Genetic polymorphisms of autophagy-related gene 5 (ATG5) rs473543 predict different disease-free survivals of triple-negative breast cancer patients receiving anthracycline- and/or taxane-based adjuvant chemotherapy.
CONCLUSION: ATG5 rs473543 genotypes may serve as a potential marker for predicting recurrence of early-stage TNBC patients who received anthracycline-and/or taxane-based regimens as adjuvant chemotherapy.
PMID: 29382381 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - February 1, 2018 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Computed tomography and magnetic resonance imaging evaluation of pelvic lymph node metastasis in bladder cancer.
CONCLUSIONS: The probability of metastatic nodes significantly increased with more advanced T stages. Once lymph nodes are detected on imaging, the characteristic signs should be paid attention to. The short diameter > 6.8 mm may indicate metastatic lymph nodes in BCa.
PMID: 29370848 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - January 28, 2018 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma.
CONCLUSIONS: FSTL1 plays a tumor suppression role possibly via repressing the NF-κB and HIF-2α signaling pathways. To increase FSTL1 expression might be a candidate therapeutic strategy for metastatic ccRCC.
PMID: 29357946 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - January 25, 2018 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The 150 most important questions in cancer research and clinical oncology series: questions 86-93 : Edited by Chinese Journal of Cancer.
Authors: Chinese Journal of Cancer
Abstract
Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which spark diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 8 more questions are presented as follows. Question 86. In which circumstances is good supportive care associated with a survival advantage in patients with cancer? Question 87. Can we develop animal models to mimic immunotherapy response of cancer patients? Question 88. What are the...
Source: Chinese Journal of Cancer - January 25, 2018 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein-Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma.
CONCLUSIONS: GTVnd and serum EBV DNA copy number are independent prognostic factors for predicting distant metastasis in NPC patients with N1 disease. The prognostic model incorporating GTVnd and EBV DNA copy number may improve metastatic risk stratification for this group of patients.
PMID: 29284539 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 31, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Famitinib versus placebo in the treatment of refractory metastatic colorectal cancer: a multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial.
CONCLUSION: Famitinib prolonged PFS in refractory mCRC patients with acceptable tolerability. Trial registration This study was registered on ClinicalTrials.gov (NCT01762293) and was orally presented in the 2015 ASCO-Gastrointestinal Symposium.
PMID: 29273089 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 25, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Prognostic value of preoperative prognostic nutritional index and its associations with systemic inflammatory response markers in patients with stage III colon cancer.
CONCLUSION: The present study identified preoperative PNI as a valuable predictor for survival outcomes in patients with stage III colon cancer receiving curative tumor resection followed by adjuvant chemotherapy.
PMID: 29268783 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 23, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Significant value of 18F-FDG-PET/CT in diagnosing small cervical lymph node metastases in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy.
CONCLUSIONS: PET/CT was more effective than MRI in identifying metastatic SCLNs, and the radiologic diagnostic criteria for metastatic lymph nodes in level IV/Vb should be re-defined.
PMID: 29258597 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 22, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Expression and clinical value of programmed cell death-ligand 1 (PD-L1) in diffuse large B cell lymphoma: a retrospective study.
CONCLUSIONS: PD-L1 expression is more common in the non-GCB subtype than in the GCB subtype. PD-L1 expression in tumor microenvironment has a negative correlation with C-Myc. PD-L1 positivity predicts short survival in DLBCL patients. For patients with PD-L1 expression, more strategy such as anti-PD-L1 antibody treatment should be recommended.
PMID: 29246182 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 19, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Survival and prognostic factors of non-small cell lung cancer patients with postoperative locoregional recurrence treated with radical radiotherapy.
CONCLUSIONS: Radical radiotherapy is effective and well-tolerated in NSCLC patients with postoperative locoregional recurrence. High BED is a predictor for long LRFS, and the presence of wild-type EGFR is a predictor for long DMFS.
PMID: 29228994 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 13, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
International Szent-Gy örgyi Prize for Progress in Cancer Research: basic and translational research recognition : Mary-Claire King received the 2016 Prize for her pioneering research that demonstrated the first evidence of genetic predisposition to breast cancer.
International Szent-Györgyi Prize for Progress in Cancer Research: basic and translational research recognition : Mary-Claire King received the 2016 Prize for her pioneering research that demonstrated the first evidence of genetic predisposition to breast cancer.
Chin J Cancer. 2017 Nov 21;36(1):92
Authors: Hartmann H, Zhao J, Ba S
Abstract
The Szent-Györgyi Prize for Progress in Cancer Research is a prestigious scientific award sponsored by the National Foundation for Cancer Research (NFCR)-a leading cancer research charitable organization in the United States that supports inn...
Source: Chinese Journal of Cancer - November 23, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The 150 most important questions in cancer research and clinical oncology series: questions 76-85 : Edited by Chinese Journal of Cancer.
Authors: Editorial Office of Chinese Journal of Cancer
Abstract
Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology to promote cancer research and accelerate collaborations. In this article, 10 questions are presented as followed. Question 76. How to develop effective therapeutics for cancer cachexia? Question 77. How can we develop preclinical animal models to recapitulate clinical situations of cancer patients for more effective anti-cancer drug development? Question 78. How can we develop novel effective therapeuti...
Source: Chinese Journal of Cancer - November 22, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Nasopharyngeal carcinoma incidence and mortality in China, 2013.
CONCLUSIONS: These results demonstrated that NPC incidence and mortality in China in 2013 were also at high levels worldwide, which suggested that its control and prevention should be enhanced.
PMID: 29122009 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - November 12, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Expression of voltage-gated sodium channel Nav1.5 in non-metastatic colon cancer and its associations with estrogen receptor (ER)- β expression and clinical outcomes.
CONCLUSIONS: High expression of Nav1.5 was associated with high expression of ER-β and indicated unfavorable oncologic prognosis in patients with non-metastatic colon cancer.
PMID: 29122010 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - November 12, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Prognostic value of plasma Epstein-Barr virus DNA level during posttreatment follow-up in the patients with nasopharyngeal carcinoma having undergone intensity-modulated radiotherapy.
CONCLUSION: Plasma EBV DNA level during posttreatment follow-up is a good marker for predicting distant metastasis but not locoregional recurrence in the patients with NPC irrespective of the pretreatment EBV DNA levels.
PMID: 29116021 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - November 9, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
