A male gametocyte osmiophilic body and microgamete surface protein of the rodent malaria parasite Plasmodium yoelii (PyMiGS) plays a critical role in male osmiophilic body formation and exflagellation
Cellular Microbiology, EarlyView. (Source: Cellular Microbiology)
Source: Cellular Microbiology - January 23, 2018 Category: Microbiology Source Type: research
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Cellular Microbiology, Ahead of Print. (Source: Cellular Microbiology)
Source: Cellular Microbiology - January 23, 2018 Category: Microbiology Source Type: research
Lysosome remodelling and adaptation during phagocyte activation
Abstract
Lysosomes are acidic and hydrolytic organelles responsible for receiving and digesting cargo acquired during endocytosis, phagocytosis, and autophagy. For macrophages and dendritic cells, the lysosome is kingpin, playing a direct role in microbe killing and antigen processing for presentation. Strikingly, the historic view that lysosomes are homogeneous and static organelles is being replaced with a more elegant paradigm, in which lysosomes are heterogeneous, dynamic and respond to cellular needs. For example, lysosomes are signaling platforms that integrate stress detection and molecular decision hubs like mTORC1...
Source: Cellular Microbiology - January 19, 2018 Category: Microbiology Authors: Victoria E.B. Hipolito, Erika Ospina ‐Escobar, Roberto J. Botelho Tags: MICROREVIEW Source Type: research
Extracellular vesicles from early ‐stage P. falciparum‐infected red blood cells contain PfEMP1 and induce transcriptional changes in human monocytes
Abstract
Pathogens can release extracellular vesicles (EVs) for cell‐cell communication and host modulation. EVs from Plasmodium falciparum, the deadliest malaria parasite species, can transfer drug resistance genes between parasites. EVs from late‐stage parasite‐infected RBC (iRBC‐EVs) are immunostimulatory and affect endothelial cell permeability, but little is known about EVs from early‐stage iRBC. We detected the parasite virulence factor PfEMP1, which is responsible for iRBC adherence and a major contributor to disease severity, in EVs only up to 12 hours‐post RBC invasion. Furthermore, using PfEMP1 transp...
Source: Cellular Microbiology - January 19, 2018 Category: Microbiology Authors: Nat ália G. Sampaio, Samantha Emery, Alexandra Garnham, Qiao Y. Tan, Xavier Sisquella, Matthew A. Pimentel, Neta Regev‐Rudzki, Louis Schofield, Emily M. Eriksson Tags: RESEARCH ARTICLE Source Type: research
Lysosome remodelling and adaptation during phagocyte activation
Cellular Microbiology,Volume 20, Issue 4, April 2018. (Source: Cellular Microbiology)
Source: Cellular Microbiology - January 19, 2018 Category: Microbiology Source Type: research
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Cellular Microbiology,Volume 20, Issue 4, April 2018. (Source: Cellular Microbiology)
Source: Cellular Microbiology - January 19, 2018 Category: Microbiology Source Type: research
Interferon regulatory factor 1 is essential for pathogenic CD8+ T cell migration and retention in the brain during experimental cerebral malaria
Cellular Microbiology, EarlyView. (Source: Cellular Microbiology)
Source: Cellular Microbiology - January 18, 2018 Category: Microbiology Source Type: research
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Cellular Microbiology, Ahead of Print. (Source: Cellular Microbiology)
Source: Cellular Microbiology - January 18, 2018 Category: Microbiology Source Type: research
The blood –brain barrier internalises Cryptococcus neoformans via the EphA2‐tyrosine kinase receptor
Abstract
Cryptococcus neoformans is an opportunistic fungal pathogen that causes life‐threatening meningitis most commonly in populations with impaired immunity. Here, we resolved the transcriptome of the human brain endothelium challenged with C. neoformans to establish whether C. neoformans invades the CNS by co‐opting particular signalling pathways as a means to promote its own entry. Among the 5 major pathways targeted by C. neoformans, the EPH‐EphrinA1 (EphA2) tyrosine kinase receptor‐signalling pathway was examined further. Silencing the EphA2 receptor transcript in a human brain endothelial cell line or b...
Source: Cellular Microbiology - January 18, 2018 Category: Microbiology Authors: Phylicia A. Aaron, Mantana Jamklang, John P. Uhrig, Angie Gelli Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: Cellular Microbiology)
Source: Cellular Microbiology - January 11, 2018 Category: Microbiology Tags: ISSUE INFORMATION Source Type: research
Tailored environments to study motile cells and pathogens
Abstract
Motile cells and pathogens migrate in complex environments and yet are mostly studied on simple 2D substrates. In order to mimic the diverse environments of motile cells a set of assays including substrates of defined elasticity, microfluidics, micropatterns, organotypic cultures and 3D gels have been developed. We briefly introduce these and then focus on the use of micro‐patterned pillar arrays, which help to bridge the gap between 2D and 3D. These structures are made from polydimethylsiloxane, a moldable plastic and their use has revealed new insights into mechanoperception in Caenorhabditis elegans, gliding ...
Source: Cellular Microbiology - January 1, 2018 Category: Microbiology Authors: Julianne Mendi Muthinja, Johanna Ripp, Timothy Kr üger, Andrea Imle, Tamás Haraszti, Oliver T. Fackler, Joachim P. Spatz, Markus Engstler, Friedrich Frischknecht Tags: MICROREVIEW Source Type: research
A male gametocyte osmiophilic body and microgamete surface protein of the rodent malaria parasite Plasmodium yoelii (PyMiGS) plays a critical role in male osmiophilic body formation and exflagellation
Abstract
Anopheles mosquitoes transmit Plasmodium parasites of mammals, including the species that cause malaria in humans. Malaria pathology is caused by rapid multiplication of parasites in asexual intraerythrocytic cycles. Sexual stage parasites are also produced during the intraerythrocytic cycle, and are ingested by the mosquito, initiating gametogenesis and subsequent sporogonic stage development. Here, we present a Plasmodium protein, termed microgamete surface protein (MiGS), which has an important role in male gametocyte osmiophilic body (MOB) formation and microgamete function. MiGS is expressed exclusively in ma...
Source: Cellular Microbiology - January 1, 2018 Category: Microbiology Authors: Mayumi Tachibana, Tomoko Ishino, Eizo Takashima, Takafumi Tsuboi, Motomi Torii Tags: RESEARCH ARTICLE Source Type: research
Interferon Regulatory Factor 1 is essential for pathogenic CD8+ T cell migration and retention in the brain during experimental cerebral malaria
Abstract
Host immune response has a key role in controlling the progression of malaria infection. In the well‐established murine model of experimental cerebral malaria (ECM) with P. berghei ANKA infection, pro‐inflammatory Th1 and CD8+ T cells response are essential for disease development. Interferon regulatory factor 1 (IRF1) is a transcription factor which promotes Th1 responses and its absence was previously shown to protect from ECM death. Yet, the exact mechanism of protection remains unknown. Here we demonstrated that IRF1‐deficient mice (IRF1KO) were protected from ECM death despite displaying early neurologi...
Source: Cellular Microbiology - December 27, 2017 Category: Microbiology Authors: Sin Yee Gun, Carla Claser, Teck Hui Teo, Shanshan W. Howland, Chek Meng Poh, Rebecca Ren Ying Chye, Lisa F.P. Ng, Laurent R énia Tags: RESEARCH ARTICLE Source Type: research
Sialic acid ‐dependent interaction of group B streptococci with influenza virus‐infected cells reveals a novel adherence and invasion mechanism
Abstract
Group B streptococci (GBS) contain a capsular polysaccharide with side chains terminating in α2,3‐linked sialic acids. Because of this linkage type, the sialic acids of GBS are recognized by lectins of immune cells. This interaction results in a dampening of the host immune response and thus promotes immune evasion. As several influenza A viruses (IAV) use α2,3‐linked sialic acid as a receptor determinant for binding to host cells, we analyzed whether GBS and influenza viruses can interact with each other and how this interaction affects viral replication and bacterial adherence to and invasion of host cells...
Source: Cellular Microbiology - December 22, 2017 Category: Microbiology Authors: Jie Tong, Yuguang Fu, Nai ‐Huei Wu, Manfred Rohde, Fandan Meng, Peter Valentin‐Weigand, Georg Herrler Tags: RESEARCH ARTICLE Source Type: research
Sialic acid ‐dependent interaction of group B streptococci with influenza virus‐infected cells reveals a novel adherence and invasion mechanism
Cellular Microbiology,Volume 20, Issue 4, April 2018. (Source: Cellular Microbiology)
Source: Cellular Microbiology - December 22, 2017 Category: Microbiology Source Type: research
