In vivo cardiac role of migfilin during experimental pressure overload
Conclusions Our findings indicate an important role of migfilin in the regulation of cardiac hypertrophy upon experimental TAC. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Haubner, B. J., Moik, D., Schuetz, T., Reiner, M. F., Voelkl, J. G., Streil, K., Bader, K., Zhao, L., Scheu, C., Mair, J., Pachinger, O., Metzler, B. Tags: Cardiac biology and remodelling Source Type: research

MicroRNA-150 protects the mouse heart from ischaemic injury by regulating cell death
Conclusion These findings reveal a pivotal role for miR-150 as a regulator of cardiomyocyte survival during cardiac injury. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Tang, Y., Wang, Y., Park, K.-m., Hu, Q., Teoh, J.-p., Broskova, Z., Ranganathan, P., Jayakumar, C., Li, J., Su, H., Tang, Y., Ramesh, G., Kim, I.-m. Tags: Cardiac biology and remodelling Source Type: research

NOD1, a new player in cardiac function and calcium handling
Conclusion Our data provide the first evidence that NOD1 activation induces cardiac dysfunction associated with excitation–contraction coupling impairment through NF-B activation and uncover a new pro-inflammatory player in the regulation of cardiovascular function. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Delgado, C., Ruiz-Hurtado, G., Gomez-Hurtado, N., Gonzalez-Ramos, S., Rueda, A., Benito, G., Prieto, P., Zaragoza, C., Delicado, E. G., Perez-Sen, R., Miras-Portugal, M. T., Nunez, G., Bosca, L., Fernandez-Velasco, M. Tags: Cardiac biology and remodelling Source Type: research

Emerging translational approaches to target STAT3 signalling and its impact on vascular disease
Acute and chronic inflammation responses characterize the vascular remodelling processes in atherosclerosis, restenosis, pulmonary arterial hypertension, and angiogenesis. The functional and phenotypic changes in diverse vascular cell types are mediated by complex signalling cascades that initiate and control genetic reprogramming. The signalling molecule's signal transducer and activator of transcription 3 (STAT3) plays a key role in the initiation and continuation of these pathophysiological changes. This review highlights the pivotal involvement of STAT3 in pathological vascular remodelling processes and discusses poten...
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Dutzmann, J., Daniel, J.-M., Bauersachs, J., Hilfiker-Kleiner, D., Sedding, D. G. Tags: REVIEWS Source Type: research

Peptidyl-prolyl isomerases: a full cast of critical actors in cardiovascular diseases
Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in multiple human tissues and regulate different cellular functions, e.g. calcium handling, protein folding, and gene expression. Moreover, these subfamilies have been shown to be consistently involved in several cardiac and vascular diseases including heart failure, arrhythmias, vascular stenosis, endothelial dysfunction, atherosclerosis, and hypertension. This review provid...
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Perrucci, G. L., Gowran, A., Zanobini, M., Capogrossi, M. C., Pompilio, G., Nigro, P. Tags: REVIEWS Source Type: research

Genetic background of Brugada syndrome is more complex than what we would like it to be!
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Abriel, H. Tags: EDITORIALS Source Type: research

IL-9: a new culprit in atherosclerosis?
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Taleb, S., Tedgui, A. Tags: EDITORIALS Source Type: research

Deadly tricks to combat atherosclerosis
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Temmerman, L., Biessen, E. A. L. Tags: EDITORIALS Source Type: research

Contents Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Editorial Board
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Cover Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Aims and Scope
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Systemic gene transfer enables optogenetic pacing of mouse hearts
Conclusions Gene transfer generates sufficient ChR2 photocurrent for reliable optogenetic pacing in vivo and lays out the basis for future optogenetic pacemaker and pain-free defibrillation therapies. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Vogt, C. C., Bruegmann, T., Malan, D., Ottersbach, A., Roell, W., Fleischmann, B. K., Sasse, P. Tags: Ion channels and arrhythmias Source Type: research

Chemokine receptors CXCR2 and CX3CR1 differentially regulate functional responses of bone-marrow endothelial progenitors during atherosclerotic plaque regression
Conclusion CXCR2 and CX3CR1 differentially regulate EPC functional responses during atheroregression. Our study improves understanding of how chemokines and chemokine receptors regulate plaque resolution, which could determine the effectiveness of interventions reducing complications of atherosclerosis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Herlea-Pana, O., Yao, L., Heuser-Baker, J., Wang, Q., Wang, Q., Georgescu, C., Zou, M.-H., Barlic-Dicen, J. Tags: Vascular biology Source Type: research

Increased atherosclerosis in P2Y13/apolipoprotein E double-knockout mice: contribution of P2Y13 to reverse cholesterol transport
Conclusion The P2Y13 receptor protects against atherosclerosis, primarily through its role in hepatobiliary RCT. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Lichtenstein, L., Serhan, N., Espinosa-Delgado, S., Fabre, A., Annema, W., Tietge, U. J. F., Robaye, B., Boeynaems, J.-M., Laffargue, M., Perret, B., Martinez, L. O. Tags: Vascular biology Source Type: research

PKC-{beta} activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis
Conclusion Our study unrevealed a new mechanism by which PKC-β activation promotes EC dysfunction caused by the de-regulation of the IL-18/IL-18BP pathway, leading to increased VCAM-1 expression, monocyte/macrophage adhesion, and accelerated atherosclerotic plaque formation in diabetes. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Durpes, M.-C., Morin, C., Paquin-Veillet, J., Beland, R., Pare, M., Guimond, M.-O., Rekhter, M., King, G. L., Geraldes, P. Tags: Vascular biology Source Type: research

Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice
Conclusion IDO-mediated Trp metabolism regulates vascular inflammation and plaque formation in hypercholesterolaemic Apoe–/– mice. Our data establish that this pathway plays a major role in the pathological process of atherogenesis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Polyzos, K. A., Ovchinnikova, O., Berg, M., Baumgartner, R., Agardh, H., Pirault, J., Gistera, A., Assinger, A., Laguna-Fernandez, A., Back, M., Hansson, G. K., Ketelhuth, D. F. J. Tags: Vascular biology Source Type: research

Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor {beta} signalling and angiogenesis
Conclusion These results indicate that SMOC1 is an ALK5 antagonist produced by endothelial cells that tips TGF-β signalling towards ALK1 activation, thus promoting endothelial cell proliferation and angiogenesis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Awwad, K., Hu, J., Shi, L., Mangels, N., Abdel Malik, R., Zippel, N., Fisslthaler, B., Eble, J. A., Pfeilschifter, J., Popp, R., Fleming, I. Tags: Vascular biology Source Type: research

Decreasing mitochondrial fission diminishes vascular smooth muscle cell migration and ameliorates intimal hyperplasia
Conclusions Mitochondrial fission is an integral process in cell migration, and controlling mitochondrial fission can limit VSMC migration and the pathological intimal hyperplasia by altering mitochondrial energetics and ROS levels. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Wang, L., Yu, T., Lee, H., O'Brien, D. K., Sesaki, H., Yoon, Y. Tags: Vascular biology Source Type: research

Targeted inhibition of ANKRD1 disrupts sarcomeric ERK-GATA4 signal transduction and abrogates phenylephrine-induced cardiomyocyte hypertrophy
Conclusion Our study reveals a novel role for ANKRD1 as a selective regulator of PE-induced signalling whereby ANKRD1 recruits and localizes GATA4 and ERK1/2 in a sarcomeric macro-molecular complex to enhance GATA4 phosphorylation with subsequent nuclear translocation of the ANKRD1 complex to induce hypertrophic gene expression. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Zhong, L., Chiusa, M., Cadar, A. G., Lin, A., Samaras, S., Davidson, J. M., Lim, C. C. Tags: Cardiac biology and remodelling Source Type: research

In vivo assessment of cardiac metabolism and function in the abdominal aortic banding model of compensated cardiac hypertrophy
Conclusion Hypertrophied hearts revealed little evidence of a switch towards increased glucose oxidation but rather an uncoupling of glycolytic metabolism from glucose oxidation. This was maintained under conditions of dietary stress provided by a WD but, at this compensated phase of hypertrophy, did not result in any contractile dysfunction. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Seymour, A.-M. L., Giles, L., Ball, V., Miller, J. J., Clarke, K., Carr, C. A., Tyler, D. J. Tags: Cardiac biology and remodelling Source Type: research

Distinct mPTP activation mechanisms in ischaemia-reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate
Conclusions Transient Ca2+/polyP-mediated mPTP opening during ischaemia may serve to protect cells against cytosolic Ca2+ overload, whereas ROS/pH-mediated sustained mPTP opening on reperfusion induces cell death. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Seidlmayer, L. K., Juettner, V. V., Kettlewell, S., Pavlov, E. V., Blatter, L. A., Dedkova, E. N. Tags: Cardiac biology and remodelling Source Type: research

Ischaemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria
In conclusion, these results suggest that SSM may be the preferential target of sarcolemmal signalling-derived post-translational protein modification (caveolae-derived eNOS/NO/SNO), thus providing an important role in IPC-induced cardioprotection. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Sun, J., Nguyen, T., Aponte, A. M., Menazza, S., Kohr, M. J., Roth, D. M., Patel, H. H., Murphy, E., Steenbergen, C. Tags: Cardiac biology and remodelling Source Type: research

Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart
Conclusions Syndecan-4 exerts a dual role in collagen cross-linking, one involving its cytosolic domain and NFAT signalling leading to collagen, OPN, and LOX induction in cardiac fibroblasts; the other involving the extracellular domain promoting LOX-dependent cross-linking. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Herum, K. M., Lunde, I. G., Skrbic, B., Louch, W. E., Hasic, A., Boye, S., Unger, A., Brorson, S.-H., Sjaastad, I., Tonnessen, T., Linke, W. A., Gomez, M. F., Christensen, G. Tags: Cardiac biology and remodelling Source Type: research

Oestrogen receptor alpha in pulmonary hypertension
Conclusion ERα is highly expressed in female hPASMCs from PAH patients and mediates oestrogen-induced proliferation of hPASMCs via mitogen-activated protein kinase and Akt signalling. Serotonin can increase ERα expression in hPASMCs and antagonism of ERα reverses serotonin-dependent PH in the mouse and increases BMPR2 expression. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Wright, A. F., Ewart, M.-A., Mair, K., Nilsen, M., Dempsie, Y., Loughlin, L., Maclean, M. R. Tags: Integrative physiology and pathophysiology Source Type: research

Good and bad consequences of altered fatty acid metabolism in heart failure: evidence from mouse models
The shift in substrate preference away from fatty acid oxidation (FAO) towards increased glucose utilization in heart failure has long been interpreted as an oxygen-sparing mechanism. Inhibition of FAO has therefore evolved as an accepted approach to treat heart failure. However, recent data indicate that increased reliance on glucose might be detrimental rather than beneficial for the failing heart. This review discusses new insights into metabolic adaptations in heart failure. A particular focus lies on data obtained from mouse models with modulations of cardiac FA metabolism at different levels of the FA metabolic pathw...
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Abdurrachim, D., Luiken, J. J. F. P., Nicolay, K., Glatz, J. F. C., Prompers, J. J., Nabben, M. Tags: REVIEWS Source Type: research

The role of high-density lipoproteins in the regulation of angiogenesis
Angiogenesis is important for postnatal physiological processes including tissue neovascularization in response to an ischaemic injury. Conversely, uncontrolled inflammatory-driven angiogenesis can accelerate atherosclerotic plaque and tumour growth. Angiogenesis-associated diseases are highly prevalent globally, with cardiovascular-related disorders and cancer being the leading causes of mortality worldwide. A vast amount of research has been conducted on the vasculoprotective effects of high-density lipoproteins (HDLs) and while current HDL-raising therapies to date have not yielded the desired benefits clinically, its r...
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Tan, J. T. M., Ng, M. K. C., Bursill, C. A. Tags: REVIEWS Source Type: research

Mitochondrias' sense of SNO: pathway to cardioprotection in ischaemic preconditioning
(Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Rassaf, T., Schulz, R. Tags: EDITORIALS Source Type: research

A step closer to cardiac optogenetics in vivo
(Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Entcheva, E. Tags: EDITORIALS Source Type: research

Syndecan-4: a novel regulator of collagen synthesis and deposition in the pressure-overloaded myocardium
(Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Yabluchanskiy, A., Ma, Y., Lindsey, M. L. Tags: EDITORIALS Source Type: research

Mitochondrial dynamics regulate neointima formation
(Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Fujiwara, K., Sheu, S.-S. Tags: EDITORIALS Source Type: research

Contents Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Editorial Board
(Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Cover Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Aims and Scope
(Source: Cardiovascular Research)
Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1
Conclusion Cardiac TRPC3 mediates Ca2+ and Na+ entry in proximity of NCX1, thereby elevating cellular Ca2+ levels and contractility. Excessive activation of TRPC3 is associated with transient cellular Ca2+ overload, spatial uncoupling between TRPC3 and NCX1, and arrhythmogenesis. We propose TRPC3-NCX micro/nanodomain communication as determinant of cardiac contractility and susceptibility to arrhythmogenic stimuli. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Doleschal, B., Primessnig, U., Wolkart, G., Wolf, S., Schernthaner, M., Lichtenegger, M., Glasnov, T. N., Kappe, C. O., Mayer, B., Antoons, G., Heinzel, F., Poteser, M., Groschner, K. Tags: Ion channels and arrhythmias Source Type: research

Dystrophic cardiomyopathy: role of TRPV2 channels in stretch-induced cell damage
Conclusion Together, these results establish the involvement of TRPV2 in a stretch-activated calcium influx pathway in dystrophic cardiomyopathy, contributing to the defective cellular Ca2+ handling in this disease. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Lorin, C., Vogeli, I., Niggli, E. Tags: Ion channels and arrhythmias Source Type: research

Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release
Conclusions Thus, our study offers the first evidence that nNav contribute to arrhythmogenic DCR, thereby providing a conceptual basis for mechanism-based antiarrhythmic therapy. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Radwałski, P. B., Brunello, L., Veeraraghavan, R., Ho, H.-T., Lou, Q., Makara, M. A., Belevych, A. E., Anghelescu, M., Priori, S. G., Volpe, P., Hund, T. J., Janssen, P. M. L., Mohler, P. J., Bridge, J. H. B., Poelzing, S., Gyorke, S. Tags: Ion channels and arrhythmias Source Type: research

miR-30e targets IGF2-regulated osteogenesis in bone marrow-derived mesenchymal stem cells, aortic smooth muscle cells, and ApoE-/- mice
Conclusion miR-30e represses the osteogenic program in MSCs and SMCs by targeting IGF2 and drives their differentiation into adipogenic or smooth muscle lineage, respectively. Our data suggest that down-regulation of miR-30e in aortas with age and atherosclerosis triggers vascular calcification. The miR-30e pathway plays an important regulatory role in vascular diseases. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Ding, W., Li, J., Singh, J., Alif, R., Vazquez-Padron, R. I., Gomes, S. A., Hare, J. M., Shehadeh, L. A. Tags: Vascular biology Source Type: research

Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca2+ entry via NOX1 and reactive oxygen species
Conclusion Our results suggest that low concentrations of SPC activate a PLC-coupled and NOX1-mediated increase in ROS, with consequent enhancement of voltage-gated Ca2+ entry and thus vasoreactivity. We speculate that this pathway is not specific for SPC, but may also contribute to vasoconstriction elicited by other G-protein coupled receptor and PLC-coupled agonists. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Shaifta, Y., Snetkov, V. A., Prieto-Lloret, J., Knock, G. A., Smirnov, S. V., Aaronson, P. I., Ward, J. P. T. Tags: Vascular biology Source Type: research

Adenosine derived from ecto-nucleotidases in calcific aortic valve disease promotes mineralization through A2a adenosine receptor
Conclusion Expression of NPP1 and 5'-nucleotidase by VICs promotes the mineralization of the aortic valve through A2aR and a cAMP/PKA/CREB pathway. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Mahmut, A., Boulanger, M.-C., Bouchareb, R., Hadji, F., Mathieu, P. Tags: Vascular biology Source Type: research

Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia
Conclusion Our results reveal that the high expression and function of Kv7 channels in the LCA and their down-regulation by diabetes critically determine the sensitivity to key regulators of coronary tone. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Morales-Cano, D., Moreno, L., Barreira, B., Pandolfi, R., Chamorro, V., Jimenez, R., Villamor, E., Duarte, J., Perez-Vizcaino, F., Cogolludo, A. Tags: Vascular biology Source Type: research

Early subcellular Ca2+ remodelling and increased propensity for Ca2+ alternans in left atrial myocytes from hypertensive rats
Conclusions In SHR, hypertension induces early subcellular LA myocyte Ca2+ remodelling during compensated LV hypertrophy. In basal conditions, atrial myocyte CaTs are not changed. At increased stimulation frequency, however, SHR atrial myocytes become more prone to arrhythmogenic Ca2+ alternans, suggesting a link between hypertension, atrial Ca2+ homeostasis, and development of atrial tachyarrhythmias. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Pluteanu, F., Hess, J., Plackic, J., Nikonova, Y., Preisenberger, J., Bukowska, A., Schotten, U., Rinne, A., Kienitz, M.-C., Schafer, M. K.- H., Weihe, E., Goette, A., Kockskamper, J. Tags: Cardiac biology and remodelling Source Type: research

Ageing is associated with deterioration of calcium homeostasis in isolated human right atrial myocytes
Aims Ageing-related cardiac disorders such as heart failure and atrial fibrillation often present with intracellular calcium homeostasis dysfunction. However, knowledge of the intrinsic effects of ageing on cellular calcium handling in the human heart is sparse. Therefore, this study aimed to analyse how ageing affects key mechanisms that regulate intracellular calcium in human atrial myocytes. Methods and results Whole membrane currents and intracellular calcium transients were measured in isolated human right atrial myocytes from 80 patients with normal left atrial dimensions and no history of atrial fibrillation. Patie...
Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Herraiz-Martinez, A., Alvarez-Garcia, J., Llach, A., Molina, C. E., Fernandes, J., Ferrero-Gregori, A., Rodriguez, C., Vallmitjana, A., Benitez, R., Padro, J. M., Martinez-Gonzalez, J., Cinca, J., Hove-Madsen, L. Tags: Cardiac biology and remodelling Source Type: research

Dual developmental role of transcriptional regulator Ets1 in Xenopus cardiac neural crest vs. heart mesoderm
Conclusion Our study shows that Ets1 is required in both the cardiac NC and heart mesoderm, albeit for different aspects of heart formation. Our results reinforce the suggestion that proper interaction between these tissues is critical for normal heart development. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Nie, S., Bronner, M. E. Tags: Cardiac biology and remodelling Source Type: research

Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves
Conclusion Cardiac defects in mutants for Robo or Slit range from membranous ventricular septum defects to bicuspid aortic valves. These ligands and receptors have unique functions during development of specific cardiac cushion derivatives, and the Slit-Robo signalling pathway likely enforces its role by regulating Notch signalling, making these mutants a valuable new model to study cardiac valve formation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Mommersteeg, M. T. M., Yeh, M. L., Parnavelas, J. G., Andrews, W. D. Tags: Cardiac biology and remodelling Source Type: research

Impaired myocardial development resulting in neonatal cardiac hypoplasia alters postnatal growth and stress response in the heart
Conclusion Impaired prenatal development leading to neonatal cardiac hypoplasia alters postnatal cardiac growth and stress response in vivo, thereby linking foetal programming to organ size control in the heart. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Drenckhahn, J.-D., Strasen, J., Heinecke, K., Langner, P., Yin, K. V., Skole, F., Hennig, M., Spallek, B., Fischer, R., Blaschke, F., Heuser, A., Cox, T. C., Black, M. J., Thierfelder, L. Tags: Cardiac biology and remodelling Source Type: research

Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice
Conclusion Lack of colVIII reduces myofibroblast differentiation and fibrosis and promotes early mortality and LV dilatation in response to pressure overload in mice. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Skrbic, B., Engebretsen, K. V. T., Strand, M. E., Lunde, I. G., Herum, K. M., Marstein, H. S., Sjaastad, I., Lunde, P. K., Carlson, C. R., Christensen, G., Bjornstad, J. L., Tonnessen, T. Tags: Cardiac biology and remodelling Source Type: research

Fibroblast growth factor 21 protects the heart from oxidative stress
Conclusion Our data indicate that Fgf21 regulates genes involved in antioxidant pathways in an autocrine manner, thus preventing ROS production in cardiac cells. Therefore, Fgf21 acts as an antioxidant factor in the heart, preventing induction of pro-oxidative pathways by inflammatory or hypertrophic conditions. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Planavila, A., Redondo-Angulo, I., Ribas, F., Garrabou, G., Casademont, J., Giralt, M., Villarroya, F. Tags: Cardiac biology and remodelling Source Type: research

Microengineering in cardiovascular research: new developments and translational applications
Microfluidic, cellular co-cultures that approximate macro-scale biology are important tools for refining the in vitro study of organ-level function and disease. In recent years, advances in technical fabrication and biological integration have provided new insights into biological phenomena, improved diagnostic measurements, and made major steps towards de novo tissue creation. Here we review applications of these technologies specific to the cardiovascular field, emphasizing three general categories of use: reductionist vascular models, tissue-engineered vascular models, and point-of-care diagnostics. With continued progr...
Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Chan, J. M., Wong, K. H. K., Richards, A. M., Drum, C. L. Tags: REVIEW Source Type: research