Melatonin: shining some light on pulmonary hypertension
This editorial refers to ‘Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension’, by J. Zhanget al., pp. 2156 –2169. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 24, 2020 Category: Cardiology Source Type: research
Standardizing translational microbiome studies and metagenomic analyses
This editorial refers to ‘Quantifying technical confounders in microbiome studies’ by T.U.P. Bartolomaeuset al., pp.863 –875. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2020 Category: Cardiology Source Type: research
Influenza-associated cardiac injury: a disease of the cardiac conduction system?
This editorial refers to ‘Human influenza A virus causes myocardial and cardiac-specific conduction system infections associated with early inflammation and premature death’, by D. Filgueiras-Ramaet al., pp.876 –889. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 18, 2020 Category: Cardiology Source Type: research
Corrigendum to: Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction
[Cardiovac Res 2020;doi:10.1093/cvr/cvaa088]. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 17, 2020 Category: Cardiology Source Type: research
Corrigendum to: The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2
[Cardiovasc Res 2020;116:1097 –1100]. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 17, 2020 Category: Cardiology Source Type: research
Long-term dual antithrombotic therapy (DAT): is it efficient and safe in women?
This editorial refers to ‘Efficacy and safety of rivaroxaban plus aspirin in women and men with chronic coronary or peripheral artery disease’, by Y. Lianget al., pp.942 –949. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 16, 2020 Category: Cardiology Source Type: research
Endothelium-restricted endothelin-1 overexpression in type 1 diabetes worsens atherosclerosis and immune cell infiltration via NOX1
ConclusionEndothelium ET-1 overexpression enhances the progression of atherosclerosis in type 1 diabetes, perivascular oxidative stress, and inflammation through NOX1. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 13, 2020 Category: Cardiology Source Type: research
Oestrogen receptors and T cells determine how sex affects aldosterone-induced hypertension
This editorial refers to ‘Aldosterone-induced hypertension is sex-dependent, mediated by T cells and sensitive to GPER activation’ by Q.N. Dinhet al., pp.960 –970. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 13, 2020 Category: Cardiology Source Type: research
Stretch-induced sarcoplasmic reticulum calcium leak is causatively associated with atrial fibrillation in pressure-overloaded hearts
ConclusionOur study demonstrated for the first time the increased SR Ca2+ leak mediated by enhanced oxidative stress in left atrial myocytes that is causatively associated with higher AF susceptibility in pressure-overloaded hearts. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 12, 2020 Category: Cardiology Source Type: research
Rare loss-of-function mutations of PTGIR are enriched in fibromuscular dysplasia
ConclusionsOur study shows that rare genetic mutations inPTGIR are enriched among FMD patients and found in SCAD patients, suggesting a role for prostacyclin signalling in non-atherosclerotic stenosis and dissection. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 12, 2020 Category: Cardiology Source Type: research
Therapeutic potential of adenosine kinase inhibition in vascular disease
This editorial refers to ‘Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation’ by Y. Wanget al., pp. 561 –575. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 12, 2020 Category: Cardiology Source Type: research
Altered atrial cytosolic calcium handling contributes to the development of postoperative atrial fibrillation
Conclusions Biochemical, functional, and modelling data implicate reduced SERCA-mediated Ca2+ reuptake into the SR as a major contributor to impaired preoperative atrial contractile function and to the pre-existing arrhythmogenic substrate in patients developing poAF. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 10, 2020 Category: Cardiology Source Type: research
Dilated cardiomyopathy-linked heat shock protein family D member 1 mutations cause up-regulation of reactive oxygen species and autophagy through mitochondrial dysfunction
ConclusionMutations inHSPD1 caused mitochondrial dysfunction and induced mitophagy. Mitochondrial dysfunction caused increased ROS and cardiac atrophy. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 10, 2020 Category: Cardiology Source Type: research
The long and winding road of cardiomyocyte maturation
AbstractKnowledge about the molecular mechanisms regulating cardiomyocyte (CM) proliferation and differentiation has increased exponentially in recent years. Such insights together with the availability of more efficient protocols for generation of CMs from induced pluripotent stem cells (iPSCs) have raised expectations for new therapeutic strategies to treat congenital and non-congenital heart diseases. However, the poor regenerative potential of the postnatal heart and the incomplete maturation of iPSC-derived CMs represent important bottlenecks for such therapies in future years. CMs undergo dramatic changes at the door...
Source: Cardiovascular Research - June 8, 2020 Category: Cardiology Source Type: research
Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart
AbstractIschaemic heart disease (IHD) is a complex disorder and a leading cause of death and morbidity in both men and women. Sex, however, affects several aspects of IHD, including pathophysiology, incidence, clinical presentation, diagnosis as well as treatment and outcome. Several diseases or risk factors frequently associated with IHD can modify cellular signalling cascades, thus affecting ischaemia/reperfusion injury as well as responses to cardioprotective interventions. Importantly, the prevalence and impact of risk factors and several comorbidities differ between males and females, and their effects on IHD developm...
Source: Cardiovascular Research - June 2, 2020 Category: Cardiology Source Type: research
