Impaired P2X signalling pathways in renal microvascular myocytes in genetic hypertension
Conclusions Our study unravels the cellular and molecular mechanisms of attenuation of P2XR-mediated preglomerular vasoconstriction that elevates glomerular susceptibility to harmful hypertensive pressures. This provides an important impetus towards understanding of the pathology of hypertensive renal injury. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 16, 2015 Category: Cardiology Authors: Gordienko, D., Povstyan, O., Sukhanova, K., Raphael, M., Harhun, M., Dyskina, Y., Lehen'kyi, V., Jama, A., Lu, Z.-L., Skryma, R., Prevarskaya, N. Tags: Integrative physiology and pathophysiology Source Type: research

Akt activation by PHLPP1 ablation prevents pathological hypertrophy by promoting angiogenesis
(Source: Cardiovascular Research)
Source: Cardiovascular Research - January 16, 2015 Category: Cardiology Authors: Li, M., Hirsch, E. Tags: EDITORIAL Source Type: research

Contents Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - January 16, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Editorial Board
(Source: Cardiovascular Research)
Source: Cardiovascular Research - January 16, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Cover Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - January 16, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Aims and Scope
(Source: Cardiovascular Research)
Source: Cardiovascular Research - January 16, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors
Conclusion The N-terminus domain constitutes an important structural determinant for the functional oligomerization of RyR2. Our findings are consistent with defective N-terminus self-association as a molecular mechanism underlying RyR2 channel deregulation in inherited arrhythmogenic cardiac disease. Significantly, the therapeutic action of dantrolene may occur via the restoration of normal RyR2 N-terminal intersubunit interactions. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Seidel, M., Lowri Thomas, N., Williams, A. J., Anthony Lai, F., Zissimopoulos, S. Tags: Ion channels and arrhythmias Source Type: research

FGFR1 mediates recombinant thrombomodulin domain-induced angiogenesis
Conclusion rTMD23 induced angiogenesis via FGFR1, a process that is independent of the APC pathway. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Kuo, C.-H., Sung, M.-C., Chen, P.-K., Chang, B.-I., Lee, F.-T., Cho, C.-F., Hsieh, T.-T., Huang, Y.-C., Li, Y.-H., Shi, G.-Y., Luo, C.-Y., Wu, H.-L. Tags: Vascular biology Source Type: research

Secretoneurin gene therapy improves hind limb and cardiac ischaemia in Apo E-/- mice without influencing systemic atherosclerosis
Conclusions SN gene therapy exerts beneficial effects in cardiovascular animal models in Apo E–/– mice without influencing atherosclerosis and might qualify as a promising therapy for cardiovascular disorders. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Theurl, M., Schgoer, W., Albrecht-Schgoer, K., Lener, D., Wolf, D., Wolf, M., Demetz, E., Tymoszuk, P., Tancevski, I., Fischer-Colbrie, R., Franz, W.-M., Marschang, P., Kirchmair, R. Tags: Vascular biology Source Type: research

Erk5 inhibits endothelial migration via KLF2-dependent down-regulation of PAK1
Conclusion Our data provide first evidence for existence of a previously unknown Erk5/KLF2/PAK1 axis, which may limit undesired cell migration in unperturbed endothelium and lower its sensitivity for migratory cues that promote vascular diseases including atherosclerosis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Komaravolu, R. K., Adam, C., Moonen, J.-R. A. J., Harmsen, M. C., Goebeler, M., Schmidt, M. Tags: Vascular biology Source Type: research

Identification of PI3K regulatory subunit p55{gamma} as a novel inhibitor of vascular smooth muscle cell proliferation and neointimal formation
Conclusion These findings mark p55 as a novel upstream regulator of the p53-p21 signalling pathway that negatively regulates VSMC proliferation, suggesting that malfunction of p55 may trigger vascular proliferative disorders. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Li, G., Xie, N., Yao, Y., Zhang, Y., Guo, J., Feng, Y., Lv, F., Xiao, R.-P., Cao, C.-M. Tags: Vascular biology Source Type: research

The role of the FPR2/ALX receptor in atherosclerosis development and plaque stability
Conclusion FPR2/ALX is proatherogenic due to effects on bone marrow-derived cells, but promoted a more stable plaque phenotype through effects on SMCs. Taken together, these results suggest a dual role of FPR2/ALX signalling in atherosclerosis by way of promoting disease progression and but increasing plaque stability. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Petri, M. H., Laguna-Fernandez, A., Gonzalez-Diez, M., Paulsson-Berne, G., Hansson, G. K., Back, M. Tags: Vascular biology Source Type: research

Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy
Conclusion Altogether, these findings demonstrate that autophagy is an adaptive response to antagonize Epac1-promoted cardiomyocyte hypertrophy. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Laurent, A.-C., Bisserier, M., Lucas, A., Tortosa, F., Roumieux, M., De Regibus, A., Swiader, A., Sainte-Marie, Y., Heymes, C., Vindis, C., Lezoualc'h, F. Tags: Cardiac biology and remodelling Source Type: research

Pharmacological inhibition of TGF{beta} receptor improves Nkx2.5 cardiomyoblast-mediated regeneration
Conclusion Pharmacological inhibition of TGFβ signalling improved cardiac function in injured mice and promoted the expansion and cardiomyogenic differentiation of Nkx2.5+ cardiomyoblasts. Direct modulation of resident cardiomyoblasts in vivo may be a promising strategy to enhance therapeutic cardiac regeneration. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Chen, W.-P., Liu, Y.-H., Ho, Y.-J., Wu, S. M. Tags: Cardiac biology and remodelling Source Type: research

Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts
Conclusions Nuclear transport changes related to increased export and decreased import are an early event in hypertrophic development. Hypertrophy can be prevented, or even reversed, by targeting import/export, which may open new therapeutic opportunities. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Chahine, M. N., Mioulane, M., Sikkel, M. B., O'Gara, P., Dos Remedios, C. G., Pierce, G. N., Lyon, A. R., Foldes, G., Harding, S. E. Tags: Cardiac biology and remodelling Source Type: research

Development of hypertrophic cardiomyopathy in perilipin-1 null mice with adipose tissue dysfunction
Conclusions Adipose tissue dysfunction may have deleterious effects on the heart and contribute to the development of hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy in Plin1–/– mice with adipose tissue dysfunction may mimic and mechanistically explain the cardiomyopathies occurring in two typical adipose tissue disorders in humans, lipodystrophy and obesity. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Liu, S., Geng, B., Zou, L., Wei, S., Wang, W., Deng, J., Xu, C., Zhao, X., Lyu, Y., Su, X., Xu, G. Tags: Cardiac biology and remodelling Source Type: research

Absence of the calcium-binding protein, S100A1, confers pulmonary hypertension in mice associated with endothelial dysfunction and apoptosis
Conclusion Our data demonstrate that the absence of S100A1 results in PH by disruption of its normal capacity to (i) enhance pulmonary EC function by induction of eNOS activity and NO levels via Akt/ERK1/2 pathways and (ii) promote EC survival. The ability of exogenously administered S100A1 to rescue this phenotype makes it an attractive therapeutic target in the treatment of PH. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Teichert-Kuliszewska, K., Tsoporis, J. N., Desjardins, J.-F., Yin, J., Wang, L., Kuebler, W. M., Parker, T. G. Tags: Integrative physiology and pathophysiology Source Type: research

Nuclear remodelling: a consequence of nucleocytoplasmic traffic run amok?
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Bossuyt, J. Tags: EDITORIALS Source Type: research

ALX-chemy: adding spice to the inflammatory soup of atherosclerosis
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Libby, P. Tags: EDITORIALS Source Type: research

Welcome to Cardiovascular Research in 2015
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Authors: Sipido, K. R., Holvoet, P., Janssens, S., Luttun, A., Sampaolesi, M. Tags: EDITORIALS Source Type: research

Guest Editors in 2014
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Tags: Guest Editors in 2014 Source Type: research

Core Reviewers
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Tags: List of Reviewers for 2014 Source Type: research

Super Reviewers
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Tags: List of Reviewers for 2014 Source Type: research

Contents Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Editorial Board
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Cover Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Aims and Scope
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 26, 2014 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Retraction of: abstract P71, In vitro and in vivo direct monitoring of miRNA-22 expression in isoproterenol-induced cardiac hypertrophy by bioluminescence imaging
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 25, 2014 Category: Cardiology Source Type: research

Retraction of: FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Dalla Costa, A. P., Clemente, C. F. M. Z., Carvalho, H. F., Carvalheira, J. B., Nadruz, W., Franchini, K. G. Tags: RETRACTION Source Type: research

LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms
Conclusion Distinct LQT1 mutations in KCNQ1 assembly domain decrease IKs using unique combinations of biophysical and trafficking mechanisms. Functional deficits in IKs observed in heterologous cells are mostly, but not completely, recapitulated in adult rat cardiomyocytes. A ‘methodological chain’ combining approaches in heterologous cells and cardiomyocytes provides mechanistic insights that may help advance personalized therapy for LQT1 mutations. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Aromolaran, A. S., Subramanyam, P., Chang, D. D., Kobertz, W. R., Colecraft, H. M. Tags: Ion channels and arrhythmias Source Type: research

Aggravation of cardiac myofibroblast arrhythmogeneicity by mechanical stress
Conclusions The findings demonstrate that both constitutive and strain-induced activity of MSCs in MFBs significantly enhance their depolarizing effect on electrotonically coupled CMCs. Ensuing aggravation of slow conduction may contribute to the precipitation of strain-related arrhythmias in fibrotically remodelled hearts. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Grand, T., Salvarani, N., Jousset, F., Rohr, S. Tags: Ion channels and arrhythmias Source Type: research

Intracellular NAMPT-NAD+-SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors
Conclusions These results demonstrate that intracellular NAMPT–NAD+–SIRT1 cascade improves post-ischaemic neovascularization. The modulation of Notch signalling may contribute to the enhanced post-ischaemic neovascularization. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Wang, P., Du, H., Zhou, C.-C., Song, J., Liu, X., Cao, X., Mehta, J. L., Shi, Y., Su, D.-F., Miao, C.-Y. Tags: Vascular biology Source Type: research

PKC{delta} is dispensible for oxLDL uptake and foam cell formation by human and murine macrophages
Conclusion PKC is dispensible for oxLDL uptake and foam cell formation by monocytes and macrophages. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Szilagyi, K., Meijer, A. B., Neele, A. E., Verkuijlen, P., Leitges, M., Dabernat, S., Forster-Waldl, E., Boztug, K., Belot, A., Kuijpers, T. W., Kraal, G., de Winther, M. P. J., van den Berg, T. K. Tags: Vascular biology Source Type: research

Hypotonic swelling promotes nitric oxide release in cardiac ventricular myocytes: impact on swelling-induced negative inotropic effect
Conclusions Our findings suggest a novel mechanism for NO release in cardiomyocytes with putative pathophysiological relevance determined, at least in part, by its capability to reduce the extent of contractile dysfunction associated with hypotonic swelling. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Gonano, L. A., Morell, M., Burgos, J. I., Dulce, R. A., De Giusti, V. C., Aiello, E. A., Hare, J. M., Vila Petroff, M. Tags: Cardiac biology and remodelling Source Type: research

Loss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes
Conclusion This study identifies a previously unknown function of Krox20 during heart valve development. These results indicate that Krox20-mediated activation of fibrillar Col1a1 and Col3a1 genes is crucial to avoid postnatal degeneration of the AoV leaflets. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Odelin, G., Faure, E., Kober, F., Maurel-Zaffran, C., Theron, A., Coulpier, F., Guillet, B., Bernard, M., Avierinos, J.-F., Charnay, P., Topilko, P., Zaffran, S. Tags: Cardiac biology and remodelling Source Type: research

FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry
Conclusion FGF10 regulates regional cardiomyocyte proliferation in the foetal heart through a FOXO3/p27kip1 pathway. In addition, FGF10 triggers cell-cycle re-entry of adult cardiomyocytes and is thus a potential target for cardiac repair. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Rochais, F., Sturny, R., Chao, C.-M., Mesbah, K., Bennett, M., Mohun, T. J., Bellusci, S., Kelly, R. G. Tags: Cardiac biology and remodelling Source Type: research

Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4
Conclusions In obese Type 2 diabetic mice, in the absence of hypoglycaemic effects, inhibition of DPP-4 decreases LV passive stiffness and improves global LV performance. These effects seem at least partially mediated by stimulatory effects on the myocardial cGMP–PKG pathway and, hence, on the phosphorylation status of titin and the hereto coupled cardiomyocyte stiffness modulus. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Hamdani, N., Hervent, A.-S., Vandekerckhove, L., Matheeussen, V., Demolder, M., Baerts, L., De Meester, I., Linke, W. A., Paulus, W. J., De Keulenaer, G. W. Tags: Cardiac biology and remodelling Source Type: research

E2F1 suppresses cardiac neovascularization by down-regulating VEGF and PlGF expression
Conclusion E2F1 limits cardiac neovascularization and functional recovery after MI by suppressing VEGF and PlGF up-regulation through p53-dependent and -independent mechanisms, respectively. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Wu, M., Zhou, J., Cheng, M., Boriboun, C., Biyashev, D., Wang, H., Mackie, A., Thorne, T., Chou, J., Wu, Y., Chen, Z., Liu, Q., Yan, H., Yang, Y., Jie, C., Tang, Y.-L., Zhao, T. C., Taylor, R. N., Kishore, R., Losordo, D. W., Qin, G. Tags: Cardiac biology and remodelling Source Type: research

ESC Working Group Cellular Biology of the Heart: Position Paper: improving the preclinical assessment of novel cardioprotective therapies
Ischaemic heart disease (IHD) remains the leading cause of death and disability worldwide. As a result, novel therapies are still needed to protect the heart from the detrimental effects of acute ischaemia–reperfusion injury, in order to improve clinical outcomes in IHD patients. In this regard, although a large number of novel cardioprotective therapies discovered in the research laboratory have been investigated in the clinical setting, only a few of these have been demonstrated to improve clinical outcomes. One potential reason for this lack of success may have been the failure to thoroughly assess the cardioprote...
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Lecour, S., Botker, H. E., Condorelli, G., Davidson, S. M., Garcia-Dorado, D., Engel, F. B., Ferdinandy, P., Heusch, G., Madonna, R., Ovize, M., Ruiz-Meana, M., Schulz, R., Sluijter, J. P. G., Van Laake, L. W., Yellon, D. M., Hausenloy, D. J. Tags: TOPICAL REVIEWS Source Type: research

Id proteins in the vasculature: from molecular biology to cardiopulmonary medicine
The inhibitors of differentiation (Id) proteins belong to the helix-loop-helix group of transcription factors and regulate cell differentiation and proliferation. Recent studies have reported that Id proteins play important roles in cardiogenesis and formation of the vasculature. We have also demonstrated that heritable pulmonary arterial hypertension (HPAH) patients have dysregulated Id gene expression in pulmonary artery smooth muscle cells. The interaction between bone morphogenetic proteins and other growth factors or cytokines regulates Id gene expression, which impacts on pulmonary vascular cell differentiation and p...
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Yang, J., Li, X., Morrell, N. W. Tags: TOPICAL REVIEWS Source Type: research

Cardiovascular Research as a forum for publications from China: present, past, and future
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Authors: Gal, D., Vandevelde, W., Cheng, H., Sipido, K. R. Tags: EDITORIAL Source Type: research

Contents Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Editorial Board
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Cover Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Aims and Scope
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2014 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Retraction of: abstract P134, Increased beta-adrenergic inotropy in ventricular myocardium from Trpm4 knockout mice
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 31, 2014 Category: Cardiology Authors: Kecskes, M., Mathar, I., Griet, J., Van Der Mieren, G., Voets, T., Herijgers, P., Vennekens, R. Tags: RETRACTION Source Type: research

Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc
Conclusions NaV1.5 and EB1 localization at the cell end is Cx43-dependent. Cx43 is part of a molecular complex that determines capture of the microtubule plus-end at the ID, facilitating cargo delivery. These observations link excitability and electrical coupling through a common molecular mechanism. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 31, 2014 Category: Cardiology Authors: Agullo-Pascual, E., Lin, X., Leo-Macias, A., Zhang, M., Liang, F.-X., Li, Z., Pfenniger, A., Lubkemeier, I., Keegan, S., Fenyo, D., Willecke, K., Rothenberg, E., Delmar, M. Tags: Ion channels and arrhythmias Source Type: research

The role of gap junctions in stretch-induced atrial fibrillation
Conclusion Gap junction modulators changed AF inducibility through their effects on atrial conduction, not by altering ERP. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 31, 2014 Category: Cardiology Authors: Ueda, N., Yamamoto, M., Honjo, H., Kodama, I., Kamiya, K. Tags: Ion channels and arrhythmias Source Type: research

SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation
Conclusion Rare SCN10A variants encoding Nav1.8 were identified in 6.6% of patients with early onset AF. In-vitro electrophysiological studies demonstrated profoundly altered function in 3/3 high-priority variants. Collectively, these data strongly support the hypothesis that rare SCN10A variants may contribute to AF susceptibility. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 31, 2014 Category: Cardiology Authors: Savio-Galimberti, E., Weeke, P., Muhammad, R., Blair, M., Ansari, S., Short, L., Atack, T. C., Kor, K., Vanoye, C. G., Olesen, M. S., LuCamp, , Yang, T., George, A. L., Roden, D. M., Darbar, D. Tags: Ion channels and arrhythmias Source Type: research

Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during {beta}-adrenergic stimulation in cardiac myocytes
Conclusions These data indicate the individual roles played by SERCA and troponin in Ca buffering during β-adrenergic stimulation and that these two buffers effectively counterbalance each other so that Ca buffering remains constant during β-adrenergic stimulation, a factor which may be physiologically important. This study also emphasizes the importance of taking into account Ca buffering, particularly in disease states where Ca binding to myofilaments or SERCA may be altered. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 31, 2014 Category: Cardiology Authors: Briston, S. J., Dibb, K. M., Solaro, R. J., Eisner, D. A., Trafford, A. W. Tags: Ion channels and arrhythmias Source Type: research