Old dog, new tricks: novel cardiac targets and stress regulation by protein kinase G
The second messenger cyclic guanosine 3'5' monophosphate (cGMP) and its downstream effector protein kinase G (PKG) have been discovered more than 40 years ago. In vessels, PKG1 induces smooth muscle relaxation in response to nitric oxide signalling and thus lowers systemic and pulmonary blood pressure. In platelets, PKG1 stimulation by cGMP inhibits activation and aggregation, and in experimental models of heart failure (HF), PKG1 activation by inhibiting cGMP degradation is protective. The net effect of the above-mentioned signalling is cardiovascular protection. Yet, while modulation of cGMP-PKG has entered clinical prac...
Source: Cardiovascular Research - July 8, 2016 Category: Cardiology Authors: Rainer, P. P., Kass, D. A. Tags: REVIEWS Source Type: research

Pathways for salvage and protection of the heart under stress: novel routes for cardiac rejuvenation
The world population is aging, and by 2017, there will be more people over the age of 65 than under age 5, and by 2050, two billion of the estimated nine billion people on Earth will be older than 60. Aging itself is a major cardiovascular risk factor, affecting morbidity and mortality of the aging population. At the same time, aging increases the likelihood of the presence of other risk factors. The aged myocardium is characterized by several structural and functional progressive changes that impair its ability to respond appropriately to stressful conditions. Although some progress to understand the complex mechanisms th...
Source: Cardiovascular Research - July 8, 2016 Category: Cardiology Authors: Cannata, A., Camparini, L., Sinagra, G., Giacca, M., Loffredo, F. S. Tags: REVIEWS Source Type: research

Succinate metabolism: a new therapeutic target for myocardial reperfusion injury
Myocardial ischaemia/reperfusion (IR) injury is a major cause of death worldwide and remains a disease for which current clinical therapies are strikingly deficient. While the production of mitochondrial reactive oxygen species (ROS) is a critical driver of tissue damage upon reperfusion, the precise mechanisms underlying ROS production have remained elusive. More recently, it has been demonstrated that a specific metabolic mechanism occurs during ischaemia that underlies elevated ROS at reperfusion, suggesting a unifying model as to why so many different compounds have been found to be cardioprotective against IR injury. ...
Source: Cardiovascular Research - July 8, 2016 Category: Cardiology Authors: Pell, V. R., Chouchani, E. T., Frezza, C., Murphy, M. P., Krieg, T. Tags: REVIEWS Source Type: research

Cardiac salvage by tweaking with beta-3-adrenergic receptors
Overstimulation of the orthosympathetic system leads to cardiovascular cell and tissue damage through prolonged activation of β-1-2 adrenergic receptors (BARs). The more recent identification of the third isotype of BAR (B3AR) in cardiac myocytes and endothelial cells with a distinctive coupling and effect on cardiac function and remodelling introduced a new facet to this paradigm. In particular, B3AR is up-regulated in cardiac disease and less prone to homologous desensitization, which may reinforce its influence on the diseased myocardium. Mice with transgenic cardiac-specific expression of the human B3AR are protec...
Source: Cardiovascular Research - July 8, 2016 Category: Cardiology Authors: Balligand, J.-L. Tags: REVIEWS Source Type: research

Virtual issue: focus on cardiovascular protection
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 8, 2016 Category: Cardiology Authors: Vandevelde, W., Sipido, K. R. Tags: INVITED EDITORIALS Source Type: research

Salvage pathways in heart rejuvenation
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 8, 2016 Category: Cardiology Authors: Hirsch, E. Tags: INVITED EDITORIALS Source Type: research

Scientists of Tomorrow at the Frontiers of Cardiovascular Biology 2016 in Florence: translating basic science into clinical practice is the next frontier
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 8, 2016 Category: Cardiology Authors: Antoniades, C., Vilahur, G., on behalf of the Scientists of Tomorrow group of the CBCS of the ESC Tags: INVITED EDITORIALS Source Type: research

Frontiers in Cardiovascular Biology: a forum for exploratory basic science and translational research from the ESC Council for Basic Cardiovascular Sciences
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 8, 2016 Category: Cardiology Authors: Cerbai, E., Sipido, K. R., Badimon, L. Tags: INVITED EDITORIALS Source Type: research

Editorial Board
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 24, 2016 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Cover Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 24, 2016 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Contents Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 24, 2016 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Aims and Scope
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 24, 2016 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development
Conclusion These findings demonstrate the essential roles of LPP3 in the maturation of EC barrier integrity and normal cardiovascular development. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 15, 2016 Category: Cardiology Authors: Chatterjee, I., Baruah, J., Lurie, E. E., Wary, K. K. Tags: Vascular Biology Source Type: research

Conformation of ryanodine receptor-2 gates store-operated calcium entry in rat pulmonary arterial myocytes
Conclusions RyR2-gated Ca2+ store contributes to SOCE in PASMCs; however, store-depletion alone is insufficient but requires a specific RyR conformation modifiable by ryanodine binding to activate Ca2+ entry. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 15, 2016 Category: Cardiology Authors: Lin, A. H. Y., Sun, H., Paudel, O., Lin, M.-J., Sham, J. S. K. Tags: Vascular Biology Source Type: research

Flt-1 (VEGFR-1) coordinates discrete stages of blood vessel formation
Conclusions These results show that VEGF-A signalling has stage-specific effects on vascular morphogenesis, and that understanding these effects on dynamic stages of angiogenesis and how they integrate to expand a vessel network may suggest new therapeutic strategies. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 15, 2016 Category: Cardiology Authors: Chappell, J. C., Cluceru, J. G., Nesmith, J. E., Mouillesseaux, K. P., Bradley, V. B., Hartland, C. M., Hashambhoy-Ramsay, Y. L., Walpole, J., Peirce, S. M., Mac Gabhann, F., Bautch, V. L. Tags: Vascular Biology Source Type: research

Heat shock factor-1 knockout enhances cholesterol 7{alpha}-hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis
Conclusion HSF-1 ablation not only eliminates heat shock response, but it also transcriptionally up-regulates CYP7A1 and MDR1/P-gp axis in WD-diet fed HSF-1–/–/LDLr–/– mice to reduce atherosclerosis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 15, 2016 Category: Cardiology Authors: Krishnamurthy, K., Glaser, S., Alpini, G. D., Cardounel, A. J., Liu, Z., Ilangovan, G. Tags: Vascular Biology Source Type: research

Mimicking the cardiac cycle in intact cardiomyocytes using diastolic and systolic force clamps; measuring power output
Conclusion Here, we introduce a new approach that by combining mechanics, electronics, and a new type optical force transducer can measure the FL relationship of a single isolated cardiomyocyte undergoing a mechanical loop that mimics the PV cycle of a beating heart. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 15, 2016 Category: Cardiology Authors: Helmes, M., Najafi, A., Palmer, B. M., Breel, E., Rijnveld, N., Iannuzzi, D., van der Velden, J. Tags: Cardiac biology and remodelling Source Type: research

The H19 long noncoding RNA is a novel negative regulator of cardiomyocyte hypertrophy
Conclusion These findings reveal a novel function of H19-miR-675 axis targeting CaMKII as a negative regulator of cardiac hypertrophy, suggesting its potential therapeutic role in cardiac diseases. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 15, 2016 Category: Cardiology Authors: Liu, L., An, X., Li, Z., Song, Y., Li, L., Zuo, S., Liu, N., Yang, G., Wang, H., Cheng, X., Zhang, Y., Yang, X., Wang, J. Tags: Cardiac biology and remodelling Source Type: research

Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress
Conclusion Using adult heterozygous zebrafish, we show that ELC S195 phosphorylation is pivotal for adaptation of cardiac function to augmented physical stress and we provide novel mechanistic insights into the pathogenesis of ELC-linked cardiomyopathy. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 15, 2016 Category: Cardiology Authors: Scheid, L.-M., Mosqueira, M., Hein, S., Kossack, M., Juergensen, L., Mueller, M., Meder, B., Fink, R. H. A., Katus, H. A., Hassel, D. Tags: Cardiac biology and remodelling Source Type: research

Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase
Conclusion Our results, using a new mouse model mimicking an acute reduction of cMLCK, suggest that cMLCK plays a pivotal role in the transition from compensated to decompensated hypertrophy via sarcomeric disorganization. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 15, 2016 Category: Cardiology Authors: Massengill, M. T., Ashraf, H. M., Chowdhury, R. R., Chrzanowski, S. M., Kar, J., Warren, S. A., Walter, G. A., Zeng, H., Kang, B.-H., Anderson, R. H., Moss, R. L., Kasahara, H. Tags: Cardiac biology and remodelling Source Type: research

Anti-platelet drugs attenuate the expansion of circulating CD14highCD16+ monocytes under pro-inflammatory conditions
Aims Levels of circulating CD14highCD16+ monocytes increase in atherosclerotic patients and are predictive of future cardiovascular events. Platelet activation has been identified as a crucial determinant in the acquisition of a CD16+ phenotype by classical CD14highCD16– cells. We tested the hypothesis that anti-platelet drugs modulate the phenotype of circulating monocytes. Methods and results Sixty healthy subjects undergoing influenza immunization were randomly assigned to either no treatment or anti-platelet therapy, namely aspirin 300 mg or 75 mg daily, or clopidogrel (300 mg loading dose followed by 75 mg), fo...
Source: Cardiovascular Research - June 15, 2016 Category: Cardiology Authors: Layne, K., Di Giosia, P., Ferro, A., Passacquale, G. Tags: Integrative physiology and pathophysiology Source Type: research

Haemodynamic unloading reverses occlusive vascular lesions in severe pulmonary hypertension
Conclusion Our results indicate that haemodynamic stress is prerequisite to the development and progression of occlusive neointimal lesions in this rat model of severe pulmonary hypertension. We conclude that perivascular inflammation and occlusive neointimal arteriopathy are driven by haemodynamic stress. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 15, 2016 Category: Cardiology Authors: Abe, K., Shinoda, M., Tanaka, M., Kuwabara, Y., Yoshida, K., Hirooka, Y., McMurtry, I. F., Oka, M., Sunagawa, K. Tags: Integrative physiology and pathophysiology Source Type: research

Ryanodine receptor-2: a necessity for gating store-operated Ca2+ channels
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 15, 2016 Category: Cardiology Authors: Song, S., Ayon, R. J., Yuan, J. X.- J. Tags: EDITORIALS Source Type: research

Is stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 15, 2016 Category: Cardiology Authors: Akoumianakis, I., Antoniades, C. Tags: EDITORIALS Source Type: research

A balancing act in cardiac hypertrophy
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 15, 2016 Category: Cardiology Authors: Matkovich, S. J. Tags: EDITORIALS Source Type: research

Myosin light chain phosphorylation, novel targets to repair a broken heart?
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 15, 2016 Category: Cardiology Authors: Szczesna-Cordary, D., de Tombe, P. P. Tags: EDITORIALS Source Type: research

Pulmonary hypertension begets pulmonary hypertension: mutually reinforcing roles for haemodynamics, inflammation, and cancer-like phenotypes
(Source: Cardiovascular Research)
Source: Cardiovascular Research - June 15, 2016 Category: Cardiology Authors: Wu, D., Archer, S. L. Tags: EDITORIALS Source Type: research

Regulation of JAK/STAT signalling by SOCS in the myocardium
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Tags: CORRIGENDA Source Type: research

A glimpse of Cre-mediated controversies in epicardial signalling
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Tags: CORRIGENDA Source Type: research

Patient-derived models link re-entrant driver localization in atrial fibrillation to fibrosis spatial pattern
Aims The mechanisms underlying persistent atrial fibrillation (AF) in patients with atrial fibrosis are poorly understood. The goal of this study was to use patient-derived atrial models to test the hypothesis that AF re-entrant drivers (RDs) persist only in regions with specific fibrosis patterns. Methods and results Twenty patients with persistent AF (PsAF) underwent late gadolinium-enhanced MRI to detect the presence of atrial fibrosis. Segmented images were used to construct personalized 3D models of the fibrotic atria with biophysically realistic atrial electrophysiology. In each model, rapid pacing was applied to in...
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Zahid, S., Cochet, H., Boyle, P. M., Schwarz, E. L., Whyte, K. N., Vigmond, E. J., Dubois, R., Hocini, M., Haïssaguerre, M., Jaïs, P., Trayanova, N. A. Tags: Ion Channels and Arrhythmias Source Type: research

Down-regulation of Fibulin-5 is associated with aortic dilation: role of inflammation and epigenetics
Conclusion We evidence the deregulation of FBLN5 in human AAA and identify a SOX9/HDAC-dependent mechanism involved in the down-regulation of FBLN5 by inflammation. HDAC inhibitors or pharmacological approaches that aimed to preserve FBLN5 could be useful to prevent the disorganization of ECM induced by inflammation in AAA. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Orriols, M., Varona, S., Marti-Pamies, I., Galan, M., Guadall, A., Escudero, J. R., Martin-Ventura, J. L., Camacho, M., Vila, L., Martinez-Gonzalez, J., Rodriguez, C. Tags: Vascular Biology Source Type: research

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins
Conclusion The present proteomics study provides unprecedented insights into the expression and degradation of structural and regulatory components of the vascular extracellular matrix in varicosis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Barallobre-Barreiro, J., Oklu, R., Lynch, M., Fava, M., Baig, F., Yin, X., Barwari, T., Potier, D. N., Albadawi, H., Jahangiri, M., Porter, K. E., Watkins, M. T., Misra, S., Stoughton, J., Mayr, M. Tags: Vascular Biology Source Type: research

Augmentation of phosphate-induced osteo-/chondrogenic transformation of vascular smooth muscle cells by homoarginine
Conclusion Homoarginine augments osteo-/chondrogenic transformation of VSMCs and vascular calcification, effects involving impaired NO formation from homoarginine. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Alesutan, I., Feger, M., Tuffaha, R., Castor, T., Musculus, K., Buehling, S. S., Heine, C. L., Kuro-O, M., Pieske, B., Schmidt, K., Tomaschitz, A., Maerz, W., Pilz, S., Meinitzer, A., Voelkl, J., Lang, F. Tags: Vascular Biology Source Type: research

Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes
Conclusion In adult cardiac myocytes, tortuosity due to physical barriers, notably mitochondria, restricts cAMP diffusion to levels that are more compatible with microdomain signalling. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Richards, M., Lomas, O., Jalink, K., Ford, K. L., Vaughan-Jones, R. D., Lefkimmiatis, K., Swietach, P. Tags: Cardiac biology and remodelling Source Type: research

Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb/E2f-signalling
Conclusions We identified Dyrk1a as a novel negative regulator of D-cyclin-mediated Rb/E2f-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy, dose-specific Dyrk1a expression and activity appears to be critical for the hyperplastic and hypertrophic growth of the developing heart. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Hille, S., Dierck, F., Kühl, C., Sosna, J., Adam-Klages, S., Adam, D., Lüllmann-Rauch, R., Frey, N., Kuhn, C. Tags: Cardiac biology and remodelling Source Type: research

Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats
This study sought to delineate the role of CatA for the development of atrial remodelling under diabetic conditions. Methods and results Zucker Diabetic Fatty rats (ZDF) were treated with vehicle (n = 20) or CatA-inhibitor (SAR; 50 mg/kg; n = 20), and compared with age-matched non-diabetic littermates (Ctr, n = 20). Left-atrial (LA) emptying function [magnetic resonance imaging (MRI)] and atrial electrophysiological parameters were measured before sacrifice for histological and biochemical analysis. The impact of enhanced cardiac CatA expression on atrial remodelling was determined using CatA-transgenic mice. At the age o...
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Linz, D., Hohl, M., Dhein, S., Ruf, S., Reil, J.-C., Kabiri, M., Wohlfart, P., Verheule, S., Böhm, M., Sadowski, T., Schotten, U. Tags: Cardiac biology and remodelling Source Type: research

The angiotensin receptor-associated protein Atrap is a stimulator of the cardiac Ca2+-ATPase SERCA2a
Conclusion We identified Atrap as a novel regulatory protein of the cardiac Ca2+-ATPase SERCA2a. We suggest that Atrap enhances the activity of SERCA2a and, consequently, facilitates ventricular relaxation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Mederle, K., Gess, B., Pluteanu, F., Plackic, J., Tiefenbach, K.-J., Grill, A., Kockskämper, J., Castrop, H. Tags: Cardiac biology and remodelling Source Type: research

Prolyl hydroxylation regulates protein degradation, synthesis, and splicing in human induced pluripotent stem cell-derived cardiomyocytes
Conclusions This study provides the first extensive characterization of the cardiac prolyl hydroxylome and demonstrates that inhibition of α-ketoglutarate hydroxylases alters protein stability, translation, and splicing. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Stoehr, A., Yang, Y., Patel, S., Evangelista, A. M., Aponte, A., Wang, G., Liu, P., Boylston, J., Kloner, P. H., Lin, Y., Gucek, M., Zhu, J., Murphy, E. Tags: Cardiac biology and remodelling Source Type: research

BMP-7 attenuates left ventricular remodelling under pressure overload and facilitates reverse remodelling and functional recovery
Conclusion The disequilibrium between BMP-7 and TGF-β signals plays a relevant role in the LV remodelling response to haemodynamic stress in TAC mice and AS patients. Our observations may provide new important insights aimed at developing novel therapies designed to prevent, halt, or reverse LV pathological remodelling in pressure overload cardiomyopathy. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Merino, D., Villar, A. V., Garcia, R., Tramullas, M., Ruiz, L., Ribas, C., Cabezudo, S., Nistal, J. F., Hurle, M. A. Tags: Cardiac biology and remodelling Source Type: research

Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice
Conclusion These findings suggest that circulating or MSC-EXOs may modulate pulmonary hypertensive effects based on their miR cargo. The ability of MSC-EXOs to reverse MCT-PH offers a promising potential target for new PAH therapies. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Aliotta, J. M., Pereira, M., Wen, S., Dooner, M. S., Del Tatto, M., Papa, E., Goldberg, L. R., Baird, G. L., Ventetuolo, C. E., Quesenberry, P. J., Klinger, J. R. Tags: Integrative physiology and pathophysiology Source Type: research

Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk
Conclusions Hsp70 induction is a novel approach to delay thrombus formation with minimal bleeding risk, and is especially promising for treating AF patients and in other situations where there is also a major bleeding hazard. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Allende, M., Molina, E., Guruceaga, E., Tamayo, I., Gonzalez-Porras, J. R., Gonzalez-Lopez, T. J., Toledo, E., Rabal, O., Ugarte, A., Roldan, V., Rivera, J., Oyarzabal, J., Montes, R., Hermida, J. Tags: Integrative physiology and pathophysiology Source Type: research

Matrix ageing and vascular impacts: focus on elastin fragmentation
Cardiovascular diseases (CVDs) are the leading cause of death worldwide and represent a major problem of public health. Over the years, life expectancy has considerably increased throughout the world, and the prevalence of CVD is inevitably rising with the growing ageing of the population. The normal process of ageing is associated with progressive deterioration in structure and function of the vasculature, commonly called vascular ageing. At the vascular level, extracellular matrix (ECM) ageing leads to molecular alterations in long half-life proteins, such as elastin and collagen, and have critical effects on vascular di...
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Duca, L., Blaise, S., Romier, B., Laffargue, M., Gayral, S., El Btaouri, H., Kawecki, C., Guillot, A., Martiny, L., Debelle, L., Maurice, P. Tags: REVIEW Source Type: research

How does fibrosis promote atrial fibrillation persistence: in silico findings, clinical observations, and experimental data
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Nattel, S. Tags: EDITORIAL Source Type: research

Beware of the content!--exosomes as benefactors and agitators
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Hoefer, I. E. Tags: EDITORIAL Source Type: research

Hsp70 preventing thrombosis: benefit without burden?
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Authors: Duerschmied, D., Bode, C. Tags: EDITORIAL Source Type: research

Editorial Board
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Cover Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Contents Page
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Aims and Scope
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 19, 2016 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: research

Nav1.5 N-terminal domain binding to {alpha}1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels
Conclusions The results demonstrate the critical role of the N-terminal domain of Nav1.5 channels in Nav1.5–Kir2.x-reciprocal interactions and suggest that the molecular mechanisms controlling atrial and ventricular cellular excitability may be different. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 19, 2016 Category: Cardiology Authors: Matamoros, M., Perez-Hernandez, M., Guerrero-Serna, G., Amoros, I., Barana, A., Nunez, M., Ponce-Balbuena, D., Sacristan, S., Gomez, R., Tamargo, J., Caballero, R., Jalife, J., Delpon, E. Tags: Ion Channels and Arrhythmias Source Type: research