Scavenger receptors and non-coding RNAs: relevance in atherogenesis
Scavenger receptors (SRs), which recognize modified low-density lipoprotein (LDL) by oxidation or acetylation, are a group of receptors on plasma membrane of macrophages and other cell types. These receptors by facilitating modified LDL uptake are a primary step in the intracellular accumulation of modified LDL and formation of fatty streak. Non-coding RNAs (ncRNAs) are a group of functional RNA nucleotides that are not translated into protein, and include microRNAs (miRs), snoRNAs, siRNAs, snRNAs, exRNAs, piRNAs, and the long ncRNAs (lncRNAs). Recently, ncRNAs have received much attention due to their effects in a variety...
Source: Cardiovascular Research - December 28, 2015 Category: Cardiology Authors: Dai, Y., Condorelli, G., Mehta, J. L. Tags: REVIEWS Source Type: research

The role of inflammatory biomarkers in developing targeted cardiovascular therapies: lessons from the cardiovascular inflammation reduction trials
Anti-inflammatory add-on therapy to conventional cardiovascular prophylaxis has been proposed as a novel therapeutic approach to potentially reduce residual cardiovascular risk. This hypothesis has been challenged by a series of unsuccessful Phase III studies testing the impact on clinical outcomes of novel agents with immunomodulatory actions. Specifically, the apparent ability of phospholipase A2 (PLA2) inhibitors and of antioxidants to ameliorate inflammation and to reduce coronary disease in Phase II trials did not translate into improved secondary cardiovascular prevention in larger population-based studies. Other ant...
Source: Cardiovascular Research - December 28, 2015 Category: Cardiology Authors: Passacquale, G., Di Giosia, P., Ferro, A. Tags: REVIEWS Source Type: research

Orphaned mitochondria in heart failure
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 28, 2015 Category: Cardiology Authors: Maack, C. Tags: EDITORIALS Source Type: research

A TRPC3 signalling complex promotes cerebral artery remodelling during hypertension
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 28, 2015 Category: Cardiology Authors: Pires, P. W., Earley, S. Tags: EDITORIALS Source Type: research

'Hypoxio-spondin: thrombospondin and its emerging role in pulmonary hypertension
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 28, 2015 Category: Cardiology Authors: Shimoda, L. A., Kuebler, W. M. Tags: EDITORIALS Source Type: research

Editorial Board
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 24, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Ryanodine receptor cluster fragmentation and redistribution in persistent atrial fibrillation enhance calcium release
Conclusion In persistent AF, ultrastructural reorganization of RyR clusters within CRUs is associated with overactive Ca2+ release, increasing the likelihood of propagating Ca2+ release. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Authors: Macquaide, N., Tuan, H.-T. M., Hotta, J.-i., Sempels, W., Lenaerts, I., Holemans, P., Hofkens, J., Jafri, M. S., Willems, R., Sipido, K. R. Tags: Ion Channels and Arrhythmias Source Type: research

Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress
Conclusion Together, these data suggest that EndMT contributes to neointimal hyperplasia and induces atherogenic differentiation of endothelial cells. Importantly, we uncovered that EndMT is modulated by shear stress in an ERK5-dependent manner. These findings provide new insights in the role of adverse endothelial plasticity in vascular disease and identify a novel atheroprotective mechanism of uniform LSS, namely inhibition of EndMT. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Authors: Moonen, J.-R. A. J., Lee, E. S., Schmidt, M., Maleszewska, M., Koerts, J. A., Brouwer, L. A., van Kooten, T. G., van Luyn, M. J. A., Zeebregts, C. J., Krenning, G., Harmsen, M. C. Tags: Vascular Biology Source Type: research

BLT1 antagonist LSN2792613 reduces infarct size in a mouse model of myocardial ischaemia-reperfusion injury
Conclusion Selective BLT1 inhibition with LSN2792613 reduces inflammation and apoptosis following IR, resulting in reduced IS, and therefore might be a promising strategy to prevent myocardial IR injury. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Authors: de Hoog, V. C., Bovens, S. M., de Jager, S. C. A., van Middelaar, B. J., van Duijvenvoorde, A., Doevendans, P. A., Pasterkamp, G., de Kleijn, D. P. V., Timmers, L. Tags: Cardiac biology and remodelling Source Type: research

Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore
Conclusion NAADP signalling plays a major role in reperfusion-induced cell death and represents a potent pathway for protection against reperfusion injury. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Authors: Davidson, S. M., Foote, K., Kunuthur, S., Gosain, R., Tan, N., Tyser, R., Zhao, Y. J., Graeff, R., Ganesan, A., Duchen, M. R., Patel, S., Yellon, D. M. Tags: Cardiac biology and remodelling Source Type: research

Lack of G{alpha}i2 leads to dilative cardiomyopathy and increased mortality in {beta}1-adrenoceptor overexpressing mice
Conclusions Gαi2 deficiency combined with cardiac β1-adrenoceptor overexpression strongly impaired survival and cardiac function. At 300 days of age, β1-adrenoceptor overexpression alone had not induced cardiac hypertrophy or dysfunction while there was overt cardiomyopathy in mice additionally lacking Gαi2. We propose an enhanced effect of increased β1-adrenergic drive by the lack of protection via Gαi2. Gαi3 up-regulation was not sufficient to compensate for Gαi2 deficiency, suggesting an isoform-specific or a concentration-dependent mechanism. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Authors: Keller, K., Maass, M., Dizayee, S., Leiss, V., Annala, S., Köth, J., Seemann, W. K., Müller-Ehmsen, J., Mohr, K., Nürnberg, B., Engelhardt, S., Herzig, S., Birnbaumer, L., Matthes, J. Tags: Cardiac biology and remodelling Source Type: research

Knockout of p21-activated kinase-1 attenuates exercise-induced cardiac remodelling through altered calcineurin signalling
Conclusions Our data suggest that Pak1 is essential for adaptive physiological cardiac remodelling and support previous evidence that demonstrates Pak1 signalling is important for cardiac growth and survival. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Authors: Davis, R. T., Simon, J. N., Utter, M., Mungai, P., Alvarez, M. G., Chowdhury, S. A. K., Heydemann, A., Ke, Y., Wolska, B. M., Solaro, R. J. Tags: Cardiac biology and remodelling Source Type: research

Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy
Conclusions Our studies suggest that downregulation of miR-448-3p leads to the increase in the expression of Ncf1 gene and p47phox protein, as well as to the substantial increase in NOX2-derived ROS production. Cellular oxidative stress subsequently triggers events that finally culminate in cardiac tissue damage and development of cardiomyopathy. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Authors: Kyrychenko, S., Kyrychenko, V., Badr, M. A., Ikeda, Y., Sadoshima, J., Shirokova, N. Tags: Cardiac biology and remodelling Source Type: research

Targeting lysosomal Ca2+ to reduce reperfusion injury
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Authors: Tsukamoto, O., Asanuma, H., Kitakaze, M. Tags: EDITORIALS Source Type: research

Plasticity of adult endothelium: how frequent and to what extent?
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Authors: Pearson, J. D. Tags: EDITORIALS Source Type: research

Hot topics and networks in Cardiovascular Research
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Authors: Gal, D., Vandevelde, W., Sipido, K. R. Tags: EDITORS ' CORNER Source Type: research

Contents Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Cover Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Aims and Scope
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT
Conclusion Our results suggest that rather than being functionally redundant, CASQ2 and HRC modulate cardiac ryanodine receptor-mediated (RyR2) Ca release in an opposing manner. In particular, while CASQ2 stabilizes RyR2 rendering it refractory in the diastolic phase, HRC enhances RyR2 activity facilitating RyR2 recovery from refractoriness. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Authors: Liu, B., Ho, H.-T., Brunello, L., Unudurthi, S. D., Lou, Q., Belevych, A. E., Qian, L., Kim, D. H., Cho, C., Janssen, P. M. L., Hund, T. J., Knollmann, B. C., Kranias, E. G., Gyorke, S. Tags: Ion Channels and Arrhythmias Source Type: research

Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialization following arterial injury
Conclusion NRP1 and NRP2 play important roles in the regulation of neointimal hyperplasia in vivo by modulating VSMC migration (via NRP1 and NRP2) and proliferation (via NRP2), independently of the role of NRPs in re-endothelialization. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Authors: Pellet-Many, C., Mehta, V., Fields, L., Mahmoud, M., Lowe, V., Evans, I., Ruivo, J., Zachary, I. Tags: Vascular Biology Source Type: research

Bone morphogenetic protein 6 and oxidized low-density lipoprotein synergistically recruit osteogenic differentiation in endothelial cells
Conclusion These findings provide a potential mechanism for the observed interactions of BMP signalling, oxidative stress, and inflammation in recruiting vascular calcification associated with atherosclerosis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Authors: Yung, L.-M., Sanchez-Duffhues, G., ten Dijke, P., Yu, P. B. Tags: Vascular Biology Source Type: research

A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis
Conclusion We developed an assay to quantify LDL transcytosis across endothelial cells and discovered an unexpected role for SR-BI. Elucidating the mechanisms of LDL transcytosis may identify novel targets for the prevention or therapy of atherosclerosis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Authors: Armstrong, S. M., Sugiyama, M. G., Fung, K. Y. Y., Gao, Y., Wang, C., Levy, A. S., Azizi, P., Roufaiel, M., Zhu, S.-N., Neculai, D., Yin, C., Bolz, S.-S., Seidah, N. G., Cybulsky, M. I., Heit, B., Lee, W. L. Tags: Vascular Biology Source Type: research

Gadd45{gamma} regulates cardiomyocyte death and post-myocardial infarction left ventricular remodelling
Conclusion This work is the first to demonstrate that Gadd45 accumulation during MI promotes the development and persistence of HF by inducing cardiomyocyte apoptosis in a p38 MAPK-dependent manner. We clearly identify Gadd45 as a therapeutic target in the development of HF. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Authors: Lucas, A., Mialet-Perez, J., Daviaud, D., Parini, A., Marber, M. S., Sicard, P. Tags: Cardiac biology and remodelling Source Type: research

Phosphoinositide 3-kinase gamma controls inflammation-induced myocardial depression via sequential cAMP and iNOS signalling
Conclusions This study reveals the lipid kinase-independent scaffold function of PI3K as a mediator of SIMD during inflammation-induced SIRS. Activation of cardiac phosphodiesterases via PI3K is shown to restrict myocardial hypercontractility early after SIRS induction as well as the subsequent inflammatory responses. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Authors: Ndongson-Dongmo, B., Heller, R., Hoyer, D., Brodhun, M., Bauer, M., Winning, J., Hirsch, E., Wetzker, R., Schlattmann, P., Bauer, R. Tags: Cardiac biology and remodelling Source Type: research

Citrullination of myofilament proteins in heart failure
Conclusion Citrullination unique to the cardiac proteome was identified. Our data indicate important structural and functional alterations to the cardiac sarcomere and the contribution of protein citrullination to this process. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Authors: Fert-Bober, J., Giles, J. T., Holewinski, R. J., Kirk, J. A., Uhrigshardt, H., Crowgey, E. L., Andrade, F., Bingham, C. O., Park, J. K., Halushka, M. K., Kass, D. A., Bathon, J. M., Van Eyk, J. E. Tags: Cardiac biology and remodelling Source Type: research

Membrane-bound Klotho is not expressed endogenously in healthy or uraemic human vascular tissue
Conclusion Using several independent and validated methods, we conclude that full-length, membrane-bound Klotho is not expressed in healthy or uraemic human vascular tissue. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Authors: Mencke, R., Harms, G., Mirkovic, K., Struik, J., Van Ark, J., Van Loon, E., Verkaik, M., De Borst, M. H., Zeebregts, C. J., Hoenderop, J. G., Vervloet, M. G., Hillebrands, J.-L., on behalf of the NIGRAM Consortium, on behalf of the NIGRAM Consortium, Bind Tags: Integrative physiology and pathophysiology Source Type: research

In vivo cardiac reprogramming using an optimal single polycistronic construct
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Authors: Ma, H., Wang, L., Yin, C., Liu, J., Qian, L. Tags: LETTER TO THE EDITOR Source Type: research

CIRCUS: a kiss of death for cardioprotection?
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Authors: Heusch, G. Tags: EDITORIALS Source Type: research

A sarcomeric protein tongue-twister: post-translation, citrullination/deimination and elimination of arginine residues
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Authors: Solaro, R. J. Tags: EDITORIALS Source Type: research

Hunt for the culprit of cardiovascular injury in kidney disease
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Authors: Faul, C., Wolf, M. Tags: EDITORIALS Source Type: research

Contents Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Editorial Board
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Cover Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Aims and Scope
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation
Conclusions Deletion of LKB1 causes early defects in atrial channel expression, action potential generation and conduction, which precede widespread atrial remodelling, fibrosis and AF. LKB1 is critical for normal atrial growth and electrophysiological function. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Kim, G. E., Ross, J. L., Xie, C., Su, K. N., Zaha, V. G., Wu, X., Palmeri, M., Ashraf, M., Akar, J. G., Russell, K. S., Akar, F. G., Young, L. H. Tags: Ion channels and arrhythmias Source Type: research

Transmural APD gradient synchronizes repolarization in the human left ventricular wall
Aims The duration and morphology of the T wave predict risk for ventricular fibrillation. A transmural gradient in action potential duration (APD) in the ventricular wall has been suggested to underlie the T wave in humans. We hypothesize that the transmural gradient in APD compensates for the normal endocardium-to-epicardium activation sequence and synchronizes repolarization in the human ventricular wall. Methods and results We made left ventricular wedge preparations from 10 human donor hearts and measured transmural activation and repolarization patterns by optical mapping, while simultaneously recording a pseudo-ECG....
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Boukens, B. J., Sulkin, M. S., Gloschat, C. R., Ng, F. S., Vigmond, E. J., Efimov, I. R. Tags: Ion channels and arrhythmias Source Type: research

Synchronization of repolarization by mechano-electrical coupling in the porcine heart
Conclusion The effect of increased LV pressure is synchronization of repolarization. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Opthof, T., Meijborg, V. M. F., Belterman, C. N. W., Coronel, R. Tags: Ion channels and arrhythmias Source Type: research

Endothelial G{alpha}q/11 is required for VEGF-induced vascular permeability and angiogenesis
Conclusion Gαq/11 critically contributes to VEGF-A-dependent permeability control and angiogenic behaviour in vitro and in vivo. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Sivaraj, K. K., Li, R., Albarran-Juarez, J., Wang, S., Tischner, D., Grimm, M., Swiercz, J. M., Offermanns, S., Wettschureck, N. Tags: Vascular biology Source Type: research

Incidence, severity, mortality, and confounding factors for dissecting AAA detection in angiotensin II-infused mice: a meta-analysis
Aims While angiotensin II-infused mice are the most popular model for preclinical aneurysm research, representative data on incidence, severity, and mortality of dissecting abdominal aortic aneurysms (AAAs) have never been established, and the influence of confounding factors is unknown. Methods and Results We performed a meta-analysis including 194 manuscripts representing 1679 saline-infused, 4729 non-treated angiotensin II-infused, and 4057 treated angiotensin II-infused mice. Incidence (60%) and mortality (20%) rates are reported overall as well as for grade I (22%), grade II (26%), grade III (29%), and grade IV (24%)...
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Trachet, B., Fraga-Silva, R. A., Jacquet, P. A., Stergiopulos, N., Segers, P. Tags: Vascular biology Source Type: research

CARD9 mediates necrotic smooth muscle cell-induced inflammation in macrophages contributing to neointima formation of vein grafts
Conclusion The innate immune protein CARD9 in macrophages may mediate necrotic SMC-induced inflammation by activating NF-B and contributed to neointima formation in the vein grafts. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Liu, Y., Wang, Y., Shi, H., Jia, L., Cheng, J., Cui, W., Li, H., Li, P., Du, J. Tags: Vascular biology Source Type: research

TWEAK/Fn14 interaction promotes oxidative stress through NADPH oxidase activation in macrophages
Conclusions Our results suggest that TWEAK regulates vascular damage by stimulating ROS production in an Nox2-dependent manner. These new insights into the TWEAK/Fn14 axis underline their potential use as therapeutic targets in atherosclerosis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Madrigal-Matute, J., Fernandez-Laso, V., Sastre, C., Llamas-Granda, P., Egido, J., Martin-Ventura, J. L., Zalba, G., Blanco-Colio, L. M. Tags: Vascular biology Source Type: research

Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis
Conclusion We established an inverse correlation between endothelial PEAR1 expression and vascular assembly both in vitro and in vivo. These findings identify PEAR1 as a novel modifier of neoangiogenesis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Vandenbriele, C., Kauskot, A., Vandersmissen, I., Criel, M., Geenens, R., Craps, S., Luttun, A., Janssens, S., Hoylaerts, M. F., Verhamme, P. Tags: Vascular biology Source Type: research

Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE
Conclusion Collectively, these data show that promoting macrophage survival provides a supplemental source of apoE, which hinders pre-existing plaque progression. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Bouchareychas, L., Pirault, J., Saint-Charles, F., Deswaerte, V., Le Roy, T., Jessup, W., Giral, P., Le Goff, W., Huby, T., Gautier, E. L., Lesnik, P. Tags: Vascular biology Source Type: research

Uncoupling of myofilament Ca2+ sensitivity from troponin I phosphorylation by mutations can be reversed by epigallocatechin-3-gallate
Conclusion We conclude that it is possible to both mimic and reverse the pathological defects in troponin caused by cardiomyopathy mutations pharmacologically. Re-coupling by EGCG may be of potential therapeutic significance for treating cardiomyopathies. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Papadaki, M., Vikhorev, P. G., Marston, S. B., Messer, A. E. Tags: Cardiac biology and remodelling Source Type: research

Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts
Conclusion This characterization of the spectrum of kinases expressed in cardiomyocytes and the heart (cardiomyocyte and cardiac kinomes) identified novel kinases, some of which are differentially expressed in failing human hearts and could serve as potential therapeutic targets. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Fuller, S. J., Osborne, S. A., Leonard, S. J., Hardyman, M. A., Vaniotis, G., Allen, B. G., Sugden, P. H., Clerk, A. Tags: Cardiac biology and remodelling Source Type: research

Jagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart
Conclusions Altogether, these data demonstrate the importance of J1ICD in the modulation of physiological and pathological hypertrophy, and reveal the existence of a novel pathway regulating cardiac homeostasis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Metrich, M., Bezdek Pomey, A., Berthonneche, C., Sarre, A., Nemir, M., Pedrazzini, T. Tags: Cardiac biology and remodelling Source Type: research

Human epicardial adipose tissue has a specific transcriptomic signature depending on its anatomical peri-atrial, peri-ventricular, or peri-coronary location
Aims Human epicardial adipose tissue (EAT) is a visceral and perivascular fat that has been shown to act locally on myocardium, atria, and coronary arteries. Its abundance has been linked to coronary artery disease (CAD) and atrial fibrillation. However, its physiological function remains highly debated. The aim of this study was to determine a specific EAT transcriptomic signature, depending on its anatomical peri-atrial (PA), peri-ventricular (PV), or peri-coronary location. Methods and results Samples of EAT and thoracic subcutaneous fat, obtained from 41 patients paired for cardiovascular risk factors, CAD, and atrial...
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Gaborit, B., Venteclef, N., Ancel, P., Pelloux, V., Gariboldi, V., Leprince, P., Amour, J., Hatem, S. N., Jouve, E., Dutour, A., Clement, K. Tags: Cardiac biology and remodelling Source Type: research

ALK7 protects against pathological cardiac hypertrophy in mice
Conclusion Our data suggest that ALK7 acts as a novel regulator of pathological cardiac hypertrophy via the negative regulation of MEK–ERK1/2 signalling and may serve as a potential therapeutic target for pathological cardiac hypertrophy. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Huang, H., Tang, Y., Wu, G., Mei, Y., Liu, W., Liu, X., Wan, N., Liu, Y., Huang, C. Tags: Cardiac biology and remodelling Source Type: research

Transplantation of adipose tissue mesenchymal cells conjugated with VEGF-releasing microcarriers promotes repair in murine myocardial infarction
Conclusions AT-MSCs conjugated with VEGF-releasing PAMs exert paracrine effects that may have therapeutic applications. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Madonna, R., Petrov, L., Teberino, M. A., Manzoli, L., Karam, J.-P., Renna, F. V., Ferdinandy, P., Montero-Menei, C. N., Yla-Herttuala, S., De Caterina, R. Tags: Cardiac biology and remodelling Source Type: research