Chemical and Pharmaceutical Bulletin This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Nucleophilic Deprotection of p-Methoxybenzyl Ethers Using Heterogeneous Oxovanadium Catalyst
Chem Pharm Bull (Tokyo). 2024;72(2):213-219. doi: 10.1248/cpb.c23-00897.ABSTRACTNucleophilic deprotection of p-methoxybenzyl (PMB) [p-methoxyphenylmethyl (MPM)] ethers was developed using a heterogeneous oxovanadium catalyst V-MPS4 and a thiol nucleophile. The deprotection method had a wide reaction scope, including PMB ethers of primary, secondary, and tertiary alcohols bearing various functional groups. In addition, the PMB ether of an oxidation-labile natural product was successfully removed by V-MPS4 catalysis, while a common oxidative method of PMB deprotection afforded a complex mixture. The V-MPS4 catalyst was reusa...
Source: Chemical and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Rei Ikeda Tomoya Nishio Kyohei Kanomata Shuji Akai Source Type: research

Effect of Ag and Ni-Doped Cerium Oxide Nanoparticles on the Formation of ROS and Evaluation as an Alternative Physical Sunscreen Material
Chem Pharm Bull (Tokyo). 2024;72(2):220-225. doi: 10.1248/cpb.c23-00512.ABSTRACTCeO2 nanoparticles (nanoceria) were proposed as an alternative physical sunscreen agent with antioxidant properties and comparable UV absorption performance. Green synthesis of nanoceria with Ag and Ni dopants resulted in doped nanoceria with lower catalytic activity and biologically-safe characteristics. The doped nanoceria was characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), Rancimat Instrument, and UV-Vis Spectrophotometer for SPF (Sun Protection Factor) determination. XRD and TEM analysis showed that nano...
Source: Chemical and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Agnes Giovanni Marsius Satria Hidayat Damar Rastri Adhika Akhmad Zein Eko Mustofa Veinardi Suendo Heni Rachmawati Source Type: research

Antiproliferative Activities of Cynaropicrin and Related Compounds against Cancer Stem Cells
In this study, we evaluated the antiproliferative activities of 21 sesquiterpenoids against human GBM U-251 MG CSCs and U-251 MG non-CSCs. Particularly, the guaianolide sesquiterpene lactone cynaropicrin (1) showed strong antiproliferative activity against U-251 MG CSCs (IC50 = 20.4 µM) and U-251 MG non-CSCs (IC50 = 10.9 µM). Accordingly, we synthesized six derivatives of 1 and investigated their structure-activity relationships. Most of the guaianolide sesquiterpene lactones with the α-methylene-γ-butyrolactone moiety showed antiproliferative activities against U-251 MG cells. We conclude that the 5,7,5-ring and the Î...
Source: Chemical and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Kousuke Araki Minami Hara Shohei Hamada Takahiro Matsumoto Seikou Nakamura Source Type: research

Nucleophilic Deprotection of p-Methoxybenzyl Ethers Using Heterogeneous Oxovanadium Catalyst
Chem Pharm Bull (Tokyo). 2024;72(2):213-219. doi: 10.1248/cpb.c23-00897.ABSTRACTNucleophilic deprotection of p-methoxybenzyl (PMB) [p-methoxyphenylmethyl (MPM)] ethers was developed using a heterogeneous oxovanadium catalyst V-MPS4 and a thiol nucleophile. The deprotection method had a wide reaction scope, including PMB ethers of primary, secondary, and tertiary alcohols bearing various functional groups. In addition, the PMB ether of an oxidation-labile natural product was successfully removed by V-MPS4 catalysis, while a common oxidative method of PMB deprotection afforded a complex mixture. The V-MPS4 catalyst was reusa...
Source: Chemical and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Rei Ikeda Tomoya Nishio Kyohei Kanomata Shuji Akai Source Type: research

Effect of Ag and Ni-Doped Cerium Oxide Nanoparticles on the Formation of ROS and Evaluation as an Alternative Physical Sunscreen Material
Chem Pharm Bull (Tokyo). 2024;72(2):220-225. doi: 10.1248/cpb.c23-00512.ABSTRACTCeO2 nanoparticles (nanoceria) were proposed as an alternative physical sunscreen agent with antioxidant properties and comparable UV absorption performance. Green synthesis of nanoceria with Ag and Ni dopants resulted in doped nanoceria with lower catalytic activity and biologically-safe characteristics. The doped nanoceria was characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), Rancimat Instrument, and UV-Vis Spectrophotometer for SPF (Sun Protection Factor) determination. XRD and TEM analysis showed that nano...
Source: Chemical and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Agnes Giovanni Marsius Satria Hidayat Damar Rastri Adhika Akhmad Zein Eko Mustofa Veinardi Suendo Heni Rachmawati Source Type: research

Antiproliferative Activities of Cynaropicrin and Related Compounds against Cancer Stem Cells
In this study, we evaluated the antiproliferative activities of 21 sesquiterpenoids against human GBM U-251 MG CSCs and U-251 MG non-CSCs. Particularly, the guaianolide sesquiterpene lactone cynaropicrin (1) showed strong antiproliferative activity against U-251 MG CSCs (IC50 = 20.4 µM) and U-251 MG non-CSCs (IC50 = 10.9 µM). Accordingly, we synthesized six derivatives of 1 and investigated their structure-activity relationships. Most of the guaianolide sesquiterpene lactones with the α-methylene-γ-butyrolactone moiety showed antiproliferative activities against U-251 MG cells. We conclude that the 5,7,5-ring and the Î...
Source: Chemical and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Kousuke Araki Minami Hara Shohei Hamada Takahiro Matsumoto Seikou Nakamura Source Type: research

Nucleophilic Deprotection of p-Methoxybenzyl Ethers Using Heterogeneous Oxovanadium Catalyst
Chem Pharm Bull (Tokyo). 2024;72(2):213-219. doi: 10.1248/cpb.c23-00897.ABSTRACTNucleophilic deprotection of p-methoxybenzyl (PMB) [p-methoxyphenylmethyl (MPM)] ethers was developed using a heterogeneous oxovanadium catalyst V-MPS4 and a thiol nucleophile. The deprotection method had a wide reaction scope, including PMB ethers of primary, secondary, and tertiary alcohols bearing various functional groups. In addition, the PMB ether of an oxidation-labile natural product was successfully removed by V-MPS4 catalysis, while a common oxidative method of PMB deprotection afforded a complex mixture. The V-MPS4 catalyst was reusa...
Source: Chemical and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Rei Ikeda Tomoya Nishio Kyohei Kanomata Shuji Akai Source Type: research

Effect of Ag and Ni-Doped Cerium Oxide Nanoparticles on the Formation of ROS and Evaluation as an Alternative Physical Sunscreen Material
Chem Pharm Bull (Tokyo). 2024;72(2):220-225. doi: 10.1248/cpb.c23-00512.ABSTRACTCeO2 nanoparticles (nanoceria) were proposed as an alternative physical sunscreen agent with antioxidant properties and comparable UV absorption performance. Green synthesis of nanoceria with Ag and Ni dopants resulted in doped nanoceria with lower catalytic activity and biologically-safe characteristics. The doped nanoceria was characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), Rancimat Instrument, and UV-Vis Spectrophotometer for SPF (Sun Protection Factor) determination. XRD and TEM analysis showed that nano...
Source: Chemical and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Agnes Giovanni Marsius Satria Hidayat Damar Rastri Adhika Akhmad Zein Eko Mustofa Veinardi Suendo Heni Rachmawati Source Type: research

Antiproliferative Activities of Cynaropicrin and Related Compounds against Cancer Stem Cells
In this study, we evaluated the antiproliferative activities of 21 sesquiterpenoids against human GBM U-251 MG CSCs and U-251 MG non-CSCs. Particularly, the guaianolide sesquiterpene lactone cynaropicrin (1) showed strong antiproliferative activity against U-251 MG CSCs (IC50 = 20.4 µM) and U-251 MG non-CSCs (IC50 = 10.9 µM). Accordingly, we synthesized six derivatives of 1 and investigated their structure-activity relationships. Most of the guaianolide sesquiterpene lactones with the α-methylene-γ-butyrolactone moiety showed antiproliferative activities against U-251 MG cells. We conclude that the 5,7,5-ring and the Î...
Source: Chemical and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Kousuke Araki Minami Hara Shohei Hamada Takahiro Matsumoto Seikou Nakamura Source Type: research

Nucleophilic Deprotection of p-Methoxybenzyl Ethers Using Heterogeneous Oxovanadium Catalyst
Chem Pharm Bull (Tokyo). 2024;72(2):213-219. doi: 10.1248/cpb.c23-00897.ABSTRACTNucleophilic deprotection of p-methoxybenzyl (PMB) [p-methoxyphenylmethyl (MPM)] ethers was developed using a heterogeneous oxovanadium catalyst V-MPS4 and a thiol nucleophile. The deprotection method had a wide reaction scope, including PMB ethers of primary, secondary, and tertiary alcohols bearing various functional groups. In addition, the PMB ether of an oxidation-labile natural product was successfully removed by V-MPS4 catalysis, while a common oxidative method of PMB deprotection afforded a complex mixture. The V-MPS4 catalyst was reusa...
Source: Chemical and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Rei Ikeda Tomoya Nishio Kyohei Kanomata Shuji Akai Source Type: research

Effect of Ag and Ni-Doped Cerium Oxide Nanoparticles on the Formation of ROS and Evaluation as an Alternative Physical Sunscreen Material
Chem Pharm Bull (Tokyo). 2024;72(2):220-225. doi: 10.1248/cpb.c23-00512.ABSTRACTCeO2 nanoparticles (nanoceria) were proposed as an alternative physical sunscreen agent with antioxidant properties and comparable UV absorption performance. Green synthesis of nanoceria with Ag and Ni dopants resulted in doped nanoceria with lower catalytic activity and biologically-safe characteristics. The doped nanoceria was characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), Rancimat Instrument, and UV-Vis Spectrophotometer for SPF (Sun Protection Factor) determination. XRD and TEM analysis showed that nano...
Source: Chemical and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Agnes Giovanni Marsius Satria Hidayat Damar Rastri Adhika Akhmad Zein Eko Mustofa Veinardi Suendo Heni Rachmawati Source Type: research

Antiproliferative Activities of Cynaropicrin and Related Compounds against Cancer Stem Cells
In this study, we evaluated the antiproliferative activities of 21 sesquiterpenoids against human GBM U-251 MG CSCs and U-251 MG non-CSCs. Particularly, the guaianolide sesquiterpene lactone cynaropicrin (1) showed strong antiproliferative activity against U-251 MG CSCs (IC50 = 20.4 µM) and U-251 MG non-CSCs (IC50 = 10.9 µM). Accordingly, we synthesized six derivatives of 1 and investigated their structure-activity relationships. Most of the guaianolide sesquiterpene lactones with the α-methylene-γ-butyrolactone moiety showed antiproliferative activities against U-251 MG cells. We conclude that the 5,7,5-ring and the Î...
Source: Chemical and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Kousuke Araki Minami Hara Shohei Hamada Takahiro Matsumoto Seikou Nakamura Source Type: research

Nucleophilic Deprotection of p-Methoxybenzyl Ethers Using Heterogeneous Oxovanadium Catalyst
Chem Pharm Bull (Tokyo). 2024;72(2):213-219. doi: 10.1248/cpb.c23-00897.ABSTRACTNucleophilic deprotection of p-methoxybenzyl (PMB) [p-methoxyphenylmethyl (MPM)] ethers was developed using a heterogeneous oxovanadium catalyst V-MPS4 and a thiol nucleophile. The deprotection method had a wide reaction scope, including PMB ethers of primary, secondary, and tertiary alcohols bearing various functional groups. In addition, the PMB ether of an oxidation-labile natural product was successfully removed by V-MPS4 catalysis, while a common oxidative method of PMB deprotection afforded a complex mixture. The V-MPS4 catalyst was reusa...
Source: Chemical and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Rei Ikeda Tomoya Nishio Kyohei Kanomata Shuji Akai Source Type: research

Effect of Ag and Ni-Doped Cerium Oxide Nanoparticles on the Formation of ROS and Evaluation as an Alternative Physical Sunscreen Material
Chem Pharm Bull (Tokyo). 2024;72(2):220-225. doi: 10.1248/cpb.c23-00512.ABSTRACTCeO2 nanoparticles (nanoceria) were proposed as an alternative physical sunscreen agent with antioxidant properties and comparable UV absorption performance. Green synthesis of nanoceria with Ag and Ni dopants resulted in doped nanoceria with lower catalytic activity and biologically-safe characteristics. The doped nanoceria was characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), Rancimat Instrument, and UV-Vis Spectrophotometer for SPF (Sun Protection Factor) determination. XRD and TEM analysis showed that nano...
Source: Chemical and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Agnes Giovanni Marsius Satria Hidayat Damar Rastri Adhika Akhmad Zein Eko Mustofa Veinardi Suendo Heni Rachmawati Source Type: research

Antiproliferative Activities of Cynaropicrin and Related Compounds against Cancer Stem Cells
In this study, we evaluated the antiproliferative activities of 21 sesquiterpenoids against human GBM U-251 MG CSCs and U-251 MG non-CSCs. Particularly, the guaianolide sesquiterpene lactone cynaropicrin (1) showed strong antiproliferative activity against U-251 MG CSCs (IC50 = 20.4 µM) and U-251 MG non-CSCs (IC50 = 10.9 µM). Accordingly, we synthesized six derivatives of 1 and investigated their structure-activity relationships. Most of the guaianolide sesquiterpene lactones with the α-methylene-γ-butyrolactone moiety showed antiproliferative activities against U-251 MG cells. We conclude that the 5,7,5-ring and the Î...
Source: Chemical and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Kousuke Araki Minami Hara Shohei Hamada Takahiro Matsumoto Seikou Nakamura Source Type: research