A Case of Corneal Melting in a Patient with HER2-Positive Breast Cancer
Trastuzumab is the cornerstone treatment for HER2-positive breast cancer. While ocular side effects are more commonly described after the use of the antibody-drug conjugate ado-trastuzumab emtansine, we here describe corneal melting in a 79-year-old patient after three cycles of trastuzumab monotherapy. Signs and symptoms persisted with subsequent trastuzumab cycles. The patient showed improvement after treatment with intense lubrication, topical antibiotics, and topical steroids. After tapering of steroids, there was recurrence of epitheliopathy after subsequent trastuzumab treatment, which subsided upon restarting topica...
Source: Case Reports in Ophthalmology - December 22, 2022 Category: Opthalmology Source Type: research
Very Challenging Cases to Diagnose: Concealed Foreign Bodies in the Upper Palpebral Conjunctiva Should Always Be Kept in Mind in Unresolved, Long-Lasting Chronic Ocular Pain
This report reviews cases in which hidden foreign bodies were responsible for unresolved, long-lasting chronic ocular pain. All records referencing the phrase “foreign body removal” were extracted from the outpatient clinic notes recorded by the author (H.T.) between 2016 and 2018 at Ashikaga Red Cross Hospital using the search engine of the computerized record system. There were 3 cases that were very difficult to diagnose: (1) a very minute iron sha rd in a 72-year-old female cataract surgery patient, (2) a deeply hidden eyelash in a 60-year-old female with varicella-zoster virus-related keratoconjunctivitis, and (3)...
Source: Case Reports in Ophthalmology - December 22, 2022 Category: Opthalmology Source Type: research
Preserflo Microshunt Surgery for Ocular Hypertension following Intravitreal Fluocinolone Acetonide Implant Removal: A Case Report
We describe here the case of a 60-year-old man with a history of bilateral DME who received an intravitreal injection of 190 µg fluocinolone acetonide (FAc) (ILUVIEN®, Alimera Sciences, Alpharetta, GA, USA) who presented a persistent ocular hypertension in one eye despite FAc removal by pars plana vitrectomy and was successfully managed by Preserflo® microshunt surgery.Case Rep Ophthalmol 2022;13:1024 –1029 (Source: Case Reports in Ophthalmology)
Source: Case Reports in Ophthalmology - December 16, 2022 Category: Opthalmology Source Type: research
< i > MFRP < /i > -Associated Retinopathy and Nanophthalmos in Two Irish Probands: A Case Report
The conjunction of nanophthalmos (NO) and retinitis pigmentosa (RP) provides challenges to effective clinical management while narrowing the genetic spectrum for targeted molecular diagnostics. This case study describes two not knowingly related adult cases ofMFRP-associated retinopathy and nanophthalmos (MARN). Structural features including short axial lengths (mean 16.4 mm), steep keratometry (mean 49.98 D), adult-onset signs, and symptoms of retinal dystrophy and acquired disease (i.e., cataract, angle-closure glaucoma) were evident in both cases. Pathogenic variants in theMFRP gene impair both prenatal eye growth and c...
Source: Case Reports in Ophthalmology - December 16, 2022 Category: Opthalmology Source Type: research
Ophthalmomyiasis Externa due to < i > Oestrus ovis < /i > Larvae: A Case Report
A 23-year-old female presented with redness, itchiness, tearing, and foreign body sensation in her right eye after spending her holiday in Egypt. Slit lamp examination revealed about 15 mobile, whitish maggots that were microbiologically classified asOestrus ovis larvae. All parasites could be removed without subsequent complications.Case Rep Ophthalmol 2022;13:1010 –1014 (Source: Case Reports in Ophthalmology)
Source: Case Reports in Ophthalmology - November 28, 2022 Category: Opthalmology Source Type: research
A Case of Pigment Dispersion Syndrome after Placement of Sulcus Intraocular Lens with 7-mm Optic Diameter after Posterior Capsule Rupture
A 48-year-old woman diagnosed with primary angle closure suspect (PACS) in the right eye underwent cataract surgery, and a 7-mm optic diameter intraocular lens (IOL) was placed in the ciliary sulcus after intraoperative posterior capsule rupture. The patient developed uveitis and blurred vision the next day. The IOL was fixed between the iris and the anterior capsule. Irregularly shaped pupils due to posterior synechia and pigmentation on the IOL surface were observed. In the Scheimpflug image, the IOL on the anterior capsule was observed and the anterior chamber depth was 2.92 mm. A diagnosis of pigment dispersion syndrom...
Source: Case Reports in Ophthalmology - November 28, 2022 Category: Opthalmology Source Type: research
Central Serous Chorioretinopathy Associated with Tadalafil
In conclusion, prescribing physicians should be aware of tadalafil’s ability to decrease vision and cause CSCR. The addition of CSCR to the list of tadalafil’s side effects should also be considered.Case Rep Ophthalmol 2022;13:1008 –1011 (Source: Case Reports in Ophthalmology)
Source: Case Reports in Ophthalmology - November 28, 2022 Category: Opthalmology Source Type: research
Focal Laser Photocoagulation for Central Serous Chorioretinopathy in Under-Represented Populations: A Retrospective Case Series
This case series examines visual and anatomic outcomes of focal laser photocoagulation in the treatment of central serous chorioretinopathy (CSCR) with subretinal fluid (SRF) in under-represented populations. We reviewed records of 25 eyes with CSCR and SRF that underwent focal laser photocoagulation. Visual acuity (VA) and central macular thickness (CMT) were recorded prior to laser, after laser treatment, and at final follow-up and were all compared using Wilcox signed-rank tests after using Shapiro-Wilk tests to determine normality. The racial and ethnic breakdown of our cohort (n = 25) includes 64% Hispanic (n = 16), 2...
Source: Case Reports in Ophthalmology - November 28, 2022 Category: Opthalmology Source Type: research
Nail-Patella Syndrome and Glaucoma: A Case Report and Review of the Literature
We report the case of a 57-year-old woman affected by NPS and having haploinsufficiency of the LMX1B gene who experienced severe bilateral chronic angle-closure glaucoma in both eyes and that was successfully managed with a flap-express procedure in the right eye. The left eye had no light perception, and medical treatment was considered. Glaucoma is the most frequent ocular abnormalities observed in association with NPS and usually presents with an open angle. Glaucoma associated with NPS typically has an early onset open-angle phenotype. In fewer cases, it may present with an angle-closure phenotype. Therefore, we emphas...
Source: Case Reports in Ophthalmology - November 24, 2022 Category: Opthalmology Source Type: research
Bilateral Conjunctivitis, Keratitis, and Anterior Uveitis in a Patient Co-infected with Parvovirus B19 and SARS-CoV-2
We report on a case of bilateral conjunctivitis, keratitis, and anterior uveitis that occurred in a patient co-infected by B19V and SARS-CoV-2. A young nurse developed, 20 days after the onset of asthenia and fever, a maculopapular rash and, in the following month, B19V-related arthritis. Shortly after a course of antibiotics and corticosteroids and the resolution of the arthritis, she began to complain of hearing loss and tinnitus. A polymerase chain reaction for SARS-CoV-2, previously negative, turned out positive; IgM for B19V decreased while IgG increased and antinuclear autoantibody and rheumatoid factor test results ...
Source: Case Reports in Ophthalmology - November 18, 2022 Category: Opthalmology Source Type: research
Case of Repeated Full-Thickness Macular Hole Formations and Spontaneous Closure following Intravitreal Bevacizumab Treatment for Central Retinal Vein Occlusion
We report a case of repeated FTMH formations and a spontaneous closure following an intravitreal injection of bevacizumab (IVB) for a central retinal vein occlusion (CRVO). A 39-year-old male patient presented with reduced vision in his right eye and was diagnosed with a CRVO. Two months later, neovascular glaucoma and macular edema (ME) developed and IVB was performed. After 2 weeks, optical coherence tomography revealed an improvement of the ME and the formation of an FTMH with a hyperreflective material in the FTMH. Two months later, there was a recurrence of the ME and a closure of the FTMH, but the hyperreflective mat...
Source: Case Reports in Ophthalmology - November 18, 2022 Category: Opthalmology Source Type: research
Epiretinal Membrane Surgery for a Patient with Dyskinesia Related to Parkinson ’s Disease Using Intravenous Dexmedetomidine Administration
We report a case in which dyskinesia related to Parkinson’s disease was attenuated by intravenous dexmedetomidine (DEX) administration, following which epiretinal membrane (ERM) and inner limited membrane peeling could be smoothly performed. A 68-year-old woman with systemic dyskines ia related to Parkinson’s disease underwent cataract surgery for her right eye with local anesthesia (topical anesthesia with 4% lidocaine and sub-Tenon’s anesthesia with 2% lidocaine and 30% nitrous oxide inhalation). During the surgery, continuous involuntary facial movement related to Parkins on’s disease remained uncontrollable. On...
Source: Case Reports in Ophthalmology - November 18, 2022 Category: Opthalmology Source Type: research
Combined Subthreshold Laser with Push-Pull Fluid Exchange for Treatment of Refractory Macular Hole
We report on a 55-year-old patient presenting with a 400 μm macular hole which failed to resolve with vitrectomy and internal limited membrane peeling. In accordance with patient wishes to avoid further surgery, subthreshold laser was applied to the macular hole followed by gas exchange with euvolemic C3F8. Successful hole closure was subsequently observ ed with vision improved by four Snellen lines. Subthreshold laser has several advantages over conventional laser techniques, including reduced collateral thermal damage to the adjacent cells. This case has demonstrated a new use for subthreshold laser, which combined with...
Source: Case Reports in Ophthalmology - November 18, 2022 Category: Opthalmology Source Type: research
En Face Images Using Ultra-Widefield Optical Coherence Tomography in 2 Cases of Traumatic Hypotony Maculopathy before and after Surgical Intervention
The aim was to investigate the structural changes of the retina using en face ultra-widefield optical coherence tomography (OCT) images during the treatment of hypotony maculopathy with traumatic cyclodialysis. Case 1 was a 43-year-old male patient with visual crowding in his left eye (metallic wire injury that occurred 3 weeks previously) who was referred to our department. Although best-corrected visual acuity was 20/20 in his left eye on initial evaluation, intraocular pressure was 6 mm Hg. Case 2 was a 20-year-old male patient with visual crowding in his left eye (baseball ball injury that occurred 4 weeks previously) ...
Source: Case Reports in Ophthalmology - November 18, 2022 Category: Opthalmology Source Type: research
Management of Submacular Hemorrhage Using Intravitreal Brolucizumab with Pneumatic Displacement: A Case Series
We present a series of 3 cases with large fresh SMH ( ≤7 days) secondary to MNV that were treated with intravitreal injection (IVI) of brolucizumab along with SF6 gas injection. A face-down position was recommended for 5 days after the injection, with follow-up visits at regular intervals. All eyes demonstrated notable improvement in visual acuity wi th complete resolution of SMH lasting up to 6 months. There were no ocular or systemic side effects. Thus, IVI brolucizumab with SF6 gas injection is efficacious and safe for the management of large SMH secondary to MNV.Case Rep Ophthalmol 2022;13:956 –962 (Source: Case Re...
Source: Case Reports in Ophthalmology - November 18, 2022 Category: Opthalmology Source Type: research
