Ageing is associated with increased variability of cellular reprogramming and wound healing
 Induced pluripotent stem cellsAgeingFibroblastsWound healingRegenerative medicine (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2020 Category: Cardiology Source Type: research

The end of the beginning for drug therapy in obstructive hypertrophic cardiomyopathy with EXPLORER-HCM
Hypertrophic cardiomyopathyMavacamtenCardiac myosin ATPaseOutflow tract obstruction (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 22, 2020 Category: Cardiology Source Type: research

Double trouble: combined cardiovascular effects of particulate matter exposure and coronavirus disease 2019
AbstractThe coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly grown into a pandemic. According to initial reports, the lungs were thought to be the primary target, but recent case studies have shown its reach can extend to other organs including the heart and blood vessels. The severity of cardiac complications of COVID-19 depends on multiple underlying factors, with air pollutant exposure being one of them, as reported by several recent studies. Airborne particulate matter (PM) attracts heightened attention due to its implication in various diseases, esp...
Source: Cardiovascular Research - October 21, 2020 Category: Cardiology Source Type: research

Correction to: Kramann N. et al. ‘B-RAF and its novel negative regulator reticulocalbin 1 (RCN1) modulates cardiomyocyte hypertrophy’
Correction to: Kramann N.et al.‘B-RAF and its novel negative regulator reticulocalbin 1 (RCN1) modulates cardiomyocyte hypertrophy’.Cardiovasc Res 2014;102(1):88 –96. doi:10.1093/cvr/cvu024 (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 20, 2020 Category: Cardiology Source Type: research

Chronic low-dose rapamycin treatment fine tunes cardioprotective signalling in ischaemia-reperfused diabetic hearts
This editorial refers to ‘STAT3-miR-17/20 signaling axis plays a critical role in attenuating myocardial infarction following rapamycin treatment in Diabetic mice’, by A.Samidurai et al. pp. 2103 –2115. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 20, 2020 Category: Cardiology Source Type: research

Omega-3 fatty acids improve flow-induced vasodilation by enhancing TRPV4 in arteries from diet-induced obese mice
ConclusionOmega-3 improve vascular function by improving flow-induced vasodilation via enhancing TRPV4 activity in the endothelium of obese mice which may be related to improved cell membrane physical property. Activation of TRPV4 in endothelium plays an important role in the protective mechanisms of omega-3 against vascular dysfunction in obesity by improving flow-mediated vasodilation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 18, 2020 Category: Cardiology Source Type: research

Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure
ConclusionStrict carbohydrate restriction suppresses pathological cardiac growth and heart failure after pressure overload through distinct anti-hypertrophic mechanisms elicited by supplemented macronutrients. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 18, 2020 Category: Cardiology Source Type: research

Haploinsufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a late-onset senescence-associated pro-fibrotic cardiomyopathy
ConclusionTMEM43 haploinsufficiency is associated with activation of the DDR and the TP53 pathways, which lead to increased expression of SASP and an age-dependent expression of a pro-fibrotic cardiomyopathy. Given that TMEM43 is a nuclear envelope protein and our previous data showing deficiency of another nuclear envelope protein, namely lamin A/C, activates the DDR/TP53 pathway, we surmise that DNA damage is a shared mechanism in the pathogenesis of cardiomyopathies caused by mutations involving nuclear envelope proteins. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 18, 2020 Category: Cardiology Source Type: research

Exogenous ketones in the healthy heart: the plot thickens
This editorial refers to ‘Ketones can become the major fuel source for the heart but do not increase cardiac efficiency’ by K.L. Hoet al., pp.1178 –1187. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 18, 2020 Category: Cardiology Source Type: research

A tribute to James Thornton Willerson, M.D. November 16, 1939 –September 16, 2020
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 18, 2020 Category: Cardiology Source Type: research

SPEG: a key regulator of cardiac calcium homeostasis
AbstractProper cardiac Ca2+ homeostasis is essential for normal excitation –contraction coupling. Perturbations in cardiac Ca2+ handling through altered kinase activity has been implicated in altered cardiac contractility and arrhythmogenesis. Thus, a better understanding of cardiac Ca2+ handling regulation is vital for a better understanding of various human disease processes. ‘Striated muscle preferentially expressed protein kinase’ (SPEG) is a member of the myosin light chain kinase family that is key for normal cardiac function. Work within the last 5 years has revealed that SPEG has a crucial role in maintaining...
Source: Cardiovascular Research - October 17, 2020 Category: Cardiology Source Type: research

The physiological and pathological functions of VEGFR3 in cardiac and lymphatic development and related diseases
AbstractVascular endothelial growth factor receptors (VEGFRs) are part of the evolutionarily conserved VEGF signalling pathways that regulate the development and maintenance of the body ’s cardiovascular and lymphovascular systems. VEGFR3, encoded by theFLT4 gene, has an indispensable and well-characterized function in development and establishment of the lymphatic system. Autosomal dominantVEGFR3 mutations, that prevent the receptor functioning as a homodimer, cause one of the major forms of hereditary primary lymphoedema; Milroy disease. Recently, we and others have shown thatFLT4 variants, distinct to those observed i...
Source: Cardiovascular Research - October 17, 2020 Category: Cardiology Source Type: research

Hypertension and SARS-CoV-2 infection: is inflammation the missing link?
Cardiovascular riskHypertensionSARS-CoV2 infectionCytokine storm; InflammationToll-like 4 receptor (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 17, 2020 Category: Cardiology Source Type: research

Full-length Dhh and N-terminal Shh act as competitive antagonists to regulate angiogenesis and vascular permeability
ConclusionThe present study highlights for the first time that FL-Dhh and N-Hh ligands have antagonistic properties especially in ECs. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 16, 2020 Category: Cardiology Source Type: research

Angiogenesis after acute myocardial infarction
AbstractAcute myocardial infarction (MI) inflicts massive injury to the coronary microcirculation leading to vascular disintegration and capillary rarefication in the infarct region. Tissue repair after MI involves a robust angiogenic response that commences in the infarct border zone and extends into the necrotic infarct core. Technological advances in several areas have provided novel mechanistic understanding of postinfarction angiogenesis and how it may be targeted to improve heart function after MI. Cell lineage tracing studies indicate that new capillary structures arise by sprouting angiogenesis from pre-existing en...
Source: Cardiovascular Research - October 16, 2020 Category: Cardiology Source Type: research