Correction to: HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome
[Cardiovasc Res 2013;99:44 –54] (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 9, 2020 Category: Cardiology Source Type: research
Protection from cardiotoxicity of cancer chemotherapy: a novel target for remote ischaemic conditioning?
This editorial refers to ‘Remote ischaemic preconditioning ameliorates anthracycline-induced cardiotoxicity and preserves mitochondrial integrity’ by C. Galán-Arriolaet al., pp.1132 –1143. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 8, 2020 Category: Cardiology Source Type: research
Lose the helpers … get ‘remote’ regulators!
This editorial refers to ‘Follicular regulatory helper T cells control the response of regulatory B cells to a high-cholesterol diet’, F. Burgeret al., pp.743 –755. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 8, 2020 Category: Cardiology Source Type: research
Tackling myocardial oxidative stress with empagliflozin: are we big enough to fight heart failure with preserved ejection fraction?
This editorial refers to ‘Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation’, by D. Kolijnet al., pp. 495 –507. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 8, 2020 Category: Cardiology Source Type: research
Risk factors for myocardial injury and death in patients with COVID-19: insights from a cohort study with chest computed tomography
ConclusionsAn increased PA diameter, as assessed by chest CT, is an independent risk factor for myocardial injury and mortality in patients with COVID-19. Myocardial injury is independently associated with an approximately two-fold increased risk of death. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 8, 2020 Category: Cardiology Source Type: research
Class switching and high-affinity immunoglobulin G production by B cells is dispensable for the development of hypertension in mice
Conclusions These results suggest that B cells and serum immunoglobulins do not play a causal role in hypertension pathology. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 1, 2020 Category: Cardiology Source Type: research
Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: a prospective, placebo-controlled randomized trial (EVAPORATE): interim results
ConclusionEVAPORATE is the first study using CCTA to evaluate the effects of IPE as an adjunct to statin therapy on atherosclerotic plaque characteristics in a high-risk CV population with persistently high triglyceride levels. It provides important mechanistic data in regards to the reduction in CV events in the REDUCE-IT clinical trial.ClinicalTrials. govIdentifierNCT029226027. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 1, 2020 Category: Cardiology Source Type: research
Ex vivo Ikk β ablation rescues the immunopotency of mesenchymal stromal cells from diabetics with advanced atherosclerosis
ConclusionsConstitutively active IKK β reduces the immunopotency of atherosclerosis+T2DM MSC by changing their secretome composition. Modulation of IKKβ in atherosclerosis+T2DM MSCs enhances their myocardial repair ability. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 1, 2020 Category: Cardiology Source Type: research
T cell aging in hypertension
This editorial refers to ‘T cell senescence accelerates angiotensin II-induced target organ damage’, by X.-X. Panet al., pp. 271 –283. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 1, 2020 Category: Cardiology Source Type: research
Remote ischaemic preconditioning ameliorates anthracycline-induced cardiotoxicity and preserves mitochondrial integrity
ConclusionIn a translatable large-animal model of AIC, RIPC applied immediately before each doxorubicin injection resulted in preserved cardiac contractility with significantly higher long-term LVEF and less cardiac fibrosis. RIPC prevented mitochondrial fragmentation and dysregulated autophagy from AIC early stages. RIPC is a promising intervention for testing in clinical trials in AIC. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 29, 2020 Category: Cardiology Source Type: research
Single-cell RNA sequencing reveals cell type- and artery type-specific vascular remodelling in male spontaneously hypertensive rats
ConclusionOur findings provide the first cell landscape of resistant and conductive arteries in hypertensive animal models. Moreover, it also offers a systematic characterization of the dysregulated gene profiles with unbiased, artery type-specific and cell type-specific manners during hypertensive vascular remodelling. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 26, 2020 Category: Cardiology Source Type: research
‘Social distancing’ of the neuronal nitric oxide synthase from its adaptor protein causes arrhythmogenic trigger-substrate interactions in long QT syndrome
This editorial refers to ‘NOS1AP polymorphisms reduce NOS1 activity and interact with prolonged repolarization in arrhythmogenesis’ by C. Ronchiet al., pp. 472 –483. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 26, 2020 Category: Cardiology Source Type: research
Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase
ConclusionMetformin activates a conserved AMPK-ATF1-M2-like pathway in mouse and human macrophages, and results in highly suppressed atherogenesis in hyperlipidaemic mice via haematopoietic AMPK. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 25, 2020 Category: Cardiology Source Type: research
Tissue-selective endothelial arousal revealed by vascular endothelial growth factor gene transfer
This editorial refers to ‘Genetic lineage tracing reveals poor angiogenic potential of cardiac endothelial cells’, by T. Kocijanet al., pp. 256 –270. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 25, 2020 Category: Cardiology Source Type: research
I ’m pickin’ up good dilations
This editorial refers to ‘Failure to vasodilate in response to salt loading blunts renal blood flow and causes salt-sensitive hypertension’ by J. Wuet al., pp. 308 –319. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 25, 2020 Category: Cardiology Source Type: research
