Whole Blood-Derived circUSP10 Acts as a Diagnostic Biomarker in Patients With Early-Stage Non-Small-Cell Lung Cancer
Cell Transplant. 2023 Jan-Dec;32:9636897231193066. doi: 10.1177/09636897231193066.ABSTRACTAccumulating evidence has indicated that differentially expressed noncoding circular RNAs (circRNAs) play essential roles in the occurrence and development of various types of cancer. Here, we aimed to identify and explore the diagnostic value of hsa_circ_0003026 (named circUSP10) in patients with early non-small-cell lung cancer (NSCLC). The differentially expressed circRNAs were screened from the microarray-based assay of human NSCLC tissues and their corresponding noncancerous tissues, and the candidate circRNAs were further verifi...
Source: Cell Transplantation - August 26, 2023 Category: Cytology Authors: Huihui Bai Meina Jiang Shuai Fang Ziyi Peng Nan Liang Yuanting Cai Yuanyuan Wang Chengwei Zhou Ying Han Weiyu Shen Zhaohui Gong Source Type: research
The Role and Applications of Exosomes in Gynecological Cancer: A Review
Cell Transplant. 2023 Jan-Dec;32:9636897231195240. doi: 10.1177/09636897231195240.ABSTRACTExosomes are phospholipid bilayer vesicles that are released by all types of cells, containing proteins, lipids, and nucleic acids such as DNAs and RNAs. Exosomes can be transferred between cells and play a variety of physiological and pathological regulatory functions. Noncoding RNAs, including micro RNAs, long noncoding RNAs, and circular RNAs, are the most studied biomolecules from exosomes and more and more studies found that noncoding RNAs play an important role in the diagnosis, prognosis, and treatment of diseases, including va...
Source: Cell Transplantation - August 26, 2023 Category: Cytology Authors: Kai-Hung Wang Dah-Ching Ding Source Type: research
Whole Blood-Derived circUSP10 Acts as a Diagnostic Biomarker in Patients With Early-Stage Non-Small-Cell Lung Cancer
Cell Transplant. 2023 Jan-Dec;32:9636897231193066. doi: 10.1177/09636897231193066.ABSTRACTAccumulating evidence has indicated that differentially expressed noncoding circular RNAs (circRNAs) play essential roles in the occurrence and development of various types of cancer. Here, we aimed to identify and explore the diagnostic value of hsa_circ_0003026 (named circUSP10) in patients with early non-small-cell lung cancer (NSCLC). The differentially expressed circRNAs were screened from the microarray-based assay of human NSCLC tissues and their corresponding noncancerous tissues, and the candidate circRNAs were further verifi...
Source: Cell Transplantation - August 26, 2023 Category: Cytology Authors: Huihui Bai Meina Jiang Shuai Fang Ziyi Peng Nan Liang Yuanting Cai Yuanyuan Wang Chengwei Zhou Ying Han Weiyu Shen Zhaohui Gong Source Type: research
The Role and Applications of Exosomes in Gynecological Cancer: A Review
Cell Transplant. 2023 Jan-Dec;32:9636897231195240. doi: 10.1177/09636897231195240.ABSTRACTExosomes are phospholipid bilayer vesicles that are released by all types of cells, containing proteins, lipids, and nucleic acids such as DNAs and RNAs. Exosomes can be transferred between cells and play a variety of physiological and pathological regulatory functions. Noncoding RNAs, including micro RNAs, long noncoding RNAs, and circular RNAs, are the most studied biomolecules from exosomes and more and more studies found that noncoding RNAs play an important role in the diagnosis, prognosis, and treatment of diseases, including va...
Source: Cell Transplantation - August 26, 2023 Category: Cytology Authors: Kai-Hung Wang Dah-Ching Ding Source Type: research
Human Cord Blood-Endothelial Progenitor Cells Alleviate Intimal Hyperplasia of Arterial Damage in a Rat Stroke Model
In this study, we used an animal model with pathological changes that mimics artery wall damage caused by stent retrievers in humans. We injected hCB-EPCs to investigate their effect on endothelial hyperplasia and dysfunction during intimal repair. Four groups were established based on the length of reperfusion (3 and 28 days), as well as the presence or absence of hCB-EPC therapy. Damage to the internal carotid artery was evaluated by hematoxylin-eosin and immunohistochemical staining. Stroke volume was not significantly different between non-EPC and EPC groups although EPC treatment alleviated intimal hyperplasia 28 days...
Source: Cell Transplantation - August 24, 2023 Category: Cytology Authors: Hongming Sun Ryuta Morihara Tian Feng Zhihong Bian Haibo Yu Xiao Hu Xinran Hu Yuting Bian Ryo Sasaki Yusuke Fukui Mami Takemoto Taijun Yunoki Yumiko Nakano Koji Abe Toru Yamashita Source Type: research
Human Cord Blood-Endothelial Progenitor Cells Alleviate Intimal Hyperplasia of Arterial Damage in a Rat Stroke Model
In this study, we used an animal model with pathological changes that mimics artery wall damage caused by stent retrievers in humans. We injected hCB-EPCs to investigate their effect on endothelial hyperplasia and dysfunction during intimal repair. Four groups were established based on the length of reperfusion (3 and 28 days), as well as the presence or absence of hCB-EPC therapy. Damage to the internal carotid artery was evaluated by hematoxylin-eosin and immunohistochemical staining. Stroke volume was not significantly different between non-EPC and EPC groups although EPC treatment alleviated intimal hyperplasia 28 days...
Source: Cell Transplantation - August 24, 2023 Category: Cytology Authors: Hongming Sun Ryuta Morihara Tian Feng Zhihong Bian Haibo Yu Xiao Hu Xinran Hu Yuting Bian Ryo Sasaki Yusuke Fukui Mami Takemoto Taijun Yunoki Yumiko Nakano Koji Abe Toru Yamashita Source Type: research
Human Cord Blood-Endothelial Progenitor Cells Alleviate Intimal Hyperplasia of Arterial Damage in a Rat Stroke Model
In this study, we used an animal model with pathological changes that mimics artery wall damage caused by stent retrievers in humans. We injected hCB-EPCs to investigate their effect on endothelial hyperplasia and dysfunction during intimal repair. Four groups were established based on the length of reperfusion (3 and 28 days), as well as the presence or absence of hCB-EPC therapy. Damage to the internal carotid artery was evaluated by hematoxylin-eosin and immunohistochemical staining. Stroke volume was not significantly different between non-EPC and EPC groups although EPC treatment alleviated intimal hyperplasia 28 days...
Source: Cell Transplantation - August 24, 2023 Category: Cytology Authors: Hongming Sun Ryuta Morihara Tian Feng Zhihong Bian Haibo Yu Xiao Hu Xinran Hu Yuting Bian Ryo Sasaki Yusuke Fukui Mami Takemoto Taijun Yunoki Yumiko Nakano Koji Abe Toru Yamashita Source Type: research
METTL3 Promotes the Growth and Invasion of Melanoma Cells by Regulating the lncRNA SNHG3/miR-330-5p Axis
In conclusion, our findings demonstrated that METTL3-mediated m6A modification of lncRNA SNHG3 promoted the growth and invasion of melanoma cells by regulating the miR-330-5p/CNBP axis.PMID:37606168 | DOI:10.1177/09636897231188300 (Source: Cell Transplantation)
Source: Cell Transplantation - August 22, 2023 Category: Cytology Authors: Shaojun Chu Yulong Li Baojin Wu Guo Rong Qiang Hou Qin Zhou Dexiang Du Yufei Li Source Type: research
METTL3 Promotes the Growth and Invasion of Melanoma Cells by Regulating the lncRNA SNHG3/miR-330-5p Axis
In conclusion, our findings demonstrated that METTL3-mediated m6A modification of lncRNA SNHG3 promoted the growth and invasion of melanoma cells by regulating the miR-330-5p/CNBP axis.PMID:37606168 | DOI:10.1177/09636897231188300 (Source: Cell Transplantation)
Source: Cell Transplantation - August 22, 2023 Category: Cytology Authors: Shaojun Chu Yulong Li Baojin Wu Guo Rong Qiang Hou Qin Zhou Dexiang Du Yufei Li Source Type: research
A Technological and Regulatory Review on Human-Animal Chimera Research: The Current Landscape of Biology, Law, and Public Opinion
We present an overview of the technological advances that allow for the creation of HACs, the patents that currently exist on these methods, as well as current public attitude and understanding that can influence HAC research policy. We complement our scientific and public attitude discussion with a regulatory overview of chimera research at both the national and state level, while also contrasting current U.S. legislation with regulations in other countries. Overall, we provide a comprehensive analysis of the legal and scientific barriers to conducting research on HACs for the generation of transplantable human organs, as...
Source: Cell Transplantation - August 21, 2023 Category: Cytology Authors: Jennifer L Brown Joseph P Voth Kennedy Person Walter C Low Source Type: research
A Technological and Regulatory Review on Human-Animal Chimera Research: The Current Landscape of Biology, Law, and Public Opinion
We present an overview of the technological advances that allow for the creation of HACs, the patents that currently exist on these methods, as well as current public attitude and understanding that can influence HAC research policy. We complement our scientific and public attitude discussion with a regulatory overview of chimera research at both the national and state level, while also contrasting current U.S. legislation with regulations in other countries. Overall, we provide a comprehensive analysis of the legal and scientific barriers to conducting research on HACs for the generation of transplantable human organs, as...
Source: Cell Transplantation - August 21, 2023 Category: Cytology Authors: Jennifer L Brown Joseph P Voth Kennedy Person Walter C Low Source Type: research
Assessment of a Synergistic Effect of Platelet-Rich Plasma and Stem Cell-Seeded Hydrogel for Healing of Rat Chronic Rotator Cuff Injuries
This study aimed to examine whether there was a synergistic and dose-dependent effect of platelet-rich plasma (PRP) on tendon-bone interface healing by combining PRP with stem cell-seeded tendon hydrogel. Human cadaveric tendons were processed into a hydrogel. PRP was prepared at two different platelet concentrations: an initial concentration (initial PRP group) and a higher concentration (concentrated PRP group). Tendon hydrogel was mixed with adipose-derived stem cells and one of the platelet concentrations. Methylcellulose, as opposed to saline, was used as a negative control due to comparable viscosity. The supraspinat...
Source: Cell Transplantation - August 18, 2023 Category: Cytology Authors: Hiroki Oda Yukitoshi Kaizawa Austin Franklin Uriel Sanchez Rangel Hunter Storaci Jung Gi Min Zhen Wang Geoffrey D Abrams James Chang Paige M Fox Source Type: research
Early and Dose-Dependent Xenogeneic Mesenchymal Stem Cell Therapy Improved Outcomes in Acute Respiratory Distress Syndrome Rodent Through Ameliorating Inflammation, Oxidative Stress, and Immune Reaction
This study tested whether human umbilical cord-derived mesenchymal stem cells (HUCDMSCs) treatment effectively protected the rat lung against acute respiratory distress syndrome (ARDS) injury, and benefits of early and dose-dependent treatment. Rat pulmonary epithelial cell line L2 (PECL2) were categorized into G1 (PECL2), G2 (PECL2 + healthy rat lung-derived extraction/50 mg/ml co-cultured for 24 h), G3 (PECL2 + ARDS rat lung-derived extraction/50 mg/ml co-cultured for 24 h), and G4 (condition as G3 + HUCDMSCs/1 × 105/co-cultured for 24 h). The result showed that the protein expressions of inflammatory (HMGB-1/TLR-2/TLR-...
Source: Cell Transplantation - August 18, 2023 Category: Cytology Authors: Kun-Chen Lin Wen-Feng Fang Pei-Hsun Sung Kuo-Tung Huang John Y Chiang Yi-Ling Chen Chi-Ruei Huang Yi-Chen Li Mel S Lee Hon-Kan Yip Source Type: research
Assessment of a Synergistic Effect of Platelet-Rich Plasma and Stem Cell-Seeded Hydrogel for Healing of Rat Chronic Rotator Cuff Injuries
This study aimed to examine whether there was a synergistic and dose-dependent effect of platelet-rich plasma (PRP) on tendon-bone interface healing by combining PRP with stem cell-seeded tendon hydrogel. Human cadaveric tendons were processed into a hydrogel. PRP was prepared at two different platelet concentrations: an initial concentration (initial PRP group) and a higher concentration (concentrated PRP group). Tendon hydrogel was mixed with adipose-derived stem cells and one of the platelet concentrations. Methylcellulose, as opposed to saline, was used as a negative control due to comparable viscosity. The supraspinat...
Source: Cell Transplantation - August 18, 2023 Category: Cytology Authors: Hiroki Oda Yukitoshi Kaizawa Austin Franklin Uriel Sanchez Rangel Hunter Storaci Jung Gi Min Zhen Wang Geoffrey D Abrams James Chang Paige M Fox Source Type: research
Early and Dose-Dependent Xenogeneic Mesenchymal Stem Cell Therapy Improved Outcomes in Acute Respiratory Distress Syndrome Rodent Through Ameliorating Inflammation, Oxidative Stress, and Immune Reaction
This study tested whether human umbilical cord-derived mesenchymal stem cells (HUCDMSCs) treatment effectively protected the rat lung against acute respiratory distress syndrome (ARDS) injury, and benefits of early and dose-dependent treatment. Rat pulmonary epithelial cell line L2 (PECL2) were categorized into G1 (PECL2), G2 (PECL2 + healthy rat lung-derived extraction/50 mg/ml co-cultured for 24 h), G3 (PECL2 + ARDS rat lung-derived extraction/50 mg/ml co-cultured for 24 h), and G4 (condition as G3 + HUCDMSCs/1 × 105/co-cultured for 24 h). The result showed that the protein expressions of inflammatory (HMGB-1/TLR-2/TLR-...
Source: Cell Transplantation - August 18, 2023 Category: Cytology Authors: Kun-Chen Lin Wen-Feng Fang Pei-Hsun Sung Kuo-Tung Huang John Y Chiang Yi-Ling Chen Chi-Ruei Huang Yi-Chen Li Mel S Lee Hon-Kan Yip Source Type: research
