Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B
ConclusionsMalonyl-CoA-dependent inhibition of CPT1B plays a crucial role in regulating FAO rate in the heart. Chronic elevation of FAO has a relatively subtle impact on cardiac function at least under baseline conditions. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 9, 2018 Category: Cardiology Source Type: research

Co-administration of resveratrol with doxorubicin in young mice attenuates detrimental late-occurring cardiovascular changes
ConclusionWe have developed a juvenile mouse model of DOX-induced cardiotoxicity that displays no immediate overt physiological dysfunction; but, leads to an impaired ability of the heart to adapt to hypertension later in life. We also show that co-administration of resveratrol during DOX treatment was sufficient to normalize molecular markers of cardiotoxicity and restore the ability of the heart to undergo adaptive remodelling in response to hypertension later in life. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 6, 2018 Category: Cardiology Source Type: research

Human adipose mesenchymal stem cells overexpressing dual chemotactic gene showed enhanced angiogenic capacity in ischaemic hindlimb model
ConclusionOur data suggest that ASC-G/S has high therapeutic effects on hind limb ischaemia via robust angiogenic and vasculogenic action. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 5, 2018 Category: Cardiology Source Type: research

Maternal diet-induced obesity programmes cardiac dysfunction in male mice independently of post-weaning diet
AbstractAimsObesity during pregnancy increases risk of cardiovascular disease (CVD) in the offspring and individuals exposed to over-nutrition during fetal life are likely to be exposed to a calorie-rich environment postnatally. Here, we established the consequences of combined exposure to a maternal and post-weaning obesogenic diet on offspring cardiac structure and function using an established mouse model of maternal diet-induced obesity.Methods and resultsThe impact of the maternal and postnatal environment on the offspring metabolic profile, arterial blood pressure, cardiac structure, and function was assessed in 8-we...
Source: Cardiovascular Research - April 4, 2018 Category: Cardiology Source Type: research

PCSK9 regulates expression of scavenger receptors and ox-LDL uptake in macrophages
AbstractAimsProprotein convertase subtilisin/kexin type 9 (PCSK9) has been shown to influence macrophage biology and modulate atherogenesis. We conducted this study to examine the regulation of scavenger receptors (SRs) (LOX-1, SRA, and CD36) and oxidized liporoptein cholesterol (ox-LDL) uptake in macrophages by PCSK9.Methods and resultsTreatment of mouse peritoneal macrophages with tumour necrosis factor alpha (TNF- α) resulted in concentration-dependent modest, but significant, increase in PCSK9 expression. Importantly, treatment of TNF-α primed macrophages with recombinant murine PCSK9 increased the expressi...
Source: Cardiovascular Research - March 29, 2018 Category: Cardiology Source Type: research

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression
ConclusionBoth endothelial cell and macrophage BH4 play important roles in the regulation of NOS function and cellular redox signalling in atherosclerosis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 27, 2018 Category: Cardiology Source Type: research

A new strategy to decrease cardiac injury in aged heart following ischaemia-reperfusion: enhancement of the interaction between AMPK and SIRT1
This editorial refers to ‘Cardiomyocyte-specific deletion ofSirt1 gene sensitizes myocardium to ischaemia and reperfusion injury ’ by L. Wanget al., pp.805 –821. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 27, 2018 Category: Cardiology Source Type: research

Katie Thomas talks to Rory Collins, international leader in population and epidemiology studies in cardiovascular disease
Watch the interview here:https://youtu.be/cVy0jjJVhX0 (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 24, 2018 Category: Cardiology Source Type: research

Why we should reward peer reviewers
Dr. Pasquale Maffia received his B.Sc. (HONS) in Pharmacy in 1994, M.Phil. in Pharmacology in 1996 and Ph.D. in Pharmacology in 2000, all from the University of Naples Federico II (Italy), where he became Aggregate Professor of Pharmacology in 2006. He then joined the University of Strathclyde as a Lecturer in Integrative Mammalian Biology, before moving to the University of Glasgow where he is currently Senior Lecturer at the Institute of Infection, Immunity and Inflammation, and the BHF Centre of Excellence in Vascular Science and Medicine. He is the Senior Honours Immunology degree programme co-ordinator in Glasgow and ...
Source: Cardiovascular Research - March 24, 2018 Category: Cardiology Source Type: research

Reperfusion in the brain: is time important? The DAWN and DEFUSE-3 trials
Professor Tom Robinson is Head of the Department of Cardiovascular Sciences at the University of Leicester, National Specialty Lead for the National Institute for Health Research Clinical Research Network, and President of the British Association of Stroke Physicians. Professor Robinson works as a Stroke Physician, and his research focus is on clinical trials in acute stroke, particularly blood pressure and thrombolysis management, and studies of cardiovascular and cerebrovascular regulatory mechanisms. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 24, 2018 Category: Cardiology Source Type: research

FRET-ting about RhoA signalling in heart and vasculature: a new tool in our cardiovascular toolbox
Dr. Susann Bruche is a postdoctoral researcher at the University of Oxford and a Junior Research Fellow at Wolfson College. After graduating in Biochemistry at University of Leipzig, Germany, she studied adherens junction signalling at Imperial College London. She now investigates the role of alternative splicing in the regulation of epicardial activation and heart repair after myocardial infarction. Susann ’s academic achievements have been acknowledged with prestigious scholarships from organizations including of the German National Merit Foundation and the British Heart Foundation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 24, 2018 Category: Cardiology Source Type: research

Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension
ConclusionsUcn-2 levels are altered in human and experimental PAH. hUcn-2 treatment attenuates PAH and RV dysfunction in MCT-induced PH, has direct anti-remodelling effects on the pressure-overloaded RV, and improves pulmonary vascular function. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 23, 2018 Category: Cardiology Source Type: research

Identification of miR-9-5p as direct regulator of ABCA1 and HDL-driven reverse cholesterol transport in circulating CD14+ cells of patients with metabolic syndrome
ConclusionsWe identified the NF- κB target miR-9-5p as a negative regulator of ABCA1 adding a novel target pathway in the relationship between inflammation and HDL-driven reverse cholesterol transport for prevention or treatment of atherosclerosis in MS. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 23, 2018 Category: Cardiology Source Type: research

Cardioprotection – is no the answer? A renewed look at nitric oxide signalling in cardiomyocytes
This editorial refers to ‘Cardioprotection by ischemic postconditioning and cyclic guanosine monophosphate-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase’ by S. Frankenreiteret al., pp.822 –829. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 23, 2018 Category: Cardiology Source Type: research

Dietary fat is a key determinant in balancing mitochondrial dynamics in heart failure: a novel mechanism underlying the obesity paradox
This editorial refers to ‘Enhancing fatty acid utilization ameliorates mitochondrial fragmentation and cardiac dysfunction via rebalancing optic atrophy 1 processing in the failing heart’ by Y. Guoet al., pp. 979 –991. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 22, 2018 Category: Cardiology Source Type: research

Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis
ConclusionsAdult injury-induced reactivation of a cardiac-specificNkx2.5 enhancer element known to specifically mark myocardial progenitor cells during embryonic development does not reflect hypothesized embryonic cardiomyogenic properties. Our data suggest a decreasing plasticity of cardiac progenitor (-like) cell populations with increasing age. A re-expression of embryonic, stem or progenitor cell features in the adult heart must be interpreted very carefully with respect to the definition of cardiac resident progenitor cells. Albeit, the abundance of scar formation after cardiac injury suggests a potential to target pr...
Source: Cardiovascular Research - March 20, 2018 Category: Cardiology Source Type: research

Cardioprotection induced by a brief exposure to acetaldehyde: role of aldehyde dehydrogenase 2
ConclusionTaken together, our findings suggest that low levels of acetaldehyde are cardioprotective whereas high levels are damaging in anex vivo model of I/R injury and that ALDH2 is a major, but not the only, regulator of cardiac acetaldehyde levels and protection from I/R. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 20, 2018 Category: Cardiology Source Type: research

Sustained release of endothelial progenitor cell-derived extracellular vesicles from shear-thinning hydrogels improves angiogenesis and promotes function after myocardial infarction
ConclusionsEPC-derived EVs delivered into ischaemic myocardium via an injectable hydrogel enhanced peri-infarct angiogenesis and myocardial haemodynamics in a rat model of MI. The STG greatly increased therapeutic efficiency and efficacy of EV-mediated myocardial preservation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 16, 2018 Category: Cardiology Source Type: research

Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: evidence from fatty acid-binding protein-4 and -5 knockout mice
ConclusionsOur data suggest that glucose is preferentially utilized for biomass synthesis rather than ATP production during pressure-overload-induced cardiac hypertrophy and that the efficient supplementation of energy substrates may restore cardiac dysfunction caused by energy insufficiency. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 15, 2018 Category: Cardiology Source Type: research

MicroRNAs in cardiomyocyte differentiation and maturation
This editorial refers to ‘Integrated transcriptomic and regulatory network analyses identify microRNA-200c as a novel repressor of human pluripotent stem cell-derived cardiomyocyte differentiation and maturation’ by E.N.-y. Poonet al., pp.894 –906. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 15, 2018 Category: Cardiology Source Type: research

Taking the right ventricle to ‘task’ in pulmonary hypertension: role of TASK1/KCNK3 in RV dysfunction
This editorial refers to ‘Loss of KCNK3 is a hallmark of RV hypertrophy/dysfunction associated with pulmonary hypertension’ by M. Lambertet al., pp.880 –893. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 15, 2018 Category: Cardiology Source Type: research

Slit –Robo signalling in heart development
AbstractThe Slit ligands and their Robo receptors are well-known for their roles during axon guidance in the central nervous system but are still relatively unknown in the cardiac field. However, data from different animal models suggest a broad involvement of the pathway in many aspects of heart development, from cardiac cell migration and alignment, lumen formation, chamber formation, to the formation of the ventricular septum, semilunar and atrioventricular valves, caval veins, and pericardium. Absence of one or more of the genes in the pathway results in defects ranging from bicuspid aortic valves to ventricular septal...
Source: Cardiovascular Research - March 10, 2018 Category: Cardiology Source Type: research

Neuregulin-1 attenuates stress-induced vascular senescence
ConclusionsThis study is the first to explore the role of NRG-1 in vascular senescence. Our data demonstrate that NRG-1 markedly inhibits stress-induced premature senescence in vascular cellsin vitro and in the aorta of diabetic micein vivo. Consistently, deficiency in the NRG-1 receptor ErbB4 provokes cellular senescencein vitro as well asin vivo. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 8, 2018 Category: Cardiology Source Type: research

Cardiomyocyte binucleation is associated with aberrant mitotic microtubule distribution, mislocalization of RhoA and IQGAP3, as well as defective actomyosin ring anchorage and cleavage furrow ingression
ConclusionTaken together, these results indicate that naturally occurring cytokinesis failure in primary cardiomyocytes is due to an aberrant mitotic microtubule apparatus resulting in inefficient anchorage of the actomyosin ring to the plasma cell membrane. Thus, cardiomyocyte binucleation and division can be discriminated by the analysis of RhoA as well as IQGAP3 localization. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 7, 2018 Category: Cardiology Source Type: research

Loss of cardiac Wnt/ β-catenin signalling in desmoplakin-deficient AC8 zebrafish models is rescuable by genetic and pharmacological intervention
ConclusionOur data point to Wnt/ β-catenin as the final common pathway underlying different desmosomal AC forms and support the zebrafish as a suitable model for detecting early signalling pathways involved in the pathogenesis of DSP-associated diseases, possibly responsive to pharmacological or genetic rescue. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 7, 2018 Category: Cardiology Source Type: research

Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A
ConclusionThese results suggest that CPC-secreted exosomes may be more cardioprotective than BMC-secreted exosomes, and that PAPP-A –mediated IGF-1 release may explain the benefit. They illustrate a general mechanism whereby exosomes may function via an active protease on their surface, which releases a ligand in proximity to the transmembrane receptor bound by the ligand. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 5, 2018 Category: Cardiology Source Type: research

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness
This article aims t o compare and contrast the role of VSMCs in driving calcification in both atherosclerosis and in the vessel media focusing on the major drivers of calcification, including aging, uraemia, mechanical stress, oxidative stress, and inflammation. The review also discusses novel findings that have also b rought attention to specific pro- and anti-calcifying proteins, extracellular vesicles, mitochondrial dysfunction, and a uraemic milieu as major determinants of vascular calcification. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 5, 2018 Category: Cardiology Source Type: research

Smooth muscle cell and arterial aging: basic and clinical aspects
AbstractArterial aging engages a plethora of key signalling pathways that act in concert to induce vascular smooth muscle cell (VSMC) phenotypic changes leading to vascular degeneration and extracellular matrix degradation responsible for alterations of the mechanical properties of the vascular wall. This review highlights proof-of-concept examples of components of the extracellular matrix, VSMC receptors which connect extracellular and intracellular structures, and signalling pathways regulating changes in mechanotransduction and vascular homeostasis in aging. Furthermore, it provides a new framework for understanding how...
Source: Cardiovascular Research - March 5, 2018 Category: Cardiology Source Type: research

Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia –reperfusion
AbstractAimsMitochondrial creatine kinase (MtCK) couples ATP production via oxidative phosphorylation to phosphocreatine in the cytosol, which acts as a mobile energy store available for regeneration of ATP at times of high demand. We hypothesized that elevating MtCK would be beneficial in ischaemia –reperfusion (I/R) injury.Methods and resultsMice were created over-expressing the sarcomeric MtCK gene with αMHC promoter at theRosa26 locus (MtCK-OE) and compared with wild-type (WT) littermates. MtCK activity was 27% higher than WT, with no change in other CK isoenzymes or creatine levels. Electron microscopy con...
Source: Cardiovascular Research - March 2, 2018 Category: Cardiology Source Type: research

Enhancing fatty acid utilization ameliorates mitochondrial fragmentation and cardiac dysfunction via rebalancing optic atrophy 1 processing in the failing heart
ConclusionsThese findings demonstrate that enhancing FA utilization ameliorates mitochondrial fragmentation and cardiac dysfunction via rebalancing OPA1 processing in pressure overload-induced HF, suggesting a unique metabolic intervention approach to improving cardiac functions in HF. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 27, 2018 Category: Cardiology Source Type: research

HDAC4 regulates vascular inflammation via activation of autophagy
ConclusionThese results suggest that HDAC4-mediated FoxO3a acetylation regulates Ang II-induced autophagy activation, which in turn plays an essential role in causing vascular inflammation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 24, 2018 Category: Cardiology Source Type: research

Intramural clefts and structural discontinuities in Brugada syndrome: the missing gap?
This editorial refers to ‘Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome’ by A. Kellyet al., pp.724 –736. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 22, 2018 Category: Cardiology Source Type: research

Dr Jyoti Patel, ESC Scientist of Tomorrow, interviews Dr Eva Van Rooij
(Source: Cardiovascular Research)
Source: Cardiovascular Research - February 21, 2018 Category: Cardiology Source Type: research

Pushing the frontiers of cardiovascular biology
The Council for Basic Cardiovascular Science (CBCS), founded in 2004 with the mission to foster and support basic research in cardiovascular biology within the European Society of Cardiology (ESC), brought together ESC working groups and societies outside the ESC that shared a common interest in various aspects of cardiovascular biology and medicine. To pursue this aim CBCS with the continuous and generous support of the ESC since then has started a host of initiatives (https://www.escardio.org/Councils/Council-on-Basic-Cardiovascular-Science-(CBCS)). CBCS launched a biennial Summer School in Cardiovascular Biology and pro...
Source: Cardiovascular Research - February 21, 2018 Category: Cardiology Source Type: research

Bariatric surgery helps to reduce blood pressure - insights from GATEWAY trial
Jesper B äckdahl is a resident in Endocrinology and PhD student under the supervision of Mikael Rydén. Dr Bäckdahl holds a master degree in Public Health from the London School of Hygiene and Tropical Medicine. His research revolves around adipose tissue and its link to arterial stiffness and hypertension . (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 21, 2018 Category: Cardiology Source Type: research

The Secret of the Kissing Cousins: an ER-mitochondrial tethering protein regulates Ca2+ crosstalk in mammalian neurons
(Source: Cardiovascular Research)
Source: Cardiovascular Research - February 21, 2018 Category: Cardiology Source Type: research

The nerve of the spleen! Causing hypertension by placental growth factor
(Source: Cardiovascular Research)
Source: Cardiovascular Research - February 20, 2018 Category: Cardiology Source Type: research

Pathophysiological understanding of HFpEF: microRNAs as part of the puzzle
AbstractHalf of all heart failure patients have preserved ejection fraction (HFpEF). Comorbidities associated with and contributing to HFpEF include obesity, diabetes and hypertension. Still, the underlying pathophysiological mechanisms of HFpEF are unknown. A preliminary consensus proposes that the multi-morbidity triggers a state of systemic, chronic low-grade inflammation, and microvascular dysfunction, causing reduced nitric oxide bioavailability to adjacent cardiomyocytes. As a result, the cardiomyocyte remodels its contractile elements and fails to relax properly, causing diastolic dysfunction, and eventually HFpEF. ...
Source: Cardiovascular Research - February 16, 2018 Category: Cardiology Source Type: research

Non-genomic effects of nuclear receptors: insights from the anucleate platelet
AbstractNuclear receptors (NRs) have the ability to elicit two different kinds of responses,genomic andnon-genomic. Although genomic responses control gene expression by influencing the rate of transcription, non-genomic effects occur rapidly and independently of transcriptional regulation. Due to their anucleate nature and mechanistically well-characterized and rapid responses, platelets provide a model system for the study of any non-genomic effects of the NRs. Several NRs have been found to be present in human platelets, and multiple NR agonists have been shown to elicit anti-platelet effects by a variety of mechanisms....
Source: Cardiovascular Research - February 14, 2018 Category: Cardiology Source Type: research

Using light to fight atrial fibrillation
This editorial refers to ‘Optogenetic termination of atrial fibrillation in mice’ by T. Bruegmannet al., pp.713 –723. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 14, 2018 Category: Cardiology Source Type: research

Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart
ConclusionOur present study demonstrates that GGPPS-mediated protein geranylgeranylation plays an indispensable role in the ventricular chamber maturation and acts as a stage-specific signal to regulate the establishment of cardiac cytoarchitecture during mid-gestation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 12, 2018 Category: Cardiology Source Type: research

Vitamin D receptor restricts T helper 2-biased inflammation in the heart
ConclusionsVDR-deficiency contributes to the pathogenesis of myocarditis. To enhance the VDR expression in CD4+, T cells haves the therapeutic potential for the treatment of myocarditis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 12, 2018 Category: Cardiology Source Type: research

Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity
This study investigated the effects of geneticSirt3 deletion on arterial thrombosis in mice in an inflammatory setting and assessed the clinical relevance of these findings in patients with ST-elevation myocardial infarction (STEMI).Methods and resultsUsing a laser-induced carotid thrombosis model with lipopolysaccharide (LPS) challenge,in vivo time to thrombotic occlusion inSirt3−/− mice (n = 6) was reduced by half compared toSirt3+/+ wild-type (n = 8,P  
Source: Cardiovascular Research - February 10, 2018 Category: Cardiology Source Type: research

Cardioprotection by ischemic postconditioning and cyclic guanosine monophosphate-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase
ConclusionsThese findings demonstrate an important role of CM NO-GC for the cardioprotective signalling following AMIin vivo. CM NO-GC function is essential for the beneficial effects on infarct size elicited by iPost and pharmacological elevation of cGMP; however, lack of CM NO-GC does not seem to disrupt the cardioprotection mediated by the BK opener NS11021. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 9, 2018 Category: Cardiology Source Type: research

Can stress make you relax?
This editorial refers to ‘Stretch-induced compliance: a novel adaptive biological mechanism following acute cardiac load’ by A.M. Leite-Moreiraet al., pp.656 –667. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 9, 2018 Category: Cardiology Source Type: research

Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening
ConclusionsThe combination of three common comorbidities leads to systemic inflammation, myocardial oxidative stress, and coronary microvascular dysfunction, which associate with myocardial stiffening and LV diastolic dysfunction with preserved ejection fraction. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 8, 2018 Category: Cardiology Source Type: research

Biomechanical defects and rescue of cardiomyocytes expressing pathologic nuclear lamins
ConclusionsAFM and molecular modeling were able to quantify distinct biomechanical and structural defects inLMNA mutations E161K, D192G, and N195K and correlate the defects with clinical phenotypic severity. Improvements in cellular biomechanical phenotype was demonstrated and may represent a mechanism of action for p38 MAPK inhibition therapy that is now being used in human clinical trials to treat laminopathies. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 8, 2018 Category: Cardiology Source Type: research

Age-dependent increase in c-Jun N-terminal kinase-2 activity: does this help to understand Ca2+-calmodulin-dependent protein-kinase II-mediated atrial arrhythmogenesis in human atrial fibrillation?
This editorial refers to ‘Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium’ by X. Gaoet al., pp.737 –746. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 8, 2018 Category: Cardiology Source Type: research

Osteoglycin attenuates cardiac fibrosis by suppressing cardiac myofibroblast proliferation and migration through antagonizing lysophosphatidic acid 3/matrix metalloproteinase 2/epidermal growth factor receptor signalling
ConclusionThese findings suggest that OGN negatively regulates cardiac fibrotic remodelling by attenuating CMF proliferation and migration through LPA3-mediated and Rho/ROCK-dependent inhibition of MT1-MMP translocation, MMP2 activation and EGFR transactivation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 5, 2018 Category: Cardiology Source Type: research

Critical role of phosphodiesterase 2A in mouse congenital heart defects
ConclusionsWe demonstrated for the first time a direct relationship between Pde2A impairment and the onset of mouse congenital heart defects, highlighting a novel role for cAMP in cardiac development regulation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 2, 2018 Category: Cardiology Source Type: research