patients with GB cancer at high risks might need further adjuvant therapy after primary treatments. The combined analysis of CSS and cancer-specific CS rates offered more accurate survival information for patients who have already survived a certain period of time after diagnosis. PMID: 29084608 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - November 2, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a hospital-based multi-center study.
CONCLUSIONS: Survival of breast cancer patients varied significantly by stage and molecular subtype. Cancer screening is encouraged for the early detection and early diagnosis of breast cancer. More advanced therapies and health care policies are needed on HER2 and triple-negative subtypes. PMID: 29070080 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - October 27, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Hepatic artery infusion chemotherapy using mFOLFOX versus transarterial chemoembolization for massive unresectable hepatocellular carcinoma: a prospective non-randomized study.
Authors: He MK, Le Y, Li QJ, Yu ZS, Li SH, Wei W, Guo RP, Shi M Abstract BACKGROUND: Transarterial chemoembolization (TACE) is recommended as the standard care for unresectable hepatocellular carcinoma (HCC) at Barcelona Clinic Liver Cancer (BCLC) stage A-B. However, the efficacy of TACE on large (≥ 10 cm) stage A-B HCC is far from satisfactory, and it is proposed that hepatic artery infusion chemotherapy (HAIC) might be a better first-line treatment of this disease. Hence, we compared the safety and efficacy of HAIC with the modified FOLFOX (mFOLFOX) regimen and those of TACE in patients with massive ...
Source: Chinese Journal of Cancer - October 26, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Chromatin remodeling factor lymphoid-specific helicase inhibits ferroptosis through lipid metabolic genes in lung cancer progression.
Authors: Jiang Y, He Y, Liu S, Tao Y PMID: 29037212 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - October 20, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Clinicopathologic features and treatment efficacy of Chinese patients with BRAF-mutated metastatic colorectal cancer: a retrospective observational study.
CONCLUSIONS: BRAF V600E mutations were commonly identified in right-sided tumors and showed a high incidence of peritoneal and distant lymph nodes metastases. This subtype of mCRC was characterized by short OS and unique patterns of metastasis. Compared with standard treatment regimens, the FOLFOXIRI regimen had acceptable and manageable toxicities and favorable efficacy on patients with BRAF-mutated mCRC. PMID: 29037218 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - October 20, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

The prognostic value of C-X-C motif chemokine receptor 4 in patients with sporadic malignant peripheral nerve sheath tumors.
CONCLUSION: High CXCR4 expression may define a specific subtype of sporadic MPNST with favorable prognosis. PMID: 29020982 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - October 13, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

The 150 most important questions in cancer research and clinical oncology series: questions 57-66 : Edited by Chinese Journal of Cancer.
Authors: Chinese Journal of Cancer Abstract Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 10 more questions are presented as followed. Question 57. What are the major stresses that drive the formation, progression, and metastasis of a cancer? Question 58. What is the mechanism responsible for altering an acidic intracellular pH and a basic extracellular pH in normal tissue cells...
Source: Chinese Journal of Cancer - October 6, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Pathologic response after preoperative therapy predicts prognosis of Chinese colorectal cancer patients with liver metastases.
In this study, we aimed to evaluate the association between the pathologic response to pre-hepatectomy chemotherapy and prognosis in a cohort of Chinese patients. PATIENTS AND METHODS: In this retrospective study, we analyzed the data of 380 liver metastases in 159 patients. The pathologic response was evaluated according to the tumor regression grade (TRG). The prognostic role of pathologic response in recurrence-free survival (RFS) and overall survival (OS) was assessed using Kaplan-Meier curves with the log-rank test and multivariate Cox models. Factors that had potential influence on pathologic response were also a...
Source: Chinese Journal of Cancer - October 5, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Tripartite motif-containing 3 (TRIM3) inhibits tumor growth and metastasis of liver cancer.
CONCLUSIONS: TRIM3 plays a tumor-suppressing role in the regulation of liver cancer development by reducing cell proliferation through cell cycle arrest at the G0/G1 phase. PMID: 28950898 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 29, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Effects of dosimetric inadequacy on local control and toxicities in the patients with T4 nasopharyngeal carcinoma extending into the intracranial space and treated with intensity-modulated radiotherapy plus chemotherapy.
CONCLUSIONS: With relative underdosed IMRT plus effective chemotherapy, the patients achieved satisfactory local control with few late toxicities of the central nervous system. Determining the acceptable extent of dosimetric inadequacy requires further exploration. PMID: 28931426 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 23, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Prognostic value of systemic immune-inflammation index in patients with gastric cancer.
Authors: Wang K, Diao F, Ye Z, Zhang X, Zhai E, Ren H, Li T, Wu H, He Y, Cai S, Chen J Abstract BACKGROUND: Inflammation-based indexes have been used to predict survival and recurrence in cancer patients. Systemic immune-inflammation index (SII) was reported to be associated with prognosis in some malignant tumors. In the present study, we aimed to explore the association between SII and the prognosis of patients with gastric cancer. METHODS: We retrospectively analyzed data from 444 gastric cancer patients who underwent gastrectomy at the First Affiliated Hospital of Sun Yat-sen University between January 1994...
Source: Chinese Journal of Cancer - September 15, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Efficacy and safety of controlled-release oxycodone/naloxone versus controlled-release oxycodone in Korean patients with cancer-related pain: a randomized controlled trial.
Authors: Lee KH, Kim TW, Kang JH, Kim JS, Ahn JS, Kim SY, Yun HJ, Eum YJ, Koh SA, Kim MK, Hong YS, Kim JE, Lee GW Abstract BACKGROUND: Controlled-release oxycodone/naloxone (OXN-CR) maintains the effect of opioid-induced analgesia through oxycodone while reducing the occurrence rate of opioid-induced constipation through naloxone. The present study was designed to assess the non-inferiority of OXN-CR to controlled-release oxycodone (OX-CR) for the control of cancer-related pain in Korean patients. METHODS: In this randomized, open-labeled, parallel-group, phase IV study, we enrolled patients aged 20 years ...
Source: Chinese Journal of Cancer - September 13, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Medical expenditure for esophageal cancer in China: a 10-year multicenter retrospective survey (2002-2011).
This study aimed to examine the medical expenditure of Chinese patients with esophageal cancer and the associated trends. METHODS: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 37 hospitals in 13 provinces/municipalities across China as a part of the Cancer Screening Program of Urban China. For each esophageal cancer patient diagnosed between 2002 and 2011, clinical information and expense data were extracted by using structured questionnaires. All expense data were reported in Chinese Yuan (CNY; 1 CNY = 0.155 USD) based on the 2011 value and inflated using the year-specific heal...
Source: Chinese Journal of Cancer - September 10, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Erythrocytosis caused by giant chromophobe renal cell carcinoma: a case report indicating a 9-year misdiagnosis of polycythemia vera.
CONCLUSIONS: Chromophobe renal cell carcinoma could cause erythrocytosis, but the clear-cut mechanism needs further research. Secondary erythrocytosis such as those related with renal tumors should be taken into consideration during the diagnosis of polycythemia vera. PMID: 28877745 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 9, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Potential factors associated with clinical stage of nasopharyngeal carcinoma at diagnosis: a case-control study.
CONCLUSIONS: Initiatives to improve NPC patient prognosis should aim to promote knowledge about early symptoms and detection, health awareness, and accessibility to health facilities among all patients, regardless of socioeconomic status. PMID: 28870229 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 6, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Erratum to: Cancer chemoprevention through dietary flavonoids: what's limiting?
Authors: Amawi H, Ashby CR, Tiwari AK PMID: 28854960 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 2, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

The 150 most important questions in cancer research and clinical oncology series: questions 50-56.
Authors: Chinese Journal of Cancer Abstract Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, seven more questions are presented as followed. Question 50. When tumor cells spread from primary site to distant sites, are they required to be "trained" or "armed" in the bone marrow niche prior to colonizing soft tissues? Question 51. Are there tipping points during c...
Source: Chinese Journal of Cancer - August 31, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

At-home cancer screening: a solution for China and other developing countries with a large population and limited number of healthcare practitioners.
Authors: Qian CN Abstract Five-year survival rate for patients with all cancers combined, in China, is only 30.9%, which is much lower than those in developed countries. The three main reasons for the low cancer curative rates in China include differences in the spectrum of cancer types, in early detection rates, and in the percentage of cancer patients receiving standardized treatment between China and developed countries. The most important mechanism for improving the curative rate is to improve early detection rates of major cancers in China using novel and affordable technologies that can be operated at home by...
Source: Chinese Journal of Cancer - August 24, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Awakening immunity against cancer: a 2017 primer for clinicians.
Authors: Jain A, Zhang Q, Toh HC Abstract Cancer immunotherapy has finally joined the pillars of cancer treatment-surgery, radiation, chemotherapy, hormonal therapy, and targeted therapy-in improving cancer patient lives. In the last 5 years, the development of immune checkpoint inhibitor and T cell therapy, particularly chimeric antigen receptor (CAR) T-cell therapy, has been remarkable for the speed, scale, and number of drug approvals. Still, these treatments may also bring unusual adverse effects and clinical outcomes including unprecedented long-term survival. Interrogating the tumor microenvironment and ...
Source: Chinese Journal of Cancer - August 23, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review.
CONCLUSION: Strong evidence supports that these 11 emerging IHC markers or their combinations may be useful in predicting prognosis and aiding personalized therapy decision-making for ESCC patients. PMID: 28818096 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 20, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Estimates of cancer incidence and mortality in China, 2013.
CONCLUSIONS: Cancer leaves serious disease burden in China with high incidence and mortality. Lung cancer was the most common cancer and the leading cause of cancer death in China. Efficient control strategy is needed, especially for major cancers. PMID: 28818111 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 20, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Comparison of efficacy, safety, and quality of life between sorafenib and sunitinib as first-line therapy for Chinese patients with metastatic renal cell carcinoma.
This study aimed to compare the efficacy, safety, and quality of life (QoL) in Chinese mRCC patients treated with sorafenib and sunitinib as first-line therapy. METHODS: Clinical data of patients with mRCC who received sorafenib (400 mg twice daily; 4 weeks) or sunitinib (50 mg twice daily; on a schedule of 4 weeks on treatment followed by 2 weeks off) were retrieved. Primary outcomes were overall survival (OS), progression-free survival (PFS), adverse events (AEs), and QoL (SF-36 scores), and secondary outcomes were associations of clinical characteristics with QoL. RESULTS: Medical record...
Source: Chinese Journal of Cancer - August 10, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells.
CONCLUSION: The RNF183-IL-8 axis is responsible for the resistance of CRC cells to the MEK1/2 inhibitor trametinib and may serve as a candidate target for combined therapy for CRC. PMID: 28756770 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 1, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Prognostic role of ABO blood type in patients with extranodal natural killer/T cell lymphoma, nasal type: a triple-center study.
Authors: Li YJ, Yi PY, Li JW, Liu XL, Tang T, Zhang PY, Jiang WQ Abstract BACKGROUND: The prognostic significance of ABO blood type for lymphoma is largely unknown. We evaluated the prognostic role of ABO blood type in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTL). METHODS: We retrospectively analyzed clinical data of 697 patients with newly diagnosed ENKTL from three cancer centers. The prognostic value of ABO blood type was evaluated using Kaplan-Meier curves and Cox proportional hazard models. The prognostic values of the International Prognostic Index (IPI) and the Korean Prognostic I...
Source: Chinese Journal of Cancer - August 1, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Prognostic value of programmed death-1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1-4N+M0 gastric adenocarcinoma.
This study aimed to analyze the expression of PD-L1, PD-L2, and PD-1 as well as CD8(+) T-cell density in primary tumors and lymph nodes from patients with stage T1-4N+M0 gastric adenocarcinoma to explore the heterogeneity of PD-1 signaling pathway molecules. METHODS: In primary tumors and metastatic as well as non-metastatic lymph nodes from patients with stage T1-4N+M0 gastric adenocarcinoma, we detected PD-L1 and PD-L2 expression with immunohistochemistry. CD8(+) T-cell density in primary tumors and PD-1 expression on CD8(+) T cells were detected with immunofluorescence. Univariate analysis was used to determine the ...
Source: Chinese Journal of Cancer - July 31, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Spatio-temporal analysis of the incidence of colorectal cancer in Guangzhou, 2010-2014.
CONCLUSIONS: This study revealed the spatio-temporal cluster pattern of the incidence of CRC in Guangzhou. This information can inform allocation of health resources for CRC screening. PMID: 28754180 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - July 31, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Transarterial chemoembolization combined with recombinant human adenovirus type  5 H101 prolongs overall survival of patients with intermediate to advanced hepatocellular carcinoma: a prognostic nomogram study.
Transarterial chemoembolization combined with recombinant human adenovirus type 5 H101 prolongs overall survival of patients with intermediate to advanced hepatocellular carcinoma: a prognostic nomogram study. Chin J Cancer. 2017 Jul 20;36(1):59 Authors: He CB, Lao XM, Lin XJ Abstract BACKGROUND: Patients with intermediate to advanced hepatocellular carcinoma (HCC) are most commonly treated with transarterial chemoembolization (TACE). Previous studies showed that TACE combined with recombinant human adenovirus type 5 (H101) may provide a clinical survival benefit. In the present study, we aimed to...
Source: Chinese Journal of Cancer - July 22, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Mortality outcomes of low-dose computed tomography screening for lung cancer in urban China: a decision analysis and implications for practice.
CONCLUSIONS: In terms of mortality outcomes, our findings favor conducting low-dose CT screening in urban China. However, approaches to reducing false diagnoses and optimizing important screening conditions such as enrollment criteria for screening are highly needed. PMID: 28709441 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - July 17, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Exploring the potential confounder of nitrogen fertilizers in the relationship between pesticide exposures and risk of leukemia: a Poisson regression with two-way fixed-effects analysis.
Authors: Fluegge K, Fluegge K PMID: 28709444 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - July 17, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

The 150 most important questions in cancer research and clinical oncology series: questions 40-49.
Authors: Chinese Journal of Cancer Abstract Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 10 more questions are presented as followed. Question 40. Why do mice being used as tumorigenesis models raised in different places or different conditions possess different tumor formation rate? Question 41. How could we generate more effective anti-metastasis drugs? Question 42. What is t...
Source: Chinese Journal of Cancer - July 15, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Immune evasion might affect survival in laryngeal cancer patients with blood group O.
Authors: Altundag K PMID: 28701231 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - July 15, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Radiotherapy among nonagenarians with anal or rectal carcinoma: should we avoid or adapt treatment?
Authors: Vallard A, Rancoule C, Guy JB, Assouline A, Falk AT, Auberdiac P, Langrand-Escure J, Chargari C, Magné N PMID: 28705218 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - July 15, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research

Different dissecting orders of the pulmonary bronchus and vessels during right upper lobectomy are associated with surgical feasibility and postoperative recovery for lung cancer patients.
CONCLUSIONS: Dissecting the right upper bronchus before turning over the lobe repeatedly and dissecting veins via the aBVA approach during RUL would promote surgical feasibility and achieve comparable postoperative recovery for lung cancer patients. PMID: 28655346 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - June 29, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research