Human cardiosphere-derived stromal cells exposed to SARS-CoV-2 evolve into hyper-inflammatory/pro-fibrotic phenotype and produce infective viral particles depending on the levels of ACE2 receptor expression
Conclusions Our findings indicate that cardiac stromal cells are susceptible to SARS-CoV-2 infection and produce variable viral yields depending on the extent of cellular ACE2 receptor expression. Interestingly, these cells also evolved towards hyper-inflammatory/pro-fibrotic phenotypes independently of ACE2 levels. Thus, SARS-CoV-2 infection of myocardial stromal cells could be involved in cardiac injury and explain the high number of complications observed in severe cases of COVID-19. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 10, 2021 Category: Cardiology Source Type: research
Damage control in broken heart: DNA damage response as a common path in arrhythmogenic cardiomyopathy
This editorial refers to ‘Haplo-insufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a Late-Onset Senescence-Associated pro-fibrotic cardiomyopathy’ by L. Rouhiet al., pp.2377 –2394. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 8, 2021 Category: Cardiology Source Type: research
Do sex hormones impact stress responses by modulating the cellular composition of the myocardium?
This editorial refers to ‘Cardiac cellularity is dependent upon biological sex and is regulated by gonadal hormones’ by G. T. Squierset al., pp. 2252 –2262. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 8, 2021 Category: Cardiology Source Type: research
Bad company: monocytes in HIV and atherosclerosis
This editorial refers to ‘Classical monocyte transcriptomes reveal significant anti-inflammatory statin effect in women with chronic HIV’ by E. Ehingeret al., pp.1166 –1177. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 6, 2021 Category: Cardiology Source Type: research
Sirtuin 5, vascular endothelium and fibrinolysis: a deadly embrace?
This editorial refers to ‘Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system’ by L. Liberaleet al., pp. 2275 –2288. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 5, 2021 Category: Cardiology Source Type: research
A biomarker for vascular calcification: shedding light on an unfinished story?
This editorial refers to ‘A combined microRNA and target protein-based panel for predicting the probability and severity of uremic vascular calcification: a translational study’ by C.T. Chaoet al., pp. 1958 –1973. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 5, 2021 Category: Cardiology Source Type: research
New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation
AbstractAtrial fibrillation (AF) is a common cardiac arrhythmia leading to many adverse outcomes and increased mortality. Yet the molecular mechanisms underlying AF remain largely unknown. Recent advances in high-throughput technologies make large-scale molecular profiling possible. In the past decade, multiomics studies of AF have identified a number of potential biomarkers of AF. In this review, we focus on the studies of multiomics profiles with AF risk. We summarize recent advances in the discovery of novel biomarkers for AF through multiomics studies. We also discuss limitations and future directions in risk assessmen...
Source: Cardiovascular Research - March 5, 2021 Category: Cardiology Source Type: research
Low-intensity pulsed ultrasound (LIPUS) in heart failure with preserved ejection fraction (HFpEF): lupus in fabula?
This editorial refers to ‘Low-intensity pulsed ultrasound ameliorates cardiac diastolic dysfunction in mice: a possible novel therapy for heart failure with preserved left ventricular ejection fraction’ by Y. Monmaet al., pp.1325 –1338. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 5, 2021 Category: Cardiology Source Type: research
A prickly situation: competitive antagonism by different hedgehog proteins
Deutsche Forschungsgemeinschaft (SFB1039/A6Cardio-Pulmonary InstituteEXC 2026390649896 (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 4, 2021 Category: Cardiology Source Type: research
Metformin again? Atheroprotection mediated by macrophage AMPK and ATF1
This editorial refers to ‘Metformin directly suppresses atherosclerosis in normoglycemic mice via haematopoietic Adenosine Monophosphate-Activated Protein Kinase (AMPK)’ by A. Seneviratneet al., pp.1295 –1308. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 3, 2021 Category: Cardiology Source Type: research
Illuminating Kir channel function in Anderson –Tawil syndrome
This editorial refers to ‘Impaired cytoplasmic domain interactions cause co-assembly defect and loss of function in the p.Glu293Lys KNCJ2 variant isolated from an Andersen–Tawil syndrome patient’, by S. Dériet al., pp. 1923 –1934. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 24, 2021 Category: Cardiology Source Type: research
Apolipoprotein B is an insufficient explanation for the risk of coronary disease associated with lipoprotein(a)
Lipoprotein(a) is a plasma lipoprotein composed of a low-density lipoprotein (LDL) particle linked to apolipoprotein(a). The risk of coronary artery disease (CAD) associated with lipoprotein(a) has been associated with both molar concentration and apolipoprotein(a) isoform size, which are inversely correlated properties and highly heritable.1 Similar to LDL, lipoprotein(a) harbours apolipoprotein B and is associated with increased risk of CAD. Apolipoprotein B is believed to be a key unifying feature of atherogenic lipoproteins.2 However, it is unclear to what extent non-apolipoprotein B-mediated mechanisms of lipoprotein(...
Source: Cardiovascular Research - February 24, 2021 Category: Cardiology Source Type: research
Scientists on the Spot: Repairing and restoring the heart
Cardiac repairRegenerationDevelopmentalEmbryonicEndogenous (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 24, 2021 Category: Cardiology Source Type: research
New trials in the scene of cardiovascular disease: innovation, controversy, and reassurance
EvinacumabLipid-loweringFish oilsOmega-3Fatty acids (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 22, 2021 Category: Cardiology Source Type: research
Corrigendum to: CD1d-dependent natural killer T cells attenuate angiotensin II-induced cardiac remodelling via IL-10 signalling in mice. Cardiovascular Research (2019) 115, 83 –93
This is a correction to: Cardiovascular Research, Volume 115, Issue 1, 1 January 2019, Pages 83 –93, doi:10.1093/cvr/cvy164. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 19, 2021 Category: Cardiology Source Type: research
