The genotypes and phenotypes of missense mutations in the proline domain of the p53 protein
Cell Death & Differentiation, Published online: 05 April 2022; doi:10.1038/s41418-022-00980-7 (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - April 5, 2022 Category: Cytology Authors: David Hoyos Benjamin Greenbaum Arnold J. Levine Source Type: research

Exploring the future of research in the Tp53 field
Cell Death & Differentiation, Published online: 05 April 2022; doi:10.1038/s41418-022-00986-1Exploring the future of research in the Tp53 field (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - April 5, 2022 Category: Cytology Authors: Arnold J. Levine Source Type: research

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
Cell Death & Differentiation, Published online: 04 April 2022; doi:10.1038/s41418-022-00983-4Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - April 4, 2022 Category: Cytology Authors: Zhuoyao Chen Rafael M. Ioris Stacey Richardson Ava N. Van Ess Iolanda Vendrell Benedikt M. Kessler Francesca M. Buffa Luca Busino Steven C. Clifford Alex N. Bullock Vincenzo D ’Angiolella Source Type: research

Cell cycle regulation: p53-p21-RB signaling
Cell Death & Differentiation, Published online: 31 March 2022; doi:10.1038/s41418-022-00988-zCell cycle regulation: p53-p21-RB signaling (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - March 31, 2022 Category: Cytology Authors: Kurt Engeland Source Type: research

Mutant p53: it’s not all one and the same
Cell Death & Differentiation, Published online: 31 March 2022; doi:10.1038/s41418-022-00989-yMutant p53: it’s not all one and the same (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - March 31, 2022 Category: Cytology Authors: Margaret C. Kennedy Scott W. Lowe Source Type: research

Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death
Cell Death & Differentiation, Published online: 31 March 2022; doi:10.1038/s41418-022-00982-5Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - March 31, 2022 Category: Cytology Authors: Farrah El-Saafin Maria I. Bergamasco Yunshun Chen Rose E. May Prabagaran Esakky Soroor Hediyeh-zadeh Mathew Dixon Stephen Wilcox Melissa J. Davis Andreas Strasser Gordon K. Smyth Tim Thomas Anne K. Voss Source Type: research

The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute
Cell Death & Differentiation, Published online: 29 March 2022; doi:10.1038/s41418-022-00976-3The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - March 29, 2022 Category: Cytology Authors: Kelvin C ésar de Andrade Elaine E. Lee Elise M. Tookmanian Chimene A. Kesserwan James J. Manfredi Jessica N. Hatton Jennifer K. Loukissas Jiri Zavadil Lei Zhou Magali Olivier Megan N. Frone Owais Shahzada William J. R. Longabaugh Christian P. Kratz David Source Type: research

Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration
Cell Death & Differentiation, Published online: 28 March 2022; doi:10.1038/s41418-022-00967-4Schematic summary of the mechanism underlying BRD4 inhibition on cGAS-STING signaling during retina degeneration. Cytosolic DNA accumulation and activation of cGAS-STING pathway were detected in retina photoreceptors after oxidative injury. BRD4 inhibition alleviates retinal inflammation and degeneration by epigenetically silencing STING transcription and by promoting autophagy-dependent cytosolic DNA clearance. (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - March 28, 2022 Category: Cytology Authors: Ming Zou Qin Ke Qian Nie Ruili Qi Xingfei Zhu Wei Liu Xuebin Hu Qian Sun Jia-Ling Fu Xiangcheng Tang Yizhi Liu David Wan-Cheng Li Lili Gong Source Type: research

Regulation of Semaphorin3A in the process of cutaneous wound healing
Cell Death & Differentiation, Published online: 26 March 2022; doi:10.1038/s41418-022-00981-6Regulation of Semaphorin3A in the process of cutaneous wound healing (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - March 26, 2022 Category: Cytology Authors: Yang Zheng Feng Jiang Chao Wang Mengjie Dong Chundi Wang Enshi Yan Yi Wang Zaiou Zhu Xianbin Xiong Xu Ding Jinhai Ye Yue He Hongchuang Zhang Junbo Zhou Wei Zhang Yunong Wu Xiaomeng Song Source Type: research

BAX and BAK dynamics control mitochondrial DNA release during apoptosis
Cell Death & Differentiation, Published online: 26 March 2022; doi:10.1038/s41418-022-00985-2BAX and BAK are generally considered as fully interchangeable for mitochondrial permeabilization and consequent apoptotic cell death. Garcia-Saez and colleagues have recently documented striking kinetic differences that influence BAX and BAK oligomerization at the mitochondrial surface. These data have important implications for inflammatory responses driven by mitochondrial DNA. (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - March 26, 2022 Category: Cytology Authors: Takahiro Yamazaki Lorenzo Galluzzi Source Type: research

Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA
Cell Death & Differentiation, Published online: 25 March 2022; doi:10.1038/s41418-022-00970-9Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - March 25, 2022 Category: Cytology Authors: Ying Zhang Meiying Luo Xiaohong Cui Douglas O ’Connell Yongfei Yang Source Type: research

BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells
Cell Death & Differentiation, Published online: 24 March 2022; doi:10.1038/s41418-022-00977-2BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - March 24, 2022 Category: Cytology Authors: Diane Moujalled Adam G. Southon Eiman Saleh Kerstin Brinkmann Francine Ke Melinda Iliopoulos Ryan S. Cross Misty R. Jenkins Duong Nhu Zilu Wang Melissa X. Shi Ruth M. Kluck Guillaume Lessene Stephanie Grabow Ashley I. Bush Andreas Strasser Source Type: research

Should mutant TP53 be targeted for cancer therapy?
Cell Death & Differentiation, Published online: 24 March 2022; doi:10.1038/s41418-022-00962-9The attributes proposed for mutant TP53 to drive tumour development and possible approaches to target them. Model depicting the three attributes by which mutant TP53 is thought to promote tumour development: loss-of-function (LOF), dominant negative effects (DNE) over wt TP53 and neomorphic gain-of-function (GOF) effects. (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - March 24, 2022 Category: Cytology Authors: Zilu Wang Andreas Strasser Gemma L. Kelly Source Type: research

Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer
Cell Death & Differentiation, Published online: 24 March 2022; doi:10.1038/s41418-022-00974-5Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - March 24, 2022 Category: Cytology Authors: Xiaopeng Xiong Sumati Hasani Lyndsay E. A. Young Dylan R. Rivas Ashley T. Skaggs Rebecca Martinez Chi Wang Heidi L. Weiss Matthew S. Gentry Ramon C. Sun Tianyan Gao Source Type: research

Mitochondrial ATP synthase c-subunit leak channel triggers cell death upon loss of its F1 subcomplex
Cell Death & Differentiation, Published online: 23 March 2022; doi:10.1038/s41418-022-00972-7Mitochondrial ATP synthase c-subunit leak channel triggers cell death upon loss of its F1 subcomplex (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - March 23, 2022 Category: Cytology Authors: Nelli Mnatsakanyan Han-A Park Jing Wu Xiang He Marc C. Llaguno Maria Latta Paige Miranda Besnik Murtishi Morven Graham Joachim Weber Richard J. Levy Evgeny V. Pavlov Elizabeth A. Jonas Source Type: research