Statins and risk of cataracts: a systematic review and meta ‐analysis of observational studies
ConclusionsThe results point out an increased risk of cataract development with statins. However, since the magnitude of the effect is low and between ‐studies heterogeneity is high, the extent in which these results have impact on the benefit/risk ratio of statins is difficult to ascertain due to the uncertainty of the findings.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - December 29, 2018 Category: Cardiology Authors: Carlos Alves,
Diogo Mendes,
Francisco Batel Marques Tags: Original Research Article Source Type: research
Hydromorphone Postconditioning Protects Isolated Rat Heart against Ischemia ‐Reperfusion Injury via Activating P13K/Akt/eNOS Signaling
ConclusionsThese findings suggest that hydromorphone postconditioning may protect isolated rat heart against reperfusion injury via activating P13K/Akt/eNOS signaling.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - December 29, 2018 Category: Cardiology Authors: Qing Liu,
Zhengfen Li,
Yuexin Liu,
Qiuxia Xiao,
Xuan Peng,
Qi Chen,
Rui Deng,
Zhiwei Gao,
Fengxu Yu,
Ying Zhang Tags: Original Research Article Source Type: research
Statins and risk of cataracts: a systematic review and meta ‐analysis of observational studies
ConclusionsThe results point out an increased risk of cataract development with statins. However, since the magnitude of the effect is low and between ‐studies heterogeneity is high, the extent in which these results have impact on the benefit/risk ratio of statins is difficult to ascertain due to the uncertainty of the findings.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - December 29, 2018 Category: Cardiology Authors: Carlos Alves,
Diogo Mendes,
Francisco Batel Marques Tags: Original Research Article Source Type: research
Role of interleukin ‐7 in fusion of rat bone marrow mesenchymal stem cells with cardiomyocytes in vitro and improvement of cardiac function in vivo
ConclusionInterleukin ‐7 is able to enhance the fusogenic properties of MSCs and improve cardiac function. This improvement may be attributed to the supportive action of IL‐7 on cell proliferation and cell survival contributing to the regeneration of damaged myocardium. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - December 6, 2018 Category: Cardiology Authors: Kanwal Haneef,
Anwar Ali,
Irfan Khan,
Nadia Naeem,
Siddiqua Jamall,
Asmat Salim Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Calcium channel blockers are associated with improved survival and lower cardiovascular mortality in patients with renovascular disease
ConclusionsCalcium channel blockers are associated with significantly increased survival and lower cardiovascular mortality particularly in patients with moderate RAS disease. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - December 4, 2018 Category: Cardiology Authors: Harshal Deshmukh,
Emma Barker,
Thineshkrishna Anbarasan,
Daniel Levin,
Samira Bell,
Miles D. Witham,
Jacob George Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Combination therapy with cilostazol and pravastatin improves antiatherogenic effects in low ‐density lipoprotein receptor knockout mice
ConclusionsOur results suggest that combination therapy with pravastatin and cilostazol exerts beneficial effects by decreasing atherosclerotic lesion progression and improving the pro ‐inflammatory state in the vascular endothelium. These effects are mediated by the reduction in adhesion molecule expression, immune cell infiltration, and cytokine levels and the antiatherosclerotic modulation of serum cholesterol levels. Therefore, we conclude that combined treatment with pravas tatin and cilostazol may be a more effective antiatherosclerotic strategy than treatment with either agent alone. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - November 29, 2018 Category: Cardiology Authors: Kyung ‐Yeon Park,
Tae‐Hwe Heo Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Fasudil exerts a cardio ‐protective effect on mice with coxsackievirus B3‐induced acute viral myocarditis
ConclusionsROCK pathway inhibition was cardio ‐protective in viral myocarditis with increased survival, decreased viral replication, and inflammatory response. These findings suggest that Fasudil might be a potential therapeutic agent for patients with viral myocarditis. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - November 28, 2018 Category: Cardiology Authors: Kezhi Dai,
Yaoyao Wang,
Sichao Tai,
Huajing Ni,
Hao Lian,
Yan Yu,
Weifang Liao,
Cheng Zheng,
Qing Chen,
Aarti Kuver,
Jia Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
The incidence of atrial fibrillation with trastuzumab treatment: A systematic review and meta ‐analysis
ConclusionsAtrial fibrillation incidence in breast cancer patients receiving trastuzumab was around 1.2%. It was not influenced by the formulation of trastuzumab, the additional use of neoplastic agents, anthracycline exposure status, or concurrent radiotherapy. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - November 28, 2018 Category: Cardiology Authors: Ming Yuan,
Gary Tse,
Zhiwei Zhang,
Xu Han,
William K. K. Wu,
Guangping Li,
Yunlong Xia,
Tong Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Upstream therapeutic strategies of valsartan and fluvastatin on hypertensive patients with non ‐permanent atrial fibrillation
ConclusionsCCB plus fluvastatin and valsartan can reduce the recurrence rate of non ‐permanent AF and to delay the progression from non‐permanent AF to permanent AF in patients with hypertension. The combined application of valsartan and fluvastatin is more effective than valsartan or CCB alone in the upstream therapies of AF. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - November 28, 2018 Category: Cardiology Authors: Zhiqiang Zhao,
Xiaowei Niu,
Zhaojie Dong,
Wenwei Qi,
Enzhao Liu,
Tong Liu,
Lifeng Li,
Yingzi Liang,
Guangping Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
The modifying effect of the MTHFR genotype on the association between folic acid supplementation and pulse wave velocity: Findings from the CSPPT
ConclusionIn a subgroup of Chinese hypertensive patients who had received 5 ‐year antihypertensive therapy, increases in folate status were associated with higher reductions in PWV, and individuals with the CC genotype showed greatest PWV response to folic acid supplementation. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - November 20, 2018 Category: Cardiology Authors: Xin Yang,
Minghua Zhang,
Rensheng Song,
Changfu Liu,
Yong Huo,
Geng Qian Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Role of IL ‐7 in Fusion of Rat Bone Marrow Mesenchymal Stem Cells with Cardiomyocytes in vitro and Improvement of Cardiac Function in vivo
ConclusionIL ‐7 is able to enhance the fusogenic properties of MSCs and improve cardiac function. This improvement may be attributed to the supportive action of IL‐7 on cell proliferation and cell survival contributing to the regeneration of damaged myocardium.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - November 19, 2018 Category: Cardiology Authors: Kanwal Haneef,
Anwar Ali,
Irfan Khan,
Nadia Naeem,
Siddiqua Jamall,
Asmat Salim Tags: Original Research Article Source Type: research
Effects of tranexamic acid on short ‐term and long‐term outcomes of on‐pump coronary artery bypass grafting: Randomized trial and 7‐year follow‐up
ConclusionsTranexamic acid significantly decreased postoperative bleeding and allogeneic transfusion in patients undergoing on ‐pump CABG. The 7‐year follow‐up suggested that the use of TXA was safe and might play a potential role in the prevention of long‐term myocardial infarction. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - November 16, 2018 Category: Cardiology Authors: Yu Zhang,
Xurong Gao,
Su Yuan,
Jingfei Guo,
Huanran Lv,
Yong Zhou,
Yuefu Wang,
Hongwen Ji,
Guyan Wang,
Lihuan Li,
Jia Shi Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
