Modulation of sympathetic activity and heart rate variability by ivabradine
Aims Bradycardic agents are currently used in the treatment of angina and heart failure; direct information on their effects on cardiac sympathetic nerve activity (SNA) may be relevant to their chronic use. The present study evaluates the effect of pacemaker inhibition on SNA; direct nerve recordings and indirect autonomic indexes are compared. Methods and results Experiments were performed in 18 anaesthetized rats. SNA (direct nerve recording) and heart rate variability (HRV) indexes were evaluated in parallel. All parameters were recorded 10 min before to 60 min after administration of the If blocker ivabradine (IVA; 2 ...
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Dias da Silva, V. J., Tobaldini, E., Rocchetti, M., Wu, M. A., Malfatto, G., Montano, N., Zaza, A. Tags: Integrative physiology and pathophysiology Source Type: research

TRPM4 in cardiac electrical activity
TRPM4 forms a non-selective cation channel activated by internal Ca2+. Its functional expression was demonstrated in cardiomyocytes of several mammalian species including humans, but the channel is also present in many other tissues. The recent characterization of the TRPM4 inhibitor 9-phenanthrol, and the availability of transgenic mice have helped to clarify the role of TRPM4 in cardiac electrical activity, including diastolic depolarization from the sino-atrial node cells in mouse, rat, and rabbit, as well as action potential duration in mouse cardiomyocytes. In rat and mouse, pharmacological inhibition of TRPM4 prevent...
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Guinamard, R., Bouvagnet, P., Hof, T., Liu, H., Simard, C., Salle, L. Tags: REVIEWS Source Type: research

Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation
Gene therapy is a promising modality for the treatment of inherited and acquired cardiovascular diseases. The identification of the molecular pathways involved in the pathophysiology of heart failure and other associated cardiac diseases led to encouraging preclinical gene therapy studies in small and large animal models. However, the initial clinical results yielded only modest or no improvement in clinical endpoints. The presence of neutralizing antibodies and cellular immune responses directed against the viral vector and/or the gene-modified cells, the insufficient gene expression levels, and the limited gene transduct...
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Rincon, M. Y., VandenDriessche, T., Chuah, M. K. Tags: REVIEWS Source Type: research

Cardiac mechano-electric coupling: a role in regulating normal function of the heart?
(Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Quinn, T. A. Tags: EDITORIAL Source Type: research

Contents Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Editorial Board
(Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Cover Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Aims and Scope
(Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

A new KCNQ1 mutation at the S5 segment that impairs its association with KCNE1 is responsible for short QT syndrome
Conclusion The F279I mutation induces a gain of function of IKs due to an impaired gating modulation of Kv7.1 induced by KCNE1, leading to a shortening of the cardiac AP. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Moreno, C., Oliveras, A., de la Cruz, A., Bartolucci, C., Munoz, C., Salar, E., Gimeno, J. R., Severi, S., Comes, N., Felipe, A., Gonzalez, T., Lambiase, P., Valenzuela, C. Tags: Ion channels and arrythmias Source Type: research

Forced fusion of human ventricular scar cells with cardiomyocytes suppresses arrhythmogenicity in a co-culture model
Aims Fibrosis increases arrhythmogenicity in myocardial tissue by causing structural and functional disruptions in the cardiac syncytium. Forced fusion of fibroblastic cells with adjacent cardiomyocytes may theoretically resolve these disruptions. Therefore, the electrophysiological effects of such electrical and structural integration of fibroblastic cells into a cardiac syncytium were studied. Methods and results Human ventricular scar cells (hVSCs) were transduced with lentiviral vectors encoding enhanced green fluorescent protein alone (eGFP-hVSCs) or together with the fusogenic vesicular stomatitis virus G protein (V...
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Engels, M. C., Askar, S. F. A., Jangsangthong, W., Bingen, B. O., Feola, I., Liu, J., Majumder, R., Versteegh, M. I. M., Braun, J., Klautz, R. J. M., Ypey, D. L., De Vries, A. A. F., Pijnappels, D. A. Tags: Ion channels and arrythmias Source Type: research

Cystathionine {gamma}-lyase regulates arteriogenesis through NO-dependent monocyte recruitment
Conclusion Endogenous CSE/H2S regulates ischaemic vascular remodelling mediated during hind limb ischaemia through NO-dependent monocyte recruitment and cytokine induction revealing a previously unknown mechanism of arteriogenesis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Kolluru, G. K., Bir, S. C., Yuan, S., Shen, X., Pardue, S., Wang, R., Kevil, C. G. Tags: Vascular biology Source Type: research

Aggravated restenosis and atherogenesis in ApoCIII transgenic mice but lack of protection in ApoCIII knockouts: the effect of authentic triglyceride-rich lipoproteins with and without ApoCIII
Conclusions Severe hypertriglyceridaemia resulting from ApoCIII overexpression promotes restenosis and atherosclerosis. Furthermore, we demonstrated that TRLs + ApoCIII promotes SMC proliferation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Li, H., Han, Y., Qi, R., Wang, Y., Zhang, X., Yu, M., Tang, Y., Wang, M., Shu, Y.-N., Huang, W., Liu, X., Rodrigues, B., Han, M., Liu, G. Tags: Vascular biology Source Type: research

Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation
Conclusion This study shows, for the first time, that CBD causes vasorelaxation of human mesenteric arteries via activation of CB1 and TRP channels, and is endothelium- and nitric oxide-dependent. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Stanley, C. P., Hind, W. H., Tufarelli, C., O'Sullivan, S. E. Tags: Vascular biology Source Type: research

Cross-talk between LOX-1 and PCSK9 in vascular tissues
Aims Lectin-like ox-LDL receptor-1 (LOX-1) plays an important role in inflammatory diseases, such as atherosclerosis. Proprotein convertase subtilisin/kexin type 9 (PCSK9) modulates LDL receptor degradation and influences serum LDL levels. The present study was designed to investigate the possible interaction between PCSK9 and LOX-1. Methods and results In the first set of experiments, human vascular endothelial cells and smooth muscle cells were studied at baseline and after lipopolysaccharide (LPS) treatment (to create an inflammatory state). Both PCSK9 and LOX-1 were strongly induced by LPS treatment. To define the rol...
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Ding, Z., Liu, S., Wang, X., Deng, X., Fan, Y., Shahanawaz, J., Shmookler Reis, R. J., Varughese, K. I., Sawamura, T., Mehta, J. L. Tags: Vascular biology Source Type: research

The cAMP-producing agonist beraprost inhibits human vascular smooth muscle cell migration via exchange protein directly activated by cAMP
Conclusions These results indicate that therapeutically relevant concentrations of beraprost can inhibit VSMC migration via a previously unknown mechanism involving the cAMP mediator Epac. This may provide a novel target that could blunt neointimal formation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: McKean, J. S., Murray, F., Gibson, G., Shewan, D. A., Tucker, S. J., Nixon, G. F. Tags: Vascular biology Source Type: research

MicroRNA-1298 is regulated by DNA methylation and affects vascular smooth muscle cell function by targeting connexin 43
Conclusion Our data demonstrate a specific role of the upstream DNA methylation/miR-1298/Cx43 pathway in regulating VSMC function and suggest that modulation of miR-1298 levels may offer a novel therapeutic approach for ASO. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Hu, W., Wang, M., Yin, H., Yao, C., He, Q., Yin, L., Zhang, C., Li, W., Chang, G., Wang, S. Tags: Vascular biology Source Type: research

Down-regulation of miR-23b induces phenotypic switching of vascular smooth muscle cells in vitro and in vivo
Conclusions We identify miR-23b as a novel regulator of VSMC phenotypic switch in vitro and following vascular injury in vivo. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Iaconetti, C., De Rosa, S., Polimeni, A., Sorrentino, S., Gareri, C., Carino, A., Sabatino, J., Colangelo, M., Curcio, A., Indolfi, C. Tags: Vascular biology Source Type: research

Thromboxane A2 induces blood flow recovery via platelet adhesion to ischaemic regions
Conclusion These results indicated that TP signalling facilitates ischaemia-induced angiogenesis via P-selectin-mediated platelet adhesion to PSGL-1 on the ECs at ischaemic sites and the supply of pro-angiogenic factors by the adherent platelets. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Amano, H., Ito, Y., Eshima, K., Kato, S., Ogawa, F., Hosono, K., Oba, K., Tamaki, H., Sakagami, H., Shibuya, M., Narumiya, S., Majima, M. Tags: Vascular biology Source Type: research

Tolerance to ischaemic injury in remodelled mouse hearts: less ischaemic glycogenolysis and preserved metabolic efficiency
This study was designed to investigate the metabolic mechanisms that may contribute to this phenomenon and to examine the relationship between ischaemic tolerance and metabolic efficiency during post-ischaemic reperfusion. Methods and results Male C57BL/6 mice were subjected to coronary artery ligation (CAL) or SHAM surgery. After 4 weeks, in vivo mechanical function was assessed by echocardiography, and then isolated working hearts were perfused in this sequence: 45 min aerobic, 15 min global no-flow ischaemia, and 30 min aerobic reperfusion. Left ventricular (LV) function, metabolic rates, and metabolic efficiency were ...
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Masoud, W. G. T., Abo Al-Rob, O., Yang, Y., Lopaschuk, G. D., Clanachan, A. S. Tags: Cardiac biology and remodelling Source Type: research

Extracellular component hyaluronic acid and its receptor Hmmr are required for epicardial EMT during heart regeneration
Conclusion HA and Hmmr are required for activated epicardial cell EMT and migration involving the FAK/Src pathway for proper heart regeneration. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Missinato, M. A., Tobita, K., Romano, N., Carroll, J. A., Tsang, M. Tags: Cardiac biology and remodelling Source Type: research

Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia
Conclusion Our results show that Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia. These findings indicate that Rip2 may be a promising novel therapeutic target to reduce excess vascular permeability in ischaemic heart disease. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Andersson, L., Scharin Tang, M., Lundqvist, A., Lindbom, M., Mardani, I., Fogelstrand, P., Shahrouki, P., Redfors, B., Omerovic, E., Levin, M., Boren, J., Levin, M. C. Tags: Cardiac biology and remodelling Source Type: research

Identification and characterization of two ankyrin-B isoforms in mammalian heart
Conclusion The identification and characterization of two functionally distinct ankyrin-B isoforms in heart provide compelling evidence that alternative splicing of the ANK2 gene regulates the fidelity of ankyrin-B interactions with proteins. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Wu, H. C., Yamankurt, G., Luo, J., Subramaniam, J., Hashmi, S. S., Hu, H., Cunha, S. R. Tags: Cardiac biology and remodelling Source Type: research

Mitochondrial complex I defect and increased fatty acid oxidation enhance protein lysine acetylation in the diabetic heart
Conclusion We identified the specific defective sites in the electron transport chain responsible for the decreased mitochondrial oxidative phosphorylation in the diabetic heart. Mitochondrial protein lysine acetylation is the common consequence of both increased fatty acid oxidation and mitochondrial Complex I defect, and may be responsible for the metabolic inflexibility of the diabetic heart. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Vazquez, E. J., Berthiaume, J. M., Kamath, V., Achike, O., Buchanan, E., Montano, M. M., Chandler, M. P., Miyagi, M., Rosca, M. G. Tags: Cardiac biology and remodelling Source Type: research

Ultrastructure of the intercellular space in adult murine ventricle revealed by quantitative tomographic electron microscopy
Conclusion We have developed a systematic method to characterize the ultrastructure of the intercellular space in the adult murine ventricle and have provided a quantitative description of the structure of the intercellular membranes and of the intercellular space. We further show that PKP2 deficiency associates with ultrastructural defects. The possible importance of the intercellular space in cardiac behaviour is discussed. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Leo-Macias, A., Liang, F.-X., Delmar, M. Tags: Cardiac biology and remodelling Source Type: research

Dermcidin: a skeletal muscle myokine modulating cardiomyocyte survival and infarct size after coronary artery ligation
Conclusion Our data demonstrate that chronic limb ischaemia activates detrimental pathways in the ischaemic heart through humoral mechanisms of remote organ crosstalk. Thus, DCD may represent a novel important myokine modulating cardiomyocyte survival and function. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Esposito, G., Schiattarella, G. G., Perrino, C., Cattaneo, F., Pironti, G., Franzone, A., Gargiulo, G., Magliulo, F., Serino, F., Carotenuto, G., Sannino, A., Ilardi, F., Scudiero, F., Brevetti, L., Oliveti, M., Giugliano, G., Del Giudice, C., Ciccarelli, Tags: Cardiac biology and remodelling Source Type: research

Modulation of cardiac fibrosis by Kruppel-like factor 6 through transcriptional control of thrombospondin 4 in cardiomyocytes
Conclusion Our present studies on the cardiac function of KLF6 show a new mechanism whereby cardiomyocytes regulate cardiac fibrosis through transcriptional control of the extracellular matrix factor, TSP4, which, in turn, modulates activation of cardiac fibroblasts. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Sawaki, D., Hou, L., Tomida, S., Sun, J., Zhan, H., Aizawa, K., Son, B.-K., Kariya, T., Takimoto, E., Otsu, K., Conway, S. J., Manabe, I., Komuro, I., Friedman, S. L., Nagai, R., Suzuki, T. Tags: Cardiac biology and remodelling Source Type: research

Netrin-1 as a novel therapeutic target in cardiovascular disease: to activate or inhibit?
Netrins are a family of laminin-like proteins, which were initially identified for their role in embryonic axonal guidance. Over recent years, it has become apparent that netrin-1 may additionally be involved in the underlying pathology of several multisystem diseases, making it an attractive potential therapeutic target. It is involved in postnatal angiogenesis, particularly in the context of an ischaemic insult, although there are conflicting reports as to whether netrin-1 acts in a pro- or anti-angiogenic capacity. In atherosclerosis, opposing effects have similarly been reported on plaque progression, due to the abilit...
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Layne, K., Ferro, A., Passacquale, G. Tags: REVIEW Source Type: research

Keep calm and carry on: miR-1298 prevents up-regulation of Cx43 and secures a quiescent vascular smooth muscle cell
(Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Schmidt, K., de Wit, C. Tags: EDITORIALS Source Type: research

Micro(RNA) management of smooth muscle cell phenotype and response to vascular injury
(Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Mcdonald, R. A., Pinel, K., Baker, A. H. Tags: EDITORIALS Source Type: research

Platelets and thromboxane receptors: pivotal players in arteriogenesis
(Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Van Hinsbergh, V. W. M., Tasev, D. Tags: EDITORIALS Source Type: research

KLF6 orchestrates cardiac myocyte-to-fibroblast communication: 'He who has ears to hear, let him hear'
(Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Balligand, J.-L. Tags: EDITORIALS Source Type: research

Contents Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Editorial Board
(Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Cover Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Aims and Scope
(Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Platelets in leucocyte recruitment and function
Platelets have a longstanding recognition as an essential cellular component of the coagulation system. However, substantial research over the last decade has added another important aspect to platelet function in that they are also an integral part of the innate immune system. Complex organisms are facing a constant threat of infections by invading pathogens, and they have developed a sophisticated and elegant measure to combat this threat, namely the immune system. Leucocyte recruitment to sites of infections is an essential step at the forefront of the immune response. Platelets have been shown to be involved in several...
Source: Cardiovascular Research - July 15, 2015 Category: Cardiology Authors: Rossaint, J., Zarbock, A. Tags: INVITED SPOTLIGHT REVIEWS Source Type: research

Intracellular signalling during neutrophil recruitment
Recruitment of leucocytes such as neutrophils to the extravascular space is a critical step of the inflammation process and plays a major role in the development of various diseases including several cardiovascular diseases. Neutrophils themselves play a very active role in that process by sensing their environment and responding to the extracellular cues by adhesion and de-adhesion, cellular shape changes, chemotactic migration, and other effector functions of cell activation. Those responses are co-ordinated by a number of cell surface receptors and their complex intracellular signal transduction pathways. Here, we revie...
Source: Cardiovascular Research - July 15, 2015 Category: Cardiology Authors: Mocsai, A., Walzog, B., Lowell, C. A. Tags: INVITED SPOTLIGHT REVIEWS Source Type: research

Chemokines as effector and target molecules in vascular biology
Chemokines are key mediators of inflammation. In pathological tissues, the main roles of chemokines are to regulate leucocyte accumulation through the activation of oriented cell migration and the activation of limited programs of gene transcription. Through these activities, chemokines exert many crucial functions, including the regulation of angiogenesis. The ‘chemokine system’ is tightly regulated at several levels, such as the post-transcriptional processing of ligands, the regulation of the expression and function of the receptors and through the expression of molecules known as ‘atypical chemokine r...
Source: Cardiovascular Research - July 15, 2015 Category: Cardiology Authors: Sozzani, S., Del Prete, A., Bonecchi, R., Locati, M. Tags: INVITED SPOTLIGHT REVIEWS Source Type: research

Development and trafficking function of haematopoietic stem cells and myeloid cells during fetal ontogeny
Fetal haematopoiesis is a highly regulated process in terms of time and location. It is characterized by the emergence of specific cell populations at different extra- and intraembryonic anatomical sites. Trafficking of haematopoietic stem cells (HSCs) between these supportive niches is regulated by a set of molecules, i.e. integrins and chemokine receptors, which are also described for the recruitment of differentiated innate immune cells. In this review, an overview will be given on fetal haematopoiesis as well as trafficking of HSCs during fetal life. In addition, we will focus on the appearance of the first differentia...
Source: Cardiovascular Research - July 15, 2015 Category: Cardiology Authors: Heinig, K., Sage, F., Robin, C., Sperandio, M. Tags: INVITED SPOTLIGHT REVIEWS Source Type: research

Regulation of leucocyte homeostasis in the circulation
The functions of blood cells extend well beyond the immune functions of leucocytes or the respiratory and hemostatic functions of erythrocytes and platelets. Seen as a whole, the bloodstream is in charge of nurturing and protecting all organs by carrying a mixture of cell populations in transit from one organ to another. To optimize these functions, evolution has provided blood and the vascular system that carries it with various mechanisms that ensure the appropriate influx and egress of cells into and from the circulation where and when needed. How this homeostatic control of blood is achieved has been the object of stud...
Source: Cardiovascular Research - July 15, 2015 Category: Cardiology Authors: Scheiermann, C., Frenette, P. S., Hidalgo, A. Tags: INVITED SPOTLIGHT REVIEWS Source Type: research

Selectins: initiators of leucocyte adhesion and signalling at the vascular wall
The selectins are transmembrane, Ca2+-dependent lectins that mediate leucocyte rolling on vascular surfaces, the first adhesive step during inflammation and immune surveillance. Leucocytes express L-selectin, activated platelets express P-selectin, and activated endothelial cells express E- and P-selectin. Rolling involves force-regulated, rapidly reversible interactions of selectins with a limited number of glycosylated cell surface ligands. Rolling permits leucocytes to interact with immobilized chemokines that convert β2 integrins to high-affinity conformations, which mediate arrest, post-arrest adhesion strengthen...
Source: Cardiovascular Research - July 15, 2015 Category: Cardiology Authors: McEver, R. P. Tags: INVITED SPOTLIGHT REVIEWS Source Type: research

Monocyte trafficking across the vessel wall
This article revisits some conventional paradigms and selectively highlights new findings, including novel insights into monocyte differentiation and recently identified functional mediators, signalling pathways, and new structural aspects of monocyte extravasation. The emerging roles of endothelial junctional molecules like vascular endothelial-cadherin and the junctional adhesion molecule family, adhesion molecules such as intercellular adhesion molecule-1, molecules localized to the lateral border recycling compartment like cluster of differentiation 99, platelet/endothelial cell adhesion molecule-1, and poliovirus rece...
Source: Cardiovascular Research - July 15, 2015 Category: Cardiology Authors: Gerhardt, T., Ley, K. Tags: INVITED SPOTLIGHT REVIEWS Source Type: research

The regulation of transendothelial migration: new knowledge and new questions
Leucocyte transendothelial migration (TEM) involves a co-operative series of interactions between surface molecules on the leucocyte and cognate counter-ligands on the endothelial cell. These interactions set up a cascade of signalling events inside the endothelial cell that both allow for the junctions to loosen and for membrane to be recruited from the lateral border recycling compartment (LBRC). The LBRC is thought to provide an increased surface area and unligated receptors to the leucocyte to continue the process. The relative importance of the individual adhesion/signalling molecules that promote transmigration may v...
Source: Cardiovascular Research - July 15, 2015 Category: Cardiology Authors: Muller, W. A. Tags: INVITED SPOTLIGHT REVIEWS Source Type: research

Fanning the flames: inflammation in cardiovascular diseases
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 15, 2015 Category: Cardiology Authors: Libby, P. Tags: EDITORIAL Source Type: research

Contents Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 15, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Editorial Board
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 15, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Cover Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 15, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Aims and Scope
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 15, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

SRT1720 counteracts glucosamine-induced endoplasmic reticulum stress and endothelial dysfunction
Conclusions Our data show that GlcN promotes a pro-apoptotic and pro-inflammatory/pro-thrombotic phenotype in endothelial cells by activating ER stress. The observation that SRT1720, inhibiting ER stress, was able to counteract GlcN effects lays the basis for future studies aimed to exploit this drug and cognate compounds in the treatment of endothelial dysfunction and atherosclerosis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Authors: Fiorentino, T. V., Procopio, T., Mancuso, E., Arcidiacono, G. P., Andreozzi, F., Arturi, F., Sciacqua, A., Perticone, F., Hribal, M. L., Sesti, G. Tags: Vascular biology Source Type: research

Developmental origin of age-related coronary artery disease
Conclusion Taken together, these data reveal heterogeneity in the fetal epicardium that is linked to coronary artery integrity, and that distortion of the coronaries epicardial origin predisposes to adult onset disease. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Authors: Wei, K., Diaz-Trelles, R., Liu, Q., Diez-Cunado, M., Scimia, M.-C., Cai, W., Sawada, J., Komatsu, M., Boyle, J. J., Zhou, B., Ruiz-Lozano, P., Mercola, M. Tags: Vascular biology Source Type: research