Vascular peroxidase 1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation, apoptosis resistance and migration
ConclusionCollectively, these results demonstrate that VPO1 promotes hypoxia-induced proliferation, apoptosis resistance, and migration in PASMCs via the NOX4/VPO1/HOCl/NF- κB signalling pathway. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 27, 2017 Category: Cardiology Source Type: research

CCR2 expression on circulating monocytes is associated with arterial wall inflammation assessed by 18F-FDG PET/CT in patients at risk for cardiovascular disease
ConclusionMonocyte CCR2 expression is associated with arterial wall inflammation in patients at increased cardiovascular risk. Our data warrant further studies to assess if inhibition of CCR2 may attenuate atherosclerotic plaque inflammation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2017 Category: Cardiology Source Type: research

Gender and cardiovascular disease: are sex-biased microRNA networks a driving force behind heart failure with preserved ejection fraction in women?
AbstractCardiovascular disease (CVD) is the primary cause of death among men and women worldwide. Nevertheless, our comprehension of how CVD progresses in women and elicits clinical outcomes is lacking, leading CVD to be under-diagnosed and under-treated in women. A clear example of this differential presentation of CVD pathophysiologies in females is the strikingly higher prevalence of heart failure with preserved ejection fraction (HFpEF). Women with a history of pre-eclampsia or those who present with co-morbidities such as obesity, hypertension, and diabetes mellitus are at increased risk of developing HFpEF. Long unde...
Source: Cardiovascular Research - November 24, 2017 Category: Cardiology Source Type: research

Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice
ConclusionThese data suggest a critical role for local sympathetic control of cardiac inflammation. Our model of myocardial sympathetic denervation in mice should prove useful to further dissect the molecular mechanisms underlying cardiac neural control. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2017 Category: Cardiology Source Type: research

Reversible Notch1 acetylation tunes proliferative signalling in cardiomyocytes
ConclusionThese results identify the reversible acetylation of Notch1 as a novel mechanism to modulate its signalling in the heart and tune the proliferative potential of cardiomyocytes. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2017 Category: Cardiology Source Type: research

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1
[Cardiovasc Res 2017;113(13):1664 –1676] (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 22, 2017 Category: Cardiology Source Type: research

Editorial highlights from Cardiovascular Research
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 22, 2017 Category: Cardiology Source Type: research

Editorial highlights from Cardiovascular Research
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 22, 2017 Category: Cardiology Source Type: research

Fighting residual cardiovascular risk in stable patients with atherosclerotic vascular disease: COMPASS in context
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 22, 2017 Category: Cardiology Source Type: research

In search for novel functions of adenosine 5 ′-triphosphate (ATP) in the heart
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 22, 2017 Category: Cardiology Source Type: research

Dr J érémy Fauconnier talks with Prof Göran K. Hansson
Dr J érémy Fauconnier: You have been associated with the Nobel Committee for several years. Can you give us a short summary of the different roles and tasks you have assumed? How has the work with the Nobel Committee influenced your scientific and academic career? (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 22, 2017 Category: Cardiology Source Type: research

Meox1 accelerates myocardial hypertrophic decompensation through Gata4
ConclusionMeox1 accelerated decompensation via the downstream target Gata4, at least in part directly. Meox1 and other foetal programme genes form a highly interconnected network, which offers multiple therapeutic entry points to dampen the aberrant expression of foetal genes and pathological hypertrophy. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2017 Category: Cardiology Source Type: research

Local production of tenascin-C acts as a trigger for monocyte/macrophage recruitment that provokes cardiac dysfunction
ConclusionsBy promoting a pro-inflammatory microenvironment and macrophage migration, TNC appears to be a key factor to enable the MO/M Φ accumulation within fibrotic hearts leading to cardiac dysfunction. As TNC is highly expressed during inflammation and sparsely during the steady state, its inhibition could be a promising therapeutic strategy to control inflammation and immune cell infiltration in heart disease. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 10, 2017 Category: Cardiology Source Type: research

qPCR —25 years old but still a matter of debate
This editorial refers to ‘Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart’ by C.E. Molinaet al., pp.247 –258. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 9, 2017 Category: Cardiology Source Type: research

Central and peripheral slow-pressor mechanisms contributing to Angiotensin II-salt hypertension in rats
ConclusionThese results suggest that in Ang II-high salt hypertension, MR-ENaC-AT1R signalling in the brain increases circulating aldosterone and endogenous ouabain, and arterial NCX1. These factors can amplify blood pressure responses to centrally-induced sympatho-excitation and thereby contribute to severe hypertension. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 8, 2017 Category: Cardiology Source Type: research

TUGging at heartstrings: control of aortic valve calcification by non-coding RNA
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 8, 2017 Category: Cardiology Source Type: research

Organotypic myocardial slices as model system to study heterocellular interactions
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 7, 2017 Category: Cardiology Source Type: research

Atheroprone flow activates inflammation via endothelial ATP-dependent P2X7-p38 signalling
ConclusionsThese findings reveal that P2X7 is regulated by shear forces leading to its accumulation at atheroprone sites that are exposed to disturbed patterns of blood flow. P2X7 promotes endothelial inflammation at atheroprone sites by transducing ATP signals into p38 activation. Thus P2X7 integrates vascular mechanical responses with purinergic signalling to promote endothelial dysfunction and may provide an attractive potential therapeutic target to prevent or reduce atherosclerosis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 6, 2017 Category: Cardiology Source Type: research

Transplantation of brown adipose tissue inhibits atherosclerosis in apoE −/− mice: contribution of the activated FGF-21-adiponectin axis
AbstractAimsBrown adipose tissue (BAT) has been identified as an endocrine organ that maintains metabolic homeostasis; however, the effects on atherosclerosis remain undefined. Here, we investigated the effect of experimental BAT transplantation on atherosclerosis.Methods and resultsInterscapular BAT was dissected from 12-week-old wild-type mice and transplanted into the visceral cavity of 12-week-oldapoE−/− mice. Oil-red O staining of whole aortas after 3 months of a high-cholesterol diet showed a significant decrease in atherosclerotic lesion area in BAT-transplanted mice by 20% compared with the sham control...
Source: Cardiovascular Research - November 2, 2017 Category: Cardiology Source Type: research

Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology
AbstractExtracellular vesicles (EVs) —particularly exosomes and microvesicles (MVs)—are attracting considerable interest in the cardiovascular field as the wide range of their functions is recognized. These capabilities include transporting regulatory molecules including different RNA species, lipids, and proteins through the extra cellular space including blood and delivering these cargos to recipient cells to modify cellular activity. EVs powerfully stimulate angiogenesis, and can protect the heart against myocardial infarction. They also appear to mediate some of the paracrine effects of cells, and have ther...
Source: Cardiovascular Research - November 2, 2017 Category: Cardiology Source Type: research

The generosity of the Cardiovascular Research community
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 27, 2017 Category: Cardiology Source Type: research

The generosity of the Cardiovascular Research community
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 27, 2017 Category: Cardiology Source Type: research

Peer review: (r)evolution needed
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 21, 2017 Category: Cardiology Source Type: research

High-density lipoprotein benefits beyond the cardiovascular system: a potential key role for modulating acquired immunity through cholesterol efflux
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 21, 2017 Category: Cardiology Source Type: research

Dr Niels Voigt talks with Dr Catherine Boileau, 2017 William Harvey Lecture of the European Society of Cardiology ‘PCSK9: a journey of discovery from genetics to clinical trials’
Check the interview here:https://youtu.be/ScNDvrkH7rg (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 21, 2017 Category: Cardiology Source Type: research

Cardiovascular Research On life talks with Dr Leonardo Sacconi, 2017 Outstanding Investigator award of the European Society of Cardiology council for Basic Cardiovascular Sciences
With this award, the ESC Council for Basic Cardiovascular Science (CBCS) honours two basic researchers with outstanding accomplishments in the early stage of their career. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 21, 2017 Category: Cardiology Source Type: research

Dr Jyoti Patel talks with Dr Oliver S öhnlein, 2017 outstanding investigator award of the European Society of Cardiology council for basic cardiovascular sciences
Check the interview here:https://youtu.be/Ke4H938MkH8 (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 21, 2017 Category: Cardiology Source Type: research

CaMKII blockade, cardiac conduction, and arrhythmia
We have read the study by Takanariet al.1 published inCardiovascular Research with interest, all the more so given that the reported results are in stark contrast with our own recent study.2 (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 20, 2017 Category: Cardiology Source Type: research

Loss of Protein Kinase Novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation, and exacerbated ischaemia-reperfusion injury
ConclusionLoss of PKN1in vivo significantly reduces endogenous cardioprotection and increases myocardial infarct size following I/R injury. Cardioprotection by PKN1 is associated with reduced CamKII δ-dependent PLB Thr17 phosphorylation at the SR and therefore may stabilize the coupling of SR Ca2+ handling and contractile function, independent of its kinase activity. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 16, 2017 Category: Cardiology Source Type: research

Therapeutic strategies utilizing SDF-1 α in ischaemic cardiomyopathy
AbstractHeart failure is rapidly increasing in prevalence and will redraw the global landscape for cardiovascular health. Alleviating and repairing cardiac injury associated with myocardial infarction (MI) is key to improving this burden. Homing signals mobilize and recruit stem cells to the ischaemic myocardium where they exert beneficial paracrine effects. The chemoattractant cytokine SDF-1 α and its associated receptor CXCR4 are upregulated after MI and appear to be important in this context. Activation of CXCR4 promotes both cardiomyocyte survival and stem cell migration towards the infarcted myocardium. These ef...
Source: Cardiovascular Research - October 13, 2017 Category: Cardiology Source Type: research

Both cardiomyocyte and endothelial cell Nox4 mediate protection against hemodynamic overload-induced remodelling
ConclusionsCardiomyocyte as well as endothelial cell Nox4 contributes to protection against chronic hemodynamic overload-induced cardiac remodelling, at least in part through common effects on myocardial capillary density. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2017 Category: Cardiology Source Type: research

Beyond the matrix: MMP2 as critical regulator of inflammation-mediated vascular dysfunction
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2017 Category: Cardiology Source Type: research

Luma is not essential for murine cardiac development and function
ConclusionOur data suggest that Luma is dispensable for murine cardiac development and function and that the Luma S358L mutation alone may not cause cardiomyopathy in mice. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 12, 2017 Category: Cardiology Source Type: research

Deficit in PINK1/PARKIN-mediated mitochondrial autophagy at late stages of dystrophic cardiomyopathy
ConclusionsOur results suggest faulty mitophagy in dystrophic hearts due to defects in the PINK1/PARKIN pathway. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 5, 2017 Category: Cardiology Source Type: research

Response to the letter from Warren et al.
With special attention, we have read the letter from Dr Warren and Dr Zaitsev. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 29, 2017 Category: Cardiology Source Type: research

Response to the letter from Warren et al.
With special attention, we have read the letter from Dr Warren and Dr Zaitsev. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 29, 2017 Category: Cardiology Source Type: research

IL-1R and MyD88 signalling in CD4+ T cells promote Th17 immunity and atherosclerosis
ConclusionWe demonstrate that both IL1R and MyD88 signalling in CD4+ T cells promote Th17 immunity, plaque growth and may regulate plaque collagen levels. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 28, 2017 Category: Cardiology Source Type: research

Spironolactone-induced degradation of the TFIIH core complex XPB subunit suppresses NF- κB and AP-1 signalling
ConclusionSPL has important anti-inflammatory effects independent of aldosterone and MR, not shared with EPL. Drug-induced, proteasome-dependent XPB degradation may be a useful therapeutic approach in cardiovascular diseases driven by inflammation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 27, 2017 Category: Cardiology Source Type: research

CD40L controls obesity-associated vascular inflammation, oxidative stress, and endothelial dysfunction in high fat diet-treated and db/db mice
ConclusionCD40L controls obesity-associated vascular inflammation, oxidative stress and endothelial dysfunction in mice and potentially humans. Thus, CD40L represents a therapeutic target in lipid metabolic disorders which is a leading cause in cardiovascular disease. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 26, 2017 Category: Cardiology Source Type: research

Avoiding phantasms
This editorial refers to ‘Hierarchical statistical techniques are necessary to draw reliable conclusions from analysis of isolated cardiomyocyte studies’ by M.B. Sikkelet al., pp.1743 –1752. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 26, 2017 Category: Cardiology Source Type: research

Physiological and pathological gestational cardiac hypertrophy: what can we learn from rodents?
(Source: Cardiovascular Research)
Source: Cardiovascular Research - September 26, 2017 Category: Cardiology Source Type: research

Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent
Cardiovasc Res 2016;111(4):410 –421] (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 23, 2017 Category: Cardiology Source Type: research

Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart
ConclusionsThe overall most stable reference genes across different heart cavities and disease conditions wereGAPDH, IPO8, POLR2A andPPIA.YWHAZ orGUSB could be added to this set for some specific experiments. This study should provide useful guidelines for reference gene selection in RT-qPCR studies in human heart. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 22, 2017 Category: Cardiology Source Type: research

Relevance of low miR-30c-5p levels in atherogenesis: a promising predictive biomarker and potential therapeutic target
This editorial refers to ‘miR-30c-5p regulates macrophage-mediated inflammation and pro-atherosclerosis pathways’ by G. Ceolottoet al., pp. 1627 –1638. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 22, 2017 Category: Cardiology Source Type: research

Cardiovascular Research turns the spotlight onto the right ventricle
This month ’s issue ofCardiovascular Research is dedicated to the right ventricle. As introduced by the guest editors, this has long been considered the ‘lesser’ ventricle. A PubMed search for ‘left ventricle’ (LV) shows 25 217 publications since 2010, whereas a search for ‘right ventricle’ (RV) results in 21 684 publications in the same time period. However, most documents include both terms, so if we compare the publications that e xclusively cover the ‘left ventricle’ we get 6 270 documents, and in contrast there are only 2 737 publication...
Source: Cardiovascular Research - September 20, 2017 Category: Cardiology Source Type: research

RNA in the spotlight: the dawn of RNA therapeutics in the treatment of human disease
Professor Konstantinos Stellos previously contributed to Cardiovascular Research OnLife14; more information on his work can be found athttp://www.stelloslab.com. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 20, 2017 Category: Cardiology Source Type: research

Dr Patrick Baeuerle, MPM Capital, talks with young scientists
Check the interview here: Opportunities for discovery research in industry and in the private sector (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 20, 2017 Category: Cardiology Source Type: research

Semaphorin-3E attenuates neointimal formation via suppressing VSMCs migration and proliferation
ConclusionOur study demonstrates that Sema3E/plexinD1 inhibits proliferation and migration of VSMCs via inactivation of Rap1-AKT signalling pathways. The mutual inhibition between PDGF-BB and Sema3E after vascular injury plays a critical role in the process of neointimal formation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 15, 2017 Category: Cardiology Source Type: research

Cardiac troponins: from myocardial infarction to chronic disease
AbstractElucidation of the physiologically distinct subunits of troponin in 1973 greatly facilitated our understanding of cardiac contraction. Although troponins are expressed in both skeletal and cardiac muscle, there are isoforms of troponin I/T expressed selectively in the heart. By exploiting cardiac-restricted epitopes within these proteins, one of the most successful diagnostic tests to date has been developed: cardiac troponin (cTn) assays. For the past decade, cTn has been regarded as the gold-standard marker for acute myocardial necrosis: the pathological hallmark of acute myocardial infarction (AMI). Whilst cTn i...
Source: Cardiovascular Research - September 14, 2017 Category: Cardiology Source Type: research

Female Clock Δ19/Δ19 mice are protected from the development of age-dependent cardiomyopathy
ConclusionsThese data demonstrate that ovarian hormones protect female ClockΔ19/Δ19 mice from the development of age-dependent cardiomyopathy even thoughClock function is disturbed. Understanding the interaction of biological sex and the circadian mechanism in cardiac growth, renewal and remodelling opens new doors for understanding and treating heart disease. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 12, 2017 Category: Cardiology Source Type: research