Human epicardial cell-conditioned medium contains HGF/IgG complexes that phosphorylate RYK and protect against vascular injury
Conclusion Early treatment with HGF/IgG complexes after myocardial ischaemia with reperfusion may rescue tissue through vasoprotection conferred by c-Met and RYK signalling. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Authors: Rao, K. S., Aronshtam, A., McElory-Yaggy, K. L., Bakondi, B., VanBuren, P., Sobel, B. E., Spees, J. L. Tags: Vascular biology Source Type: research

Slit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle via reduced eNOS activity
Conclusion Combining Slit2 with VEGFs adjusts VEGFR2-mediated angiogenic effects into a more physiological direction. This possibly allows the use of higher VEGF vector doses to achieve a more widespread vector and VEGF distribution in the target tissues leading to a better therapeutic outcome while reducing excess vascular permeability. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Authors: Nieminen, T., Toivanen, P. I., Laakkonen, J. P., Heikura, T., Kaikkonen, M. U., Airenne, K. J., Yla-Herttuala, S. Tags: Vascular biology Source Type: research

MAb therapy against the IFN-{alpha}/{beta} receptor subunit 1 stimulates arteriogenesis in a murine hindlimb ischaemia model without enhancing atherosclerotic burden
Conclusion Monoclonal anti-IFNAR1 therapy during a 4-week treatment period stimulates collateral artery growth in mice and did not enhance atherosclerotic burden. This is the first reported successful strategy using MAbs to stimulate arteriogenesis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Authors: Teunissen, P. F. A., Boshuizen, M. C., Hollander, M. R., Biesbroek, P. S., van der Hoeven, N. W., Mol, J.-Q., Gijbels, M. J., van der Velden, S., van der Pouw Kraan, T. C., Horrevoets, A. J., de Winther, M. P., van Royen, N. Tags: Vascular biology Source Type: research

Combination therapy with remote ischaemic conditioning and insulin or exenatide enhances infarct size limitation in pigs
Conclusions GIK and exenatide activate cardioprotective pathways different from those of RIC, and have additive effects with RIC on infarct size reduction in pigs. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Authors: Alburquerque-Bejar, J. J., Barba, I., Inserte, J., Miro-Casas, E., Ruiz-Meana, M., Poncelas, M., Vilardosa, U., Valls-Lacalle, L., Rodriguez-Sinovas, A., Garcia-Dorado, D. Tags: Cardiac biology and remodelling Source Type: research

AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism
Aims AMP-activated protein kinase (AMPK) is thought to be a central player in regulating myocardial metabolism and its activation has been shown to inhibit cardiac hypertrophy. Recently, mice with muscle-specific deletion of AMPK β1/β2 subunits (AMPKβ1β2-deficient mice, β1β2M-KO) have been generated and possess
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Authors: Sung, M. M., Zordoky, B. N., Bujak, A. L., Lally, J. S. V., Fung, D., Young, M. E., Horman, S., Miller, E. J., Light, P. E., Kemp, B. E., Steinberg, G. R., Dyck, J. R. B. Tags: Cardiac biology and remodelling Source Type: research

Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model
Conclusion Treatment of mice with an AT1R biased ligand, acting via β-arrestin signalling, is able to induce an increase in cardiac contractility associated with an increase in ventricular myosin light chain-2 phosphorylation. AT1R biased ligands may prove to be a novel inotropic approach in familial DCM. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Authors: Tarigopula, M., Davis, R. T., Mungai, P. T., Ryba, D. M., Wieczorek, D. F., Cowan, C. L., Violin, J. D., Wolska, B. M., Solaro, R. J. Tags: Cardiac biology and remodelling Source Type: research

Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers
Conclusion Nebulette is dispensable for normal cardiac function, although Z-line widening and up-regulation of cardiac stress markers were found in nebl–/– heart. These results suggest that the nebulette disease causing mutations have dominant gain-of-function effects. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Authors: Mastrototaro, G., Liang, X., Li, X., Carullo, P., Piroddi, N., Tesi, C., Gu, Y., Dalton, N. D., Peterson, K. L., Poggesi, C., Sheikh, F., Chen, J., Bang, M.-L. Tags: Cardiac biology and remodelling Source Type: research

SH2B1 is critical for the regulation of cardiac remodelling in response to pressure overload
Conclusion Taken together, our data demonstrate, for the first time, that SH2B1 is a key positive mediator of pathological cardiac hypertrophy, and that it primarily acts by regulating JAK2/STAT3 signalling. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Authors: Wu, G., Liu, Y., Huang, H., Tang, Y., Liu, W., Mei, Y., Wan, N., Liu, X., Huang, C. Tags: Cardiac biology and remodelling Source Type: research

Stimulating arteriogenesis but not atherosclerosis: IFN-{alpha}/{beta} receptor subunit 1 as a novel therapeutic target
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Authors: Cochain, C., Zernecke, A. Tags: INVITED EDITORIALS Source Type: research

SH2B1: a new player in the regulation of cardiac hypertrophic response in failing hearts
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Authors: Ikeda, Y., Takimoto, E., Komuro, I. Tags: INVITED EDITORIALS Source Type: research

Contents Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Editorial Board
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Cover Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Aims and Scope
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII
Conclusion Late INa exerts distinct effects on Ca2+ homeostasis in atrial myocardium through activation of CaMKII and PKA. Inhibition of late INa represents a potential approach to attenuate CaMKII activation and decreases SR-Ca2+-leak in atrial rhythm disorders. The interconnection with the cAMP/PKA system further increases the antiarrhythmic potential of late INa inhibition. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Fischer, T. H., Herting, J., Mason, F. E., Hartmann, N., Watanabe, S., Nikolaev, V. O., Sprenger, J. U., Fan, P., Yao, L., Popov, A.-F., Danner, B. C., Schondube, F., Belardinelli, L., Hasenfuss, G., Maier, L. S., Sossalla, S. Tags: Ion channels and arrhythmias Source Type: research

Stochastic spontaneous calcium release events trigger premature ventricular complexes by overcoming electrotonic load
Aims Premature ventricular complexes (PVCs) due to spontaneous calcium (Ca) release (SCR) events at the cell level can precipitate ventricular arrhythmias. However, the mechanistic link between SCRs and PVC formation remains incompletely understood. The aim of this study was to investigate the conditions under which delayed afterdepolarizations resulting from stochastic subcellular SCR events can overcome electrotonic source–sink mismatch, leading to PVC initiation. Methods and results A stochastic subcellular-scale mathematical model of SCR was incorporated in a realistic model of the rabbit ventricles and Purkinje...
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Campos, F. O., Shiferaw, Y., Prassl, A. J., Boyle, P. M., Vigmond, E. J., Plank, G. Tags: Ion channels and arrhythmias Source Type: research

A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia
Conclusion The findings demonstrate that human R25C-PLN is associated with super-inhibition of SERCA2a and Ca2+ transport as well as increased SR Ca2+ leak, promoting arrhythmogenesis under stress conditions. This is the first mechanistic evidence that increased PLN inhibition may impact both SR Ca2+ uptake and Ca2+ release activities and suggests that the human R25C-PLN may be a prognostic factor for increased ventricular arrhythmia risk in DCM carriers. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Liu, G.-S., Morales, A., Vafiadaki, E., Lam, C. K., Cai, W.-F., Haghighi, K., Adly, G., Hershberger, R. E., Kranias, E. G. Tags: Ion channels and arrhythmias Source Type: research

Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis
Conclusion The minimal binding domains of Notch ligands are sufficient to interfere with Notch signalling. The corresponding soluble Notch1 EGF11-13 peptide binds stronger to inhibitory Notch ligands and thereby promotes Notch signalling in endothelial cells. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Klose, R., Berger, C., Moll, I., Adam, M. G., Schwarz, F., Mohr, K., Augustin, H. G., Fischer, A. Tags: Vascular biology Source Type: research

Context-specific interactions between Notch and ALK1 cannot explain ALK1-associated arteriovenous malformations
Conclusion Control of Notch targets in arterial endothelium is context-dependent, with gene-specific and region-specific requirements for Notch and Alk1. Alk1 is not required for arterial identity, and perturbations in Notch signalling cannot account for alk1 mutant-associated AVMs. These data suggest that AVMs associated with ALK1 mutation are not caused by defective arterial specification or altered Notch signalling. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Rochon, E. R., Wright, D. S., Schubert, M. M., Roman, B. L. Tags: Vascular biology Source Type: research

Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation
Conclusion ISM is a novel VP inducer that functions through cell-surface GRP78-mediated Src activation as well as induction of apoptosis. It induces a direct GRP78-Src interaction, leading to cytoplasmic Src activation. ISM contributes to pulmonary vascular hyperpermeability of LPS-induced ALI in mice. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Venugopal, S., Chen, M., Liao, W., Er, S. Y., Wong, W.-S. F., Ge, R. Tags: Vascular biology Source Type: research

Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats
Conclusion Circulating mtDNA and impaired deoxyribonuclease activity may lead to the activation of the innate immune system, via TLR9, and contribute to elevated arterial pressure and vascular dysfunction in SHR. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: McCarthy, C. G., Wenceslau, C. F., Goulopoulou, S., Ogbi, S., Baban, B., Sullivan, J. C., Matsumoto, T., Webb, R. C. Tags: Vascular biology Source Type: research

Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs
Conclusions BMP4 acts downstream of HIF-1 and mediates hypoxia-induced up-regulation of TRPC, leading to increased basal [Ca2+]i in PASMCs, promoting CHPH pathogenesis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Wang, J., Fu, X., Yang, K., Jiang, Q., Chen, Y., Jia, J., Duan, X., Wang, E. W., He, J., Ran, P., Zhong, N., Semenza, G. L., Lu, W. Tags: Vascular biology Source Type: research

Regulatory T cells in human and angiotensin II-induced mouse abdominal aortic aneurysms
This study tested whether AAA patients are Treg-insufficient and the Treg molecular mechanisms that control AAA pathogenesis. Methods and results ELISA determined the Foxp3 concentration in blood cell lysates from 485 AAA patients and 204 age- and sex-matched controls. AAA patients exhibited lower blood cell Foxp3 expression than controls (P
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Zhou, Y., Wu, W., Lindholt, J. S., Sukhova, G. K., Libby, P., Yu, X., Shi, G.-P. Tags: Vascular biology Source Type: research

Lymphatic vascular integrity is disrupted in type 2 diabetes due to impaired nitric oxide signalling
Conclusion In conclusion, we identified the first lymphatic vascular defect in type 2 diabetes, an enhanced permeability caused by low NO bioavailability. Further, this demonstrates that PDE3 inhibition is required to maintain lymphatic vessel integrity and represents a viable therapeutic target for lymphatic endothelial dysfunction in metabolic disease. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Scallan, J. P., Hill, M. A., Davis, M. J. Tags: Vascular biology Source Type: research

Liver X receptor activation enhances CVB3 viral replication during myocarditis by stimulating lipogenesis
Conclusion LXR agonism does not modulate cardiac inflammation, but exacerbates virus-mediated myocardial damage during VM by stimulating lipid biosynthesis and enhancing CVB3 replication. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Papageorgiou, A.-P., Heggermont, W., Rienks, M., Carai, P., Langouche, L., Verhesen, W., De Boer, R. A., Heymans, S. Tags: Cardiac biology and remodelling Source Type: research

Oestrogen enhances cardiotoxicity induced by Sunitinib by regulation of drug transport and metabolism
Conclusion We identify the specific pathways affected by tyrosine kinase inhibitors in mammalian cardiomyocytes, interactions with biological sex, and a role for oestrogen in modulating drug efflux and metabolism. These findings represent a critical step toward reducing the incidence of cardiotoxicity with tyrosine kinase inhibitor chemotherapeutics. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Harvey, P. A., Leinwand, L. A. Tags: Cardiac biology and remodelling Source Type: research

Interplay between troponin T phosphorylation and O-N-acetylglucosaminylation in ischaemic heart failure
Conclusion These data demonstrate interplay between Ser208 phosphorylation and Ser190 O-GlcNAcylation of TnT in ischaemic HF, linked to decreased activity of both PKC and O-GlcNAcase and increased O-GlcNAc transferase activity. Modulation of these post-translational modifications of TnT may be a new therapeutic strategy in HF. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Dubois-Deruy, E., Belliard, A., Mulder, P., Bouvet, M., Smet-Nocca, C., Janel, S., Lafont, F., Beseme, O., Amouyel, P., Richard, V., Pinet, F. Tags: Cardiac biology and remodelling Source Type: research

The role of elastic restoring forces in right-ventricular filling
Aims The physiological determinants of RV diastolic function remain poorly understood. We aimed to quantify the contribution of elastic recoil to RV filling and determine its sensitivity to interventricular interaction. Methods and results High-fidelity pressure–volume loops and simultaneous 3-dimensional ultrasound sequences were obtained in 13 pigs undergoing inotropic modulation, volume overload, and acute pressure overload induced by endotoxin infusion. Using a validated method, we isolated elastic restoring forces from ongoing relaxation using conventional pressure–volume data. The RV contracted below the...
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Perez Del Villar, C., Bermejo, J., Rodriguez-Perez, D., Martinez-Legazpi, P., Benito, Y., Antoranz, J. C., Desco, M. M., Ortuno, J. E., Barrio, A., Mombiela, T., Yotti, R., Ledesma-Carbayo, M. J., Del Alamo, J. C., Fernandez-Aviles, F. Tags: Cardiac biology and remodelling Source Type: research

Soluble VE-cadherin is involved in endothelial barrier breakdown in systemic inflammation and sepsis
Conclusion Taken together, formation of sVE-cadherin is associated and contributes to inflammation-induced breakdown of endothelial barrier functions by inhibition of VE-cadherin binding. The underlying mechanism of VE-cadherin cleavage involves ADAM10 and appears to be of clinical relevance since sVE-cadherin was augmented in patients with severe sepsis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Flemming, S., Burkard, N., Renschler, M., Vielmuth, F., Meir, M., Schick, M. A., Wunder, C., Germer, C.-T., Spindler, V., Waschke, J., Schlegel, N. Tags: Integrative physiology and pathophysiology Source Type: research

Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension
Conclusions Perlecan HS chains are important for normal vascular arborization and recruitment of pericytes to pulmonary vessels. Perlecan HS deficiency also attenuates hypoxia-induced PH, where the underlying mechanisms involve impaired FGF2/FGFR1 interaction, inhibition of PASMC growth, and altered cell–matrix interactions. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Chang, Y.-T., Tseng, C.-N., Tannenberg, P., Eriksson, L., Yuan, K., de Jesus Perez, V. A., Lundberg, J., Lengquist, M., Botusan, I. R., Catrina, S.-B., Tran, P.-K., Hedin, U., Tran-Lundmark, K. Tags: Integrative physiology and pathophysiology Source Type: research

Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling
Conclusions Deletion of IR (i) increases platelet count and volume, (ii) does not cause platelet hyperactivity, and (iii) reduces GPVI-mediated platelet function and platelet priming by IGF-1 and IGF-2. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Moore, S. F., Williams, C. M., Brown, E., Blair, T. A., Harper, M. T., Coward, R. J., Poole, A. W., Hers, I. Tags: Integrative physiology and pathophysiology Source Type: research

Right ventricular suction: an important determinant of cardiac performance
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: La Gerche, A., Claus, P. Tags: INVITED EDITORIALS Source Type: research

Linking superinhibitory PLN mutations to CaMKII activation: a new arrhythmogenic mechanism in genetic DCM?
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Wagner, M., Weber, S., El-Armouche, A. Tags: INVITED EDITORIALS Source Type: research

Dual signals underlying diabetic lymphatic barrier dysregulation
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Alexander, J. S., Becker, F. Tags: INVITED EDITORIALS Source Type: research

Guido Tarone (1951-2015)
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Hirsch, E. Tags: IN MEMORIAM Source Type: research

Contents Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Editorial Board
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Cover Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Aims and Scope
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study
Aims Brugada syndrome (BrS) remains genetically heterogeneous and is associated with slowed cardiac conduction. We aimed to identify genetic variation in BrS cases at loci associated with QRS duration. Methods and results A multi-centre study sequenced seven candidate genes (SCN10A, HAND1, PLN, CASQ2, TKT, TBX3, and TBX5) in 156 Caucasian SCN5A mutation-negative BrS patients (80% male; mean age 48) with symptoms (64%) and/or a family history of sudden death (47%) or BrS (18%). Forty-nine variants were identified: 18 were rare (MAF
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Behr, E. R., Savio-Galimberti, E., Barc, J., Holst, A. G., Petropoulou, E., Prins, B. P., Jabbari, J., Torchio, M., Berthet, M., Mizusawa, Y., Yang, T., Nannenberg, E. A., Dagradi, F., Weeke, P., Bastiaenan, R., Ackerman, M. J., Haunso, S., Leenhardt, A., Tags: Ion channels and arrhythmias Source Type: research

PKC{varepsilon}-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis
Conclusions PKC activity in the vascular endothelium regulates HO-1 via a pathway requiring CREB1 and Nrf2. Given the potent protective actions of HO-1, we propose that this mechanism is an important contributor to the emerging role of PKC in the maintenance of endothelial homeostasis and resistance to injury. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Mylroie, H., Dumont, O., Bauer, A., Thornton, C. C., Mackey, J., Calay, D., Hamdulay, S. S., Choo, J. R., Boyle, J. J., Samarel, A. M., Randi, A. M., Evans, P. C., Mason, J. C. Tags: Vascular biology Source Type: research

Cytosolic Hsp60 orchestrates the survival and inflammatory responses of vascular smooth muscle cells in injured aortic vessels
Conclusions This study provides the first evidence that cytosolic Hsp60 could be a therapeutic target for preventing VSMC hyperplasia and inflammatory response in the injured vessels. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Choi, B., Choi, M., Park, C., Lee, E. K., Kang, D. H., Lee, D. J., Yeom, J. Y., Jung, Y., Kim, J., Lee, S., Kang, S. W. Tags: Vascular biology Source Type: research

DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1
Conclusion DNA-PK directly phosphorylates NOR-1 and, this way, modulates SMC proliferation. These data add to our understanding of vascular remodelling processes and opens new avenues for treatment of vascular proliferative diseases. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Medunjanin, S., Daniel, J.-M., Weinert, S., Dutzmann, J., Burgbacher, F., Brecht, S., Bruemmer, D., Kahne, T., Naumann, M., Sedding, D. G., Zuschratter, W., Braun-Dullaeus, R. C. Tags: Vascular biology Source Type: research

Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice
Conclusions Ackr1 deficiency appears to be protective in the ApoE knockout model of atherogenesis, but it is associated with only modest changes in cytokine and chemokine expression as well as T-cell subset frequency and inflammatory macrophage content. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Wan, W., Liu, Q., Lionakis, M. S., Marino, A. P. M. P., Anderson, S. A., Swamydas, M., Murphy, P. M. Tags: Vascular biology Source Type: research

Angiopoietin-1 inhibits toll-like receptor 4 signalling in cultured endothelial cells: role of miR-146b-5p
Conclusion Ang-1 disrupts TLR4 signalling, resulting in inhibition of LPS-induced inflammatory responses in endothelial cells. This inhibition occurs through selective targeting of IRAK1 and TRAF6 proteins by miR-146b-5p. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Echavarria, R., Mayaki, D., Neel, J.-C., Harel, S., Sanchez, V., Hussain, S. N. A. Tags: Vascular biology Source Type: research

IL-9 aggravates the development of atherosclerosis in ApoE-/- mice
Conclusion Our results demonstrated that IL-9 exerted pro-atherosclerotic effects in ApoE–/– mice at least partially by inducing VCAM-1 expression, which mediated inflammatory cell infiltration into atherosclerotic lesions. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Zhang, W., Tang, T., Nie, D., Wen, S., Jia, C., Zhu, Z., Xia, N., Nie, S., Zhou, S., Jiao, J., Dong, W., Lv, B., Xu, T., Sun, B., Lu, Y., Li, Y., Cheng, L., Liao, Y., Cheng, X. Tags: Vascular biology Source Type: research

Phosphatidylserine liposomes mimic apoptotic cells to attenuate atherosclerosis by expanding polyreactive IgM producing B1a lymphocytes
Conclusion Targeting B1a cell activation by PSLs may be a potentially potent therapeutic strategy to attenuate atherosclerosis and reduce the incidence of atherosclerosis-dependent myocardial infarction and stroke. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Hosseini, H., Li, Y., Kanellakis, P., Tay, C., Cao, A., Tipping, P., Bobik, A., Toh, B.-H., Kyaw, T. Tags: Vascular biology Source Type: research

Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway
Conclusions Our findings demonstrate (i) that administration of NaHS induces cardioprotection via a cGMP/PKG/PLN pathway and (ii) contribution of nitric oxide to the H2S response is species-specific. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Bibli, S.-I., Andreadou, I., Chatzianastasiou, A., Tzimas, C., Sanoudou, D., Kranias, E., Brouckaert, P., Coletta, C., Szabo, C., Kremastinos, D. T., Iliodromitis, E. K., Papapetropoulos, A. Tags: Cardiac biology and remodelling Source Type: research

Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence
Conclusion Our results define the cardiac ageing inflammatory signature and assign MMP-9 roles in mediating the inflammaging profile by indirectly and directly modifying macrophage polarization. Our results explain early mechanisms that stimulate ageing-induced cardiac fibrosis and diastolic dysfunction. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Ma, Y., Chiao, Y. A., Clark, R., Flynn, E. R., Yabluchanskiy, A., Ghasemi, O., Zouein, F., Lindsey, M. L., Jin, Y.-F. Tags: Cardiac biology and remodelling Source Type: research

Inhibition of type 5 phosphodiesterase counteracts {beta}2-adrenergic signalling in beating cardiomyocytes
Conclusion These data identify a new effect of PDE5 inhibitors on the modulation of cardiomyocyte response to adrenergic stimulation via PDE5–PDE2-mediated cross-talk. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Isidori, A. M., Cornacchione, M., Barbagallo, F., Di Grazia, A., Barrios, F., Fassina, L., Monaco, L., Giannetta, E., Gianfrilli, D., Garofalo, S., Zhang, X., Chen, X., Xiang, Y. K., Lenzi, A., Pellegrini, M., Naro, F. Tags: Cardiac biology and remodelling Source Type: research