Phytochemical and anti-neuropathic investigations of Crocus sativus via alleviating inflammation, oxidative stress and pancreatic beta-cells regeneration
ConclusionThe oxidative stress reduction, insulin secretagogue, and pancreatic beta-cells regeneration potentials might be responsible for the mechanism underlying the anti-diabetic, anti-inflammatory and anti-diabetic neuropathy activities. Thus, the cultivated Crocus sativus might be clinically useful for protecting against many serious-disorders. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - December 28, 2019 Category: Complementary Medicine Source Type: research

Integrated chemical and transcriptomic analyses unveils synthetic characteristics of different medicinal root parts of Angelica sinensis
ConclusionChemical and transcriptomic analyses revealed the distribution contents and pivotal transcripts of the ferulic acid biosynthesis-related pathways. The spatial gene expression pattern partially explained the discrepancy of integral medicinal activities of three medicinal root parts. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Attenuation of inflammation in streptozotocin-induced diabetic rabbits by Matricaria chamomilla oil: A focus on targeting NF-κB and NLRP3 signaling pathways
ConclusionCollectively, our findings demonstrated that chamomile oil possesses anti-hyperglycemic, and anti-inflammatory activities in STZ induced diabetic rabbits by targeting inflammatory cytokines and NF-κB and NLRP3 signaling pathways. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Role of semi-purified andrographolide from Andrographis paniculata extract as nano-phytovesicular carrier for enhancing oral absorption and hypoglycemic activity
ConclusionHence, the prepared semi-purified extract nano-phytovesicular system is helpful in solving the problem of rapid clearance of AN. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Chinese herbal medicine resources: Where we stand
This study helps international scholars understand the status quo of CHM research and provides theoretical support for the healthy, modern, and international development of CHM, and it will facilitate the sustainable development of the traditional Chinese medicine industry. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - December 21, 2019 Category: Complementary Medicine Source Type: research

Mangiferin exerts neuroprotective activity against lead-induced toxicity and oxidative stress via Nrf2 pathway
ConclusionMGN ameliorated morphological damage in the hippocampus. Its neuroprotective effects were achieved by the activation of the Nrf2 downstream genes. The data from this in vitro study indicates that MGN targeting Nrf2 activation is a feasible approach to reduce adverse health effects associated with Pb exposure. Thus, MGN could be an effective candidate agent for the Pb-induced oxidative stress and neurotoxicity in the human body. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - December 15, 2019 Category: Complementary Medicine Source Type: research

Quantification of Chinese yam processing methods based on pyrolysis characteristics and its relation to Maillard reaction
ConclusionThe results verified and quantified the firepower of traditional processing of SY, and also provided scientific reference for other studies related to SY processing. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - December 10, 2019 Category: Complementary Medicine Source Type: research

Pharmacokinetic studies of multi-bioactive components in rat plasma after oral administration of Xintiantai Ⅰ extract and effects of guide drug borneol on pharmacokinetics
ConclusionGuide drug borneol enhanced the absorption of G-Rd, palmatine, hyperin, curcumin, demethoxycurcumin and bisdemethoxycurcumin. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - December 10, 2019 Category: Complementary Medicine Source Type: research

New insights into roles of basophils in initiating T helper type 2 immunity
Publication date: Available online 6 December 2019Source: Chinese Herbal MedicinesAuthor(s): Tian-xiang Ma, Yuan GaoAbstractAllergic diseases, mainly mediated by T helper type 2 (Th2) immunity, have become a worldwide public health problem. Traditional Chinese medicine (TCM) has long been used in treating and preventing allergic symptoms. As the new target of anti-allergy TCM, basophils, after approximately 140 years since their discovery, are just now gaining respect as important contributors in the pathogenesis underlying allergic inflammation and disease. In addition to their role as effector cells, basophils can releas...
Source: Chinese Herbal Medicines - December 6, 2019 Category: Complementary Medicine Source Type: research

A reliable and rapid pharmacokinetic study of pueraria isoflavones using pueraria reference extractive substance in beagle plasma: Application to study of Yufeng Ningxin Tablets
ConclusionPueraria reference extractive substance can be seen as an alternative to the standard substance to overcome the scarcity of standard substance for the analysis of biological samples. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - November 25, 2019 Category: Complementary Medicine Source Type: research

Critical pharmaceutical process identification considering chemical composition, biological activity, and batch-to-batch consistency: A case study of notoginseng total saponins
ConclusionBased on a comprehensive and objective examination of the role of each process, critical pharmaceutical processes can be identified. A similar method can also be applied to other TCM processes. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - November 22, 2019 Category: Complementary Medicine Source Type: research

Critical process parameter identification of manufacturing processes of Astragali Radix extract with a weighted determination coefficient method
ConclusionUsing the weighted determination coefficient method, CPPs can be determined with all the CQAs considered based on their importance. The determination of CPP number is more objective compared with the SPRC method. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - November 16, 2019 Category: Complementary Medicine Source Type: research

Gynura procumbens aqueous extract alleviates nonalcoholic steatohepatitis through CFLAR-JNK pathway in vivo and in vitro
ConclusionsThese results indicated that the activation on CFLAR-JNK pathway might be the main anti-NASH mechanism of GPAE, which on the one hand promote the β-oxidation and efflux of fatty acids in liver, and finally reduce hepatic lipid accumulation, on the other hand increase the activities of anti-oxidant enzymes and inhibit the activities of ROS generation enzymes by activating NRF2, and therefore attenuates hepatic oxidative stress damage. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - October 2, 2019 Category: Complementary Medicine Source Type: research

Bioactivity of methanolic extract of Brassica juncea in animal model of diabetes mellitus
ConclusionThe study showed anti-hyperglycemic and anti-oxidative properties of methanolic extract of B. juncea. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - September 26, 2019 Category: Complementary Medicine Source Type: research

New progress of interdisciplinary research between network toxicology, quality markers and TCM network pharmacology
Publication date: Available online 24 September 2019Source: Chinese Herbal MedicinesAuthor(s): Shao Li, Qing-yang Ding (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - September 25, 2019 Category: Complementary Medicine Source Type: research